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Evidence based information about the health effects of edible mushrooms, especially of their effects on immune function and cancer risk.
Updated on 2009-10-29
Created on 2009-04-12
Category: Health & Wellness
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Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density
Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density.
Abreu MT, Kantorovich V, Vasiliauskas EA, Gruntmanis U, Matuk R, Daigle K, Chen S, Zehnder D, Lin YC, Yang H, Hewison M, Adams JS.
Gut. 2004 Aug;53(8):1129-36.
PMID: 15247180
doi: 10.1136/gut.2003.036657.
Conclusions: These data demonstrate that elevated 1,25(OH)2D is more common in CD than previously appreciated and is independently associated with low bone mineral density. The source of the active vitamin D may be the inflamed intestine. Treatment of the underlying inflammation may improve metabolic bone disease in this subgroup of patients. -
Various Selected Vegetables, Fruits, Mushrooms and Red Wine Residue Inhibit Bone Resorption in Rats -- Mühlbauer et al. 133 (11): 3592 -- Journal of Nutrition
Various selected vegetables, fruits, mushrooms and red wine residue inhibit bone resorption in rats.
Mühlbauer RC, Lozano A, Reinli A, Wetli H.
J Nutr. 2003 Nov;133(11):3592-7.
PMID: 14608079 -
Ergothioneine - Wikipedia, the free encyclopedia
Ergothioneine is a naturally-occurring amino acid and is a thiourea derivative of histidine, containing a sulfur atom in the imidazole ring. This compound is made in rather few organisms, notably Actinobacteria and filamentous fungi.[1] Ergothioneine was discovered in 1909 and named after the ergot fungus from which it was first purified, with its structure being determined later, in 1911.[2] This amino acid has antioxidant properties, but its chemistry differs from conventional sulfur-containing antioxidants such as glutathione or lipoic acid.
Although ergothioneine cannot be made in human cells, it is present in some tissues at high levels as it is absorbed from the diet.[3] In humans ergothioneine is taken up from the gut and concentrated in the tissues by a specific transporter called the novel organic cation transporter. However, even today, one hundred years after its discovery, precisely what ergothioneine does in the human body remains a mystery -
Mushrooms are top source for one antioxidant, ergothioneine
Using a new, more sensitive-testing approach they developed for fungi, Penn State food scientists have found that mushrooms are a better natural source of the antioxidant ergothioneine than either of the two dietary sources previously believed to be best.
The researchers found that white button mushrooms, the most commonly consumed kind in the U.S., have about 12 times more of the antioxidant than wheat germ and 4 times more than chicken liver, the previous top-rated ergothioneine sources based on available data. Until the Penn State researchers developed their testing approach, known as an assay, there was no method employing the most sensitive modern instrumentation and analytical techniques to quantify the amount of ergothioneine in fungi. The researchers say that their assay can be used for other plants, too, not just mushrooms. -
White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell proliferation. - J Nutr. 2001 Dec
White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell proliferation.
Grube BJ, Eng ET, Kao YC, Kwon A, Chen S.
J Nutr. 2001 Dec;131(12):3288-93.
PMID: 11739882 -
Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus). - Cancer Res. 2006 Dec 15
Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus).
Chen S, Oh SR, Phung S, Hur G, Ye JJ, Kwok SL, Shrode GE, Belury M, Adams LS, Williams D.
Cancer Res. 2006 Dec 15;66(24):12026-34.
PMID: 17178902
doi: 10.1158/0008-5472.CAN-06-2206 -
White button mushroom (Agaricus bisporus) exhibits antiproliferative and proapoptotic properties and inhibits prostate tumor growth in athymic mice. - [Nutr Cancer. 2008] - PubMed Result
White button mushroom (Agaricus bisporus) exhibits antiproliferative and proapoptotic properties and inhibits prostate tumor growth in athymic mice. Adams LS, Phung S, Wu X, Ki L, Chen S.
