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Vitamin D, nervous system and aging. - Tuohimaa et al. - Psychoneuroendocrinology Volume 34, Supplement 1, December 2009, Pages S278-S286 (full text PDF)
Vitamin D, nervous system and aging.
P. Tuohimaaa, T. Keisalaa, A. Minasyana, J. Cachatc and A. Kalueffc.
Psychoneuroendocrinology, Volume 34, Supplement 1, December 2009, Pages S278-S286
NEUROACTIVE STEROIDS: EFFECTS AND MECHANISMS OF ACTION
doi:10.1016/j.psyneuen.2009.07.003
This is a mini-review of vitamin D3, its active metabolites and their functioning in the central nervous system (CNS), especially in relation to nervous system pathologies and aging. The vitamin D3 endocrine system consists of 3 active calcipherol hormones: calcidiol (25OHD3), 1α-calcitriol (1α,25(OH)2D3) and 24-calcitriol (24,25(OH)2D3). The impact of the calcipherol hormone system on aging, health and disease is discussed. Low serum calcidiol concentrations are associated with an increased risk of several chronic diseases including osteoporosis, cancer, diabetes, autoimmune disorders, hypertension, atherosclerosis and muscle weakness all of which can be considered aging-related diseases. The relationship of many of these diseases and aging-related changes in physiology show a U-shaped response curve to serum calcidiol concentrations. Clinical data suggest that vitamin D3 insufficiency is associated with an increased risk of several CNS diseases, including multiple sclerosis, Alzheimer's and Parkinson's disease, seasonal affective disorder and schizophrenia. In line with this, recent animal and human studies suggest that vitamin D insufficiency is associated with abnormal development and functioning of the CNS. Overall, imbalances in the calcipherol system appear to cause abnormal function, including premature aging, of the CNS.
Vitamin D and Disease Incidence Prevention | Free The Animal
"For what reason I don't know, but this January 2009 editorial by William Faloon of the Life Extension Foundation is making the rounds. Perhaps it just came available on the web.
It's a good read, particularly in light of the billions and trillions of dollars the thieves & thugs in DC are about to flush down the crapper on your behalf. Some notable excerpts.
A large number of new vitamin D studies have appeared in the scientific literature since I wrote my plea to the federal government. These studies don’t just confirm what we knew 16 months ago—they show that optimizing vitamin D intake will save even more lives than what we projected.
For instance, a study published in June 2008 showed that men with low vitamin D levels suffer 2.42 times more heart attacks. Now look what this means in actual body counts.
Each year, about 157,000 Americans die from coronary artery disease-related heart attacks. Based on this most recent study, if every American optimized their vitamin D status, the number of deaths prevented from this kind of heart attack would be 92,500.
To put the number of lives saved in context, tens of millions of dollars are being spent to advertise that Lipitor® reduces heart attacks by 37%. This is certainly a decent number, but not when compared with how many lives could be saved by vitamin D. According to the latest study, men with the higher vitamin D levels had a 142% reduction in heart attacks."
Vitamin D, nervous system and aging - ScienceDirect - Psychoneuroendocrinology
Vitamin D, nervous system and aging.
P. Tuohimaaa, T. Keisalaa, A. Minasyana, J. Cachatc and A. Kalueffc.
Psychoneuroendocrinology, Volume 34, Supplement 1, December 2009, Pages S278-S286
NEUROACTIVE STEROIDS: EFFECTS AND MECHANISMS OF ACTION
doi:10.1016/j.psyneuen.2009.07.003
This is a mini-review of vitamin D3, its active metabolites and their functioning in the central nervous system (CNS), especially in relation to nervous system pathologies and aging. The vitamin D3 endocrine system consists of 3 active calcipherol hormones: calcidiol (25OHD3), 1α-calcitriol (1α,25(OH)2D3) and 24-calcitriol (24,25(OH)2D3). The impact of the calcipherol hormone system on aging, health and disease is discussed. Low serum calcidiol concentrations are associated with an increased risk of several chronic diseases including osteoporosis, cancer, diabetes, autoimmune disorders, hypertension, atherosclerosis and muscle weakness all of which can be considered aging-related diseases. The relationship of many of these diseases and aging-related changes in physiology show a U-shaped response curve to serum calcidiol concentrations. Clinical data suggest that vitamin D3 insufficiency is associated with an increased risk of several CNS diseases, including multiple sclerosis, Alzheimer's and Parkinson's disease, seasonal affective disorder and schizophrenia. In line with this, recent animal and human studies suggest that vitamin D insufficiency is associated with abnormal development and functioning of the CNS. Overall, imbalances in the calcipherol system appear to cause abnormal function, including premature aging, of the CNS.
