Matti Narkia's Library tagged 2003 →  View Popular

"Helsingin Sanomat kertoo 13.12.03 suomalaistutkijoiden löydöstä seuraavasti:

"Tampereen yliopiston anatomian professorin Pentti Tuohimaan ja solubiologian professorin Timo Ylikomin tutkimusryhmät ovat sekoittaneet D-vitamiinitutkimuksen koko mailmassa. Niiden mukaan D-vitamiinia ei ole olemassakaan, ei ainakaan sellaista kuin on luultu.

Sitä vastoin tutkijat ovat löytäneet uuden hormonin ja sen myötä uuden hormonijärjestelmän. Havainto muuttaa käsityksiä syövän ja monien muiden tautien hoidosta, sillä hormoni vaikuttaakin koko elimistöön".

Kirjoituksen mukaan tutkimusryhmän kiinalaisjäsen Yan-Ru Lou teki vuosi sitten mullistavan havainnon, jonka mukaan maksan tuottama kalsidioli, jota aikaisemmin on pidetty mitättömänä, on hormoni joka vaikuttaa kaikkiin kudoksiin. Se viestittää niille ympäristön tilasta, kertoo milloin niiden pitää jakautua, ja myös estää niitä jakautumasta. D-vitamiinin puutos saa kudokset villiintymään ja voi aiheuttaa syöpää.

Tutkimuksen mukaan tämä maksan tuottama D-vitamiini ehkäisee eturauhassyöpää tai lykkää sen puhkeamista. Se vähentää myös rintasyövän, paksusuolen, peräsuolen, munuaisen, munasarjan, haiman, virtsarakon, ruokatorven, sappirakon ja mahalaukun syövän riskiä, samoin alttiutta sairastua lymfoomaan tai leukemiaan.


Lamberg-Allardtin mukaan monet tutkimustulokset viittaavat siihen, että nykyinen D-vitamiinin saantisuositus ei riitä nostamaan veren kalsidiolipitoisuuksia sopivalle tasolle. D-vitamiinin liikasaanti on haitallista, mutta tällöin puhutaan aivan toisista annoksista kuin mitä ruuasta voi saada. "

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2003 joulukuu uutinen terveys ravitsemus D-vitamiini 25ohd kalsidioli uusi tutkimuslöytö Tuohimaa Ylikomi Lou hormoni Lamberg-Allardt Välimäki

Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils.
Leaf A, Kang JX, Xiao YF, Billman GE.
Circulation. 2003 Jun 3;107(21):2646-52. Review.
PMID: 12782616
doi: 10.1161/01.CIR.0000069566.78305.33

This review will be limited specifically to the beneficial prevention by the n-3 polyunsaturated fatty acids (PUFAs) of arrhythmic deaths, including sudden cardiac death, which annually causes some 300 000 deaths in the United States and millions more worldwide. We will also show that the growing body of positive clinical studies is supported by what has been learned in animal and laboratory studies regarding the mechanism by which n-3 PUFAs prevent cardiac arrhythmias.

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2003 June Circulation Leaf study review humans omega-3 sudden cardiac death sudden_death arrhythmia clinical prevention CVD EPA DHAnutrition medline mechanisms fish oils mechanism

Cardiac benefits of fish consumption may depend on the type of fish meal consumed: the Cardiovascular Health Study.
Mozaffarian D, Lemaitre RN, Kuller LH, Burke GL, Tracy RP, Siscovick DS; Cardiovascular Health Study.
Circulation. 2003 Mar 18;107(10):1372-7.
PMID: 12642356
doi: 10.1161/01.CIR.0000055315.79177.16

Conclusions— Among adults aged >=65 years, modest consumption of tuna or other broiled or baked fish, but not fried fish or fish sandwiches, is associated with lower risk of IHD death, especially arrhythmic IHD death. Cardiac benefits of fish consumption may vary depending on the type of fish meal consumed.

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2003 March Circulation study research epidemiological humans elderly old oldwer fish consumption cardiac benefits omega-3 broiled baked fried nutrition CVD CHD IHD arrhythmia Mozaffarian cooking method cooking_method type meal medline

Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study.
Salonen RM, Nyyssönen K, Kaikkonen J, Porkkala-Sarataho E, Voutilainen S, Rissanen TH, Tuomainen TP, Valkonen VP, Ristonmaa U, Lakka HM, Vanharanta M, Salonen JT, Poulsen HE; Antioxidant Supplementation in Atherosclerosis Prevention Study.
Circulation. 2003 Feb 25;107(7):947-53.
PMID: 12600905
doi: 10.1161/01.CIR.0000050626.25057.51

Conclusions— These data replicate our 3-year findings confirming that the supplementation with combination of vitamin E and slow-release vitamin C slows down atherosclerotic progression in hypercholesterolemic persons.

