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Cell - Dietary and Genetic Control of Glucose Transporter 2 Glycosylation Promotes Insulin Secretion in Suppressing Diabetes
Dietary and genetic control of glucose transporter 2 glycosylation promotes insulin secretion in suppressing diabetes.
Ohtsubo K, Takamatsu S, Minowa MT, Yoshida A, Takeuchi M, Marth JD.
Cell. 2005 Dec 29;123(7):1307-21.
PMID: 16377570 -
Researchers Discover Mechanistic Link Between High-Fat Diet and Type 2 Diabetes
"In an article published in the December 29, 2005, issue of the journal
Cell, the researchers report that knocking out a single gene encoding
the enzyme GnT-4a glycosyltransferase (GnT-4a ) disrupts insulin
production. Importantly, the scientists showed that a high-fat diet
suppresses the activity of GnT-4a and leads to type 2 diabetes due to
failure of the pancreatic beta cells.
"We have discovered a mechanistic explanation for beta cell failure
in response to a high-fat diet and obesity, a molecular trigger which
begins the chain of events leading from hyperglycemia to insulin
resistance and type 2 diabetes," said Jamey Marth, a Howard Hughes
Medical Institute investigator at the University of California, San
Diego (UCSD). Marth and first author Kazuaki Ohtsubo at UCSD
collaborated on the studies with researchers from the Kirin Brewery Co.
Ltd., and the University of Fukui, both in Japan." -
Corrigendum to “Omega-3 fatty acids in major depressive disorder A preliminary double-blind, placebo-controlled trial” [Eur. Neuropsychoparmacol. 13 (2003) 267–271]
Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial.
Su KP, Huang SY, Chiu CC, Shen WW.
Eur Neuropsychopharmacol. 2003 Aug;13(4):267-71. Erratum in: Eur Neuropsychopharmacol. 2004 Mar;14(2):173.
PMID: 12888186
From the preliminary findings in this study, omega-3 PUFAs could improve the short-term course of illness and were well tolerated in patients in major depressive disorder. -
Brain (as food) - Wikipedia, the free encyclopedia
"The brain, like most other internal organs, or offal, can serve as nourishment. Brains used for nourishment include those of pigs, squirrels, horses, cattle, monkeys, chickens and goats. In many cultures, different types of brain are considered a delicacy.
In the Southern United States, canned pork brain in gravy can be purchased for consumption as food. This form of brain is often fried with scrambled eggs to produce "Eggs n' Brains".[1] They are part of the menu in many family owned restaurants throughout the region.
The brain of animals also features in French cuisine, in dishes such as cervelle de veau and tête de veau." -
Hyperlipid: Kwasniewski; praise the lard
"This article was originally published in 2004 in the Chicago Tribune. It's still knocking around on the web in various places but the original seems to have disappeared. You can't have too much of a good thing. Obviously Stephan's recent posts on lard prompted me to put this one up. The imported nutritionist doesn't seem quite as dismissive as you might expect! But notice in the last paragraph that the big bogeyman is protein overload damaging the kidneys! On 60g/d of protein??? Sobor clearly knows nothing about high fat diets, certainly not the one he is commenting so authoritatively about in this case!"
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Hyperlipid: A brief discussion of ketosis - Hyperlipid
"Let's get the religion out of the way first. I follow an eating pattern loosely based around Dr Jan Kwasniewski's Optimal Diet. I vary from the OD in that I tend to vary my protein sources somewhat more than specified, I think a little omega 3 supplementation is worthwhile, that having a "normal" vitamin D level is probably worth while (though this is an interesting subject) and in that I specifically avoid gluten and most other grains. So I do my own thing somewhat, while still keeping a heavy emphasis on animal fat, egg yolks and trying to keep to real food as far as I practically can. When I say I avoid ketosis because Kwasniewski says avoid ketosis, that's religion.
My follow on problem from this that, when you can get hold of the data, Kwasniewski is usually correct. My even bigger problem is that, when you get beyond simple diet information, some of JKs ideas are very far off the wall. And some of the off the wall ones also seem to be correct to me, which is a little uncomfortable! So religion is a real non starter." -
Consumption of cod and weight loss in young overweight and obese adults on an energy reduced diet for 8-weeks - Nutr Metab Cardiovasc Dis. 2009 Dec;19(10):690-6
Consumption of cod and weight loss in young overweight and obese adults on an energy reduced diet for 8-weeks.
