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Defining Adequate Vitamin D Intake : Cross-sectional and Intervention Studies
Defining Adequate Vitamin D Intake : Cross-sectional and Intervention Studies
Viljakainen, Heli Tuulikki
University of Helsinki
2008-05-23
Doctoral dissertation (article-based)
In summary, vitamin D intake remains inadequate among the target groups of this thesis, as reflected by seasonal variation in calcitropic hormones and bone metabolism. Dietary intake of vitamin D should be increased to achieve at least an adequate vitamin D status (S-25-OHD>50 nmol/l) and possibly an optimal vitamin D status (S-25-OHD>80 nmol/l) throughout the year. This could be accomplished by introducing new vitamin D-fortified foods to the market.
Fatigue fractures in military conscripts : A study on risk factors, diagnostics and long-term consequences (full text PDF available)
Fatigue fractures in military conscripts : A study on risk factors, diagnostics and long-term consequences
Ruohola, Juha-Petri
University of Helsinki, Faculty of Medicine, Institute of Clinical Medicine, Orthopaedics and Traumatology, Helsinki University Central Hospital
Centre of Military Medicine, Helsinki
2007-03-09
Doctoral dissertation (article-based)
It seems likely that low vitamin D levels are related to fatigue fractures, and that an increasing trend exists between TRACP-5b bone resorption marker elevation and fatigue fracture incidence. Though seldom detected by plain radiography, fatigue fractures often underlie unclear lower leg stress-related pain occurring in the distal parts of the tibia. Femoral neck fatigue fractures, when displaced, lead to long-term morbidity in a high percentage of patients, whereas, when non-displaced, they do not predispose patients to subsequent adverse complications. Importantly, an educational intervention can diminish the incidence of fracture displacement by enhancing awareness and providing instructions for earlier diagnosis of fatigue fractures
YouTube - Vitamin D: It's Not Just For Bones Anymore
David Feldman, MD, professor of medicine at Stanford, explores the biological action of Vitamin D beyond its widely understood role in the information and maintenance of bone. Emerging therapeutic uses of the vitamin include the prevention and treatment of breast, prostate and colon cancer, chronic kidney disease and arthritis, among other conditions.
Low Vitamin D Status despite Abundant Sun Exposure -- Binkley et al. 92 (6): 2130 -- Journal of Clinical Endocrinology & Metabolism
Low vitamin D status despite abundant sun exposure.
Binkley N, Novotny R, Krueger D, Kawahara T, Daida YG, Lensmeyer G, Hollis BW, Drezner MK.
J Clin Endocrinol Metab. 2007 Jun;92(6):2130-5. Epub 2007 Apr 10.
PMID: 17426097
doi:10.1210/jc.2006-2250
CONCLUSIONS: These data suggest that variable responsiveness to UVB radiation is evident among individuals, causing some to have low vitamin D status despite abundant sun exposure. In addition, because the maximal 25(OH)D concentration produced by natural UV exposure appears to be approximately 60 ng/ml, it seems prudent to use this value as an upper limit when prescribing vitamin D supplementation.
Diagnosis & Treatment of Vitamin D Deficiency - Seminar Presentations (PDF Slides) - University of California, San Diego 2008
Diagnosis & Treatment of Vitamin D Deficiency
Wednesday, April 9, 2008 * 12:30pm - 6:00pm
Garren Auditorium, University of California, San Diego
Seminar Presentations
YouTube - Vitamin D: It's Not Just For Bones Anymore
Vitamin D: It's Not Just For Bones Anymore. A presentation professor David Feldman
YouTube - Vitamin D and Cancer Prevention
YouTube - Vitamin D and Cancer Prevention. A presentation by Dr. Cedric Garland.
YouTube - Vitamin D and Prevention of Chronic Diseases
Vitamin D and Prevention of Chronic Diseases. A presentation by professor Michael F. Holick
YouTube - Vitamin D and Cardiovascular Disease Prevention
Vitamin D and Cardiovascular Disease Prevention by Dr. David C. Sane
YouTube - Possible 75% cancer mortality reduction with Vitamin D
Possible 75% cancer mortality reduction with Vitamin D Interview with Dr. Cedric Garland
YouTube - Connection with Vitamin D and Cancer
Connection with Vitamin D and Cancer by Dr. Donald L. Trump
YouTube - Vitamin D and Diabetes-Can We Prevent it?
Vitamin D and Diabetes-Can We Prevent it? Frank C. Garland
YouTube - Whats a Vitamin D Deficiency?
Professor Robert P. Heaney's talk about vitamin D deficiency and what actions should be taken
Vitamin D (Cholecalciferol, Calcitriol)
Bioactive vitamin D or calcitriol is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. More recently, it has become clear that receptors for vitamin D are present in a wide variety of cells, and that this hormone has biologic effects which extend far beyond control of mineral metabolism.
The active form of vitamin D binds to intracellular receptors that then function as transcription factors to modulate gene expression. Like the receptors for other steroid hormones and thyroid hormones, the vitamin D receptor has hormone-binding and DNA-binding domains. The vitamin D receptor forms a complex with another intracellular receptor, the retinoid-X receptor, and that heterodimer is what binds to DNA. In most cases studied, the effect is to activate transcription, but situations are also known in which vitamin D suppresses transcription.
Each of the forms of vitamin D is hydrophobic, and is transported in blood bound to carrier proteins. The major carrier is called, appropriately, vitamin D-binding protein. The halflife of 25-hydroxycholecalciferol is several weeks, while that of 1,25-dihydroxycholecalciferol is only a few hours.
The vitamin D receptor binds several forms of cholecalciferol. Its affinity for 1,25-dihydroxycholecalciferol is roughly 1000 times that for 25-hydroxycholecalciferol, which explains their relative biological potencies
Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation. - [Clin Biochem. 2009] - PubMed Result
BACKGROUND: To determine the effect of vitamin D binding protein (DBP) genotypes on 25-hydroxyvitamin D [25(OH)D] changes with vitamin D supplements, we studied 98 adults receiving 600 or 4000 IU/d vitamin D(3) for one year. METHODS: The DBP functional variant, T436K, was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: Mean 25(OH)D increases were 97% for TT (n=48), 151% for TK (n=31) and 307% (n=6) for KK genotypes (p=.004). CONCLUSIONS: As with baseline 25(OH)D, T436K genotype predicts 25(OH)D changes after long-term vitamin D supplementation.
Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation.
Fu L, Yun F, Oczak M, Wong BY, Vieth R, Cole DE.
Clin Biochem. 2009 Jul;42(10-11):1174-7. Epub 2009 Mar 18.
PMID: 19302999
Artemisinin - Bioengineering, UW College of Engineering
Below is a list of publications covering the research being done by UW and other institutions on artemisinin and cancer. The list is organized into two categories: publications related to the effects of artemisinin and its analogs on cancer and artemisinin pharmacology and pharmacokinetics. You may find them useful when consulting with your personal physician. We have also compiled a comprehensive list of artemisinin-related articles (more than 350 publications) that you may also find useful.
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