Not only did the extra income appear to lower the instance of behavioral and emotional disorders among the children, but, perhaps even more important, it also boosted two key personality traits that tend to go hand in hand with long-term positive life outcomes.
The first is conscientiousness. People who lack it tend to lie, break rules and have trouble paying attention. The second is agreeableness, which leads to a comfort around people and aptness for teamwork. And both are strongly correlated with various forms of later life success and happiness.
Sleep is a crucial biological process is regulated through complex interactions between multiple brain regions and neuromodulators. As sleep disorders can have deleterious impacts on health and quality of life, a wide variety of pharmacotherapies have been developed to treat conditions of excessive wakefulness and excessive sleepiness. The neurotransmitter norepinephrine (NE), through its involvement in the ascending arousal system, impacts the efficacy of many wake- and sleep-promoting medications. Wake-promoting drugs such as amphetamine and modafinil increase extracellular levels of NE, enhancing transmission along the wake-promoting pathway. GABAergic sleep-promoting medications like benzodiazepines and benzodiazepine-like drugs that act more specifically on benzodiazepine receptors increase the activity of GABA, which inhibits NE and the wake-promoting pathway. Melatonin and related compounds increase sleep by suppressing the activity of the neurons in the brain’s circadian clock, and NE influences the synthesis of melatonin. Antihistamines block the wake-promoting effects of histamine, which shares reciprocal signaling with NE. Many antidepressants that affect the signaling of NE are also used for treatment of insomnia. Finally, adrenergic antagonists that are used to treat cardiovascular disorders have considerable sedative effects. Therefore, NE, long known for its role in maintaining general arousal, is also a crucial player in sleep pharmacology. The purpose of this review is to consider the role of NE in the actions of wake- and sleep-promoting drugs within the framework of the brain arousal systems.
Never talen CoQ10 as a nootropic but:
I took pure CoQ10 a few years ago to boost endurance.
Within about 3 weeks i went from walking at a normal pace for several blocks to running the same distance with no problems. My cardio has been something that has always let me down.
As a martial artist it really helped with my cardio endurance immensely. going from being worn out from a warm up to wanting to do ALOT more training at the end of every class.
I've been taking Idebenone on and off for years. It's good for skin and wound healing. I put it in cuts and it makes them heal very quickly. I think it's even a common ingredient in high-end skin cream. It's also good for calming down and relaxing and clearing up brain fog and/or too many catecholamines (i.e anxiety). It's a bit annoying because it's not really soluble, but the taste is fine when taken straight.
Here's a few studies:
Idebenone and Resveratrol Extend Lifespan and Improve Motor Function of HtrA2 Knockout Mice.
The effects of idebenone on mitochondrial bioenergetics.
Use of Noben (idebenone) in the treatment of dementia and memory impairments without dementia.
Don't take too much though:
Idebenone [in high concentration] induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells.
We present a case of a 52-year-old male patient suffering from chronic schizophrenia stabilized on risperidone long-acting injection (37,5 mg/2 weeks) and biperiden 4 mg/day. Residual symptoms are affective flattening, alogia, avolition, and asociality. Memantine 10 mg/day was added. After 1.5 months, the patient spontaneously referred to "feel better being in company of my relatives." The following scales have been completed: the Scale for the Assessment of Negative Symptoms (96), the Scale for the Assessment of Positive Symptoms (3), the Mini Mental Scale Examination (26), and the Calgary Depression for Schizophrenia Scale (2). Memantine was increased to 20 mg/day and biperiden was decreased to 2 mg/day. Two months later, apathy and asociality considerably improved and affective flattening, alogia, and attention slightly got better (SANS 76, SAPS 1, MMSE 26, and CDSS 1). After two more months, the improvement continued in the same domains (SANS: 70, SAPS: 1 MMSE: 27, and CDSS: 1). Positive symptoms remained in full remission. It has been hypothesized that one of the causes of schizophrenia is glutamate excitotoxicity. Memantine, a glutamate receptor antagonist, could possibly ameliorate schizophrenia symptoms, the negative ones among them, used as add-on therapy to atypical antipsychotics. Memantine could be of potential help in schizophrenia patients with severe residual negative symptoms.
