Matti Narkia's Library tagged review →  View Popular

Meta-analysis of vitamin D, calcium and the prevention of breast cancer.
Chen P, Hu P, Xie D, Qin Y, Wang F, Wang H.
Breast Cancer Res Treat. 2009 Oct 23. [Epub ahead of print]
PMID: 19851861

These results provide strong evidence that vitamin D and calcium have a chemopreventive effect against breast cancer.

www.ncbi.nlm.nih.gov/...19851861 - Preview

2009 October study review meta-analysis humans women vitamin_D 25ohd calcium breast cancer breast_cancer prevention risk nutrition medline

African Americans, 25-hydroxyvitamin D, and osteoporosis: a paradox.
Aloia JF.
Am J Clin Nutr. 2008 Aug;88(2):545S-550S. Review.
PMID: 18689399

African Americans have lower serum 25-hydroxyvitamin D concentrations and a lower risk of fragility fractures than do other populations. I review the evidence on factors other than vitamin D that might explain this paradox and the calcium economy in different life stages.

www.ajcn.org/...545S - Preview

2008 August ajcn study review Aloia African Americans black humans 25ohd calcidiol vitamin_D status osteoporosis bone health paradox fractures nutrition fracture risk medline blacks African_Americans skin color

Measuring 25-hydroxyvitamin D in a clinical environment: challenges and needs.
Hollis BW.
Am J Clin Nutr. 2008 Aug;88(2):507S-510S. Review.
PMID: 18689391

In this article, I provide an overview of the techniques available for measuring 25(OH)D, compare these techniques with one another, and assess their clinical utility. I also briefly discuss the stability of 25(OH)D in biological media and present an overview of the Vitamin D External Quality Assessment Scheme.

www.ajcn.org/...507S - Preview

2008 August ajcn study review measuring measurement test testing 25ohd calcidiol vitamin_D Hollis clinical environment DiaSorin RIA HPLC LC-MS nutrition

Is the MP Treatment for Sarcoidosis Helpful for Other Chronic Diseases?
MP’s Vitamin D Theories Are Not Supported by Lab Studies.
Updated July 2, 2008

"The MP treatment plan was originally designed to treat an inflammatory condition known as sarcoidosis. The treatment consists of using the drug Benicar, combined with the avoidance of all sources of vitamin D, and eventually adding various antibiotics, especially minocycline. After being used by sarcoidosis patients for some years, it was then theorized and claimed that the treatment could treat other inflammatory conditions. Eventually it was also claimed that it could treat fibromyalgia and CFS, conditions which are not recognized by the medical literature as being inflammatory in nature. "

stuff.mit.edu/...universe.htm - Preview

2008 July review critique marshall protocol MP treatment sarcoidosis chronic diseases vitamin_D theories nutrition CFS Fibromyalgia lab studies

"It's well known that African Americans have low levels of vitamin D in their blood. In fact, this seems to be generally true for humans of tropical origin. In a study from Hawaii, vitamin D status was assessed in healthy, visibly tanned young adults who averaged 22.4 hours per week of unprotected sun exposure. Yet 51% had levels below the current recommended minimum of 75 nmol/L (Binkley et al., 2007). In a study from south India, levels below 50 nmol/L were found in 44% of the men and 70% of the women. The subjects are described as "agricultural workers starting their day at 0800 and working outdoors until 1700 with their face, chest, back, legs, arms, and forearms exposed to sunlight" (Harinarayan et al., 2007). In a study from Saudi Arabia, levels below 25 nmol/L were found in respectively 35%, 45%, 53%, and 50% of normal male university students of Saudi, Jordanian, Egyptian, and other origins (Sedrani, 1984)."

evoandproud.blogspot.com/...n-americans-and-vitamin-d.html - Preview

2009 July evoandproud blog_article review African Americans African_Americans black dark skin color vitamin_D 25ohd UVB nutrition Peter Frost references

A Review - Vitamin D and Calcium in Sarcoidosis\nTrevor G Marshall, PhD, 5 July 2003

www.sarcinfo.com/calcium.htm - Preview

2003 July study review Marshall vitamin_D calcium sarcoidosis 1.25(OH)2D calcitriol nutrition medline

Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.
Manolagas SC.
Endocr Rev. 2000 Apr;21(2):115-37. Review.
PMID: 10782361

edrv.endojournals.org/...115 - Preview

2000 April study review birth death bone cells mechanisms mechanism osteoporosis osteoblasts osteocytes osteoclasts cytokines PTH medline hormones

Review of fat and fatty acid requirements and criteria for developing dietary guidelines.
Smit LA, Mozaffarian D, Willett W.
Ann Nutr Metab. 2009;55(1-3):44-55. Epub 2009 Sep 15.
PMID: 19752535
DOI: 10.1159/000228995

content.karger.com/...produkte.asp - Preview

2009 September study review fat fatty acid fatty_acids requirements criteria developing dietary guidelines nutrition Willett medline SFA MUFA PUFA CVD CHD DRI DRIs trans_fat cancer

