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Today's Blog Music / The Hype Machine - discover, listen and buy music discussed on the best mp3 blogs
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Elements of SEO Wordpress Theme | Alibi Productions
Simple, nice typeface, three columns, SEO optimized
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Lightning Wordpress Theme - Free Wordpress Theme
Low key but well laid out them with colorful sidebar that highlights past items
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Useful customizable magazine type theme
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Solventus™ Home Page
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Diagnosis and treatment of vitamin B12 deficiency--an update -- Hvas and Nexo 91 (11): 1506 -- Haematologica
Nice review - PDF file, downloads when link is clicked (no HTML for some reason)
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|| DukeMedNews || Blocked Brain Enzyme Decreases Appetite and Promotes Weight Loss
Activation of the enzyme CaMKK2 is just one step in the appetite stimulation pathway located in the hypothalamus section of the brain. An empty stomach releases the hormone ghrelin, which launches a cascade of signals that ultimately results in increased appetite. Means and colleagues believed that CaMKK2 in the ghrelin pathway might be a likely candidate for study, because it activates AMPK, an enzyme that stimulates animals to eat and gain weight. They tested their theory in several ways, the results of which are published in the May issue of Cell Metabolism. The work was funded by NIH grants, as well as by the Australian Research Council, National Heart Foundation and the National Health and Medical Research Council of Australia. First they blocked CaMKK2 in mice with a specialized molecule inhibitor and then measured food intake. These mice ate significantly less food than untreated mice during the six days in which they were evaluated, and also lost body weight, which led the scientists to think they might be on to something. Next they studied a group of mice that normally do not make CaMKK2 and found that the molecule inhibitor did not change feeding behavior or reduce weight. "The fact that blocking CaMKK2 worked in normal mice to make them eat less and lose weight, but not in mice missing the enzyme, provides compelling evidence that CaMKK2 signaling is a requirement for appetite control," Means said. They also studied both normal mice and mice missing CaMKK2 to learn how these types responded to low-fat and high-fat diets. After nearly 30 weeks on the specific diets, the normal mice on the high-fat diet became diabetic – they were unable to respond to insulin and weren't able to manage blood sugar levels well. In contrast, the normal mice on a low-fat diet stayed healthy. In mice missing CaMKK2, the scientists found that they stayed healthy regardless of whether they were on a low-fat or high-fat diet. The CAMKK2-negative mice apparently were protected from changes that lead to diabetes in a high-fat diet.
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