Here's the recommended Namenda dosing:
The recommended starting dose of NAMENDA is 5 mg (2.5 mL) once daily. The dose should be increased in 5 mg increments to 10 mg/day (2.5 mL twice daily), 15 mg/day (2.5 mL and 5 mL as separate doses), and 20 mg/day (5 mL twice daily). The minimum recommended interval between dose increases is one week. The dosage shown to be effective in controlled clinical trials is 20 mg/day (5 mL twice daily).
One thing I had to realize when I was on metformin was that it is a sloooow process by which it works. You're not going to see anything dramatic within a month, so it takes a while. But I would stick with it at least 3 months before evaluating weight loss. And because Zyprexa is such a potent weight-gainer, the metformin might actually do more to prevent future gain rather than promoting weight loss. Still beneficial, not to mention it might lessen the chance of developing type 2 diabetes. In the end, that is probably the most important thing.
After taking the metformin and kind of forgetting about it's effects, over a 6+ month period I did lose significant weight while I was still on AAP's. It just took a long time . I've also found that, like I stated with a previous post on this thread when I first went on Zyprexa, at first I really don't notice any weight gain and seem to think it's not going to happen "this time." But somehow over the long-term, I start gaining between unconscious calorie increases and the metabolic weirdness of the drug(s). I guess the best thing for many is to try the less metabolically risky AAP's first: Abilify, Geodon, Latuda, Saphris, etc. And don't forget that some of the older, typical AP's don't seem to cause as much weight gain, particularly the high-potency ones such as Haldol (haloperidol), Prolixin (fluphenazine), and Trilafon (perphenazine), among others. One in particular -Moban (molindone) - can actually cause weight loss but as far as I know is no longer available in the US.
Just never, ever give up trying to recover and trying to live as healthily as possible. Every little bit helps! The only possible failure is not trying.
liver disease; or
a history of heart disease.
Before taking this medicine
Some people develop a life-threatening condition called lactic acidosis while taking metformin. You may be more likely to develop lactic acidosis if you have liver or kidney disease, congestive heart failure, a severe infection, if you are dehydrated, or if you drink large amounts of alcohol. Talk with your doctor about your individual risk.
You should not use this medication if you are allergic to metformin, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking metformin.
To make sure you can safely take metformin, tell your doctor if you have any of these other conditions:
FDA pregnancy category B. Metformin is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether metformin passes into breast milk or if it could harm a nursing baby. Do not take metformin without first talking to your doctor if you are breast-feeding a baby. Metformin should not be given to a child younger than 10 years old. Extended-release metformin (Glucophage XR) should not be given to a child younger than 17 years old.
Zyprexa medication<!-- start: shared_blocks.99581402#below-h1 --><!-- end: shared_blocks.99581402#below-h1 -->
Zyprexa medication is an atypical anti-psychotic also known by the generic name olanzapine.
According to NIMH (National Institute of Mental Health), Zyprexa is most helpful for folks with severe or psychotic depression, often accompanied by a break with reality, hallucinations, or delusions.
Zyprexa is manufactured by US pharma giant Eli Lilly.
I met you in the rain on the last day of 1972, the same day I resolved to kill myself.
One week prior, at the behest of Richard Nixon and Henry Kissinger, I'd flown four B-52 sorties over Hanoi. I dropped forty-eight bombs. How many homes I destroyed, how many lives I ended, I'll never know. But in the eyes of my superiors, I had served my country honorably, and I was thusly discharged with such distinction.
And so on the morning of that New Year's Eve, I found myself in a barren studio apartment on Beacon and Hereford with a fifth of Tennessee rye and the pang of shame permeating the recesses of my soul. When the bottle was empty, I made for the door and vowed, upon returning, that I would retrieve the Smith & Wesson Model 15 from the closet and give myself the discharge I deserved.
I walked for hours. I looped around the Fenway before snaking back past Symphony Hall and up to Trinity Church. Then I roamed through the Common, scaled the hill with its golden dome, and meandered into that charming labyrinth divided by Hanover Street. By the time I reached the waterfront, a charcoal sky had opened and a drizzle became a shower. That shower soon gave way to a deluge. While the other pedestrians darted for awnings and lobbies, I trudged into the rain. I suppose I thought, or rather hoped, that it might wash away the patina of guilt that had coagulated around my heart. It didn't, of course, so I started back to the apartment.