Meta-analysis of longitudinal studies: Serum vitamin D and prostate cancer risk - ScienceDirect - Cancer Epidemiology
Meta-analysis of longitudinal studies: Serum vitamin D and prostate cancer risk.
Yin L, Raum E, Haug U, Arndt V, Brenner H.
Cancer Epidemiol. 2009 Dec;33(6):435-45. Epub 2009 Nov 25.
PMID: 19939760
doi:10.1016/j.canep.2009.10.014
CONCLUSIONS: According to available evidence from longitudinal studies, serum 25(OH)D is not associated with PC incidence.
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.
Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL, Hatcher B, Cox CL, Dyachenko A, Zhang W, McGahan JP, Seibert A, Krauss RM, Chiu S, Schaefer EJ, Ai M, Otokozawa S, Nakajima K, Nakano T, Beysen C, Hellerstein MK, Berglund L, Havel PJ.
J Clin Invest. 2009 May;119(5):1322-34. Epub 2009 Apr 20.
PMID: 19381015
doi: 10.1172/JCI37385.
Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and the 23-hour postprandial triglyceride AUC were increased specifically during fructose consumption. Similarly, markers of altered lipid metabolism and lipoprotein remodeling, including fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant-like particle–triglyceride and –cholesterol significantly increased during fructose but not glucose consumption. In addition, fasting plasma glucose and insulin levels increased and insulin sensitivity decreased in subjects consuming fructose but not in those consuming glucose. These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults.
NEJM -- Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease
Genetic variants associated with Lp(a) lipoprotein level and coronary disease.
Clarke R, Peden JF, Hopewell JC, Kyriakou T, Goel A, Heath SC, Parish S, Barlera S, Franzosi MG, Rust S, Bennett D, Silveira A, Malarstig A, Green FR, Lathrop M, Gigante B, Leander K, de Faire U, Seedorf U, Hamsten A, Collins R, Watkins H, Farrall M; PROCARDIS Consortium.
N Engl J Med. 2009 Dec 24;361(26):2518-28.
PMID: 20032323
Conclusions We identified two LPA variants that were strongly associated with both an increased level of Lp(a) lipoprotein and an increased risk of coronary disease. Our findings provide support for a causal role of Lp(a) lipoprotein in coronary disease.
New cholesterol type - Prof WatkinsNew BHF-funded research from the University of Oxford shows that a type of cholesterol called Lipoprotein(a) definitely plays a role in causing heart disease. - British Heart Foundation
"23/12/2009
Convincing evidence that a third type of cholesterol plays a role in causing heart disease
Prof WatkinsNew BHF-funded research from the University of Oxford shows that a type of cholesterol called Lipoprotein(a) definitely plays a role in causing heart disease.
Published today in the New England Journal of Medicine, the findings could add new medicines to doctors' toolkits for preventing heart disease, and open new avenues of research for treatments.
Lipoprotein(a), or Lp(a), has been associated with heart disease since the 1990s, but until now it has not been possible to distinguish whether it actually causes heart disease. Now a study analysing the genes of nearly 16,000 people from the UK and across Europe has provided evidence that two variations of the gene for Lp(a) are strongly linked to heart disease risk, indicating a causal role in disease development."
Strongest evidence yet that Lp(a) causes heart disease - New genetic study unequivocally proves role of Lp(a) in heart disease - theheart.org
"Strongest evidence yet that Lp(a) causes heart disease
December 23, 2009 | Lisa Nainggolan
Oxford, UK - New genetic research has identified two relatively rare single nucleotide polymorphisms (SNPs) that explain just over a third of the variance in lipoprotein(a) (Lp[a]) levels in individuals of European descent [1]. The work confirms unequivocally that Lp(a) is a causal factor for coronary disease, say Dr Robert Clarke (University of Oxford, UK) and colleagues in their paper in the December 24, 2009 issue of the New England Journal of Medicine.
"This is the most convincing evidence so far that this protein [Lp(a)] is directly part of the pathway that causes heart disease rather than a bystander. If we can target it through treatment, we might expect to lower the risk of disease," coauthor Dr Hugh Watkins (University of Oxford) told heartwire. "
Näin pidät luusi kasassa pidempään - Studio55.fi
"Älä unohda D-vitamiinia
Kalsiumin merkitys luuston hyvinvoinnin kannalta on pureutunut ihmisten mieliin tukevasti, mutta D-vitamiinin tärkeys luustolle on jostain syystä jäänyt vähemmälle huomiolle. Se on luiden haurastumisen ehkäisyn kannalta kuitenkin yhtä ratkaisevan tärkeässä asemassa kuin kalsiumkin.
Ihminen saa D-vitamiinia erityisesti auringonvalosta, joka tekee suomalaisista pohjoisen pallonpuoliskon valottomuuden "uhreja".