Ramel A, Jonsdottir MT, Thorsdottir I.
Nutr Metab Cardiovasc Dis. 2009 Dec;19(10):690-6. Epub 2009 Apr 8.
PMID: 19356912
Conclusion
A dose-response relationship between cod consumption and weight loss during an 8-week energy restriction diet is found and 5×150g cod/week results in 1.7kg greater weight loss in young overweight or obese adults than a isocaloric diet without seafood -
Vitamin D replacement in Asians with diabetes may increase insulin resistance.
Vitamin D replacement in Asians with diabetes may increase insulin resistance.
Taylor AV, Wise PH.
Postgrad Med J. 1998 Jun;74(872):365-6.
PMID: 9799895
We report three cases of vitamin D replacement in British Asians with vitamin D deficiency and non-insulin-dependent diabetes mellitus. In all cases, replacement resulted in an increase in insulin resistance and a deterioration of glycaemic control -
Association of vitamin D deficiency with cognitive impairment in older women. Cross-sectional study -- Annweiler et al., 10.1212/WNL.0b013e3181beecd3 -- Neurology
Association of vitamin D deficiency with cognitive impairment in older women. Cross-sectional study.
Annweiler C, Schott AM, Allali G, Bridenbaugh SA, Kressig RW, Allain P, Herrmann FR, Beauchet O.
Neurology. 2009 Sep 30. [Epub ahead of print]
PMID: 19794127
doi:10.1212/WNL.0b013e3181beecd3
Conclusions: 25-Hydroxyvitamin D deficiency was associated with cognitive impairment in this cohort of community-dwelling older women. -
Vitamin D and depressive symptoms in women during the winter: A pilot study - Appl Nurs Res. 2009 Aug;22(3):221-5.
Vitamin D and depressive symptoms in women during the winter: a pilot study.
Shipowick CD, Moore CB, Corbett C, Bindler R.
Appl Nurs Res. 2009 Aug;22(3):221-5.
PMID: 19616172
doi:10.1016/j.apnr.2007.08.001
ESULTS: Vitamin D supplementation was associated not only with an increase in the serum D levels by an average of 27 ng/ml but also with a decline in the BDI-II scores of an average of 10 points. DISCUSSION: This study suggests that supplemental vitamin D3 reduces depressive symptoms. -
Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men - J Neurol Neurosurg Psychiatry. 2009 Jul;80(7):722-9.
Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men.
Lee DM, Tajar A, Ulubaev A, Pendleton N, O'Neill TW, O'Connor DB, Bartfai G, Boonen S, Bouillon R, Casanueva FF, Finn JD, Forti G, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean ME, Punab M, Silman AJ, Vanderschueren D, Wu FC; EMAS study group.
J Neurol Neurosurg Psychiatry. 2009 Jul;80(7):722-9. Epub 2009 May 21.
PMID: 19460797
doi:10.1136/jnnp.2008.165720
Conclusion: In this study, lower 25(OH)D levels were associated with poorer performance on the DSST. Further research is warranted to determine whether vitamin D sufficiency might have a role in preserving cognitive function in older adults. -
Vitamin D deficiency is associated with worse cognitive performance and lower bone density in older African Americans. - [J Natl Med Assoc. 2009] - PubMed result
Vitamin D deficiency is associated with worse cognitive performance and lower bone density in older African Americans.
Wilkins CH, Birge SJ, Sheline YI, Morris JC.
J Natl Med Assoc. 2009 Apr;101(4):349-54.
PMID: 19397226
CONCLUSIONS: Vitamin D deficiency in older African Americans was associated with worse cognitive performance and lower BMD of the hip -
Correlation of symptoms with vitamin D deficiency and symptom response to cholecalciferol treatment: a randomized controlled trial. - Endocr Pract. 2009 May-Jun;15(3):203-12. - AACE Online - Article
Correlation of symptoms with vitamin D deficiency and symptom response to cholecalciferol treatment: a randomized controlled trial.
Arvold DS, Odean MJ, Dornfeld MP, Regal RR, Arvold JG, Karwoski GC, Mast DJ, Sanford PB, Sjoberg RJ.
Endocr Pract. 2009 May-Jun;15(3):203-12.
PMID: 19364687
Conclusions: Compared with participants in the placebo group, patients in the treatment group showed mild short-term improvement in the overall fibromyalgia impact score, but did not show significant improvement in most musculoskeletal symptoms or in activities of daily living. -
Association between depressive symptoms and 25-hydroxyvitamin D in middle-aged and elderly Chinese
Association between depressive symptoms and 25-hydroxyvitamin D in middle-aged and elderly Chinese.