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2003 February Circulation Salonen study research clinical_trial humans vitamin_C vitamin_E supplementation carotid artery IMT CIMT CVD arteriosclerosis progression nutrition antioxidants Finland Finnish hypercholesterolemic lipids medline

A diet rich in coconut oil reduces diurnal postprandial variations in circulating tissue plasminogen activator antigen and fasting lipoprotein (a) compared with a diet rich in unsaturated fat in women.
Müller H, Lindman AS, Blomfeldt A, Seljeflot I, Pedersen JI.
J Nutr. 2003 Nov;133(11):3422-7.
PMID: 14608053

In conclusion, our results indicate that a coconut oil–based diet (HSAFA-diet) lowers postprandial t-PA antigen concentration, and this may favorably affect the fibrinolytic system and the Lp(a) concentration compared with the HUFA-diet. The proportions of dietary saturated fatty acids more than the percentage of saturated fat energy seem to have a beneficial influence on Lp(a) levels.

The connection between Lp(a) and atherosclerosis is not entirely understood. Different studies have provided strong evidence that Lp(a) level is an independent risk factor for developing coronary artery disease in men (47,48), but the question of causality continues to be debated. Recent data suggest that Lp(a) might be atherogenic (49), in particular when combined with other risk factors. High levels of Lp(a) combined with other risk factors such as the ratio of plasma total/HDL cholesterol have been shown to increase the risk for coronary heart diseases (50). It has also been reported that when substantial LDL cholesterol reductions were obtained in men with coronary heart disease, persistent elevations of Lp(a) were no longer atherogenic or clinically threatening (51).

In conclusion, the present results show that the HSAFA-diet lowered postprandial t-PA antigen and thus potentially improved fibrinolysis compared with the HUFA-diet. Diets with either high or low levels of saturated fatty acids from coconut oil beneficially decrease Lp(a) compared with a HUFA-diet. The proportions of dietary saturated fatty acids more than the percentage of saturated fat energy may be of importance if the goal is to decrease Lp(a).

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2003 November jn study research clinical_trial rct humans women coconut oil coconut_oil PUFA SFA SAFA HSAFA LSAFA HUFA nutrition diet CVD LP(a) fibrinolysis coagulation UFA medline

"Some people promote coconut oil as a healthy addition to a weight-loss diet, even though it has higher levels of saturated fat.

WebMD Feature

Reviewed By Brunilda Nazario

Is it possible to add fat to your diet and lose weight? Yes, if it's the right fat, says naturopath Bruce Fife, ND, author of Eat Fat Look Thin. He recommends adding coconut oil and substituting it for polyunsaturated oils to suppress appetite, boost metabolism, and bring about weight loss.

"Lots of people have reported that when they add coconut oil to their diet, it was enough to promote weight loss," says Fife. "Some people don't notice a drop in weight, which often means they're simply eating too much. Calories are important." His own experience with coconut oil produced a gradual weight loss over six months of about 20 pounds, which he'd been unable to lose previously through diet and exercise.

He advises using about three tablespoons of natural coconut oil, either virgin or processed, daily. His patients use it in place of polyunsaturated fats for stir-frying and salad dressings, add it to other foods, or take it straight. The fat is also present in canned coconut milk (not the liquid inside the coconut), which can be substituted for milk in many recipes, and fresh coconut fruit, which can be eaten as a snack or grated over fruits and salads"

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2003 August medicinenet news coconut oil coconut_oil weight loss weight_loss weight-loss diet nutrition MCT

Zingiber officinale (ginger). Monograph.
[No authors listed]
Altern Med Rev. 2003 Aug;8(3):331-5.
PMID: 12946242

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2003 August study review bGinger Monograph health herbal herbs medicinal cam nutrition food thorne medline spice spices

Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease.
Kidd P.
Altern Med Rev. 2003 Aug;8(3):223-46. Review.
PMID: 12946237

Th1 pathways typically produce activation of cytotoxic T
lymphocytes (Tc), NK cells, macrophages, and monocytes, all of
which can attack cancer cells and generally defend against tumors.
55 IFN-gamma and other Th1 cytokines are typically lower in
advanced cancer patients, while the Th2 marker IL-4 can be higher
or unchanged.56 Nodules of non-small cell lung cancer freshly
removed from patients expressed a marked imbalance toward Th2, as
did biopsy samples from basal cell carcinoma.57 In prostate cancer
patients IL-2 was low (Th1) and IL-10 high.58 IL-10 is a confirmed
Th1-suppressive cytokine, and heightened IL-10 is a common factor
in cancer.55

