The group with greater fish consumption exhibited lower incidence of early atherosclerosis...apparent beneficial effects of fish consumption may possibly be mediated via protective effects on inflammation in view of recent evidence that DHA and EPA can produce anti-inflammatory factors known as protectin and resolvins.
This newly-reported study evaluated the potential relationship between omega-3 fatty acid levels in the circulating blood lipid and the progression of coronary artery atherosclerosis among women with established coronary artery disease (CAD)...women with higher levels of DHA had a significantly lesser progression of coronary atherosclerosis over the 3.2 year (measured by artery diameter, % stenosis) and significantly fewer lesions (plaque)...
...blood level measures of EPA/DHA may serve as a potentially new and modifiable risk factor for ACS and that average daily intakes of 500 to 1000mg/ day of EPA/DHA (combined) from oily fish (such as mackerel, herring, sardines, salmon, others at 2-3 servings/week) and/or omega-3 supplementation may be sufficient to provide for a lower risk of ACS and associated higher levels of EPA/DHA in the circulating blood.
PubMed abstracts and citations of landmark studies concerning PUFAs, omega-3 fatty acids, vitamine E, fish oils, and guidelines from the American Heart Association.
Omega-3 (n-3) fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary and secondary-prevention studies: a systematic review || Wang C., et al || Am J Clin Nutr (2006) || Tufts-New England
Fatty acid analyses of serum (or plasma) phospholipid, a recognized biomarker for EPA and DHA intakes and overall physiological status, have exhibited an inverse correlation between n-3 PUFA and particularly the DHA levels and the development of coronary heart disease (CHD) in men...