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Evidence for alteration of the vitamin D-endocrine system in obese subjects.
Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S.
J Clin Invest. 1985 Jul;76(1):370-3.
PMID: 2991340

The results provide evidence that alteration of the vitamin D-endocrine system in obese subjects is characterized by secondary hyperparathyroidism which is associated with enhanced renal tubular reabsorption of calcium and increased circulating 1,25(OH)2D. The reduction of serum 25-OHD in them is attributed to feedback inhibition of hepatic synthesis of the precursor by the increased serum 1,25(OH)2D.

www.jci.org/111971 - Preview

1985 July jci study research clinical_trial humans obesity vitamin_D vitamin D-endocrine system alteration obese subjects nutrition medline PTH 25ohd calcitriol

"
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If you decide to try Google Public DNS, your client programs will perform all DNS lookups using Google Public DNS. "

code.google.com/public-dns - Preview

Google Public DNS global Domain Name System free

"If you're running low on vitamin D - as an estimated 70 percent of the U.S. population is - your immune system may not be functioning as well as it should. As a result, you may be more vulnerable to infectious diseases than you would if your vitamin D levels were optimal. Worse, you could be at higher than normal risk of a long list of diseases including heart disease and several kinds of cancer. A report recently published journal, Future Microbiology, highlighted research at the Linus Pauling Institute at Oregon State University, which has shown that vitamin D induces expression of an antimicrobial peptide gene called cathelicidin that is the "first line of defense" in the immune system's response to minor wounds, cuts and bacterial and viral infections. The regulation of cathelicidin by vitamin D could help explain its vital role in immune function. The report noted that vitamin D is a key cofactor in reducing inflammation, in blood pressure control and helping to protect against heart disease. Author Adrian Gombart explains that there is still much to explore about D's mechanisms of action, the potential use of synthetic analogs of it in new treatments, and its duty in fighting infection."

www.drweil.com/...eficiency-Lead-to-Disease.html - Preview

2009 November drweil blog_article vitamin_D deficiency prevalence lead risk disease diseases nutrition CVD CHD cancer cathelicidin immune system function

"Below is a list of summary of actions of Vitamin D (Hormone D)"

nephropal.blogspot.com/...amin-d-summary-of-actions.html - Preview

2009 November nephropal blog_article vitamin_D summary actions CVD cardiovascular mineral muscoskeletal endocrine immune system kidney cancer nutrition

Googlen julkaisi tänään järjestetyssä lehdistötilaisuudessa odotetusti tietoja yrityksen Chrome-käyttöjärjestelmästä. Avoimen lähdekoodin käyttöjärjestelmää Googlen puolelta esittelivät tuotehallinnan varapääjohtaja Sundar Pichai ja käyttöjärjestelmän kehitystyötä johtava Matthew Papakipos.

fin.afterdawn.com/...teli_chrome_kayttojarjestelman - Preview

2009 marraskuu afterdawn uutinen Google Chrome OS revealed operating system operating_system Linux open-source software OSS browser käyttöjärjestelmä

"Google had a low-key event today to preview Chrome OS, its new operating system based on Linux and the Chrome browser. Things are still pretty early -- it's not even in beta yet, let alone on shipping products -- but that's the first official screen shot right there, and the big features are all roughed out. The entire system is web-based and runs in the Chrome browser -- right down to USB drive contents, which show up in a browser tab, and the notepad, which actually creates a Google Docs document. Web apps are launched from a persistent apps panel, which includes Gmail, Facebook, Twitter, and Hulu, among others, and background apps like Google Talk can be minimized to "panels" that dock to the bottom of the screen"

www.engadget.com/...googles-chrome-os-revealed - Preview

2009 November engadget news Google Chrome OS revealed operating system operating_system Linux open-source software OSS browser

"I recently received an email from the Vitamin D Council regarding recent evidence that having adequate serum Vitamin D levels could be very important to avoiding illness from the H1N1 (swine) flu that is making the rounds. That will seem intuitive to those of you who read my earlier post about D, but it’s good to see some real evidence. Some of you may have seen this information already on other blogs, including Richard’s, but I have some new information and some comments to add."

www.paleonu.com/...in-d3-and-innate-immunity.html - Preview

2009 September paleonu blog_article vitamin_D H1N1 influenza innate immunity innate_immunite immune system paleolithic diet paleolithic_diet epidemic epidemiology nutrition

"People with coeliac disease may be more susceptible to osteoporosis because their own immune system attacks their bone tissue, a study suggests.

