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01 Mar 07

Merck Chemicals UK - Calbiochem: Cytoskeletal

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collagen eds medicine

Collagen Metabolism

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collagen eds medicine

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collagen eds medicine

28 Feb 07

The Ehlers-Danlos National Foundation - Chronic Pain is a Manifestation of the Ehlers–Danlos Syndrome

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eds medicine

he percentages of individuals experiencing dysfunction in various areas are presented in Figure 2. Sleep and physical activity were most frequently noted (70%) with sexual activity the least, although still substantial (45%).
Respondents identified a total of 13 principal locations of their pain, ranging from 22 individuals (43%) noting elbow pain to 41 (80%) reporting pain in the shoulders at one time or another. Similar numbers of individuals reported pain in their hands (38, 75%), knees( 36, 71%), and spine (34, 67%). Interestingly, almost half of the patients reported frequent headaches and a third had stomach aches. Approximately 70% of all patients reported continuous pain in their lower extremities, ankles, feet, toes, and hips. The description of pain qualities suggested a pattern of significant distress, described primarily as aching, sharp, throbbing or burning.
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- The mean number of pain locations for all 51 respondents was 8.0.
- Forty–six of the 51 individuals interviewed indicated they had chronic pain over the last 6 months or longer
- The present study indicates that chronic, frequently debilitating pain of early onset and diverse distribution is a constant feature in most individuals affected with different types of EDS. The presence of pain in association with the absence of a systematic approach for chronic pain management impacts dramatically on the well being of affected individuals and, as a previous study suggested, influences their social interactions.

The Ehlers-Danlos National Foundation - Mandibular Joint, Orthodontic and Dental Findings in EDS

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eds medicine

The periodontal status in the patients also needs to be closely monitored both clinically and radiographically in these patients. These tissues are very prone to gingivitis, periodontitis, and severe bleeding after invasive procedures.
Previous studies have shown that the oral findings in EDS play a significant role in treating these patients. The high frequency of TMJ subluxation is a major concern when dealing with these patients.

Clinical Manifestations of Ehlers-Danlos Syndrome

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eds medicine

fibromuscular

dysplasia

bnormalities of the spine appear frequently

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- NIH study has also found lipid
  
  abnormalities even in young persons with EDS
  
  and an increased cardiovascular risk is suggested
  
  by abnormal lipid profiles.
- EDS can affect the endocrine systems, partic-
  
  ularly adrenal secretions, growth hormones
  
  and testosterone.
- Sleep disturbance is common. Most EDS patients
  
  have trouble sleeping and an absence of deep
  
  sleep. In some, this may be due to pain which is
  
  higher than normal; both general and localized
  
  pain in EDS patients. The sleep problems have
  
  been correlated with generalized pain, but the
  
  studies have found sleep disturbance without
  
  generalized pain also.
- increased heart
  
  rates at night and some periods of tachycardia.
- Autonomic dysfunctions noted in the ongoing
  
  study include postural orthostatic tachycardia,
  
  chronic orthostatic intolerance (a large drop in
  
  pressure when standing, or a large increase in
  
  heart rate when standing), hypersensitivity to
  
  heat and cold and multiple medication allergies.
- he current study now headed by Dr. McDonnell
  
  included echocardiography data on 38 EDS
  
  patients ages 12-60. Findings include abnormal
  
  parameters in 24 of 38 and easily visible right
  
  coronary artery in 26/38. These studies also
  
  found an impaired left ventricular relaxation and
  
  impairment of the heart muscle in those persons
  
  over 40 years of age.

Ehlers-Danlos Syndromes Causes, Information, Symptoms, Treatment, and Types on MedicineNet.com

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eds medicine

In 2001, researchers discovered a new form of Ehlers-Danlos syndrome that is caused by an inherited abnormality in a protein other than collagen that also normally
plays a role in binding together the cells of our tissues (including the skin, tendons, muscle, and blood vessels). Abnormalities in this protein, called tenascin, also lead to a form of Ehlers-Danlos syndrome.
The fragile skin and loose joints is often a result of abnormal genes that produce abnormal proteins that form an inherited frailty of collagen

Ehlers-Danlos syndrome - MayoClinic.com

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eds medicine

Diseases that are caused by dominant gene mutations are called autosomal dominant disorders. The hypermobility and classical subtypes of EDS are autosomal dominant disorders.