This link has been bookmarked by 3 people . It was first bookmarked on 16 Aug 2013, by Matt Perez.
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16 Aug 13
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Each cell type can be distinguished based on its transcription factors
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It is critical that the pattern of transcription factor binding in the genome be maintained.
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During each cell division, the transcription factors are removed from DNA and must find their way back to the right spot after the cell has divided.
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there is so much DNA in a cell that it would be impossible for the transcription factors to find their way back within a reasonable time frame
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a large protein complex called cohesin is positioned as a ring around the two DNA strands that are formed when a cell divides, marking virtually all the places on the DNA where transcription factors were bound.
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