Home
Matti Narkia's Library tagged → View Popular
The role of Vitamin D3 metabolism in prostate cancer - ScienceDirect - The Journal of Steroid Biochemistry and Molecular Biology
The role of Vitamin D3 metabolism in prostate cancer.
Lou YR, Qiao S, Talonpoika R, Syvälä H, Tuohimaa P.
J Steroid Biochem Mol Biol. 2004 Nov;92(4):317-25. Epub 2004 Dec 19. Review.
PMID: 15663995
doi:10.1016/j.jsbmb.2004.10.007
In summary, the local metabolism of hormonal Vitamin D seems to play an important role in the development and progression of prostate cancer.
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer - British Journal of Cancer
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer.
Michelakis ED, Webster L, Mackey JR.
Br J Cancer. 2008 Oct 7;99(7):989-94. Epub 2008 Sep 2. Review.
PMID: 18766181
doi:10.1038/sj.bjc.6604554
The unique metabolism of most solid tumours (aerobic glycolysis, i.e., Warburg effect) is not only the basis of diagnosing cancer with metabolic imaging but might also be associated with the resistance to apoptosis that characterises cancer. The glycolytic phenotype in cancer appears to be the common denominator of diverse molecular abnormalities in cancer and may be associated with a (potentially reversible) suppression of mitochondrial function. The generic drug dichloroacetate is an orally available small molecule that, by inhibiting the pyruvate dehydrogenase kinase, increases the flux of pyruvate into the mitochondria, promoting glucose oxidation over glycolysis. This reverses the suppressed mitochondrial apoptosis in cancer and results in suppression of tumour growth in vitro and in vivo. Here, we review the scientific and clinical rationale supporting the rapid translation of this promising metabolic modulator in early-phase cancer clinical trials
More than 40 nonrandomised trials of DCA in small cohorts of patients have been reported, but the first two randomised control trials of chronic oral therapy with DCA in congenital mitochondrial diseases were reported in 2006. In the first, a blinded placebo-controlled study was performed with oral DCA administered at 25 mg kg-1 day-1 in 30 patients with MELAS syndrome (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes) (Kaufmann et al, 2006). Most patients enrolled in the DCA arm developed symptomatic peripheral neuropathy, compared with 4 out of 15 in the placebo arm, leading to the termination of the study. Seventeen out of 19 patients had at least partial resolution of peripheral neurological symptoms by 9 months after discontinuation of DCA. This neurotoxicity resembled the pattern of length-dependent, axonal,
Weight-gain: the Fall and Vitamin D Conspiracy: Why We Eat More in Autumn and Winter and How Not to | Suite101.com
"The major factor which stimulates weight gain in winter months is vitamin D. Human bodies get vitamin D from sunlight; as the hours of sunlight become less with the onset of fall, so our levels of vitamin D decrease.
Low levels of vitamin D affect the brain's production of the hormone leptin. Leptin plays a vital role in controlling appetite and metabolism; so as the amount of vitamin D in our bodies decreases so does the leptin, and this causes an increase in our appetite and a change in our metabolism.
Researchers at Aberdeen University found that obese people had 10% less vitamin D than people of average weight. The study also found that excess body fat absorbed vitamin D so the body couldn’t use it. Scientists now believe that there is a direct correlation between obesity and low levels of vitamin D.
Fats and Fatty Acids in Human Nutrition - Annals of Nutrition and Metabolism 2009, Vol. 55, No. 1-3
Fats and Fatty Acids in Human Nutrition
Annals of Nutrition and Metabolism 2009, Vol. 55, No. 1-3
Also available as ISBN 978-3-8055-9261-1
Hypovitaminosis D is associated with insulin resistance and {beta} cell dysfunction -- Chiu et al. 79 (5): 820 -- American Journal of Clinical Nutrition
Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction.
Chiu KC, Chu A, Go VL, Saad MF.
Am J Clin Nutr. 2004 May;79(5):820-5.
PMID: 15113720
Conclusions: The data show a positive correlation of 25(OH)D concentration with insulin sensitivity and a negative effect of hypovitaminosis D on ß cell function. Subjects with hypovitaminosis D are at higher risk of insulin resistance and the metabolic syndrome. Further studies are required to explore the underlying mechanisms.
