Home
Matti Narkia's Library tagged → View Popular
Use of vitamin D in clinical practice. - Altern Med Rev. 2008 Mar
Use of vitamin D in clinical practice.
Cannell JJ, Hollis BW.
Altern Med Rev. 2008 Mar;13(1):6-20.
PMID: 18377099
The recent discovery--from a meta-analysis of 18 randomized controlled trials--that supplemental cholecalciferol (vitamin D) significantly reduces all-cause mortality emphasizes the medical, ethical, and legal implications of promptly diagnosing and adequately treating vitamin D deficiency. Not only are such deficiencies common, and probably the rule, vitamin D deficiency is implicated in most of the diseases of civilization. Vitamin D's final metabolic product is a potent, pleiotropic, repair and maintenance, seco-steroid hormone that targets more than 200 human genes in a wide variety of tissues, meaning it has as many mechanisms of action as genes it targets. One of the most important genes vitamin D up-regulates is for cathelicidin, a naturally occurring broad-spectrum antibiotic. Natural vitamin D levels, those found in humans living in a sun-rich environment, are between 40-70 ng per ml, levels obtained by few modern humans. Assessing serum 25-hydroxy-vitamin D (25(OH)D) is the only way to make the diagnosis and to assure treatment is adequate and safe. Three treatment modalities exist for vitamin D deficiency: sunlight, artificial ultraviolet B (UVB) radiation, and vitamin D3 supplementation. Treatment of vitamin D deficiency in otherwise healthy patients with 2,000-7,000 IU vitamin D per day should be sufficient to maintain year-round 25(OH)D levels between 40-70 ng per mL. In those with serious illnesses associated with vitamin D deficiency, such as cancer, heart disease, multiple sclerosis, diabetes, autism, and a host of other illnesses, doses should be sufficient to maintain year-round 25(OH)D levels between 55 -70 ng per mL. Vitamin D-deficient patients with serious illness should not only be supplemented more aggressively than the well, they should have more frequent monitoring of serum 25(OH)D and serum calcium. Vitamin D should always be adjuvant treatment in patients with serious ill
Diagnosis and treatment of vitamin D deficiency; Expert Opinion on Pharmacotherapy - 9(1):Pages 107-118 - Informa Healthcare
Diagnosis and treatment of vitamin D deficiency.
Cannell JJ, Hollis BW, Zasloff M, Heaney RP.
Expert Opin Pharmacother. 2008 Jan;9(1):107-18.
PMID: 18076342
The recent discovery – in a randomised, controlled trial – that daily ingestion of 1100 IU of colecalciferol (vitamin D) over a 4-year period dramatically reduced the incidence of non-skin cancers makes it difficult to overstate the potential medical, social and economic implications of treating vitamin D deficiency. Not only are such deficiencies common, probably the rule, vitamin D deficiency stands implicated in a host of diseases other than cancer. The metabolic product of vitamin D is a potent, pleiotropic, repair and maintenance, secosteroid hormone that targets > 200 human genes in a wide variety of tissues, meaning it has as many mechanisms of action as genes it targets. A common misconception is that government agencies designed present intake recommendations to prevent or treat vitamin D deficiency. They did not. Instead, they are guidelines to prevent particular metabolic bone diseases. Official recommendations were never designed and are not effective in preventing or treating vitamin D deficiency and in no way limit the freedom of the physician – or responsibility – to do so. At this time, assessing serum 25-hydroxy-vitamin D is the only way to make the diagnosis and to assure that treatment is adequate and safe. The authors believe that treatment should be sufficient to maintain levels found in humans living naturally in a sun-rich environment, that is, > 40 ng/ml, year around. Three treatment modalities exist: sunlight, artificial ultraviolet B radiation or supplementation. All treatment modalities have their potential risks and benefits. Benefits of all treatment modalities outweigh potential risks and greatly outweigh the risk of no treatment. As a prolonged ‘vitamin D winter’, centred on the winter solstice, occurs at many temperate latitudes, ≤ 5000 IU (125 μg) of vitamin D/day may be required in obese, aged and/or dark-skinned patients
Venice under water - The Big Picture - Boston.com
"The recent "acqua alta" (high water) in Venice, Italy reached a depth of 1.56 meters (5 ft, 1 in.) on Monday - the deepest flood in 22 years, and the fourth highest flood level in recent history, claimed Venice's Tide Center. The water began to subside on Tuesday, while residents and tourists made their way through the city, hip-waders or not - one man even took the opportunity to ride his wakeboard through Piazza San Marco (until police stepped in). Although this flood was severe enough for the mayor to ask tourists to temporarily stay home, Venetian floods are fairly routine, several occurring every year, and residents usually take it all in stride. (25 photos total)"
[Vitamin K2] [Clin Calcium. 2008] - PubMed result
[Vitamin K2]
Ishida Y.
