Resolvins and Gum Disease Topical application of the eicosapentaenoic acid-derived Resolvin E1 (RvE1) helps prevent soft tissue inflammation and destruction, as well as bone loss associated with periodontal disease. Inflammation may be a good target in the treatment of gum disease. Resolvins are a new family of biologically active products of omega-3 fatty acids and natural regulators of the inflammatory process. Gum disease is similar to other chronic inflammatory diseases, such as arthritis, where inflammation causes tissue damage. Currently, oral hygiene and regular dental care are used to control plaque and prevent gum disease. However, plaque control may not be enough to prevent gum disease in susceptible people with a high inflammatory response.