Todd Suomela's Library tagged → View Popular, Search in Google
The world's first peer-reviewed video journal gives scientists a better way to show others how to replicate experiments.
"The recent analysis published in JAMA reviewed the success of ClinicalTrials.gov in two time periods – 2004-2007 and 2007-2010. The findings are rather troubling if you want your studies to meet the highest possible standards — between 2007 and 2010, only 48% of eligible trials were registered before patient enrollment had commenced. Granted, this was up from 33% in the earlier period, but it’s still the minority. The majority (52%) were registered after patient enrollment had started.
This means that most clinical trials are being registered after it’s theoretically possible that investigators have had a chance to peek at early data and tweak the enrollment criteria to generate a “better” trial."
"Alarming cracks are starting to penetrate deep into the scientific edifice. They threaten the status of science and its value to society. And they cannot be blamed on the usual suspects — inadequate funding, misconduct, political interference, an illiterate public. Their cause is bias, and the threat they pose goes to the heart of research."
Criticism of The Republican Brain by Chris Mooney
"In it, a group of researchers led by Jenny Tung and Yoav Gilad at the University of Chicago looked at the effects of status on rhesus macaques. Experience has shown that these monkeys display the simian equivalent of the Whitehall studies’ findings. The high risk of disease among those at the bottom of the heap in both cases suggests that biochemical responses to low status affect a creature’s immune system. Those responses must, in turn, depend on changes in the way the creatures’ genes are expressed. To investigate this phenomenon means manipulating social hierarchies, but that would be hard (and probably unethical) if it were done to human beings. You can, however, do it to monkeys, and the researchers did."
"In an increasingly knowledge-based economy, this push to position government-funded research as an engine of economic growth may seem logical. But there are innumerable problems with this commercialization strategy, beyond the reality that it is unclear how areas such as stem cell research and genetics will generate billions in profits."
-
First, in addition to all the well-documented social issues associated with industry/researcher collaborations and commercialization pressure – biased results, reduced researcher collaborations, data withholding and the potential for the premature and possibly harmful application of technologies – the emphasis on economics will inevitably lead to more of the kind of hype and overly optimistic predictions described above. When research funding is conditional on the potential for economic growth and rapid translation, the research community will find ways to promise economic growth and rapid translation.
Second, as more and more of the publicly funded research community becomes associated with this commercialization agenda, it will become increasingly difficult to find truly independent voices to critique the hype and calibrate expectations. The best science is dispassionate, independent and objective. The promised pursuit of profits is one of the surest ways to erode these qualities.
Third, it will reduce public trust in the science and the scientific community. Our research team recently completed a survey of more than 1,200 Albertans. We found university researchers funded by government to be among the most trusted. But that trust erodes significantly when those same researchers receive funds from industry.
Finally, this strategy fails to recognize how science usually unfolds. It is very difficult to predict what research will be beneficial or commercially viable. This is especially so in areas as scientifically complex as genetics and stem cell research.
In a paper published April 26 in Nature, Medzhitov and his colleagues argue that allergies are triggered by potentially dangerous substances in the environment or food to protect us.
"Indeed, the growing science of politics has uncovered a variety of interventions that can shift liberal people temporarily to the political right. And notably, none of them seem to have anything substantive to do with policy, or with the widely understood political differences between Democrats and Republicans.
Here is a list of five things that can make a liberal change his or her stripes:"
-
Distraction. Several studies have shown that “cognitive load”—in other words, requiring people to do something that consumes most or all of their attention, like listening to a piece of music and noting how many tones come before each change in pitch —produces a conservative political shift.
-
Drunkenness. Alcohol intoxication is not unlike cognitive load, in that it cuts down the capacity for in-depth, nuanced thinking, and privileges economical, quick responses. Sure enough, in a recent study of 85 bar patrons, blood alcohol content was related to increased political conservatism for liberals and conservatives alike.
- 1 more annotation(s)...
"I know this post has been a long time coming. In the first part of this series, I told you that allergies are the result of an immune response against an external, but normally not harmful substance. In part 2, I told you that allergies are the result of a specific type of immune response called "Th2," which leads to the production of IgE antibodies, and that this immune response is thought to have evolved to combat infections caused by worms. But what makes your immune system think it's supposed to be battling a worm?"
"A new study has looked at the reliability of fMRI brain scanning results over time, finding that the same experiment will only only be moderately reproducible when conducted at two different times, suggesting that fMRI is much less reliable than most researchers assume."
"Here is a list of peer reviewed papers that I’ve found that only discuss liberal-conservative differences in brain structure and function, in physiology, or in the kinds of stimuli that attract attention. And of course this is only one small area of research on liberal-conservative differences:"
"Despite the uncertainty in future climate-change impacts, it is often assumed that humans would be able to adapt to any possible warming. Here we argue that heat stress imposes a robust upper limit to such adaptation. Peak heat stress, quantified by the wet-bulb temperature TW, is surprisingly similar across diverse climates today. TW never exceeds 31 °C. Any exceedence of 35 °C for extended periods should induce hyperthermia in humans and other mammals, as dissipation of metabolic heat becomes impossible. While this never happens now, it would begin to occur with global-mean warming of about 7 °C, calling the habitability of some regions into question. With 11–12 °C warming, such regions would spread to encompass the majority of the human population as currently distributed. Eventual warmings of 12 °C are possible from fossil fuel burning. One implication is that recent estimates of the costs of unmitigated climate change are too low unless the range of possible warming can somehow be narrowed. Heat stress also may help explain trends in the mammalian fossil record. "
"Jaroslav Flegr is no kook. And yet, for years, he suspected his mind had been taken over by parasites that had invaded his brain. So the prolific biologist took his science-fiction hunch into the lab. What he’s now discovering will startle you. Could tiny organisms carried by house cats be creeping into our brains, causing everything from car wrecks to schizophrenia? A biologist’s science- fiction hunch is gaining credence and shaping the emerging science of mind- controlling parasites."
Nature Education is delighted to announce the launch of a new series of affordable, high quality interactive textbooks in college-level science. The first textbook in the series, Principles of Biology, is intended for university-level biology courses. The first title in the series is Principles of Biology, intended for introductory biology classes.
"This is the Gompertz law, in cartoon form: your body is deteriorating over time at a particular rate. When its “internal policemen” are good enough to patrol every spot that might contain a criminal 14 times a day, then you have the body of a 25-year-old and a 0.03% chance of dying this year. But by the time your police force can only patrol every spot 7 times per day, you have the body of a 95-year-old with only a 2-in-3 chance of making it through the year."
A tiny number of ideas can go a long way, as we've seen. And the Internet makes that more and more likely. What's happening is that we might, in fact, be at a time in our history where we're being domesticated by these great big societal things, such as Facebook and the Internet. We're being domesticated by them, because fewer and fewer and fewer of us have to be innovators to get by. And so, in the cold calculus of evolution by natural selection, at no greater time in history than ever before, copiers are probably doing better than innovators. Because innovation is extraordinarily hard. My worry is that we could be moving in that direction, towards becoming more and more sort of docile copiers.
Selected Tags
Related Tags
Top Contributors
Groups interested in biology
-
Science Resources
A list of resources for Scie...
Items: 169 | Visits: 216
Created by: Dianne Krause
-
virtual_zoo
Collection of sample website...
Items: 6 | Visits: 110
Created by: Kristin Hokanson
-
Biology
focus on science of living t...
Items: 118 | Visits: 1907
Created by: Sheryl A. McCoy
Diigo is about better ways to research, share and collaborate on information. Learn more »
Join Diigo
