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Member since Mar 14, 2009, follows 5 people, 2 public groups, 113 public bookmarks (186 total).

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  • NEJM -- Genomic Medicine -- An Updated Primer on 2010-05-28
  • Ethics of UC Berkeley's gene testing questioned on 2010-05-21
    • Next month, about 5,500 first-year students will receive testing kits in the mail and be asked to submit DNA swabs to test three genes. The genes include those related to the ability to break down lactose, metabolize alcohol and absorb folates.
    • But the Center for Genetics and Society, a Berkeley public interest organization, and the Council for Responsible Genetics, which is based in Cambridge, Mass., say the project disregards the potential harmful use of the information.
    • "What we hoped to do is expose our students to the science behind personalized medicine and engage them in the discussion about what the future may hold," Schlissel said. "We could have sent all the students a magazine article or book to read, but we thought it would be far more engaging to actually involve in them in a genetic test."
  • Mapping the Personal Genomics Landscape on 2010-05-05
  • Conn. woman alleges genetic discrimination at work - BostonHerald.com on 2010-04-29
  • Looking Into My Genome Reveals Risks I’ll Never Unsee - 23andme - Gizmodo on 2010-04-28
  • Genetic Testing on 2010-04-21
  • PHG Foundation | Copy number variants not responsible for common disease on 2010-04-19
    • The failure of genome-wide association studies (GWAS) to uncover common genetic variants which confer a substantial risk to common disease has raised the question of where the so-called ‘missing heritability’ may lie. Rather than being due to single nucleotide polymorphisms (SNPs), it has been widely suggested that copy number variants (CNVs) might explain a large proportion of genetic susceptibility to common disease (see previous news).
    • However, this hypothesis has now been largely disproven by the Wellcome Trust Case Control Consortium [Craddock N, et al. Nature (2010) 464:713-20]. In the first GWAS of CNVs, researchers used an array-based approach to evaluate over 10,000 CNVs in 3,000 controls and around 2,000 cases of eight diseases: bipolar disorder, breast cancer, coronary artery disease, Crohn’s disease, hypertension, rheumatoid arthritis, type 1 diabetes and type 2 diabetes. Although several known susceptibility loci that had previously been detected through SNP association studies were confirmed – such as the involvement of the human leukocyte antigen system in all three autoimmune diseases – no convincing new associations of any of the diseases with common CNVs were found. The authors therefore concluded that “common CNVs typable on current platforms are unlikely to have a major role in the genetic basis of common diseases… [and are] unlikely to account for a substantial proportion of the ‘missing heritability’ for these diseases.”
  • A New Technology Era: Personalized Medicine For Cancer Patients on 2010-04-17
    • Formed in 2008, the consortium brings together leading cancer researchers from around the world, working together to catalogue the genetic changes of the 50 most common cancers - 500 genomes from each cancer type - and make the results freely available on the internet. 
    • "Given the tremendous potential for relatively low-cost genomic sequencing to reveal clinically useful information, we anticipate that in the not so distant future, partial or full cancer genomes will routinely be sequenced as part of the clinical evaluation of cancer patients," say the authors in the paper.
    • "For example, you might find that the aberrations in a subtype of colon cancer are the same as the aberrations in a subtype of melanoma. In that case, the treatment that works in the colon cancer may be appropriate for the melanoma. So you'd go ahead and test it." 

       "The problem we have is the complexity of cancer. No two tumours are the same, even within the same type of cancer. They may look the same under the microscope, but their molecular aberrations vary greatly."

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  • Tools for Data Analysis - for genes on 2010-04-13
  • HeLa - Wikipedia, the free encyclopedia on 2010-04-08
    • A HeLa cell (also Hela or hela cell) is a cell type in an immortal cell line used in scientific research. It is one of the oldest and most commonly used human cell lines.[1] The line was derived from cervical cancer cells taken from a patient named Henrietta Lacks, who eventually died of her cancer on October 4, 1951. The cell line was found to be remarkably durable and prolific as illustrated by its contamination of many other cell lines used in research.[2]

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