4thGeneration Mushfa's List: P53

• Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

• Oncogene 28, 3857-3865 (5 November 2009)
• p53 responsive elements in human retrotransposonsRole of p53 responsive elements
• DNA elements that are capable of altering the human genome through retrotransposition
• L1 elements
• which have a rich history of causing changes in the genome, and the p53 protein
• increased expression of L1 mRNAs by p53 actually increases, rather than decreases, the genomic stability through amplification of p53-dependent processes for genomic protection

4 more annotations...

• Dual Role of p53 in Innate Antiviral Immunity

• Role of p53 in Cell Death and Human Cancers
• Exceptions include TP53 mutations
• The Prognostic Impact of p53 Expression on Sporadic Colorectal Cancer Is Dependent on p21 Status

1 more annotation...

• Tumor Suppressor Genes
• ras, p53, cancer and cell signaling pathways
• Multiple mutations underlie the development of cancer

1 more annotation...

• p53 gene mutation and loss of heterozygosity of chromosome 11