Factors associated with clinical benefit from epidermal growth factor receptor inhibitors in recurrent and metastatic squamous cell carcinoma of the head and neck.
Cohen EE, Halpern AB, Kasza K, Kocherginsky M, Williams R, Vokes EE.
Oral Oncol. 2009 Oct;45(10):e155-60. Epub 2009 Jul 7.
PMID: 19586795

www.oncologystat.com/...noma_of_the_Head_and_Neck.html - Preview

2009 October oncologystat study review humans patients EGFR tyrosine kinase inhibitors TKI head_and_neck cancer head_and_neck_cancer hnca scchn recurrent metastatic advanced factors clinical benefits survival medline

Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry.
Freeman MP, Hibbeln JR, Wisner KL, Davis JM, Mischoulon D, Peet M, Keck PE Jr, Marangell LB, Richardson AJ, Lake J, Stoll AL.
J Clin Psychiatry. 2006 Dec;67(12):1954-67. Review. Erratum in: J Clin Psychiatry. 2007 Feb;68(2):338.
PMID: 17194275

Conclusions: The preponderance of epidemiologic and tissue compositional studies supports a protective effect of omega-3 EFA intake, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in mood disorders. Meta-analyses of randomized controlled trials demonstrate a statistically significant benefit in unipolar and bipolar depression (p=.02). The results were highly heterogeneous, indicating that it is important to examine the characteristics of each individual study to note the differences in design and execution. There is less evidence of benefit in schizophrenia. EPA and DHA appear to have negligible risks and some potential benefit in major depressive disorder and bipolar disorder, but results remain inconclusive in most areas of interest in psychiatry. Treatment recommendations and directions for future research are described. Health benefits of omega-3 EFA may be especially important in patients with psychiatric disorders, due to high prevalence rates of smoking and obesity and the metabolic side effects of some psychotropic medications.

www.biovita.fi/...APA_2006.pdf - Preview

2006 December study review humans omega-3 evidence basis treatment psychiatry nutrition depression bipolar disorder schizophrenia dementia borderline personality EPA DHA Freeman Hibbeln Peet Stoll medline

How to optimize vitamin D supplementation to prevent cancer, based on cellular adaptation and hydroxylase enzymology.
Vieth R.
Anticancer Res. 2009 Sep;29(9):3675-84. Review.
PMID: 19667164

ar.iiarjournals.org/...3675.abstract - Preview

2009 September ar Vieth study review humans how-to howto optimize vitamin_D supplementation optimal prevent cancer prevention nutrition cellular adaptation hydroxylase enzymology enzymes enzyme 25ohd fluctuation medline prostate pancreatic kinetics

Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes.
Bischoff-Ferrari HA.
Adv Exp Med Biol. 2008;624:55-71. Review.
PMID: 18348447
DOI: 10.1007/978-0-387-77574-6_5

Recent evidence suggests that higher vitamin D intakes beyond current recommendations may be associated with better health outcomes. In this chapter, evidence is summarized from different studies that evaluate threshold levels for serum 25(OH)D levels in relation to bone mineral density (BMD), lower extremity function, dental health, risk of falls, admission to nursing home, fractures, cancer prevention and incident hypertension. For all endpoints, the most advantageous serum levels for 25(OH)D appeared to be at least 75 nmol/l (30 ng/ml) and for cancer prevention, desirable 25(OH)D levels are between 90–120 nmol/l (36–48 ng/ml). An intake of no less than 1000IU (25 meg) of vitamin D3 (cholecalciferol) per day for all adults may bring at least 50% of the population up to 75 nmol/l. Thus, higher doses of vitamin D are needed to bring most individuals into the desired range. While estimates suggest that 2000 IU vitamin D3 per day may successfully and safely achieve this goal, the implications of 2000 IU or higher doses for the total adult population need to be addressed in future studies.

www.springerlink.com/...g3667t4457872372 - Preview

2008 study review Bischoff-Ferrari humans vitamin_D optimal serum 25ohd levels for multiple health outcomes nutrition medline

Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials.
Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, Orav JE, Stuck AE, Theiler R, Wong JB, Egli A, Kiel DP, Henschkowski J.
BMJ. 2009 Oct 1;339:b3692. doi: 10.1136/bmj.b3692.
PMID: 19797342
doi: 10.1136/bmj.b3692

Conclusions Supplemental vitamin D in a dose of 700-1000 IU a day reduced the risk of falling among older individuals by 19% and to a similar degree as active forms of vitamin D. Doses of supplemental vitamin D of less than 700 IU or serum 25-hydroxyvitamin D concentrations of less than 60 nmol/l may not reduce the risk of falling among older individuals.

www.bmj.com/...b3692 - Preview

2009 October BMJ study review meta-analysis clinical_trials rcts humans elderly old older fall falls prevention vitamin_D supplementation nutrition Bischoff-Ferrari medline 25ohd 1.25(OH)2D calcitriol