Overview of general physiologic features and functions of vitamin D -- DeLuca 80 (6): 1689S -- American Journal of Clinical Nutrition
Overview of general physiologic features and functions of vitamin D.
DeLuca HF.
Am J Clin Nutr. 2004 Dec;80(6 Suppl):1689S-96S. Review.
PMID: 15585789
Low-carbohydrate nutrition and metabolism -- Westman et al. 86 (2): 276 -- American Journal of Clinical Nutrition
Low-carbohydrate nutrition and metabolism.
Westman EC, Feinman RD, Mavropoulos JC, Vernon MC, Volek JS, Wortman JA, Yancy WS, Phinney SD.
Am J Clin Nutr. 2007 Aug;86(2):276-84. Review.
PMID: 17684196
Amino acid supplementation alters bone metabolism during simulated weightlessness -- Zwart et al. 99 (1): 134 -- Journal of Applied Physiology
Zwart SR, Davis-Street JE, Paddon-Jones D, Ferrando AA, Wolfe RR, Smith SM.
Amino acid supplementation alters bone metabolism during simulated weightlessness.
J Appl Physiol. 2005 Jul;99(1):134-40. Epub 2005 Feb 3.
PMID: 15691900
NEJM -- Improved Mineral Balance and Skeletal Metabolism in Postmenopausal Women Treated with Potassium Bicarbonate
Sebastian A, Harris ST, Ottaway JH, Todd KM, Morris RC Jr.
Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate.
N Engl J Med. 1994 Jun 23;330(25):1776-81.
PMID: 8190153 [PubMed - indexed for MEDL
The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis -- Pittas et al. 92 (6): 2017 -- Journal of Clinical Endocrinology & Metabolism
The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis.
Pittas AG, Lau J, Hu FB, Dawson-Hughes B.
J Clin Endocrinol Metab. 2007 Jun;92(6):2017-29. Epub 2007 Mar 27. Review.
PMID: 17389701
.CONCLUSIONS: Vitamin D and calcium insufficiency may negatively influence glycemia, whereas combined supplementation with both nutrients may be beneficial in optimizing glucose metabolism.
Vitamin D in preventive medicine: are we ignoring the evidence?
Vitamin D in preventive medicine: are we ignoring the evidence?
Zittermann A.
Br J Nutr. 2003 May;89(5):552-72. Review.
PMID: 12720576
Vitamin D is metabolised by a hepatic 25-hydroxylase into 25-hydroxyvitamin D (25(OH)D) and by a renal 1alpha-hydroxylase into the vitamin D hormone calcitriol. Calcitriol receptors are present in more than thirty different tissues. Apart from the kidney, several tissues also possess the enzyme 1alpha-hydroxylase, which is able to use circulating 25(OH)D as a substrate. Serum levels of 25(OH)D are the best indicator to assess vitamin D deficiency, insufficiency, hypovitaminosis, adequacy, and toxicity. European children and young adults often have circulating 25(OH)D levels in the insufficiency range during wintertime. Elderly subjects have mean 25(OH)D levels in the insufficiency range throughout the year. In institutionalized subjects 25(OH)D levels are often in the deficiency range. There is now general agreement that a low vitamin D status is involved in the pathogenesis of osteoporosis. Moreover, vitamin D insufficiency can lead to a disturbed muscle function. Epidemiological data also indicate a low vitamin D status in tuberculosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, hypertension, and specific types of cancer. Some intervention trials have demonstrated that supplementation with vitamin D or its metabolites is able: (i) to reduce blood pressure in hypertensive patients; (ii) to improve blood glucose levels in diabetics; (iii) to improve symptoms of rheumatoid arthritis and multiple sclerosis. The oral dose necessary to achieve adequate serum 25(OH)D levels is probably much higher than the current recommendations of 5-15 microg/d.
High Prevalence of Vitamin D Inadequacy and Implications for Health - Mayo Clinic Proceedings
High prevalence of vitamin D inadequacy and implications for health.