– Suomalaiset eivät saa riittävästi auringonvaloa, minkä takia kärsimme D-vitamiinin puutteesta oikeastaan ympäri vuoden, Tuppurainen kertoo.
D-vitamiinin saaminen tulisikin turvata toisin keinoin, esimerkiksi ruokavalion avulla: luustolle korvaamattoman arvokasta vitamiinia saa etenkin kalasta."
Viikon etelänmatkalta koko talven D-vitamiinit - Studio55.fi
Päivän ohjelman vieras, emeritusprofessori Pentti Tuohimaa on tukinut Tampereen yliopistossa D-vitamiinia. Merkittävää on ollut huomata, että kalsidioli, joka on yksi D-vitamiinin muoto, on hormonaalisesti aktiivinen. Se taas merkitsee sitä, että d-vitamiini vaikuttaa ihmisen terveyteen paljon laajemmin, kuin mitä on tähän asti luultu.
– D-vitamiinin puutos saattaa lisätä riskiä kaikkiin vanhenemiseen liittyviin kroonisiin sairauksiin, Pentti Tuohimaa sanoi päivän ohjelmassa.
Toisaalta myös liian suuret D-vitamiinipitoisuudet lisäävät sairastuvuutta.
– D-vitamiinin vaikutus tautiriskeihin on U-kirjaimen muotoinen eli sekä hyvin matalilla että hyvin korkeilla D-vitamiinipitoisuuksilla sairastumisriski lisääntyy, Tuohimaa selitti.
– Englantilaisen tutkimuksen mukaan lapsena koetut palamiset auringossa vähentävät riskiä sairastua eturauhassyöpään.
D-vitamiinilla lisää ikävuosia - 21.12 Hyvällä mielellä - Studio55
"D-vitamiinilla lisää ikävuosia
Studio55 saa tänään vieraakseen emeritusprofessori Pentti Tuohimaan, joka saapuu ohjelmaan puhumaan D-vitamiinista. Tuohimaa arvelee, että D-vitamiinin terveydelliset vaikutukset olisi syytä arvioida uudelleen. Siitä voi olla hyötyä jopa kausi-influenssan torjunnassa, mutta suurimmat kansainterveydelliset vaikutukset saataisiin kroonisten vanhuuteen liittyvien sairauksien ehkäisyssä. Nettisivuilla käsitellään laajemmin terveys-aihetta ja puhutaan muun muassa luustosta"
Hyperlipid: Cholesterol within nations studies
"These are the slides from the within-countries discussion on cholesterol and heart disease. I've allowed the sarcasm back in, which was strictly limited when the slides were originally presented. OK, there is a correlation. In fact, if you are a bloke, having a cholesterol above that certain magic number on the graph is clearly catastrophic and boy, are you in trouble. No statins to save your life in those days!"
Tässä ovat vuoden 2009 parhaat Nokia-laitteet ja -palvelut
"Vuosi 2009 alkaa lähestyä loppuun. Nokialle kyseessä oli melko vaikea vuosi kokonaisuudessaan, mutta myös vaikeaan vuoteen mahtui paljon hyviäkin uusia laitteita sekä tärkeitä palvelujulkistuksia. Nokian oma Nokia Conversations -blogi on joulukuun aikana kysellyt lukijoidensa mielipiteitä Nokian vuoden 2009 parhaasta laitteesta sekä parhaasta palveluista, kuin myös parhaimmista Nokiaan liittyvistä ohjelmista ja sovelluksista.
Nokia Conversationsin tulokset ovat nyt tässä: vuoden parhaaksi laitteeksi äänestettiin ylivoimaisesti Nokia N900, parhaan palvelun tittelin jakoivat tasatuloksella Ovi Store -sisältökauppa ja Ovi Maps -karttapalvelu, minkä ohella parhaimmaksi Nokia-sovellukseksi valittiin Twitterin käyttöön tarkoitettu kolmannen osapuolen Gravity-sovellus.
Laitekategorissa N900:n parhaaksi valitsi jopa 59 prosenttia äänestäjistä. Kakkossijalle sijoittunut Nokia E72 ja kolmossijalle yltänyt Nokia N97 mini jäivät kymmenen ja yhdeksän prosentin ääniosuuksillaan todella kauas taakse. N900:n hyvyydestä voidaan toki aina kiistellä sen Maemo-alustan tietynlaisen keskeneräisyyden vuoksi, mutta joka tapauksessa N900 oli loppupeleissä selkeän enemmistönkin mielestä Nokian paras laitejulkistus vuonna 2009.
