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Retinol-induced Intestinal Tumorigenesis in Min/+ Mice and Importance of Vitamin D Status. - [Anticancer Res. 2009] - PubMed result
"Retinol-induced Intestinal Tumorigenesis in Min/+ Mice and Importance of Vitamin D Status.
Hetland RB, Alexander J, Berg JP, Svendsen C, Paulsen JE.
Anticancer Res. 2009 Nov;29(11):4353-60.
PMID: 20032378
The effects of life-long dietary exposure, starting in utero, to high retinol, low vitamin D, or high retinol in combination with low vitamin D on intestinal tumorigenesis in Min/+ mice were investigated. In males, high retinol alone significantly increased the number (2.6-fold) and size (1.3-fold) of small intestinal tumours; in females no significant increase in tumour number or size was seen. In both genders, low vitamin D intake alone did not affect intestinal tumorigenesis. In males, intake of the combined high retinol/low vitamin D diet did not further increase the effects caused by high retinol alone. In females, however, the high retinol/low vitamin D-induced increase in tumour number (3.1-fold) and tumour size (1.5-fold) exceeded that of high retinol alone. In conclusion, a high dietary intake of retinol stimulated intestinal tumorigenesis in Min/+ mice. Furthermore, the results indicate a combined effect of high retinol and low vitamin D on tumorigenesis in females"
SUNARC - Sunlight, Nutrition And Health Research Center
"Cancer mortality rates and multiple sclerosis prevalence rates for U.S. states compared to UVB doses for July"
Reducing the Burden of Disease Through Adequate Intake of Vitamin D3 by William B. Grant, Ph.D.
Reducing the Burden of Disease Through Adequate Intake of Vitamin D3.
A presentation at University of California, San Diego,
April 9, 2008
by William B. Grant, Ph.D
Vitamin D 5000iu (120 softgels) [NOW V47] - £13.99 : Vitamin UK, The premier site for healthy living
Vitamin D 5000iu (120 softgels)
£15.99 £13.99
NOW Vitamin D softgels supply this key vitamin in a highly-absorbable liquid softgel form. Vitamin D is normally obtained from the diet or produced by the skin from the ultra-violet energy of the sun. However, it is not abundant in food. As more people avoid sun exposure, Vitamin D supplementation becomes even more necessary to ensure that your body receives an adequate supply. Suggested Use: As a dietary supplement, take 1 softgel every 3 days with a meal or as directed by your health care practitione"
Dr. Joe's E-News - A Diabetes Newsletter: East German Infants Taking Vitamin D
"From 1955 to 1990, all infants in East Germany received 600,000 IU of Vitamin D every three months for a total of 3,600,000 IU at age 18 months.
With the 400 IU/day recommendation of the American Pediatric Association in mind, I ran across this amazing paper while surfing Medline for Vitamin D. According to this paper, all infants in the German Democratic Republic (East Germany) received dangerously high doses of Vitamin D every three months in their doctors office. The policy was in place for 35 years. The first 600,000 IU dose was given at three months and then every three months until the child was 18 months of age. This works out to an average of 6,000 IU per day (actually, for several technical reasons it is not equivalent) for 18 months. The authors collected blood before the dose and then 2 weeks after the quarterly dose to obtain 25(OH)D, 1,25(OH)D, and calcium levels on a total of 43 infants.
Before the first dose, at 3 months of age, the average infant was extremely deficient (median 25(OH)D of 7 ng/ml). Two weeks after the first dose the average 25(OH)D level was 120 ng/ml, the second dose 170 ng/ml, the third dose, 180 ng/ml, the fourth dose, 144 ng/ml, the fifth dose, 110 ng/ml and after the sixth and final dose, 3.6 million total units, at age 18 months, the children had mean levels of 100 ng/ml. That is, by the 15 and 18 month doses, the children were beginning to effectively handle these massive doses.
The highest level recorded in any of the 43 infants was 408 ng/ml at age 9 months, two weeks after the third 600,000 IU dose. Thirty-four percent of the infants had at least one episode of hypercalcemia but only 3 had an elevated serum 1,25(OH)D. The authors reported that all the infants appeared healthy, even the infant with a level of 408 ng/ml, that is, no clinical toxicity was noted in any of these infants."
The Vitamin D Research Library is open for your learning pleasure
"Do Your Vitamin D Research Here
Links to all the Latest Research Studies
Welcome to the Vitamin D Research Library.
Here you'll find links to all of the latest Vitamin D Facts and Research studies, clinical trials and other scholarly Vitamin D Facts. The Research Library is Open 24/7 and is always growing. I'll be adding more and more links all of the time.
Can't find what you are looking for or just don't want to spend the time doing the research yourself? Chances are, I've already done the Vitamin D Research myself and can answer your question.
Read Frequently Asked Questions about Vitamin D
OR
Ask Your Question About Vitamin D Here
and I'll answer your Question about Vitamin D Personally based on the best available Vitamin D Research."
The Vitamin D Research Library is open for your learning pleasure - section 8
"Do Your Vitamin D Research Here
Links to all the Latest Research Studies
Welcome to the Vitamin D Research Library.
