VPython is the Python programming language plus a 3D graphics module called "Visual" originated by David Scherer in 2000. VPython makes it easy to create navigable 3D displays and animations, even for those with limited programming experience. Because it is based on Python, it also has much to offer for experienced programmers and researchers.
Pygame is a set of Python modules designed for writing games. Pygame adds functionality on top of the excellent SDL library. This allows you to create fully featured games and multimedia programs in the python language. Pygame is highly portable and runs on nearly every platform and operating system. Pygame itself has been downloaded millions of times, and has had millions of visits to its website.
Pygame is free. Released under the LGPL licence, you can create open source, free, freeware, shareware, and commercial games with it. See the licence for full details.
PyODE is a set of open-source Python bindings for The Open Dynamics Engine, an open-source physics engine. PyODE also includes an XODE parser. Like ODE, PyODE may be distributed under the terms of either the GNU Lesser General Public License or a BSD-style license.
The weave package allows the inclusion of C/C++ within Python code and is useful in accelerating Python code.
IronPython is an implementation of the Python programming language running under .NET and Silverlight. It supports an interactive console with fully dynamic compilation. It's well integrated with the rest of the .NET Framework and makes all .NET libraries easily available to Python programmers, while maintaining compatibility with the Python language.
IronPython is an open source project freely available under the Microsoft Public License. You can grab the latest sources by clicking on the Source Code tab at the top of this page or simply by clicking here. Using Team Explorer from inside Visual Studio will give a richer view of source history.