Cancer, inflammation and the AT1 and AT2 receptors.
Smith GR, Missailidis S.
J Inflamm (Lond). 2004 Sep 30;1(1):3.
PMID: 15813980

www.journal-inflammation.com/...3 - Preview

2004 September study review cancer and inflammation AT! AT2 receptors medline

Why cancer and inflammation?
Rakoff-Nahoum S.
Yale J Biol Med. 2006 Dec;79(3-4):123-30. Review.
PMID: 17940622

www.pubmedcentral.nih.gov/articlerender.fcgi - Preview

2006 December study review humans why cancer and inflammation

Strong correlations have been noted between cardiovascular diseases and low bone density / osteoporosis—connections so strong that the presence of one is considered a likely predictor of the other. This relationship has led to the hypothesis that these conditions share core pathophysiological mechanisms. Recent advances in our understanding of the complimentary roles played by vitamin D3 and vitamin K2 in vascular and bone health provide support for this hypothesis, along with insight into key metabolic dysfunctions underlying cardiovascular disease and osteoporosis.

Part II, The Vitamin K Connection to Cardiovascular Health, reviews the ways in which vitamin K regulates calcium utlization, preventing vascular and soft tissue calcification while complimenting the bone-building actions of vitamin D, and also discusses vitamin K safety and dosage issues, and the necessity of providing vitamin K and vitamin A along with vitamin D to preclude adverse effects associated with hypervitaminosis D.

www.lmreview.com/...VitaminD-VitaminK_part2.html - Preview

mreview info review vitamin_D vitamin_K vitamin_K2 synergy team up team_up CVD risk risk_reduction nutrition part_II CHD prevention arterial coronary calcification vitamin_A toxicity safety MK-4 MK-7 Gamma-carboxylation Gla MGP

Strong correlations have been noted between cardiovascular diseases and low bone density / osteoporosis—connections so strong that the presence of one type of pathology is considered a likely predictor of the other. This potentially causal relationship has led to the hypothesis that these conditions share core mechanisms. Recent advances in our understanding of the complimentary roles played by vitamin D3 and vitamin K2 in vascular and bone health provide support for this hypothesis, along with insight into key metabolic dysfunctions underlying cardiovascular disease and osteoporosis.

Part I of this review summarizes current research linking vitamin D deficiency to cardiovascular disease, the physiological mechanisms underlying vitamin D's cardiovascular effects, and leading vitamin D researchers' recommendations for significantly higher supplemental doses of the pro-hormone. Part II reviews the vitamin K connection to cardiovascular disease; the ways in which vitamin D and vitamin K pair up to prevent inflammation, vascular calcification and osteoporosis; and the necessity of providing vitamin K along with vitamin D to preclude adverse effects associated with hypervitaminosis D, which include vascular and other soft tissue calcification.

www.lmreview.com/...VitaminD-VitaminK_part1.html - Preview

lmreview info review vitamin_D vitamin_K vitamin_K2 synergy team up team_up CVD risk risk_reduction nutrition part_I PTH TNF-alpha CRP MMPs dosage dosing supplementation

www.westonaprice.org/...vitamina-osteo.html - Preview

westonaprice info osteoporosis antagonism vitamin_D vitamin_A nutrition Chris Masterjohn bone health bone_health review

Vitamin K2 is produced by animal tissues, including the mammary glands, from vitamin K1, which occurs in rapidly growing green plants.

A growing body of published research confirms Dr. Price's discoveries, namely that vitamin K2 is important for the utilization of minerals, protects against tooth decay, supports growth and development, is involved in normal reproduction, protects against calcification of the arteries leading to heart disease, and is a major component of the brain.

Vitamin K2 works synergistically with the two other "fat-soluble activators" that Price studied, vitamins A and D. Vitamins A and D signal to the cells to produce certain proteins and vitamin K then activates these proteins.

Vitamin K2 plays a crucial role in the development of the facial bones, and its presence in the diets of nonindustrialized peoples explains the wide facial structure and freedom from dental deformities that Weston Price observe

www.westonaprice.org/...vitamin-k2.html - Preview

westonaprice info review X-Factor vitamin_K vitamin_K2 nutrition vitamin_A vitamin_D interactions synergy teeth bone heart CVD CHD brain references Chris Masterjohn foods food sources

Vitamin D and autoimmune rheumatic diseases.
Cutolo M.
Rheumatology (Oxford). 2009 Mar;48(3):210-2. Epub 2008 Oct 17.
PMID: 18930963
doi:10.1093/rheumatology/ken394

rheumatology.oxfordjournals.org/...210 - Preview

2009 March rheumatology study editorial review humans vitamin_D utoimmune rheumatic diseases RA VDR immunomodulation immune immunosuppressive arthritis SLE 25OHD nutrition rheumatoid rheumatoid_arthritis immunosuppression medline