Osteoporosis is a known risk of coeliac disease and has been explained by a failure to absorb calcium or vitamin D. "

news.bbc.co.uk/...8295438.stm - Preview

2009 October BC news coeliac disease celiac osteoporosis risk vitamin_D nutrition bone health loss immune system

The New England Journal of Medicine recently published an article from a joint collaboration between several cancer centers on both the east and west coast. A 52 year-old man with stage IV malignant melanoma, a very aggressive and potentially lethal form of skin cancer, donated blood to the scientists who have developed a technique to isolate specific CD4+ T cells and clone them in vitro.

AccuracyIn our bodies, our immune system is responsible for attacking all cells that may pose a threat to our well-being, whether they be bacteria, viruses, foreign bodies, or even cancerous cells. Each T cell is responsible for recognizing a specific cell line which is potentially threatening, then targeting (where the “T” comes from) those cells for destruction by the production of antibodies, and large vacuum cleaner-type cells called macrophages. The trouble with cancer is that the cells are multiplying very rapidly, and there are only a few circulating T cells which are specific to that cancerous cell line. Therefore the cancerous cells overwhelm our ability to tag them fast enough, and the cancer grows and spreads.

What the scientists in this study have done is isolate the T cells which are targeted towards the malignant melanoma. Then they used a chemical and biological process to multiply those T cells several thousands of times over. Finally, they injected those thousands of T cells back into the patient, and let them go to work. Now there were so many T cells compared to cancerous cells, that tagging them was easy and the body was naturally able to break down the cancer using its own immune system. The man went into complete remission and has stayed there for the past two years.

brainblogger.com/...the-smart-bomb-of-tomorrow - Preview

2008 July brainblogger blog_article Smart Bomb Eradicating Cancer T-cells malignant melanoma immunr system immunity

They found some important trends. Granulocytes from people over 50 years old had a reduced ability to kill cancer cells, as did granulocytes from people with cancer. This raises the possibility that cancer is not simply the result of getting too old, but a very specific weakening of the immune system.

The most important finding, however, was that the granulocytes' kung-fu grip declined dramatically during the winter months. Here's Dr. Cui:

Nobody seems to have any cancer-killing ability during the
winter months from November to April.

wholehealthsource.blogspot.com/...cancer-and-immune-system.html - Preview

2008 July wholehealthsource blog_article cancer immune system immune_system granulocytes elderly older old winter vitamin_D

Vitamin D, nervous system and aging.
Tuohimaa P, Keisala T, Minasyan A, Cachat J, Kalueff A.
Psychoneuroendocrinology. 2009 Aug 4. [Epub ahead of print]
PMID: 19660871

www.sciencedirect.com/science - Preview

2009 August study review humans Tuohimaa vitamin_D 25ohd calcidiol calcitriol premature aging nervous system neurodegeneration chronic diseases nutrition U-shaped risk U-shape medline

Overview of general physiologic features and functions of vitamin D.
DeLuca HF.
Am J Clin Nutr. 2004 Dec;80(6 Suppl):1689S-96S. Review.
PMID: 15585789

www.ajcn.org/...1689S - Preview

2004 December study review humans vitamin_D metabolism bone calcium homeostasis tetany endocrine system autoimmune diseases Overview physiologic features functions nutrition ajcn medline DeLuca

October 6th, 2008

A study led by researchers at the University of California, San Diego School of Medicine suggests that use of oral Vitamin D supplements bolsters production of a protective chemical normally found in the skin, and may help prevent skin infections that are a common result of atopic dermatitis, the most common form of eczema.