Nutr Cancer. 2008;60(6):744-56. n
PMID: 19005974 -
Sloan-Kettering - Coriolus Versicolor
Coriolus versicolor is a mushroom of the Basidiomycetes class. It was used initially in Traditional Chinese medicine as a tonic, but recent studies suggest that it has immunostimulant and anti-tumor properties. Polysaccharide-K (PSK), a proprietary product derived from Coriolus, was developed for cancer treatment in Japan. When used as an adjuvant, PSK appears to improve survival rates in patients with gastric (1) (2) and colorectal (3) (4) (5) cancers. Other Coriolus extracts, such as polysaccharide-peptide (PSP) and VPS, are available as dietary supplements. When used in conjunction with chemotherapy, PSP may benefit patients with advanced non-small cell lung cancer (7). Other clinical studies using Coriolus extract alone or in combination with other botanicals also suggest positive immunomodulatory effects (8) (9). However, studies on breast cancer (10), hepatocellular carcinoma (11), and leukemia (12) produced mixed results. A hot water extract of Coriolus, VPS, was found to enhance development of large intestinal tumors in mice (21). Coriolus extracts are generally well tolerated but minor adverse effects have been reported.
Many over-the-counter Coriolus products are not standardized, making it difficult to compare potency between brands. It is also unclear if PSK, PSP and other Coriolus extracts have comparable effects. -
Immunomax sienirihmastovalmiste 80 kaps. - 39,90EUR - Verkkoapteekki.fi
Immunomax on vahva immunostimulantti.
Immunomax kapselit sisältävät biologisesti aktivoitua sienirihmastovalmistetta. Aktiiviset aineosat, erityisesti polysakkaridit ja glykoproteiinit, tehostavat elimistön puolustusjärjestelmää.
Tiedemiehet ovat jo pitkään tutkineet Kaukoidän sieniä löytääkseen niistä elimistön immuunijärjestelmää vahvistavia aineita. Tutkimuksissa shiitakesta eristetty ja biologisesti aktivoitu soluseinän komponentti on osoittautunut tehokkaaksi elimistön puolustusjärjestelmien vahvistajaksi. -
AHCC : Dan Kenner, Bookplus.fi
AHCC
Active Hexose Correlated Compound
Dan Kenner
Kustantaja: Woodland Publishing
Ilmoitettu julkaisupäivä/vuosi: 30.09.2001
ISBN: 9781580543408
Hinta: 5,95
Saatavuus: Tilattavissa
Kieli: Englanti
Sivuja: 30
Kuuluu sarjaan: WOODLAND HEALTH SERIES
Tuotemuoto: Pehmeäkantinen, nidottu
Mitat (leveys x korkeus cm): 14 x 21
Paino: 50
Etsi tälle tuotteelle vaihtoehtoiset teokset (eri muoto, eri julkaisija...) muoto, eri julkaisija...) -
AHCC :: Home
What is AHCC?
The world’s most researched specialty immune supplement with over 80 supporting research studies.
Japan’s leading alternative cancer therapy used in hundreds of cancer clinics throughout Asia.
Highly effective immuno-modulator used in over 700 clinics as a standard preventative regiment for all incoming patient to reduce the risk of hospital infections.
The daily immune supplement of tens of thousands of healthy people in Japan and worldwide, seeking to help their bodies to fight the formation of abnormal cells, whose growth can lead to cancer, chronic disease and infections (such as the influenza / flu virus). -
Study Demonstrates That AHCC(R) Provides Immune Enhancement Against The West Nile Virus
A recently completed study from researchers at Colorado State University supported by the Division of Vector-Borne Infectious Diseases with the Centers for Disease Control and Prevention (CDC) has demonstrated that AHCC(R) (Active Hexose Correlated Compound) enhances host resistance by boosting protective immune responses specific to the West Nile Virus.
Since its discovery in the United States in 1999, infections caused by the West Nile Virus have become a major public health concern. West Nile Virus is caused by people being bitten by mosquitoes infected with the virus. According to the CDC, there have been 28,018 reported cases with 1,092 deaths since 1999. In 2003, the highest number of cases was reported at nearly 10,000. Currently there is no effective treatment for the disease. -
A Phase I study of the safety of the nutritional supplement, active hexose correlated compound, AHCC, in healthy volunteers. - JNSV : Vol. 53 (2007) , No. 6 pp.536-539
A Phase I study of the safety of the nutritional supplement, active hexose correlated compound, AHCC, in healthy volunteers.