And then I saw you.
You'd taken shelter under the balcony of the Old State House. You were wearing a teal ball gown, which appeared to me both regal and ridiculous. Your brown hair was matted to the right side of your face, and a galaxy of freckles dusted your shoulders. I'd never seen anything so beautiful.
When I joined you under the balcony, you looked at me with your big green eyes, and I could tell that you'd been crying. I asked if you were okay. You said you'd been better. I asked if you'd like to have a cup of coffee. You said only if I would join you. Before I could smile, you snatched my hand and led me on a dash through Downtown Crossing and into Neisner's.
Halogenated amphetamines are generally neurotoxic indeed, but fluorine is a bit different as a chemical moiety than the other ones: for example it is quite quite small. Of course still very electronegative but the steric hindrance should be much less. From what we know it seems the fluorinated ones aren't really that toxic but I understand if people would just rather stay away altogether. Definitely stay away from stuff like brephedrone (bromo-mephedrone... probably quite harmful, yet it is available)
2-FA resembles dexamphetamine most of the fluoramphs in my opinion. 3 and 4 are exceedingly more serotonergic and effective for other purposes than studying. Forget about the (meth)cathinone and methamphetamine varieties, they are probably more harmful and also more meant for recreation.
PEAs with deprenyl is a quite dangerous plan and I would always recommend against such things. I have tried beta-PEA on it's own and it gave a very warm and sweet feeling but it was extremely fleeting, went away in not more than a few minutes. So gave up on that. Didn't even improve attention, only lovey-dovey stuff.
Desoxypipradrol always seemed like an interesting one on paper and I still have it lying around, have it for years now I think. But it can easily spiral out of control with that one. Very tricky shit if you cross the line with it. And sleep is virtually impossible for a good time afterwards, probably the entire following night. If you take a little more than necessary and add a little extra to get that nice little boost-y feeling, then possibly the next thing you know is that you can't sleep for multiple nights and get into an amphetamine-psychosis like state pretty damn fast. Which is why I still dare not touch it with a 10 ft pole.
Ethylphenidate felt alright to me, maybe a little more useful than methylphenidate.
My advice is: modafinil.
And potentially in the future (I have yet to try it): other racetams than the piracetam I have yet used extensively (such as aniracetam) and Noopept. I have no use for studying myself but to make cartoon work and to put some hours into music production, who knows how useful they can be. And - including modafinil - relatively much safer than the truly monoamine releasing or reuptake inhibiting stims.
Onto the next generation of drugs!
(I think there was another ampakine peptide available on Russian prescription but alas I forgot the name!)
How many milligrams of yohimbine there were in each pill?
I had very different experiences with the yohimbe bark tea (orally), or yohimbine hcl powder (10-15mg orally + 5-10mg insufflated). But both were very strong, with nice pros and cons.
For sex I think that yohimbe bark tea is WAY better than yohimbine HCL. The bark contains a lot of alkaloids other than yohimbine. You have more "sexual effect" and less "speedy effect".
With that tea, I was able to have sex, go wash my teeth, and came back without losing any degree of erection. It was nice and empathic even if I had to stop from time because I was feeling my heart was going to explode. I had mild visuals and euphoria. Definitely psychedelic.
With the powder + alcohol I totally lost any inhibition. I spent a whole party in my guesthouse with my pants down, even in front of strangers. And there are a lot of pictures around -_-. I guess it is not far from amphetamines, but more sex-related.
With both of them I didn't sleep and had unpleasant racing heart all night (expecialy mixed with alcohol, in retrospect it was a very dangeous thing!). And add the paranoia for my control-free behaviour (I'm usually well-mannered).
Anyway If you don't take a light dose you are going to have fun, but you know you WILL have to PAY pretty bad side effect. And it is going to last A LOT.
And it is definitely a drug, not a supplement. You can just go to the hospital or worse if you think it is a game or you are not in perfect shape. Everybody reacts different. If you have to do it, please start very low. Take care.
