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A randomised comparison of increase in serum 25-hydroxyvitamin D concentration after 4 weeks of daily oral intake of 10 μg cholecalciferol from multivitamin tablets or fish oil capsules in healthy young adults
A randomised comparison of increase in serum 25-hydroxyvitamin D concentration after 4 weeks of daily oral intake of 10 microg cholecalciferol from multivitamin tablets or fish oil capsules in healthy young adults.
Holvik K, Madar AA, Meyer HE, Lofthus CM, Stene LC.
Br J Nutr. 2007 Sep;98(3):620-5. Epub 2007 Apr 24.
PMID: 17456248
We conclude that fish oil capsules and multivitamin tablets containing 10 microg cholecalciferol administered over a 4-week period produced a similar mean increase in s-25(OH)D concentration.
Effect of Fish Oil on Heart Rate in Humans: A Meta-Analysis of Randomized Controlled Trials -- Mozaffarian et al. 112 (13): 1945 -- Circulation
Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials.
Mozaffarian D, Geelen A, Brouwer IA, Geleijnse JM, Zock PL, Katan MB.
Circulation. 2005 Sep 27;112(13):1945-52. Epub 2005 Sep 19.
PMID: 16172267
doi: 10.1161/CIRCULATIONAHA.105.556886
Conclusions— In randomized controlled trials in humans, fish oil reduces HR, particularly in those with higher baseline HR or longer treatment duration. These findings provide firm evidence that fish oil consumption directly or indirectly affects cardiac electrophysiology in humans. Po
Fish intake is associated with a reduced progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease -- Erkkilä et al. 80 (3): 626 -- American Journal of Clinical Nutrition
Fish intake is associated with a reduced progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease.
Erkkilä AT, Lichtenstein AH, Mozaffarian D, Herrington DM.
Am J Clin Nutr. 2004 Sep;80(3):626-32.
PMID: 15321802
Conclusions: Consumption of fish is associated with a significantly reduced progression of coronary artery atherosclerosis in women with coronary artery disease.
Serum 25(OH)-Vitamin D Concentration and Risk of Esophageal Squamous Dysplasia — Cancer Epidemiology, Biomarkers & Prevention
Serum 25(OH)-vitamin D concentration and risk of esophageal squamous dysplasia.
Abnet CC, Chen W, Dawsey SM, Wei WQ, Roth MJ, Liu B, Lu N, Taylor PR, Qiao YL.
Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1889-93.
PMID: 17855710
doi: 10.1158/1055-9965.EPI-07-0461
Background: Squamous dysplasia is the precursor lesion for esophageal squamous cell carcinoma, and nutritional factors play an important role in the etiology of this cancer. Previous studies using a variety of measures for vitamin D exposure have reached different conclusions about the association between vitamin D and the risk of developing esophageal cancer.
Conclusions: Higher serum 25(OH)D concentrations were associated with significantly increased risk of squamous dysplasia. No obvious source of measured or unmeasured confounding explains this finding.
In conclusion, we found that a higher serum 25(OH)D concentration was associated with an increased risk of esophageal squamous dysplasia, the precursor lesion for ESCC. This finding concurs with our previous prospective study which found that higher vitamin D status was associated with increased risk of incident ESCC in this same population. These unexpected findings suggest that further studies of the association of vitamin D and digestive tract cancers are needed before the effect of vitamin D in different populations can be elucidated.
Docosahexaenoic Acid Inhibits Superoxide Dismutase 1 Gene Transcription in Human Cancer Cells: The Involvement of Peroxisome Proliferator-Activated Receptor α and Hypoxia-Inducible Factor-2α Signaling - Molecular Pharmacology
Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling.
Tuller ER, Beavers CT, Lou JR, Ihnat MA, Benbrook DM, Ding WQ.
Mol Pharmacol. 2009 Sep;76(3):588-95. Epub 2009 Jun 15.
PMID: 19528198
Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation - ScienceDirect - Clinical Biochemistry
Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation.
Nevin KG, Rajamohan T.
Clin Biochem. 2004 Sep;37(9):830-5.