Palvelukategoriassa Ovi Store oli vuoden ehdottomasti tärkein julkistus, mutta toisaalta Ovi Maps säilynee yhä Nokian palveluista toimivampana. Molemmat keräsivät itselleen 23 prosenttia annetuista äänistä. Kolmospaikan parhaan palvelun kisassa valtasi muun muassa helpon push-sähköpostin mukanaan tuova Nokia Messaging -viestintäsovellus. Nokia Messagingiin tullaan lisäämään sähköpostin ohella myös pikaviesti- ja yhteisöpalvelutoiminnot, mutta näiden osalta ollaan vielä valmista versiota edeltävässä beetatestivaiheessa. "
Unexpected Perks of Coffee Consumption - The Early Show - CBS News
"(CBS) Your daily cup of java may deliver some unexpected health benefits. Studies have shown it may lower your risk for Type II diabetes and certain types of cancer (colon, mouth and throat), and protect against heart disease and cavities.
Dr. Alanna Levine, a primary care physician, said on "The Early Show" researchers aren't sure exactly why coffee has these benefits, but speculated that perhaps the coffee has antioxidant properties. "
Liisan lista: vuodenvaihteeseen Orionin merkeissä – Artikkelit – Pörssisäätiö
"Liisan listan kärki jatkaa vuodenvaihteessa tutuissa merkeissä Orionin johdolla. Uusia nousijoita listakärkeen ovat mm. Marimekko ja Elisa.
Tästä listalla on kaiken kaikkiaan kyse: lue lisää Liisan listasta.
Oletko eri mieltä? Katso Liisan listan tosiaikainen tilanne juuri nyt. Voit tutustua listan taustadataan ja luoda helposti oman ranking-listasi >>
* Liisan lista >>
* Tulosparantajat >>
* Arvoyhtiöt >>"
Neidonhiuspuu-uute ei estä dementiaa | Ohjelmaopas | yle.fi
"Neidonhiuspuu-uute ei estä dementiaa
(29.12.2009 klo 23.00) Neidonhiuspuu-uute ei estä dementiaa
Neidonhiuspuun uute ei estä dementiaa eikä hidasta sen etenemistä, osoittaa Yhdysvalloissa tehty kaksoissokkotutkimus. Yli 3000 ihmisellä tehty seurantatutkimus on laajin aiheesta tehty satunnaistettu kaksoissokkotutkimus ja tuloksiltaan yhdenmukainen aiempien, pienempään koehenkilöiden joukkoon perustuvien tutkimusten kanssa.
Neidonhiuspuun eli Gingko biloba -puun uutetta mainostetaan dementiaa ja Alzheimerin tautia estävänä tuotteena myös Suomessa. Sen hyödystä ei ole kunnollista tieteellistä tutkimusta ja väitteet perustuvat lyhyisiin kokeisiin pienillä koehenkilöiden määrillä. Äskettäin ilmestynyt ns. Cochrane-tutkimus joka kokoaa kriittisesti aiempia tutkimuksia, päätyi arvioon että uutteesta ei ole hyötyä.
Arvovaltaisessa JAMA-lehdessä julkaistu amerikkalaistutkimus aloitettiin vuonna 2000 ja siihen on osallistunut 3069 ihmistä, iältään 72-90-vuotiaita. Tutkimuksen alussa he asuivat itsenäisesti kotonaan ja olivat henkisesti hyväkuntoisia, älyllisiltä toiminnoiltaan normaaleja tai kärsivät korkeintaan lievästä älyllisten toimintojen heikkenemisestä."
Ginkgo Biloba Doesn't Slow Mental Decline
"Dec. 29, 2009 - The hot-selling herbal supplement ginkgo biloba doesn't slow age-related mental decline, a six-year clinical study shows.
The study has already shown that ginkgo does not prevent dementia or Alzheimer's disease in the elderly.
Now study leader Steven T. DeKosky, MD, and colleagues have sifted through the data to look for some sign that ginkgo might slow mental decline in healthy, aging individuals -- or, perhaps, in those already showing the first signs of cognitive impairment.
No such sign was found.
"Compared with placebo, the use of Ginkgo biloba, 120 mg twice daily, did not result in less cognitive decline in older adults with normal cognition or with mild cognitive impairment," the researchers conclude."
Drug from mushroom may help treat cancer - UPI.com
"NOTTINGHAM, England, Dec. 29 (UPI) -- A drug derived from a mushroom -- cordycepin -- may be used to treat some cancers, British researchers say.
Dr. Cornelia de Moor of The University of Nottingham in England and colleagues are investigating the drug originally extracted from a rare parasitic mushroom called cordyceps that grows on caterpillars.
The researchers say low-dose cordycepin seems to inhibit the uncontrolled growth and division of cells and at high doses it also inhibits growth by stopping cells from sticking together. Both of these effects, they say, probably have the same underlying mechanism -- interfering with the production of cell proteins.
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