Schlaggar and his colleagues use an approach to brain scanning called resting state functional connectivity. By correlating increases and decreases in blood flow to the various brain regions as subjects rest in the scanner, scientists determine which of these regions work together in brain networks.
In a study published in 2009, Washington University scientists showed that as the brain matures, these brain networks change. The overall organization switches from networks involving regions physically close to each other, which is the dominant motif in a child's brain, to networks that connect distant regions, the primary organizational principal in adult brains.