PMID: 15329324
doi:10.1016/j.clinbiochem.2004.04.010
Conclusion: The results demonstrated the potential beneficiary effect of virgin coconut oil in lowering lipid levels in serum and tissues and LDL oxidation by physiological oxidants. This property of VCO may be attributed to the biologically active polyphenol components present in the oil
Coconut Oil Extract May Be A Weapon Against Food Bacteria
"ScienceDaily (Sep. 10, 2009) — Monolaurin, an extract from coconut oil could be used as a microbial agent in foods, according to a study in the Journal of Food Science, published by the Institute of Food Technologists."
How Coconut Oil Could Help Reduce The Symptoms Of Type 2 Diabetes
A new study in animals demonstrates that a diet rich in coconut oil protects against 'insulin resistance' (an impaired ability of cells to respond to insulin) in muscle and fat. The diet also avoids the accumulation of body fat caused by other high fat diets of similar calorie content. Together these findings are important because obesity and insulin resistance are major factors leading to the development of Type 2 diabetes. "
Blood pressure and atherogenic lipoprotein profiles of fish-diet and vegetarian villagers in Tanzania: the Lugalawa study - The Lancet
Blood pressure and atherogenic lipoprotein profiles of fish-diet and vegetarian villagers in Tanzania: the Lugalawa study.
Pauletto P, Puato M, Caroli MG, Casiglia E, Munhambo AE, Cazzolato G, Bittolo Bon G, Angeli MT, Galli C, Pessina AC.
Lancet. 1996 Sep 21;348(9030):784-8.
PMID: 8813985
Interpretation
In these villagers, consumption of freshwater fish (300-600 g daily) was associated with raised plasma concentrations of n-3 polyunsaturated fatty acids, lower blood pressure, and lower plasma lipid concentrations.
In conclusion, our findings confirm that the favourable risk factor profile originally described for Eskimos living on a diet rich in n-3 polyunsaturated fatty acids is real, and not overestimated.
Combining Radiotherapy and Temozolomide With Dichloracetate in Patients With Newly Diagnosed Glioblastoma - Full Text View - ClinicalTrials.gov
"This is a study to see whether radiotherapy plus chemotherapy (Temozolomide) plus Dichloracetate (DCA) improves overall survival and offers better control of the disease in patients with newly diagnosed Glioblastoma Multiforme Tumours"
Duration of vitamin D synthesis from weather model data for use in prospective epidemiological studies. - Int J Biometeorol. 2009 Sep - SpringerLink - Journal Article
Duration of vitamin D synthesis from weather model data for use in prospective epidemiological studies.
Edvardsen K, Engelsen O, Brustad M.
Int J Biometeorol. 2009 Sep;53(5):451-9. Epub 2009 May 15.
PMID: 19444487
DOI: 10.1007/s00484-009-0231-6
Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression - ScienceDirect - Metabolism
Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.
Zhang H, Wei J, Xue R, Wu JD, Zhao W, Wang ZZ, Wang SK, Zhou ZX, Song DQ, Wang YM, Pan HN, Kong WJ, Jiang JD.
Metabolism. 2009 Sep 3
doi:10.1016/j.metabol.2009.07.029
Liver function was improved greatly in these patients by showing reduction of liver enzymes. Our results confirmed the activity of BBR on InsR in humans and its relationship with the glucose-lowering effect. Together with our previous report, we strongly suggest BBR as an ideal medicine for T2DM with a mechanism different from metformin and rosiglitazone.
Vitamin D effective ultraviolet wavelengths due to scattering in shade - ScienceDirect - The Journal of Steroid Biochemistry and Molecular Biology
Vitamin D effective ultraviolet wavelengths due to scattering in shade.
Turnbull DJ, Parisi AV, Kimlin MG.
J Steroid Biochem Mol Biol. 2005 Sep;96(5):431-6. Epub 2005 Jul 6.
PMID: 16005208
Decreased bioavailability of vitamin D in obesity -- Wortsman et al. 72 (3): 690 -- American Journal of Clinical Nutrition
Decreased bioavailability of vitamin D in obesity.
Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF.
Am J Clin Nutr. 2000 Sep;72(3):690-3. Erratum in: Am J Clin Nutr. 2003 May;77(5):1342.