(And watch out for interactions: yohimbine is quite deadly with many other drugs, even if taken days before or after. [Irreversible MAOI].
In object-oriented programming and computer science, a passive data structure (PDS) is a term for a record, to contrast with objects. That is, a PDS is a data structure that is represented only as passive collections of field values (instance variables), without using object-oriented features. It is also known as a plain old data structure, or plain old data.
Passive data structures are appropriate when there is a part of a system where it should be clearly indicated that the detailed logic for data manipulation and integrity are elsewhere. PDSs are often found at the boundaries of a system, where information is being moved to and from other systems or persistent storage and the problem domain logic that is found in other parts of the system is not relevant. For example, PDS would be convenient for representing the field values of objects that are being constructed from external data, in a part of the system where the semantic checks and interpretations needed for valid objects have not yet been applied.
A PDS type in C++ is defined as either a scalar type or a PDS class. A PDS class has no user-defined copy assignment operator, no user-defined destructor, and no non-static data members that are not themselves PDS. Moreover, a PDS class must be an aggregate, meaning it has no user-declared constructors, no private nor protected non-static data, no base classes and no virtual functions. The standard includes statements about how PDS must behave in C++. The type_traits library in the C++ Standard Library, provides a function known as is_pod that can be used to determine whether a given type is a POD.
In certain contexts, C++ allows only PDS types to be used. For example, a union in C++98 cannot contain a class that has virtual functions or nontrivial constructors or destructors. This restriction is imposed because the compiler cannot determine which constructor or destructor should be called for a union. PDS types can also be used for interfacing with C, which supports only PDS.
In Java, some developers consider that the PDS concept corresponds to a class with public data members and no methods (Java Code Conventions 10.1), i.e., a data transfer object. Others would also include POJOs (a class that has methods but only getters and setters, with no logic) and Java Beans to fall under the PDS concept if they do not use event handling and do not implement additional methods beyond getters and setters. However, POJOs and Java Beans do have encapsulation and so violate the fundamental definition of PDS.
In PHP associated arrays and stdClass objects can be considered PDS.
Kingston University graduate Tim Sanders’ Microscopic Vinyl Record Grooves project is a winner. Firstly, becuase it eases one of the mysteries in my own brain: how does a piece of plastic actually play music. And secondly, because the combination of dedicated documentation and visual know-how make the final piece absolutely worthy. In the artist’s own words, the piece shows “two full rotations of the grooves within three different genres of vinyl records. This allows the viewer to see and understand how audio is translated when pressed into a vinyl record. The patterns of grooves are explained and compared between genres of music.” Groovy.
<!-- // .story-intro --> <!-- google_ad_section_start(name=story_body, weight=high) -->
A NEW pill that treats a type of lung cancer that strikes young people and non-smokers has successfully shrunk tumours in a world-first trial. <!-- google_ad_section_end(name=story_introduction) -->
The drug switches off a gene in lung cancer patients, stopping cancer cells from growing and spreading.
Peter MacCallum Cancer Centre led the Australian arm of the trial of the drug called ceretinib.
Medical oncologist Associate Professor Ben Solomon said the drug was for patients with ALK-positive lung cancer, which made up 3-5 per cent of all lung cancer cases.
Associate Prof Solomon said these patients have the ALK gene switched on permanently, which allows cancer cells to grow and spread.
The drug is an ALK inhibitor, which switches the gene off, leading to tumour shrinkage.
The majority of the 130 patients (around 60 per cent) got benefit from the drug during the phase 1 clinical trial of ceretinib.
- Taking a beta-alanine supplement
As explained above, if you do decide to take a supplement, instead of taking carnosine, I recommend taking its primary precursor, beta-alanine, based on the science in this area. Beta-alanine has also been shown to be helpful for preventing muscle soreness when working out.
- Taking a beta-alanine supplement
Major TP fan, also Christopher Moore, Aspirin. Post those, have greatly enjoyed Jim Butcher's Dresden Files series, about a modern wizard in Chicago. More violent, gritty, and noir than the others, but still engaging and funny. More balanced presentation of religion than is usual in modern fiction. I was recommended to start with #3, so I did, and have raced on through #9; there currently are 10, I think. Love them!