IL-10 has a variety of suppressive effects that include inhibiting
Th1 cytokine production, down-regulating APC and NK cell function,
and lowering overall T-cell proliferation.57 Especially under the
influence of IL-4 (Th2), tumor cells apparently up-regulate IL-10
that suppresses nearby killer cells. Tumor-derived IL-10 has been
documented in lymphoma, ovarian carcinoma, melanoma, neuroblastoma,
and renal cell and colon carcinoma.57 IL-12 is another cytokine
that can be up-regulated by Th1 activity and inhibited by Th2.59 A
low IL-12/IL-10 ratio was found in cervical cancer patients.55
Recent clinical studies suggest elevated IL-10 is predictive of a
poor prognosis. 57 With both IL-4 and IL-10 being proven inhibitors
of Th1 and promoters of Th2 activity, the recognized capability of
cancerous tissue to suppress immunity is readily rationalized.

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2003 August study review Th1_Th2 balance Th:Th2 Th1 Th2 immune function immunity hypothesis limitations implications health medline altmed cam nutrition plant sterols phytosterols melatonin probiotics progesterone selenium zinc thorne cancer

[Dichloroacetate treatment for adult patients with mitochondrial disease]
Oishi K, Yoshioka M, Ozawa R, Yamamoto T, Oya Y, Ogawa M, Kawai M.
Rinsho Shinkeigaku. 2003 Apr;43(4):154-61. Japanese.
PMID: 12892050

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2003 April study research clinical_trial humans Dichloroacetate DCA mitochondrial disease diseases side effects adveres toxicty peripheral neuropathy dosisng dosage cancer medline

Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.
Zeng XH, Zeng XJ, Li YY.
Am J Cardiol. 2003 Jul 15;92(2):173-6.
PMID: 12860219
doi:10.1016/S0002-9149(03)00533-2

Thus, berberine improved quality of life and decreased VPCs and mortality in patients with CHF.

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2003 July study research clinical_trial humans patients berberine efficacy safety herbs nutrition congestive heart failure heart:failure chf hf cardiomyopathy CVD mortality medline

Vitamin D3 and 25-hydroxyvitamin D3 in raw and cooked pork cuts.
Ina Clausen, Jette Jakobsen, Torben Leth and Lars Ovesen.
Journal of Food Composition and Analysis
Volume 16, Issue 5, October 2003, Pages 575-585
doi:10.1016/S0889-1575(03)00064-4

Meat 25OHD3 contributes significantly to vitamin D activity. Food databases should include concentrations of both vitamin D and 25OHD.

www.sciencedirect.com/science - Preview

2003 October study research in_vitro vitamin_D vitamin_D3 25ohd calcidiol content raw cooked pork cuts meat nutrition food

Low vitamin D status, high bone turnover, and bone fractures in centenarians.
Passeri G, Pini G, Troiano L, Vescovini R, Sansoni P, Passeri M, Gueresi P, Delsignore R, Pedrazzoni M, Franceschi C.
J Clin Endocrinol Metab. 2003 Nov;88(11):5109-15.
PMID: 14602735

We conclude that the extreme decades of life are characterized by a pathophysiological sequence of events linking vitamin D deficiency, low serum calcium, and secondary hyperparathyroidism with an increase in bone resorption and severe osteopenia. These data offer a rationale for the possible prevention of elevated bone turnover, bone loss, and consequently the reduction of osteoporotic fractures and fracture-induced disability in the oldest olds through the supplementation with calcium and vitamin D.

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2003 November jcem study research epidemiological humans centenarians old older oldest vitamin_D deficiency prevalence 25ohd undetectable nutrition status osteopenia secondary_hyperparathyroidism PTH IL-6 medline bone fractures turnover resorption

Vitamin D, nutritional deficiency, and the medical paradigm.
Heaney RP.
J Clin Endocrinol Metab. 2003 Nov;88(11):5107-8. Review. No abstract available.
PMID: 14602734

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2003 November jcem study editorial review Heaney vitamin_D nutritional deficiency medical paradigm nutrition medline elderly old older humans centenarians oldest 25ohd undetectable

Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial.
Su KP, Huang SY, Chiu CC, Shen WW.
Eur Neuropsychopharmacol. 2003 Aug;13(4):267-71. Erratum in: Eur Neuropsychopharmacol. 2004 Mar;14(2):173.
PMID: 12888186

From the preliminary findings in this study, omega-3 PUFAs could improve the short-term course of illness and were well tolerated in patients in major depressive disorder.

