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Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sunny country? - Eur J Nutr. 2009 Nov 28. - SpringerLink - Journal Article
Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sunny country?
Pignotti GA, Genaro PS, Pinheiro MM, Szejnfeld VL, Martini LA.
Eur J Nutr. 2009 Nov 28. [Epub ahead of print]
PMID: 19946776
CONCLUSION: The dose given (400 IU/day) was not enough to achieve 25(OH)D concentration, considered optimal for bone health.
Vitamin D deficiency is associated with worse cognitive performance and lower bone density in older African Americans. - [J Natl Med Assoc. 2009] - PubMed result
Vitamin D deficiency is associated with worse cognitive performance and lower bone density in older African Americans.
Wilkins CH, Birge SJ, Sheline YI, Morris JC.
J Natl Med Assoc. 2009 Apr;101(4):349-54.
PMID: 19397226
CONCLUSIONS: Vitamin D deficiency in older African Americans was associated with worse cognitive performance and lower BMD of the hip
Effects Of Vitamin D Deficiency Amplified By Shortage Of Estrogen
"Researchers at Johns Hopkins are reporting what is believed to be the first conclusive evidence in men that the long-term ill effects of vitamin D deficiency are amplified by lower levels of the key sex hormone estrogen, but not testosterone.
In a national study in 1010 men, to be presented Nov. 15 at the American Heart Association's (AHA) annual Scientific Sessions in Orlando, researchers say the new findings build on previous studies showing that deficiencies in vitamin D and low levels of estrogen, found naturally in differing amounts in men and women, were independent risk factors for hardened and narrowed arteries and weakened bones. Vitamin D is an essential part to keeping the body healthy, and can be obtained from fortified foods, such as milk and cereals, and by exposure to sunlight.
Low Vitamin D Levels May Raise Heart Risk
"Study Shows Vitamin D Supplements May Be Useful in Preventing Heart Disease
Nov. 16, 2009 (Orlando, Fla.) -- Some men with low levels of vitamin D in their blood are at particularly high risk of developing heart disease and weakened bones that can lead to osteoporosis, researchers report.
In a study of more than 1,000 men, those with low levels of both vitamin D and the sex hormone estrogen were at significantly increased risk of having cardiovascular disease, says study head Erin Michos, MD, a cardiologist at Johns Hopkins.
"They were also at dramatically increased risk of osteopenia," or bone loss that can lead to osteoporosis, she says.
"Our results suggest that vitamin D supplements, which are already prescribed to treat osteoporosis, may also be useful in preventing heart disease," Michos tells WebMD.
Men with low levels of vitamin D and testosterone, on the other hand, were not at heightened risk for heart disease or osteopenia."
Dietary protein and bone health: a systematic review and meta-analysis -- Darling et al. 90 (6): 1674 -- American Journal of Clinical Nutrition
Dietary protein and bone health: a systematic review and meta-analysis.
Darling AL, Millward DJ, Torgerson DJ, Hewitt CE, Lanham-New SA.
Am J Clin Nutr. 2009 Nov 4. [Epub ahead of print]
PMID: 19889822
Effectiveness and safety of vitamin D in relation to bone health. - [Evid Rep Technol Assess (Full Rep). 2007] - PubMed result
Effectiveness and safety of vitamin D in relation to bone health.
Cranney A, Horsley T, O'Donnell S, Weiler H, Puil L, Ooi D, Atkinson S, Ward L, Moher D, Hanley D, Fang M, Yazdi F, Garritty C, Sampson M, Barrowman N, Tsertsvadze A, Mamaladze V.
Evid Rep Technol Assess (Full Rep). 2007 Aug;(158):1-235. Review.
PMID: 18088161
Defining Adequate Vitamin D Intake : Cross-sectional and Intervention Studies
Defining Adequate Vitamin D Intake : Cross-sectional and Intervention Studies
Viljakainen, Heli Tuulikki
University of Helsinki
2008-05-23
Doctoral dissertation (article-based)
In summary, vitamin D intake remains inadequate among the target groups of this thesis, as reflected by seasonal variation in calcitropic hormones and bone metabolism. Dietary intake of vitamin D should be increased to achieve at least an adequate vitamin D status (S-25-OHD>50 nmol/l) and possibly an optimal vitamin D status (S-25-OHD>80 nmol/l) throughout the year. This could be accomplished by introducing new vitamin D-fortified foods to the market.
Coeliac bone loss link uncovered - BBC NEWS | Health
"People with coeliac disease may be more susceptible to osteoporosis because their own immune system attacks their bone tissue, a study suggests.
Osteoporosis is a known risk of coeliac disease and has been explained by a failure to absorb calcium or vitamin D. "
African Americans, 25-hydroxyvitamin D, and osteoporosis: a paradox -- Aloia 88 (2): 545S -- American Journal of Clinical Nutrition
African Americans, 25-hydroxyvitamin D, and osteoporosis: a paradox.
Aloia JF.
Am J Clin Nutr. 2008 Aug;88(2):545S-550S. Review.
PMID: 18689399
African Americans have lower serum 25-hydroxyvitamin D concentrations and a lower risk of fragility fractures than do other populations. I review the evidence on factors other than vitamin D that might explain this paradox and the calcium economy in different life stages.
Aggressive Vitamin D Treatment for Osteoporosis
"May 19, 2008 (Orlando, Florida) — A new study shows that a proactive vitamin D treatment plan should be considered when caring for all osteoporosis patients, and that such treatment might help decrease the likelihood of developing vitamin D deficiency.
