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Fish intake and risk of incident atrial fibrillation.
Mozaffarian D, Psaty BM, Rimm EB, Lemaitre RN, Burke GL, Lyles MF, Lefkowitz D, Siscovick DS.
Circulation. 2004 Jul 27;110(4):368-73. Epub 2004 Jul 19.
PMID: 15262826
doi: 10.1161/01.CIR.0000138154.00779.A5

Conclusions— Among elderly adults, consumption of tuna or other broiled or baked fish, but not fried fish or fish sandwiches, is associated with lower incidence of AF. Fish intake may influence risk of this common cardiac arrhythmia.

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2004 July Circulation study research epidemiological humans elderly old older fish consumption atrial fibrillation atrial_fibrillation AF CVD nutrition cardiac arrhythmia aging broiled baked fried medline Mozaffarian cooking_method cooking method

Cardiac benefits of fish consumption may depend on the type of fish meal consumed: the Cardiovascular Health Study.
Mozaffarian D, Lemaitre RN, Kuller LH, Burke GL, Tracy RP, Siscovick DS; Cardiovascular Health Study.
Circulation. 2003 Mar 18;107(10):1372-7.
PMID: 12642356
doi: 10.1161/01.CIR.0000055315.79177.16

Conclusions— Among adults aged >=65 years, modest consumption of tuna or other broiled or baked fish, but not fried fish or fish sandwiches, is associated with lower risk of IHD death, especially arrhythmic IHD death. Cardiac benefits of fish consumption may vary depending on the type of fish meal consumed.

circ.ahajournals.org/...1372 - Preview

2003 March Circulation study research epidemiological humans elderly old oldwer fish consumption cardiac benefits omega-3 broiled baked fried nutrition CVD CHD IHD arrhythmia Mozaffarian cooking method cooking_method type meal medline

Fish consumption and risk of subclinical brain abnormalities on MRI in older adults.
Virtanen JK, Siscovick DS, Longstreth WT Jr, Kuller LH, Mozaffarian D.
Neurology. 2008 Aug 5;71(6):439-46.
PMID: 18678827
doi: 10.1212/01.wnl.0000324414.12665.b0

Conclusions:
Among older adults, modest consumption of tuna/other fish, but not fried fish, was associated with lower prevalence of subclinical infarcts and white matter abnormalities on MRI examinations. Our results add to prior evidence that suggest that dietary intake of fish with higher eicosapentaenoic acid and docosahexaenoic acid content, and not fried fish intake, may have clinically important health benefits

www.ncbi.nlm.nih.gov/...PMC2676980 - Preview

2008 August Neurology Virtanen study research epidemiological humans older old elderly modest fish consumption omega-3 EPA DHA subclinical brain abnormalities nutrition infarcts risk MRI Mozaffarian medline

A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women.
Gleason CE, Carlsson CM, Barnet JH, Meade SA, Setchell KD, Atwood CS, Johnson SC, Ries ML, Asthana S.
Age Ageing. 2009 Jan;38(1):86-93. Epub 2008 Dec 2.
PMID: 19054783
doi:10.1093/ageing/afn227

Conclusions: these data suggest that administration of 100 mg/day of isoflavones was well tolerated. Plasma genistein and daidzein levels, but not equol, increased with isoflavone administration. Finally, data support the potential cognitive effects of soy isoflavones in older adults.

ageing.oxfordjournals.org/...86 - Preview

2009 January study preliminary research clinical_trial rct humans elderly older old soy isoflavone isoflavones supplementation cognition nutrition genistein daidzein equol aging cognitive function efficacy safety feasibility phytoestrogens herbs

High tofu intake is associated with worse memory in elderly Indonesian men and women.
Hogervorst E, Sadjimim T, Yesufu A, Kreager P, Rahardjo TB.
Dement Geriatr Cogn Disord. 2008;26(1):50-7. Epub 2008 Jun 27.
PMID: 18583909
DOI: 10.1159/000141484

CONCLUSION: The results for tofu consumption as a risk factor for low memory function may tie in with the Honolulu Asia Aging Study data. It is unclear whether these negative associations could be attributed to potential toxins or to its phytoestrogen levels. Estrogen (through which receptors phytoestrogens can exert effects) was found to increase dementia risk in women over 65 years of age. Tempe contains high levels of phytoestrogens, but (due to fermentation) also exhibits high folate levels which may exert protective effects. Future studies should validate these findings and investigate potential mechanisms.

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2008 June study research epidemiological humans elderly old older Indonesian Indonesia high tofu intake consumption memory impairment nutrition dementia cognition brain aging medline soy tempe tempeh folata folic_acid

Low vitamin D status, high bone turnover, and bone fractures in centenarians.
Passeri G, Pini G, Troiano L, Vescovini R, Sansoni P, Passeri M, Gueresi P, Delsignore R, Pedrazzoni M, Franceschi C.
J Clin Endocrinol Metab. 2003 Nov;88(11):5109-15.
PMID: 14602735

We conclude that the extreme decades of life are characterized by a pathophysiological sequence of events linking vitamin D deficiency, low serum calcium, and secondary hyperparathyroidism with an increase in bone resorption and severe osteopenia. These data offer a rationale for the possible prevention of elevated bone turnover, bone loss, and consequently the reduction of osteoporotic fractures and fracture-induced disability in the oldest olds through the supplementation with calcium and vitamin D.