PMID: 10966885
Conclusions: Obesity-associated vitamin D insufficiency is likely due to the decreased bioavailability of vitamin D3 from cutaneous and dietary sources because of its deposition in body fat compartments.
Obesity and Vitamin D - vitamindcouncil.org
Obesity and Vitamin D
One third of Americans are obese. While much of that epidemic is surely due to playing Nintendo instead of baseball, or the consumption of soft drinks instead of water, does that explain
it all? Is it a coincidence that the twin epidemics of obesity and vitamin D deficiency are occurring together?
Are we meat eaters or vegetarians? Part II | The Blog of Michael R. Eades, M.D.
"Meat eating made us human. The anthropological evidence strongly supports the idea that the addition of increasingly larger amounts of meat in the diet of our predecessors was essential in the evolution of the large human brain. Our large brains came at the metabolic expense of our guts, which shrank as our brains grew.
In April 1995 an article appeared in the journal Current Anthropology that was an intellectual tour de force and, in my view, an example of a perfect theoretical paper. “The Expensive-Tissue Hypothesis” (ETH) by Leslie Aiello and Peter Wheeler demonstrated by a brilliant thought experiment that our species didn’t evolve to eat meat but evolved because it ate meat.
It was our gradual drift toward the much higher quality diet provided by food from animal sources that allowed us to develop the large brains we have. It was hunting and meat eating that reduced our GI tracts and freed up our brains to grow. As I wrote at the start of this post, the evidence indicates that we didn’t evolve to eat meat – we evolved because we ate meat."
Are we meat eaters or vegetarians? Part I | The Blog of Michael R. Eades, M.D.
"One of the problems - if it could be called a problem - in writing this blog and moderating the comments is most readers are pretty intelligent. Occasionally I have the angry vegetarian wander in, take me to task for my errant ways, and, after a comeback or two on my part, drift away to never be heard from again. Thanks to the confirmation bias, this blog pretty much selects against the non-meat eater. So, I tend to forget how many people there are out there who are pretty much clueless about basic nutrition, and how many people there are who bobble through life spouting cliches they've heard along the way as great nutritional truths. Based on the comments I get on this blog, it seems to me that most people are pretty nutritionally sophisticated and reasonable."
How to Optimize Vitamin D Supplementation to Prevent Cancer, Based on Cellular Adaptation and Hydroxylase Enzymology (full text PDF in slideshare)
How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology.
Vieth R.
Anticancer Res. 2009 Sep;29(9):3675-84. Review.
PMID: 19667164
Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model. - [Phytomedicine. 2009] - PubMed result
Berberine inhibits human tongue squamous carcinoma cancer tumor growth in a murine xenograft model.
Ho YT, Yang JS, Lu CC, Chiang JH, Li TC, Lin JJ, Lai KC, Liao CL, Lin JG, Chung JG.
Phytomedicine. 2009 Sep;16(9):887-90. Epub 2009 Mar 20.
PMID: 19303753
Our primary studies showed that berberine induced apoptosis in human tongue cancer SCC-4 cells in vitro. But there is no report to show berberine inhibited SCC-4 cancer cells in vivo on a murine xenograft animal model. SCC-4 tumor cells were implanted into mice and groups of mice were treated with vehicle, berberine (10mg/kg of body weight) and doxorubicin (4mg/kg of body weight). The tested agents were injected once per four days intraperitoneally (i.p.), with treatment starting 4 weeks prior to cells inoculation. Treatment with 4mg/kg of doxorubicin or with 10mg/kg of berberine resulted in a reduction in tumor incidence. Tumor size in xenograft mice treated with 10mg/kg berberine was significantly smaller than that in the control group. Our findings indicated that berbeirne inhibits tumor growth in a xenograft animal model. Therefore, berberine may represent a tongue cancer preventive agent and can be used in clinic.
Hypercalcemia in advanced head and neck squamous cell carcinoma: prevalence and potential impact on palliative care. - [J Support Oncol. 2009 Sep-Oct] - PubMed result
Hypercalcemia in advanced head and neck squamous cell carcinoma: prevalence and potential impact on palliative care.
Alsirafy SA, Sroor MY, Al-Shahri MZ.
J Support Oncol. 2009 Sep-Oct;7(5):154-7.
PMID: 19831158
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