Vitamin D deficiency is widespread among patients being treated for osteoporosis, and such deficiency should be treated aggressively, according to the findings presented here at the American Association of Clinical Endocrinologists 17th Annual Meeting and Clinical Congress."
Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women -- Dawson-Hughes et al. 65 (1): 67 -- American Journal of Clinical Nutrition (full text PDF)
Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women.
Dawson-Hughes B, Harris SS, Dallal GE.
Am J Clin Nutr. 1997 Jan;65(1):67-71.
PMID: 8988915
Plasma calcidiol and serum PTH concentrations were inversely related, with PTH rising slowly as calcidiol concentrations declined below 110 nmol/L (95 CI: 60, 168 nmol/L). More than 90% of the men and women had calcidiol concentrations below this value in the wintertime. The high prevalence of lower wintertime calcidiol values may increase risk of bone loss in elderly men and women.
Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis -- Manolagas 21 (2): 115 -- Endocrine Reviews
Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.
Manolagas SC.
Endocr Rev. 2000 Apr;21(2):115-37. Review.
PMID: 10782361
Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women. - JNSV : Vol. 55 (2009) , No. 1 pp.15-21 (free full text PDF available)
Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women.
Koitaya N, Ezaki J, Nishimuta M, Yamauchi J, Hashizume E, Morishita K, Miyachi M, Sasaki S, Ishimi Y.
J Nutr Sci Vitaminol (Tokyo). 2009 Feb;55(1):15-21.
PMID: 19352059
These results suggest that supplementation with 1.5 mg/d MK-4 accelerated the degree of OC gamma-carboxylation. The concentrations of serum lipids and other indices were not different between the groups at either intervention period. Thus, the additional intake of MK-4 might be beneficial in the maintenance of bone health in postmenopausal Japanese women.
Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis
Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis.
Avenell A, Gillespie WJ, Gillespie LD, O'Connell D.
Cochrane Database Syst Rev. 2009 Apr 15;(2):CD000227. Review.
PMID: 19370554
DOI: 10.1002/14651858.CD000227.pub3
AUTHORS' CONCLUSIONS: Frail older people confined to institutions may sustain fewer hip fractures if given vitamin D with calcium. Vitamin D alone is unlikely to prevent fracture. Overall there is a small but significant increase in gastrointestinal symptoms and renal disease associated with vitamin D or its analogues. Calcitriol is associated with an increased incidence of hypercalcaemia.
Vitamin K and the Prevention of Fractures: Systematic Review and Meta-analysis of Randomized Controlled Trials, June 26, 2006, Cockayne et al. 166 (12): 1256 - Arch Intern Med
Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
Cockayne S, Adamson J, Lanham-New S, Shearer MJ, Gilbody S, Torgerson DJ.
Arch Intern Med. 2006 Jun 26;166(12):1256-61. Review.
PMID: 16801507
Conclusions This systematic review suggests that supplementation with phytonadione and menaquinone-4 reduces bone loss. In the case of the latter, there is a strong effect on incident fractures among Japanese patients.
Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density
Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density.
Abreu MT, Kantorovich V, Vasiliauskas EA, Gruntmanis U, Matuk R, Daigle K, Chen S, Zehnder D, Lin YC, Yang H, Hewison M, Adams JS.
Gut. 2004 Aug;53(8):1129-36.
PMID: 15247180
doi: 10.1136/gut.2003.036657.
Conclusions: These data demonstrate that elevated 1,25(OH)2D is more common in CD than previously appreciated and is independently associated with low bone mineral density. The source of the active vitamin D may be the inflamed intestine. Treatment of the underlying inflammation may improve metabolic bone disease in this subgroup of patients.
Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density -- Outila et al. 74 (2): 206 -- American Journal of Clinical Nutrition
Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density.
Outila TA, Kärkkäinen MU, Lamberg-Allardt CJ.
Am J Clin Nutr. 2001 Aug;74(2):206-10.
PMID: 11470722
Conclusion: A large percentage of adolescent females have low vitamin D status during the winter in Finland, which seems to have negative effects on bone health.
NEJM -- Vitamin D3 and calcium to prevent hip fractures in the elderly women
Vitamin D3 and calcium to prevent hip fractures in the elderly women.
Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ.
N Engl J Med. 1992 Dec 3;327(23):1637-42.
PMID: 1331788
CONCLUSIONS. Supplementation with vitamin D3 and calcium reduces the risk of hip fractures and other nonvertebral fractures among elderly women.
Vitamin D deficiency and bone health in healthy adults in Finland: could this be a concern in other parts of Europe? - .[J Bone Miner Res. 2001] - PubMed Result
Vitamin D deficiency and bone health in healthy adults in Finland: could this be a concern in other parts of Europe?
Lamberg-Allardt CJ, Outila TA, Kärkkainen MU, Rita HJ, Valsta LM.
J Bone Miner Res. 2001 Nov;16(11):2066-73.
PMID: 11697803
Low vitamin D status was prevalent in these young adults in northern Europe in winter, although the vitamin D intake met the recommendation. This probably is not a local problem for northern Europe, because the natural sources of vitamin D are scarce and fortification is not very common in Europe, and with the exception of the southern part of Europe, sunshine is not very abundant in this part of the world. Thus, the results of this study indicate that more attention should be focused on vitamin D status and the sources of vitamin D in these countries.
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