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    • Most of the funding for medical research is being done by big pharmaceutical companies. They will not study magnesium because they can’t patent it.

      Up to 80% of Americans are Magnesium deficient
    • Christine Hermes Sales, from the University of Sao Paulo (Brazil), and colleagues assessed magnesium intake status in 51 adults with type 2 diabetes.

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  • Apr 26, 11

    Magnesium
     
    A Cochrane data analysis in 2001 found three small trials comparing magnesium with placebo for relief of primary dysmenorrhea.65 Magnesium was more effective, but the dose and regime were widely variable. Magnesium has been given as magnesium pidolate.66 In one study, magnesium reduced menstrual fluid PGF2[alpha] to 45% of its pretreatment levels,67 which provides a mechanistic rationale for this therapy. Currently, it is not clear what dose, preparation, and regime to use for magnesium in treating primary dysmenorrhea. Further studies are needed.

     
    Calcium Antagonists
     
    Nifedipine, a calcium channel blocker, inhibits myometrial contractility, thereby relieving primary dysmenorrhea.68-70 By blocking calcium entry into smooth muscle cell, intracellular free calcium is reduced, the muscle relaxes, contractions are reduced, vasodilatation is promoted, and ionic stimulation of prostanoids release is decreased. Adverse effects reported from the studies include transient facial flush, increased pulse rate, palpitations, and headache.

  • Apr 26, 11

    "Magnesium is an essential mineral with evidence of effectiveness in treating eclampsia and preeclampsia, arrhythmia, severe asthma, and migraine (Table 3).

    Studies have shown the effectiveness of magnesium in eclampsia and preeclampsia, arrhythmia, severe asthma, and migraine. Other areas that have shown promising results include lowering the risk of metabolic syndrome, improving glucose and insulin metabolism, relieving symptoms of dysmenorrhea, and alleviating leg cramps in women who are pregnant. The use of magnesium for constipation and dyspepsia are accepted as standard care despite limited evidence."

    "Early signs of magnesium deficiency include loss of appetite, nausea, vomiting, fatigue, and weakness. Persons may experience numbness, tingling, muscle contractions and cramps, seizures, personality changes, abnormal heart rhythms, and coronary spasms as magnesium levels decrease. "

    "There are challenges in diagnosing magnesium deficiency because of its distribution in the body. Magnesium is an intracellular cation and its blood concentrations may not accurately mirror magnesium status.6 However, reductions in normal serum magnesium concentrations (1.8 to 2.3 mg per dL [0.74 to 0.95 mmol per L]) signify deficiency. Therefore, serum magnesium concentrations are specific, but not sensitive, to magnesium deficiency.7"

    "wo Cochrane reviews showed that magnesium use in patients with eclampsia was superior to that of phenytoin (Dilantin) and lytic cocktail,21,22 with another study showing magnesium to be more effective than nimodipine (Nimotop).23 A different 2003 Cochrane review showed that 1 to 2 g of intravenous magnesium sulfate per hour reduced the risk of eclampsia in patients with preeclampsia by more than one half.24 "

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