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2003 August study research clinical_trial rct humans patients depressed Chines China fish_oil omega-3 EPA DHA depression nutrition pilot medline

D-vitamiinin turvallisuutta tarkasteltaessa pitää huomioida ainakin
seuraavat kaksi asiaa:

1) Nykyiset saantisuositukset ja turvallisuurajat ovat aivan liian pieniä, kts. Viethin tutkimukset ja esim. Merckin manuaalista "Vitamin D toxicity".

2) On olemassa näyttöä siitä, että nykyisenkaltaisten suositusten
seuraaminen voi altistaa tietyille kroonisille taudeille monia yksilöitä, joiden auringonvalon saanti on syystä tai toisesta rajoitettu (talvisaika 40 leveyasteiden ulkopuolella, liian peittävä vaatetus (musliminaiset) jne..). Tällaisia tauteja ovat mm. tyypin 1 diabetes, multippeli skleroosi ja muut autoimmuunisairaudet, monet syövät (eturauhassyövästä on aika hyvää näyttöä), reuma, osteoporoosi, korkea verenpaine, kaamosmasennus, jne ....

Jättiannokset ovat myrkyllisiä, mutta liian vähäinen saantikin voi olla huomattava turvallisuusriski.

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2003 lokakuu groups.google sfnet.keskustelu.terveys ravitsemus usenet D-vitamiini saantisuositus saantisuositukset hyödyt turvallisuus linkkejä Matti Narkia terveys linkkikokoelma diabetes syöpä MS osteoporoosi kaamosmasennus puute puutos

Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction.
Singh RB, Neki NS, Kartikey K, Pella D, Kumar A, Niaz MA, Thakur AS.
Mol Cell Biochem. 2003 Apr;246(1-2):75-82.
PMID: 12841346

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2003 April study research clinical_trial rct humans statin statins acute myocardial infarction myocardial_infarction MI CVD CHD vitamin_E Coenzyme Q10 Coenzyme_Q10 unstable atheroma nutrition medline ubiquinone ubidecarenone coq10

Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial.
Thies F, Garry JM, Yaqoob P, Rerkasem K, Williams J, Shearman CP, Gallagher PJ, Calder PC, Grimble RF.
Lancet. 2003 Feb 8;361(9356):477-85.
PMID: 12583947
doi:10.1016/S0140-6736(03)12468-3

Interpretation
Atherosclerotic plaques readily incorporate n-3 PUFAs from fish-oil supplementation, inducing changes that can enhance stability of atherosclerotic plaques. By contrast, increased consumption of n-6 PUFAs does not affect carotid plaque fatty-acid composition or stability over the time course studied here. Stability of plaques could explain reductions in non-fatal and fatal cardiovascular events associated with increased n-3 PUFA intake

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2003 February Lancet study research clinical_trial rct humans omega-3 fish_oil EPA DHA PUFA CVD CHD atherosclerotic plaques plaque nutrition stability stable inflammation anti-inflammatory carotid

Effects of vitamin D supplementation on strength, physical performance, and falls in older persons: a systematic review.
Latham NK, Anderson CS, Reid IR.
J Am Geriatr Soc. 2003 Sep;51(9):1219-26. Review.
PMID: 12919233
DOI: 10.1046/j.1532-5415.2003.51405.

Conclusion: Although there is insufficient evidence that vitamin D supplementation alone improves physical performance in older people, some data suggest a benefit from vitamin D combined with calcium supplementation, but this requires confirmation in large, well-designed trials.

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2003 September study systematic review humans elderly older old vitamin_D supplementation muscle strength falls muscle_strength physical function performance physical_performance

"Vitamin D may be more important to colon cancer prevention than previously believed, according to a study published in the Journal of the American Medical Association (Vol. 290, No. 22: 2959-2967).

The study examined people with no symptoms of colon cancer to determine what role diet, exercise, smoking, and other behaviors played in the development or not of colon polyps, small growths in the colon that can turn into cancer if they aren't removed."

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2003 December ACS news colon cancer prevention colon_cancer polyps nutrition vitamin_D 25ohd fiber NSAID NSAIDs cereal smoking lifestyle

VITAMIN D LOWERS C-REACTIVE PROTEIN (CRP)
Van den Berghe and colleagues at the University of Leuven in Belgium appear to be the first to show that simple, natural and cheap vitamin D (cholecalciferol) lowers CRP in critically ill patients. Even small amounts of cholecalciferol (500 IU) lowered CRP by more than 25% in a small group of critically ill patients. Another marker of inflammation (IL-6) was reduced even more. The researchers also found that critically ill patients were profoundly deficient in vitamin D.

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2003 November vitamindcouncil vitamin_D studies humans critically ill patients lowerss C-reactive_protein CRP inflammation nutrition cholecalciferol vitamin_D3 IL-6 interleukin-6