Clin Calcium. 2008 Oct;18(10):1476-82. Review. Japanese.
PMID: 18830045
"Vitamin K2 has been approved for the treatment of osteoporosis in Japan since 1995. Vitamin K2 treatment in osteoporosis has been shown to inhibit the occurrence of new bone fractures and to maintain BMD. The uniqueness of the prevention of bone fractures by vitamin K2 is that there has been no direct evidence of the relationship between increase of BMD and a decrease in the occurrence of bone fractures. A recent systematic review of seven Japanese randomized controlled trials by Cockayne has also shown that supplementation with phytonadione (Vitamin K1) and menaquinone (Vitamin K2) , particularly menaquinone-4, is associated with increased BMD and reduced fracture incidence. To confirm these results, a larger well design RCT using fractures as the primary endpoint is clearly needed."
Vitamin D can aid fertility - Telegraph
"Women with fertility problems may benefit from taking vitamin D supplements, research has found.
A study has found a link between low levels of Vitamin D and problems with ovulation.
The research may offer a simple, cheap and safe option for women to try before resorting to drugs."
Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine -- Zhang et al. 93 (7): 2559 -- Journal of Clinical Endocrinology & Metabolism
Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine.
Zhang Y, Li X, Zou D, Liu W, Yang J, Zhu N, Huo L, Wang M, Hong J, Wu P, Ren G, Ning G.
J Clin Endocrinol Metab. 2008 Jul;93(7):2559-65. Epub 2008 Apr 8.
PMID: 18397984
doi:10.1210/jc.2007-2404
Conclusions: Berberine is effective and safe in the treatment of type 2 diabetes and dyslipidemia.
Maitohappobakteerit - sfnet.keskustelu.terveys | Google Groups
Keskustelua maitohappobakteereista ja probiooteista sfnet.keskustelu.terveys -ryhmassä 17.8.2008.
A vitamin D nutritional cornucopia: new insights concerning the serum 25-hydroxyvitamin D status of the US population -- Norman 88 (6): 1455 -- American Journal of Clinical Nutrition
A vitamin D nutritional cornucopia: new insights concerning the serum 25-hydroxyvitamin D status of the US population.
Norman AW.
Am J Clin Nutr. 2008 Dec;88(6):1455-6.
PMID: 19064502
doi:10.3945/ajcn.2008.27049
In summary, the report of Looker et al should be required reading for all nutritionists, clinicians, and vitamin D aficionados who are decision makers with regard to 25(OH)D assays, vitamin D nutritional policy, and the care of patients with vitamin D–related diseases.
Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004 -- Looker et al. 88 (6): 1519 -- American Journal of Clinical Nutrition
Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004.
Looker AC, Pfeiffer CM, Lacher DA, Schleicher RL, Picciano MF, Yetley EA.
Am J Clin Nutr. 2008 Dec;88(6):1519-27.
PMID: 19064511
doi:10.3945/ajcn.2008.26182
Conclusions: Overall, mean serum 25(OH)D was lower in 2000–2004 than 1988–1994. Assay changes unrelated to changes in vitamin D status accounted for much of the difference in most population groups. In an adult subgroup, combined changes in BMI, milk intake, and sun protection appeared to contribute to a real decline in vitamin D status.
In summary, age-standardized mean serum 25(OH)D concentrations based on observed values were significantly lower in 2000–2004 than in 1988–1994 in all groups examined. Adjustment for assay changes noticeably reduced the difference between surveys. However, mean serum 25(OH)D concentrations remained significantly lower in males (except Mexican Americans) in NHANES 2000–2004 than in NHANES III, even after adjustment for assay differences. This remaining difference likely represents a real decline in vitamin D status. Changes in BMI, milk intake, and sun protection appeared to contribute to this decline in a subgroup of non-Hispanic white adults. The possibility that trends in overweight, sun protection, and milk intake may continue supports the need to continue monitoring the serum 25(OH)D status of the population
Mechanisms of Berberine (Natural Yellow 18)-Induced Mitochondrial Dysfunction: Interaction with the Adenine Nucleotide Translocator -- Pereira et al. 105 (2): 408 -- Toxicological Sciences
Mechanisms of berberine (natural yellow 18)-induced mitochondrial dysfunction: interaction with the adenine nucleotide translocator.
Pereira CV, Machado NG, Oliveira PJ.
Toxicol Sci. 2008 Oct;105(2):408-17. Epub 2008 Jul 3.