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2003 November jcem study research epidemiological humans centenarians old older oldest vitamin_D deficiency prevalence 25ohd undetectable nutrition status osteopenia secondary_hyperparathyroidism PTH IL-6 medline bone fractures turnover resorption

Vitamin D, nutritional deficiency, and the medical paradigm.
Heaney RP.
J Clin Endocrinol Metab. 2003 Nov;88(11):5107-8. Review. No abstract available.
PMID: 14602734

jcem.endojournals.org/...5107 - Preview

2003 November jcem study editorial review Heaney vitamin_D nutritional deficiency medical paradigm nutrition medline elderly old older humans centenarians oldest 25ohd undetectable

Vitamin D and mortality in older men and women.
Pilz S, Dobnig H, Nijpels G, Heine RJ, Stehouwer CD, Snijder MB, van Dam RM, Dekker JM.
Clin Endocrinol (Oxf). 2009 Nov;71(5):666-72. Epub 2009 Feb 18.
PMID: 19226272
DOI: 10.1111/j.1365-2265.2009.03548.x

Conclusions Low 25(OH)D levels are associated with all-cause mortality and even more pronounced with cardiovascular mortality, but it remains unclear whether vitamin D deficiency is a cause or a consequence of a poor health status. Therefore, intervention studies are warranted to evaluate whether vitamin D supplementation reduces mortality and cardiovascular diseases.

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2009 November study research epidemiological humans older old elder vitamin_D 25ohd low_levels CVD mortality all-cause all-causes nutrition medline

Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community-dwelling women.
Semba RD, Houston DK, Ferrucci L, Cappola AR, Sun K, Guralnik JM, Fried LP.
Nutr Res. 2009 Aug;29(8):525-30.
PMID: 19761886
doi:10.1016/j.nutres.2009.07.007

Older community-dwelling women with low 25(OH)D levels are at an increased risk of death.

www.nrjournal.com/...abstract - Preview

2009 August nrjournal study research epidemiological humans women older old elderly vitamin_D 25ohd low_levels aging mortality all-cause all-causes survival nutrition medline community-dwelling

Consumption of 2 and 4 egg yolks/d for 5 wk increases macular pigment concentrations in older adults with low macular pigment taking cholesterol-lowering statins.
Vishwanathan R, Goodrow-Kotyla EF, Wooten BR, Wilson TA, Nicolosi RJ.
Am J Clin Nutr. 2009 Nov;90(5):1272-9. Epub 2009 Sep 16.
PMID: 19759170

Conclusions: Consumption of 4 egg yolks/d, and possibly of 2 egg yolks/d, for 5 wk benefited macular health in older adults with low MPOD. Serum HDL cholesterol increased without an increase in LDL cholesterol in this study population, most of whom were taking cholesterol-lowering statins.

www.ajcn.org/...1272 - Preview

2009 November study research clinical_trial humans older old elderly egg eggs yolk yolks consumption intake nutrition macular health macula retina eye eyes eyesight vision lutein zeaxanthin age-related_macular_degeneration AMD ARMD medline

Association of vitamin D deficiency with cognitive impairment in older women. Cross-sectional study.
Annweiler C, Schott AM, Allali G, Bridenbaugh SA, Kressig RW, Allain P, Herrmann FR, Beauchet O.
Neurology. 2009 Sep 30. [Epub ahead of print]
PMID: 19794127
doi:10.1212/WNL.0b013e3181beecd3

Conclusions: 25-Hydroxyvitamin D deficiency was associated with cognitive impairment in this cohort of community-dwelling older women.

www.neurology.org/...WNL.0b013e3181beecd3v1 - Preview

2009 September Neurology study research epidemological humans women older old elderly vitamin_D deficiency 25ohd low_levels cognition nutrition cognitive impairment cognitive_impairment medline cross-sectional

Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men.
Lee DM, Tajar A, Ulubaev A, Pendleton N, O'Neill TW, O'Connor DB, Bartfai G, Boonen S, Bouillon R, Casanueva FF, Finn JD, Forti G, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean ME, Punab M, Silman AJ, Vanderschueren D, Wu FC; EMAS study group.
J Neurol Neurosurg Psychiatry. 2009 Jul;80(7):722-9. Epub 2009 May 21.
PMID: 19460797
doi:10.1136/jnnp.2008.165720

Conclusion: In this study, lower 25(OH)D levels were associated with poorer performance on the DSST. Further research is warranted to determine whether vitamin D sufficiency might have a role in preserving cognitive function in older adults.

jnnp.bmj.com/...722.abstract - Preview

2009 July study research epidemiological humans middle-aged middle-age older old elderly European men vitamin_D 25ohd status cogntion nutrition cognitive performance medline Europe

Vitamin D deficiency is associated with worse cognitive performance and lower bone density in older African Americans.
Wilkins CH, Birge SJ, Sheline YI, Morris JC.
J Natl Med Assoc. 2009 Apr;101(4):349-54.
PMID: 19397226