Here you'll find links to all of the latest Vitamin D Facts and Research studies, clinical trials and other scholarly Vitamin D Facts. The Research Library is Open 24/7 and is always growing. I'll be adding more and more links all of the time.
Can't find what you are looking for or just don't want to spend the time doing the research yourself? Chances are, I've already done the Vitamin D Research myself and can answer your question."
Know the Vitamin D facts. Your Health Depends Upon It
"Vitamin D facts are not well known - even though this fat soluble vitamin is essential to our good health. As more and more Vitamin D facts are being discovered in Vitamin D research, this vitamin is being found to be IMPERATIVE to our good health in many different ways."
NephroPal: PPARs
"Summer vs Winter Mode: Explaining AMPK
Last year I read an article which made a statement that has not left my mind. The statement went as follows: "You are only good as your mitochondria." In fact, the more a dwell into the details of human metabolism, the more I sense that this is true - especially with the metabolic syndrome.
For those who are not familiar with the concept of mitochondria, they are the tiny energy factories within the cells that produce cellular energy through aerobic means (meaning oxygen). Mitochondria utilize oxygen to ultimately produce Adenosine Triphosphate or simply ATP. ATP relays energy by donating a phosphate bond resulting in Adenosine Diphosphate (ADP). Another phosphate release would entail Adenosine Monophosphate or AMP. ATP is one of the main sources of cellular energy in the body
NephroPal: Vitamin D - The saga goes on...
"Had enough about reading/hearing about Vitamin D? Well, it keeps on coming. And for my lack of surprise, the medical community in general is not catching on like wild fire. I really don't understand it.
A recent study from the Heart Institute at Intermountain Medical Center in Salt Lake City (click) followed 27,686 patients greater than 50 years of age with no prior history of cardiovascular disease. The Vitamin D levels were checked and classified as such:
* normal - greater than 30 ng/ml
* low - 15 to 30
* very low - less than 15
The results of the study showed that patients with very low Vitamin D levels in comparison to normal had:
* 77% greater risk of death
* 45% increased risk of coronary artery disease
* 78% increased risk of stroke
* twice the risk of developing heart failure"
Manninen Nutraceuticals: Pharma D3 - Vahva D-vitamiinivalmiste
"Lukuisat tieteelliset tutkimuksen ovat osoittaneet, että valtaosa suomalaisista kärsii D-vitamiinin puutoksesta, joten Manninen Nutraceuticals Oy on lanseerannut oman D-vitamiinivalmisteen. Nimensä mukaisesti Pharma D3 sisältää D3-vitamiini eli kolekalsiferolia, mikä on selvästi D2-vitamiinia eli ergokalsiferolia tehokkaampaa. Pharma D3 valmistetaan GMP- ja HACCP- ja EOFS-sertifioidussa lääketehtaassa. Pharma D3 on kliinisesti ADME-testattu eli imeytyminen (Absorption), jakautuminen (Distribution), aineenvaihdunta (Metabolism) ja erittyminen (Excretion) on kliinisissä tutkimuksissa dokumentoitu.
Suositeltava vuorokausiannos: 1 tabletti vuorokaudessa
Suositeltu vuorokausiannos sisältää:
D3-vitamiini eli kolekalsiferoli 25 mcg (500 %)*
*Vuorokautisen saannin vertailuarvosta"
The Bioavailability of Vitamin D from Fortified Cheeses and Supplements Is Equivalent in Adults -- Wagner et al. 138 (7): 1365 -- Journal of Nutrition
The bioavailability of vitamin D from fortified cheeses and supplements is equivalent in adults.
Wagner D, Sidhom G, Whiting SJ, Rousseau D, Vieth R.
J Nutr. 2008 Jul;138(7):1365-71.
PMID: 18567762
Compared with baseline, serum parathyroid hormone decreased with both fortification (P = 0.003) and supplementation (P = 0.012). These data demonstrate that vitamin D is equally bioavailable from fortified hard cheeses and supplements, making cheese suitable for vitamin D fortification
Bread Fortified with Cholecalciferol Increases the Serum 25-Hydroxyvitamin D Concentration in Women as Effectively as a Cholecalciferol Supplement -- Natri et al. 136 (1): 123 -- Journal of Nutrition
Bread fortified with cholecalciferol increases the serum 25-hydroxyvitamin D concentration in women as effectively as a cholecalciferol supplement.
Natri AM, Salo P, Vikstedt T, Palssa A, Huttunen M, Kärkkäinen MU, Salovaara H, Piironen V, Jakobsen J, Lamberg-Allardt CJ.
J Nutr. 2006 Jan;136(1):123-7.
PMID: 16365070
Both fortified breads increased serum 25-hydroxyvitamin D concentration as effectively as the cholecalciferol supplement. Supplementation or fortification did not affect serum intact parathyroid hormone concentration or urinary calcium excretion. In conclusion, fortified bread is a safe and feasible way to improve vitamin D nutrition.