PMID: 18599498
doi: 10.1124/jpet.107.128017
The data from the present work appear to show that berberine also presents some degree of toxicity to "nontumor" systems, which should be carefully understood. ANT inhibition in nontumor cells by berberine would be responsible for a decrease in energy production and could also result in MPT induction. To the best of our knowledge, no full toxicity assessment exists for berberine in humans, although its use in several commercially available supplements suggests that the compound may present a relatively wide safety interval. In fact, a study with patients with congestive heart failure treated with 1.2 g/day of oral berberine revealed low toxicity and resulted into an average plasma concentration of 0.11 mg/l which would translate into 0.3µM (Zeng and Zeng, 1999Go). Repeated cumulative treatments, alternative forms of formulation (e.g., topical application vs. injection) or more importantly, active mitochondrial accumulation due to its positive charge would be expected to increase its concentration in cells into the range of concentrations used in this study.
Empirical data from nontraditional medicines plus the use of extensive clinical assays would allow the use of berberine as a promising antimelanoma agent while maintaining its safety for humans. In radial/vertical forms of melanoma, a possible topical application of berberine would also be possible, thus minimizing side effects on other organs.
In conclusion, the present work identifies the ANT as an important target for berberine, with clear relevance for its proposed antitumor effects.
More Good News About Vitamin D | Print Article | Newsweek.com
"For more than 80 years, scientists have known that vitamin D is important for building bones. And for most of those 80 years, people thought this was the only thing it was good for. In the past decade, however, we've learned two important things about vitamin D: it appears to have many other important health effects, and many Americans don't get enough of it. In 2008, new research pointed to a vitamin D deficiency as a possible contributing factor in heart disease. And the suspected link between vitamin D deficiency and cancer grew even stronger. This surely will spur much new research in 2009.
Why is vitamin D deficiency so common? The vitamin is made in our skin when sunlight strikes it. Many Americans—especially those who live in the northern part of the country, are elderly or have dark skin—don't soak up enough sun. And the vitamin isn't found in many foods. The main sources are fatty fish (such as salmon, mackerel, herring and sardines) and milk, cereal and juices that have been fortified with it. Vitamin D deficiency often is unsuspected because it causes no direct symptoms; like high blood pressure, it does its damage silently."
Eggs modulate the inflammatory response to carbohydrate restricted diets in overweight men - Nutrition & Metabolism | Full text
Eggs modulate the inflammatory response to carbohydrate restricted diets in overweight men.
Ratliff JC, Mutungi G, Puglisi MJ, Volek JS, Fernandez ML.
Nutr Metab (Lond). 2008 Feb 20;5:6.
PMID: 18289377
Carbohydrate restricted diets (CRD) consistently lower glucose and insulin levels and improve atherogenic dyslipidemia [decreasing triglycerides and increasing HDL cholesterol (HDL-C)]. We have previously shown that male subjects following a CRD experienced significant increases in HDL-C only if they were consuming a higher intake of cholesterol provided by eggs compared to those individuals who were taking lower concentrations of dietary cholesterol. Here, as a follow up of our previous study, we examined the effects of eggs (a source of both dietary cholesterol and lutein) on adiponectin, a marker of insulin sensitivity, and on inflammatory markers in the context of a CRD.
Conclusion
A CRD with daily intake of eggs decreased plasma CRP and increased plasma adiponectin compared to a CRD without eggs. These findings indicate that eggs make a significant contribution to the anti-inflammatory effects of CRD, possibly due to the presence of cholesterol, which increases HDL-C and to the antioxidant lutein which modulates certain inflammatory responses
Egg breakfast enhances weight loss - Int J Obes (Lond). 2008 Oct;32(10):1545-51.
Egg breakfast enhances weight loss.
Vander Wal JS, Gupta A, Khosla P, Dhurandhar NV.
Int J Obes (Lond). 2008 Oct;32(10):1545-51. Epub 2008 Aug 5.
PMID: 18679412
doi: 10.1038/ijo.2008.130
Conclusions
The egg breakfast enhances weight loss, when combined with an energy-deficit diet, but does not induce weight loss in a free-living condition. The inclusion of eggs in a weight management program may offer a nutritious supplement to enhance weight loss.
Biochemical effects of consumption of eggs containing omega-3 polyunsaturated fatty acids.- Ups J Med Sci. 2008] - PubMed result
Biochemical effects of consumption of eggs containing omega-3 polyunsaturated fatty acids.
Ohman M, Akerfeldt T, Nilsson I, Rosen C, Hansson LO, Carlsson M, Larsson A.
