This newly-reported study evaluated the potential relationship between omega-3 fatty acid levels in the circulating blood lipid and the progression of coronary artery atherosclerosis among women with established coronary artery disease (CAD)...women with higher levels of DHA had a significantly lesser progression of coronary atherosclerosis over the 3.2 year (measured by artery diameter, % stenosis) and significantly fewer lesions (plaque)...
...blood level measures of EPA/DHA may serve as a potentially new and modifiable risk factor for ACS and that average daily intakes of 500 to 1000mg/ day of EPA/DHA (combined) from oily fish (such as mackerel, herring, sardines, salmon, others at 2-3 servings/week) and/or omega-3 supplementation may be sufficient to provide for a lower risk of ACS and associated higher levels of EPA/DHA in the circulating blood.
PubMed abstracts and citations of landmark studies concerning PUFAs, omega-3 fatty acids, vitamine E, fish oils, and guidelines from the American Heart Association.
Omega-3 (n-3) fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary and secondary-prevention studies: a systematic review || Wang C., et al || Am J Clin Nutr (2006) || Tufts-New England
Fatty acid analyses of serum (or plasma) phospholipid, a recognized biomarker for EPA and DHA intakes and overall physiological status, have exhibited an inverse correlation between n-3 PUFA and particularly the DHA levels and the development of coronary heart disease (CHD) in men...