www.physorg.com/news142521505.html - Preview

2008 October physorg news vitamin_D supplementation skin infection infections atopic dermatitis atopic_dermatitis atopy immune system nutrition

Evolution and function of vitamin D.
Holick MF.
Recent Results Cancer Res. 2003;164:3-28. Review.
PMID: 12899511

www.ncbi.nlm.nih.gov/...12899511 - Preview

2003 study review humans Holick vitamin_D evolution function plankton zooplankton phytoplankton sunlight diet VDR 25ohd calcitriol immune system regulation renin-angiotensin MS diabetes nutrition medline latitude PTH hypertension CVD

From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health.
Norman AW.
Am J Clin Nutr. 2008 Aug;88(2):491S-499S. Review.
PMID: 18689389

www.ajcn.org/...491S - Preview

2008 August ajcn study review vitamin_D hormone fundamentals endocrine system essential health nutrition VDR calcitriol 25ohd immune innate adaptive immunity organs

Conclusion

We demonstrated that the VDRE in the CAMP gene originated from the exaptation of an AluSx SINE in the lineage leading to humans, apes, OWMs and NWMs and remained under purifying selection for the last 55–60 million years. We present convincing evidence of an evolutionarily fixed, Alu-mediated divergence in steroid hormone nuclear receptor gene regulation between humans/primates and other mammals. Evolutionary selection to place the primate CAMP gene under regulation of the vitamin D pathway potentiates the innate immune response and may counter the anti-inflammatory properties of vitamin D.

Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates.
Gombart AF, Saito T, Koeffler HP.
BMC Genomics. 2009 Jul 16;10:321.
PMID: 19607716
doi:10.1186/1471-2164-10-321

www.biomedcentral.com/...321 - Preview

2009 Jyly study research vitamin_D receptor binding element VDR VDRE primates humans immune system evolution innate_immunity innate immunity cathelicidin antimicrobial peptide immune_system immune_response response nutrition

A new study has concluded that one key part of the immune system, the ability of vitamin D to regulate anti-bactericidal proteins, is so important that is has been conserved through almost 60 million years of evolution and is shared only by primates, including humans - but no other known animal species.

www.physorg.com/news169831861.html - Preview

2009 August physorg news primates humans vitamin_D immune system evolution innate_immunity innate immunity cathelicidin antimicrobial peptide immune_system immune_response response nutrition

Antitumor activity of human papillomavirus type 16 E7-specific T cells against virally infected squamous cell carcinoma of the head and neck.
Albers A, Abe K, Hunt J, Wang J, Lopez-Albaitero A, Schaefer C, Gooding W, Whiteside TL, Ferrone S, DeLeo A, Ferris RL.
Cancer Res. 2005 Dec 1;65(23):11146-55.
PMID: 16322265

cancerres.aacrjournals.org/...11146 - Preview

2005 December study research clinical_trial humans patients HPV virus head_and_neck_cancer cancer scchn hnca scc immunity immune system immunology medline immunotherapy HPV-16 T_cells

Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe?
Nunn AV, Bell JD, Guy GW.
Nutr Metab (Lond). 2009 Apr 16;6:16.
PMID: 19371409
doi:10.1186/1743-7075-6-16

www.nutritionandmetabolism.com/...16 - Preview

2009 April study review humans lifestyle-induced metabolic inflexibility accelerated ageing syndrome aging insulin_resistance medline mitochondria hormesis metabolic_syndrome redox-thriftiness calorie restriction caloric CR immune system inflammation

Tregs and allergic disease.
Robinson DS, Larché M, Durham SR.
J Clin Invest. 2004 Nov;114(10):1389-97. Review.
PMID: 15545986
doi:10.1172/JCI23595

www.jci.org/23595 - Preview

2004 November study review humans Tregs T-regulatory cells T-suppressor immunity immune system allergic disease allergy allergies medline atopy atopic asthma Th1 Th2 immunotherapy