Pan A, Lu L, Franco OH, Yu Z, Li H, Lin X.
J Affect Disord. 2009 Nov;118(1-3):240-3. Epub 2009 Feb 27.
PMID: 19249103
doi:10.1016/j.jad.2009.02.002
Conclusions
Depressive symptoms are not associated with 25(OH)D concentrations in middle-aged and elderly Chinese. Further prospective studies are required to determine whether they are correlated. -
Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial - J Intern Med. 2008 Dec;264(6):599-609 - Wiley InterScience :: Article :: HTML Full Text
Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial.
Jorde R, Sneve M, Figenschau Y, Svartberg J, Waterloo K.
J Intern Med. 2008 Dec;264(6):599-609. Epub 2008 Sep 10.
PMID: 18793245
Conclusions. It appears to be a relation between serum levels of 25(OH)D and symptoms of depression. Supplementation with high doses of vitamin D seems to ameliorate these symptoms indicating a possible causal relationship. -
Vitamin D and mood disorders among women: an integrative review. - [J Midwifery Womens Health. 2008 Sep-Oct] - PubMed result
Vitamin D and mood disorders among women: an integrative review.
Murphy PK, Wagner CL.
J Midwifery Womens Health. 2008 Sep-Oct;53(5):440-6. Review.
PMID: 18761297
Four of six studies reviewed imparted significant results, with all four showing an association between low 25(OH)D levels and higher incidences of four mood disorders: premenstrual syndrome, seasonal affective disorder, non-specified mood disorder, and major depressive disorder. This review indicates a possible biochemical mechanism occurring between vitamin D and mood disorders affecting women, warranting further studies of these variables using rigorous methodologies. -
Arch Gen Psychiatry -- Depression Is Associated With Decreased 25-Hydroxyvitamin D and Increased Parathyroid Hormone Levels in Older Adults, May 2008, Hoogendijk et al. 65 (5): 508
Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults.
Hoogendijk WJ, Lips P, Dik MG, Deeg DJ, Beekman AT, Penninx BW.
Arch Gen Psychiatry. 2008 May;65(5):508-12.
PMID: 18458202
Conclusion The results of this large population-based study show an association of depression status and severity with decreased serum 25(OH)D levels and increased serum PTH levels in older individuals. -
Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus. The EURODIAB Substudy 2 Study Group. - Diabetologia. 1999 Jan;42(1):51-4 (full text PDF)
Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus. The EURODIAB Substudy 2 Study Group.
[No authors listed]
Diabetologia. 1999 Jan;42(1):51-4.
PMID: 10027578
DOI: 10.1007/s001250051112
In conclusion, this large multicentre trial covering many different European settings consistently showed a protective effect of vitamin D supplementation in infancy. The findings indicate that activated vitamin D might contribute to immune modulation and thereby protect or arrest an ongoing immune process initiated in susceptible people by early environmental
exposures. -
Vitamin D receptor gene polymorphisms influence susceptibility to type 1 diabetes mellitus in the Taiwanese population - Clin Endocrinol (Oxf). 2000 May;52(5):575-80. - Wiley InterScience :: Article :: HTML Full Text
Vitamin D receptor gene polymorphisms influence susceptibility to type 1 diabetes mellitus in the Taiwanese population.
Chang TJ, Lei HH, Yeh JI, Chiu KC, Lee KC, Chen MC, Tai TY, Chuang LM.
Clin Endocrinol (Oxf). 2000 May;52(5):575-80.
PMID: 10792336
DOI: 10.1046/j.1365-2265.2000.00985.x
CONCLUSIONS
Vitamin D receptor gene polymorphisms were associated with type 1 diabetes in a Taiwanese population. However, functional studies are needed to establish the role of the vitamin D receptor in the pathogenesis of type 1 diabetes mellitus. -
Vitamin D receptor allele combinations influence genetic susceptibility to type 1 diabetes in Germans. — Diabetes
Vitamin D receptor allele combinations influence genetic susceptibility to type 1 diabetes in Germans.
Pani MA, Knapp M, Donner H, Braun J, Baur MP, Usadel KH, Badenhoop K.
Diabetes. 2000 Mar;49(3):504-7.
PubMed PMID: 10868975.
doi: 10.2337/diabetes.49.3.504
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