A randomised comparison of increase in serum 25-hydroxyvitamin D concentration after 4 weeks of daily oral intake of 10 μg cholecalciferol from multivitamin tablets or fish oil capsules in healthy young adults
A randomised comparison of increase in serum 25-hydroxyvitamin D concentration after 4 weeks of daily oral intake of 10 microg cholecalciferol from multivitamin tablets or fish oil capsules in healthy young adults.
Holvik K, Madar AA, Meyer HE, Lofthus CM, Stene LC.
Br J Nutr. 2007 Sep;98(3):620-5. Epub 2007 Apr 24.
PMID: 17456248
We conclude that fish oil capsules and multivitamin tablets containing 10 microg cholecalciferol administered over a 4-week period produced a similar mean increase in s-25(OH)D concentration.
Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology - European Journal of Clinical Nutrition - Abstract of article
Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology.
Peterlik M, Cross HS.
Eur J Clin Nutr. 2009 Dec;63(12):1377-86. Epub 2009 Sep 2.
PMID: 19724293
doi:10.1038/ejcn.2009.105
A compromised vitamin D status, characterized by low 25-hydroxyvitamin D (25-(OH)D) serum levels, and a nutritional calcium deficit are widely encountered in European and North American countries, independent of age or gender. Both conditions are linked to the pathogenesis of many degenerative, malignant, inflammatory and metabolic diseases. Studies on tissue-specific expression and activity of vitamin D metabolizing enzymes, 25-(OH)D-1alpha-hydroxylase and 25-(OH)D-24-hydroxylase, and of the extracellular calcium-sensing receptor (CaR) have led to the understanding of how, in non-renal tissues and cellular systems, locally produced 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) and extracellular Ca2+ act jointly as key regulators of cellular proliferation, differentiation and function. Impairment of cooperative signalling from the 1,25-(OH)2D3-activated vitamin D receptor (VDR) and from the CaR in vitamin D and calcium insufficiency causes cellular dysfunction in many organs and biological systems, and, therefore, increases the risk of diseases, particularly of osteoporosis, colorectal and breast cancer, inflammatory bowel disease, insulin-dependent diabetes mellitus type I, metabolic syndrome, diabetes mellitus type II, hypertension and cardiovascular disease. Understanding the underlying molecular and cellular processes provides a rationale for advocating adequate intake of vitamin D and calcium in all populations, thereby preventing many chronic diseases worldwide.
Pharma D3 1700 tabl. (HINTAPOMMI!) / Vitamiinit ja mineraalit / Manninen Nutraceuticals
"Pharma D3 1700 tabl. (HINTAPOMMI!)
Hinta: 54.90EUR (hinta sis. alv 12%)
Valmistaja: Manninen Nutraceuticals
Kerro kaverille
Tuotearvioinnit: 0
Tuotekuvaus
1700 tabletin jättipakkaus markkinoiden korkealuokkaisinta D3-vitamiinia huippudullisesti!"
Vitamin D may curb diabetes - Pharmacy News
A New Zealand study has found that South Asian women with insulin resistance improved markedly after taking vitamin D supplements
Nutrition researcher Pamela von Hurst of the Institute of Food, Nutrition and Human Health at Albany, said while diet and exercise played a major part in the onset of type-2 diabetes, her findings reinforced the importance of vitamin D from the sun and supplements to prevent type-2 diabetes.
Initial screening of 235 Auckland women from India, Pakistan and Sri Lanka aged 20 and older, revealed 47 per cent were insulin deficient and 84 per cent were vitamin D deficient. The 81 recruited for the study were split into two groups for a randomised controlled trial and given a vitamin D supplement or placebo. As well as an improvement in insulin resistance among those who took vitamin D for six months, Ms Von Hurst said post-menopausal women in the study also showed a reduced rate of bone breakdown.
On the Trail of the Elusive X-Factor: A Sixty-Two-Year-Old Mystery Finally Solved
In 1945, Dr. Weston Price described "a new vitamin-like activator" that played an influential role in the utilization of minerals, protection from tooth decay, growth and development, reproduction, protection against heart disease and the function of the brain.
Using a chemical test, he determined that this compound—which he called Activator X—occurred in the butterfat, organs and fat of animals consuming rapidly growing green grass, and also in certain sea foods such as fish eggs.
Vitamin K2 is produced by animal tissues, including the mammary glands, from vitamin K1, which occurs in rapidly growing green plants.
A growing body of published research confirms Dr. Price's discoveries, namely that vitamin K2 is important for the utilization of minerals, protects against tooth decay, supports growth and development, is involved in normal reproduction, protects against calcification of the arteries leading to heart disease, and is a major component of the brain
sunlightD.org - Main -sunlightandvitamind.com
sunlightD.org
Grassroots Health and ZRT Labs are working together to help us all make sure we have enough vitamin D. Participate in understanding vitamin D. Visit grassrootshealth.net and join the research project. You'll get your D tested twice a year for five years. The cost is just $40 a test, $80 a year, more than reasonable for accurate D testing, and you'll help provide real answers, for yourself and for us all, about how much D we get and how much we need. Join now. Do commit to the full 5 years if you decide to sign on. If not joining for the full test period please use the testing links below.
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