Spierings EL, Fujii H, Sun B, Walshe T.
J Nutr Sci Vitaminol (Tokyo). 2007 Dec;53(6):536-9.
PMID: 18202543
doi:10.3177/jnsv.53.536 -
Supplementation with active hexose correlated compound increases survival following infectious challenge in mice. - Nutr Rev. 2008 Sep - Wiley InterScience :: JOURNALS :: Nutrition Reviews
Supplementation with active hexose correlated compound increases survival following infectious challenge in mice.
Ritz BW.
Nutr Rev. 2008 Sep;66(9):526-31. Review.
PMID: 18752476
DOI: 10.1111/j.1753-4887.2008.00085.x -
Active Hexose Correlated Compound shown to enhances immune system by increasing production of key dendritic cells
A recently published study in Nutrition and Cancer (60(5), 643-651) by researchers at Kansai Medical University in Osaka, Japan has shown that AHCC (Active Hexose Correlated Compound) enhances immune function by increasing the number of dendritic cells (DCs).
DCs are a key part of the immune system responsible for presenting foreign substances to other immune system cells.
The study was conducted in a double-blind randomized fashion where twenty-one healthy subjects received a placebo or AHCC at 3.0 g/day for 4 weeks. Blood samples were obtained and measured at baseline and at 4 weeks. The number of circulating types of DCs was measured which included CD 11c+ DCs (myeloid DC population; DC1) and CD11c- DCs (lymphoid DC population; DC2). Other parameters measured included mixed-leukocyte reaction (MLR), natural killer (NK) cell activity, the proliferative response of T lymphocytes toward mitogen (phytohemagglutinin [PHA]) and cytokine production of interleukin (IL)-2, IL-4, IL-6, IL-10, interferon gamma-gamma, and (alpha)-tumor necrosis factor. -
Evaluation of active hexose correlated compound hepatic metabolism and potential for drug interactions with chemotherapy agents. - .[J Soc Integr Oncol. 2008] - PubMed Result
Evaluation of active hexose correlated compound hepatic metabolism and potential for drug interactions with chemotherapy agents.
Mach CM, Fugii H, Wakame K, Smith J.
J Soc Integr Oncol. 2008 Summer;6(3):105-9.
PMID: 19087767 -
Low-dose supplementation with active hexose correlated compound improves the immune response to acute influenza infection in C57BL/6 mice - Nutr Res. 2009 Feb
Low-dose supplementation with active hexose correlated compound improves the immune response to acute influenza infection in C57BL/6 mice.
Nogusa S, Gerbino J, Ritz BW.
Nutr Res. 2009 Feb;29(2):139-43.
PMID: 19285605
doi:10.1016/j.nutres.2009.01.005 -
Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice. - J Nutr. 2009 Mar
Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice.
Wang S, Welte T, Fang H, Chang GJ, Born WK, O'Brien RL, Sun B, Fujii H, Kosuna K, Wang T.
J Nutr. 2009 Mar;139(3):598-602. Epub 2009 Jan 13.
PMID: 19141700
doi:10.3945/jn.108.100297 -
Immunological effect of active hexose correlated compound (AHCC) in healthy volunteers: a double-blind, placebo-controlled trial. - [Nutr Cancer. 2008] - PubMed Result
Immunological effect of active hexose correlated compound (AHCC) in healthy volunteers: a double-blind, placebo-controlled trial.
Terakawa N, Matsui Y, Satoi S, Yanagimoto H, Takahashi K, Yamamoto T, Yamao J, Takai S, Kwon AH, Kamiyama Y.
Nutr Cancer. 2008;60(5):643-51.
PMID: 18791928 -
Active hexose correlated compound acts as a prebiotic and is antiinflammatory in rats with hapten-induced colitis - J Nutr. 2007 May
Active hexose correlated compound acts as a prebiotic and is antiinflammatory in rats with hapten-induced colitis.
Daddaoua A, Martínez-Plata E, López-Posadas R, Vieites JM, González M, Requena P, Zarzuelo A, Suárez MD, de Medina FS, Martínez-Augustin O.
J Nutr. 2007 May;137(5):1222-8.
PMID: 17449585
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