Ups J Med Sci. 2008;113(3):315-23.P
MID: 18991244
Today, eggs with an increased content of -3 fatty acids are available but there are few publications on the effects of consumption of such eggs on the lipoproteins and acute phase markers in humans. The aim of the present study was to evaluate the effects of consumption of standard eggs and -3 enriched eggs on lipoproteins, glucose and inflammation markers. Nineteen healthy volunteers consumed one extra egg per day of either standard eggs or omega-3 enriched eggs in a double-blind, cross-over study. The duration of each period was 1 month. The effects of the different egg diets on apolipoprotein A1 and B (Apo A1 and B), lipoprotein (a), creatinine, cystatin C, C-reactive protein, serum amyloid protein A, interleukin 6, triglycerides, glucose, total-, high-density lipoprotein and low-density lipo-protein cholesterol concentrations were analyzed. Addition of one regular egg per day to the normal diet had no negative impact on blood lipids or inflammation markers. Consumption of omega-3 enriched eggs resulted in higher levels of ApoA1, lower ApoB/ApoA1 ratio and lower plasma glucose. These effects have been associated in previous studies with a reduced risk for cardiovascular mortality and diabetes.
Egg consumption in relation to cardiovascular disease and mortality: the story gets more complex -- Eckel 87 (4): 799 -- American Journal of Clinical Nutrition
Egg consumption in relation to cardiovascular disease and mortality: the story gets more complex.
Eckel RH.
Am J Clin Nutr. 2008 Apr;87(4):799-800.
PMID: 1840069
Egg consumption in relation to cardiovascular disease and mortality: the Physicians' Health Study -- Djoussé and Gaziano 87 (4): 964 -- American Journal of Clinical Nutrition
Egg consumption in relation to cardiovascular disease and mortality: the Physicians' Health Study.
Djoussé L, Gaziano JM.
Am J Clin Nutr. 2008 Apr;87(4):964-9.
PMID: 18400720
Results: In an average follow-up of 20 y, 1550 new myocardial infarctions (MIs), 1342 incident strokes, and 5169 deaths occurred. Egg consumption was not associated with incident MI or stroke in a multivariate Cox regression. In contrast, adjusted hazard ratios (95% CI) for mortality were 1.0 (reference), 0.94 (0.87, 1.02), 1.03 (0.95, 1.11), 1.05 (0.93, 1.19), and 1.23 (1.11, 1.36) for the consumption of <1, 1, 2–4, 5–6, and ≥7 eggs/wk, respectively (P for trend < 0.0001). This association was stronger among diabetic subjects, in whom the risk of death in a comparison of the highest with the lowest category of egg consumption was twofold (hazard ratio: 2.01; 95% CI: 1.26, 3.20; P for interaction = 0.09).
Conclusions: Infrequent egg consumption does not seem to influence the risk of CVD in male physicians. In addition, egg consumption was positively related to mortality, more strongly so in diabetic subjects, in the study population.
Dietary Cod Protein Reduces Plasma C-Reactive Protein in Insulin-Resistant Men and Women -- Ouellet et al. 138 (12): 2386 -- Journal of Nutrition
Dietary cod protein reduces plasma C-reactive protein in insulin-resistant men and women.
Ouellet V, Weisnagel SJ, Marois J, Bergeron J, Julien P, Gougeon R, Tchernof A, Holub BJ, Jacques H.
J Nutr. 2008 Dec;138(12):2386-91.
PMID: 19022962
Therefore, these results show that CP can lower hsCRP, a marker of inflammation associated with insulin resistance and type 2 diabetes.
Hyperlipid: Kwasniewski; praise the lard
"This article was originally published in 2004 in the Chicago Tribune. It's still knocking around on the web in various places but the original seems to have disappeared. You can't have too much of a good thing. Obviously Stephan's recent posts on lard prompted me to put this one up. The imported nutritionist doesn't seem quite as dismissive as you might expect! But notice in the last paragraph that the big bogeyman is protein overload damaging the kidneys! On 60g/d of protein??? Sobor clearly knows nothing about high fat diets, certainly not the one he is commenting so authoritatively about in this case!"
Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial - J Intern Med. 2008 Dec;264(6):599-609 - Wiley InterScience :: Article :: HTML Full Text
Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial.
Jorde R, Sneve M, Figenschau Y, Svartberg J, Waterloo K.
J Intern Med. 2008 Dec;264(6):599-609. Epub 2008 Sep 10.
PMID: 18793245
Conclusions. It appears to be a relation between serum levels of 25(OH)D and symptoms of depression. Supplementation with high doses of vitamin D seems to ameliorate these symptoms indicating a possible causal relationship.
Selected Tags
Related Tags
Sponsored Links
Top Contributors
Groups interested in 2008
-
Hawaii vacation planning
My Winter 2008 Hawaii trip ...
Items: 30 | Visits: 309
Created by: Maggie Tsai
-
Emerging Technologies for Careers Services
Links for a talk by Matt Li...
Items: 42 | Visits: 199
Created by: Matt Lingard
-
CRM en Latinoamerica 2008
Selección de posts del blog...
Items: 120 | Visits: 213
Created by: Jesus Hoyos
Diigo is about better ways to research, share and collaborate on information. Learn more »
Join Diigo