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How to cure diseases before they have even evolved - health - 10 August 2009 - New Scientist
Goldblatt and a few other researchers think they have the answer. They are working on an entirely new class of antiviral drugs that should do something seemingly impossible: work against a wide range of existing viruses and also be effective against viruses that have not even evolved yet.
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What if, Goldblatt wondered, some host proteins are essential for viral replication but not for the survival of the host? If so, disabling these proteins should block viral replication without killing healthy cells.
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It remains early days for host-targeted antiviral therapy, as this approach is known. Indeed, many experts are sceptical about the entire notion. "People in infectious disease are comfortable with targeting the pathogen. They're not comfortable with targeting the host," says Goldblatt. One reason is the higher risk of side effects, especially with infections that require lengthy treatment.
"Until we can get these things into humans and test them, it's a little bit of a crapshoot as to whether they will work," says Michael Kurilla, who coordinates biodefence research at the US National Institute of Allergy and Infectious Diseases in Bethesda, Maryland.
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