Holick MF.
Mayo Clin Proc. 2006 Mar;81(3):353-73. Review
PMID: 16529140
doi: 10.4065/81.3.353
Vitamin D (Cholecalciferol, Calcitriol)
Bioactive vitamin D or calcitriol is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, and in mineralization of bone. More recently, it has become clear that receptors for vitamin D are present in a wide variety of cells, and that this hormone has biologic effects which extend far beyond control of mineral metabolism.
The active form of vitamin D binds to intracellular receptors that then function as transcription factors to modulate gene expression. Like the receptors for other steroid hormones and thyroid hormones, the vitamin D receptor has hormone-binding and DNA-binding domains. The vitamin D receptor forms a complex with another intracellular receptor, the retinoid-X receptor, and that heterodimer is what binds to DNA. In most cases studied, the effect is to activate transcription, but situations are also known in which vitamin D suppresses transcription.
Each of the forms of vitamin D is hydrophobic, and is transported in blood bound to carrier proteins. The major carrier is called, appropriately, vitamin D-binding protein. The halflife of 25-hydroxycholecalciferol is several weeks, while that of 1,25-dihydroxycholecalciferol is only a few hours.
The vitamin D receptor binds several forms of cholecalciferol. Its affinity for 1,25-dihydroxycholecalciferol is roughly 1000 times that for 25-hydroxycholecalciferol, which explains their relative biological potencies
Polyamine metabolism and transforming growth factor-beta signaling are affected in Caco-2 cells by differentially cooked broccoli extracts. - J Nutr. 2008 Oct
Polyamine metabolism and transforming growth factor-beta signaling are affected in Caco-2 cells by differentially cooked broccoli extracts.
Furniss CS, Bennett RN, Bacon JR, LeGall G, Mithen RF.
J Nutr. 2008 Oct;138(10):1840-5. Erratum in: J Nutr. 2009 Feb;139(2):400.
PMID: 18806090
Lipid mediators: lipoxin and aspirin-triggered 15-epi-lipoxins. - Bentham Science Publishers
Lipid mediators: lipoxin and aspirin-triggered 15-epi-lipoxins.
Romano M.
Inflamm Allergy Drug Targets. 2006 Apr;5(2):81-90. Review.
PMID: 16613567
Leptin - Wikipedia, the free encyclopedia
Leptin (Greek leptos meaning thin) is a 16 kDa protein hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism. Leptin is one of the most important adipose derived hormones.[1] The Ob(Lep) gene (Ob for obese, Lep for leptin) is located on chromosome 7 in humans
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer - British Journal of Cancer - Abstract of article
Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer.\nMichelakis ED, Webster L, Mackey JR.\nBr J Cancer. 2008 Oct 7;99(7):989-94. Epub 2008 Sep 2. Review.\nPMID: 18766181 \ndoi:10.1038/sj.bjc.6604554 \n
The Role of Vitamin D and Calcium in Type 2 Diabetes. A Systematic Review and Meta-Analysis -- Pittas et al. 92 (6): 2017 -- Journal of Clinical Endocrinology & Metabolism
Pittas AG, Lau J, Hu FB, Dawson-Hughes B.
The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis.
J Clin Endocrinol Metab. 2007 Jun;92(6):2017-29. Epub 2007 Mar 27. Review.
PMID: 17389701 [PubMed - indexed for MEDL
Eicosanoid metabolism in squamous cell carcinoma cell lines derived from primary and metastatic head and neck cancer and its modulation by celecoxib - Landes Bioscience - Home
Schroeder CP, Yang P, Newman RA, Lotan R.
Eicosanoid metabolism in squamous cell carcinoma cell lines derived from primary and metastatic head and neck cancer and its modulation by celecoxib.
Cancer Biol Ther. 2004 Sep;3(9):847-52. Epub 2004 Sep 18.
P
Selected Tags
Related Tags
Sponsored Links
Top Contributors
Groups interested in metabolism
Highlighter, Sticky notes, Tagging, Groups and Network: integrated suite dramatically boosting research productivity. Learn more »
Join Diigo