CONCLUSIONS: Vitamin D deficiency in older African Americans was associated with worse cognitive performance and lower BMD of the hip

www.ncbi.nlm.nih.gov/...19397226 - Preview

2009 April study research epidemiological humans older old elderly African Americans vitamin_D deficiency 25ohd low_levels worse cognitive performance cognition nutrition African_Americans BMD bone hip osteoporosis medline

Association between depressive symptoms and 25-hydroxyvitamin D in middle-aged and elderly Chinese.
Pan A, Lu L, Franco OH, Yu Z, Li H, Lin X.
J Affect Disord. 2009 Nov;118(1-3):240-3. Epub 2009 Feb 27.
PMID: 19249103
doi:10.1016/j.jad.2009.02.002

Conclusions
Depressive symptoms are not associated with 25(OH)D concentrations in middle-aged and elderly Chinese. Further prospective studies are required to determine whether they are correlated.

www.jad-journal.com/...abstract - Preview

2009 November study research epidemiological cross-sectional humans middle-aged middle-age elderly old older Chinese China vitamin_D 25ohd depression nutrition medline symptoms

Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults.
Hoogendijk WJ, Lips P, Dik MG, Deeg DJ, Beekman AT, Penninx BW.
Arch Gen Psychiatry. 2008 May;65(5):508-12.
PMID: 18458202

Conclusion The results of this large population-based study show an association of depression status and severity with decreased serum 25(OH)D levels and increased serum PTH levels in older individuals.

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2008 May archpsyc study research epidemiological humans elderly old older vitamin_D depression 250hd deficiency low_levels nutrition medline severity PTH adults

Urgent action needed to improve vitamin D status among older people in England!
Hirani V, Tull K, Ali A, Mindell J.
Age Ageing. 2009 Nov 23. [Epub ahead of print]
PMID: 19934073

CONCLUSIONS: poor vitamin D status of older people continues to be a public health problem in England. Hypovitaminosis D is associated with many risk factors and poor health outcomes. There is now an urgent need for a uniform policy on assessment and dietary supplementation of vitamin D in older people to prevent poor vitamin D status and its negative consequences

www.ncbi.nlm.nih.gov/...19934073 - Preview

2009 November study research epidemiological humans older old elderly Urgent action needed improve vitamin_D status deficiency prevalence England UK nutrition hypovitaminosis_D supplementation medline poor

"Good research is good for medicine. The only thing more important than good research is ethical research. The February 16th issue of the New England Journal of Medicine (NEJM) had a research paper on vitamin D and colon cancer. Was it good research? Was it ethical research? At stake are the lives of 36,000 older American women who agreed to participate in the Women's Health Initiative. "

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2006 May vitamindcouncil newsletter vitamin_D low-dose colon cancer colon_cancer NEJM Women's Health Initiative Women's_Health_Initiative WHI women old older elderly nutrition critique Cannell unethical ethics

Effects of vitamin D supplementation on strength, physical performance, and falls in older persons: a systematic review.
Latham NK, Anderson CS, Reid IR.
J Am Geriatr Soc. 2003 Sep;51(9):1219-26. Review.
PMID: 12919233
DOI: 10.1046/j.1532-5415.2003.51405.

Conclusion: Although there is insufficient evidence that vitamin D supplementation alone improves physical performance in older people, some data suggest a benefit from vitamin D combined with calcium supplementation, but this requires confirmation in large, well-designed trials.

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2003 September study systematic review humans elderly older old vitamin_D supplementation muscle strength falls muscle_strength physical function performance physical_performance

Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer in elderly men.
Tang JY, Parimi N, Wu A, John Boscardin W, Shikany JM, Chren MM, Cummings SR, Epstein EH Jr, Bauer DC; for the Osteoporotic Fractures in Men (MrOS) Study Group.
Cancer Causes Control. 2009 Nov 18. [Epub ahead of print]
PMID: 19921445

Our results suggest that a diagnosis of NMSC is not a surrogate for adequate 25(OH)D levels or increased UV exposure, and high 25(OH)D levels may be associated with a reduced risk of NMSC.

www.ncbi.nlm.nih.gov/...19921445 - Preview

2009 November study research epidemiological humans men elderly old older nutrition vitamin_D 25ohd levels non-melanoma skin cancer skin_cancer NMSC medline

Calcium and vitamin D intakes may be positively associated with brain lesions in depressed and nondepressed elders.
Payne ME, Anderson JJ, Steffens DC.
Nutr Res. 2008 May;28(5):285-92.
PMID: 19083421
doi: 10.1016/j.nutres.2008.02.013

In conclusion, calcium and vitamin D consumption were associated with brain lesions in elderly subjects even after controlling for potentially explanatory variables. These associations may be due to vascular calcification or other mechanism. The possibility of adverse effects of high intakes of calcium and vitamin D needs to be further explored in longitudinal studies of elderly subjects.

www.ncbi.nlm.nih.gov/...PMC2516961 - Preview

2008 May study research epidemiological humans elderly old older calcium vitamin_D intake diet brain lesions nutrition medline