Skip to main content

Oneweb

Oneweb's Public Library

  • A dramatic increase in TSPO levels occurs in glial cells in response to brain injury or inflammati
  • The fact that TSPO levels are low in the brain parenchyma and regionally increase in the injured brain makes TSPO an ideal and sensitive marker to detect sma
  • Increased [11C]-PK11195 binding ratio in the striatum (67%) and substantia nigra (45%) was demonstrated after 3 weeks of 6-OHDA treatment using the cerebellum as reference region ().

1 more annotation...

09 Apr 14

The latest evidence suggests that TSPO may not only serve as a biomarker of active brain disease but also the use of TSPO-specific ligands may have therapeutic implications in brain injury and repair. This review presents an overview of the history and function of TSPO focusing on studies related to its use as a sensor of active brain disease in experimental animals and in human studies

  • The latest evidence suggests that TSPO may not only serve as a biomarker of active brain disease but also the use of TSPO-specific ligands may have therapeutic implications in brain injury and repair. This review presents an overview of the history and function of TSPO focusing on studies related to its use as a sensor of active brain disease in experimental animals and in human studies.
  • The RCT system finds many drugs effective not because they cure anything but because they change some marker or risk factor for disease, such as reducing your cholesterol level or the size of your tumour. But often changing these markers has no effect on long term outcome. For instance Ezetimibe is very effective at lowering cholesterol; however there is no evidence it has any effect on your chances of developing heart disease.
  •   An RCT is a highly specialised set up: the patients are carefully selected. Usually they are younger and healthier than the people who will actually be taking drug. They will only have one thing wrong with them and only be taking that one drug. People in the real world will be older and very likely have two or three conditions for which they are also taking five or more drugs.
  • But there is a strong tendency for drugs passed by the RCT magic bullet model, to be seen as automatically effective and appropriate for everyone. They are fire-and-forget treatments to be used according to guidelines.

  • On the issue of neuro-inflammation, Komaroff said: “There is, and you’ve heard it repeatedly in the last three days, a theory that CFS might reflect an ongoing activation of immune cells in the brain, not in the periphery, but in the brain” and he went on to discuss the Japanese study that clearly showed an increased signal, giving evidence of immune activation in multiple areas of the brain, the intensity of the signal correlating with cognitive impairment.

  • Subjects who had low levels of serum TNF-alpha throughout the study showed no cognitive decline over the 6-month period.

    CONCLUSIONS:

    Both acute and chronic systemic inflammation, associated with increases in serum tumor necrosis factor alpha, is associated with an increase in cognitive decline in Alzheimer disease.

  • :

    In the nonhuman-primate brain, LPS-induced systemic inflammation produces a robust increase in the level of TSPO that is readily detected with [(11)C]PBR28 PET. The effect of LPS on [(11)C]PBR28 binding is likely mediated by inflammatory cytokines. Activation of microglia

02 Apr 14

Cool animated guide to immune system, inc cytokine appendix (B-cell activation appendix)

31 Mar 14

How microbiome cues lead to regulation of get immune system via Tregs, damping down inflammation

in list: Microbiome

  • Regulation of intestinal tolerance thus represents the main task of the immune  system of the gut mucosa. Accumulated evidence suggests that gut commensals contribute to the maintenance of intestinal homeostasis,  partly through their ability to control the differentiation of effector T lymphocytes in the mucosa and to modulate inflammatory  responses through the induction of regulatory T cells (Tregs) and interleukin-10 (IL-10) production.
  • MNPs have been shown to contribute to the maintenance of intestinal immune tolerance  through the induction or expansion of Tregs in the intestine.
  • Microbial cues sensed by intestinal MPs lead  to IL-1β release
  • Graphic

1 more annotation...

    • New Inroads into Understanding the Mechanisms of CFS and ME

       

      Speaker: Professor Stephen Holgate

       
         
      • Date: Friday, 16 May 2014
1 - 20 of 238 Next › Last »
20 items/page

Diigo is about better ways to research, share and collaborate on information. Learn more »

Join Diigo