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Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus: A systematic review with meta-analysis.
Huxley R, Lee CM, Barzi F, Timmermeister L, Czernichow S, Perkovic V, Grobbee DE, Batty D, Woodward M.
Arch Intern Med. 2009 Dec 14;169(22):2053-63.
PMID: 20008687

Conclusions Owing to the presence of small-study bias, our results may represent an overestimate of the true magnitude of the association. Similar significant and inverse associations were observed with decaffeinated coffee and tea and risk of incident diabetes. High intakes of coffee, decaffeinated coffee, and tea are associated with reduced risk of diabetes. The putative protective effects of these beverages warrant further investigation in randomized trials.

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2009 December archinte study review systematic meta-analysis humans coffee decaf decaffeinated_coffee tea consumption drinking incident risk type_2 diabetes prevention nutrition medline

C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis.
The Lancet, Early Online Publication, 22 December 2009
doi:10.1016/S0140-6736(09)61717-7

Interpretation
CRP concentration has continuous associations with the risk of coronary heart disease, ischaemic stroke, vascular mortality, and death from several cancers and lung disease that are each of broadly similar size. The relevance of CRP to such a range of disorders is unclear. Associations with ischaemic vascular disease depend considerably on conventional risk factors and other markers of inflammation.

www.thelancet.com/...abstract - Preview

2009 December Lancet study review meta-analysis humans CRP CVD CHD stroke risk mortality nutrition medline

Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials.
Mozaffarian D, Geelen A, Brouwer IA, Geleijnse JM, Zock PL, Katan MB.
Circulation. 2005 Sep 27;112(13):1945-52. Epub 2005 Sep 19.
PMID: 16172267
doi: 10.1161/CIRCULATIONAHA.105.556886

Conclusions— In randomized controlled trials in humans, fish oil reduces HR, particularly in those with higher baseline HR or longer treatment duration. These findings provide firm evidence that fish oil consumption directly or indirectly affects cardiac electrophysiology in humans. Po

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2005 September Circulation study review humans meta-analysis clinical_trials rcts fish_oil omega-3 heart_rate HR heart rate pulse nutrition CVD medline fish oil Mozaffarian

Mortality in vegetarians and nonvegetarians: detailed findings from a collaborative analysis of 5 prospective studies.
Key TJ, Fraser GE, Thorogood M, Appleby PN, Beral V, Reeves G, Burr ML, Chang-Claude J, Frentzel-Beyme R, Kuzma JW, Mann J, McPherson K.
Am J Clin Nutr. 1999 Sep;70(3 Suppl):516S-524S.
PMID: 10479225

Further categorization of diets showed that, in comparison with regular meat eaters, mortality from ischemic heart disease was 20% lower in occasional meat eaters, 34% lower in people who ate fish but not meat, 34% lower in lactoovovegetarians, and 26% lower in vegans. There were no significant differences between vegetarians and nonvegetarians in mortality from cerebrovascular disease, stomach cancer, colorectal cancer, lung cancer, breast cancer, prostate cancer, or all other causes combined.

See especially

TABLE 7. All-studies death rate ratios and 95% CIs and the number of deaths by diet category
http://www.ajcn.org/cgi/content/full/70/3/516S/T7

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1999 ajcn study review meta-analysis epidemiological prospective humans nutrition vegetarians vegans meat-eaters fish-eaters nonvegetarians comparison mortality CVD colorectal_cancer breast prostate cancer IHD CHD medline prostate_cancer breast_cancer

Benefit-risk assessment of vitamin D supplementation.
Bischoff-Ferrari HA, Shao A, Dawson-Hughes B, Hathcock J, Giovannucci E, Willett WC.
Osteoporos Int. 2009 Dec 3. [Epub ahead of print]
PMID: 19957164

Conclusion Our analysis suggests that mean serum 25(OH)D levels of about 75 to 110 nmol/l provide optimal benefits for all investigated endpoints without increasing health risks. These levels can be best obtained with oral doses in the range of 1,800 to 4,000 IU vitamin D per day; further work is needed, including subject and environment factors, to better define the doses that will achieve optimal blood levels in the large majority of the population.

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2009 December study review meta-analysis humans rcts clinical_trials vitamin_D supplementation falls fractures hypercalcemia optimal dose optimal_dose nutrition Willett Giovannucci Bischoff-Ferrari recommendations Dawson-Hughes medline

Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials.
Rosenfeldt FL, Haas SJ, Krum H, Hadj A, Ng K, Leong JY, Watts GF.
J Hum Hypertens. 2007 Apr;21(4):297-306. Epub 2007 Feb 8.
PMID: 17287847

We conclude that coenzyme Q10 has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side effects.

www.nature.com/...1002138a.html - Preview

2007 April study review meta-analysis clinical_trials humans Coenzyme Q10 Coenzyme_Q10 hypertension nutrtion medline blood_pressure bp CVD ubiquinone ubidecarenone coq10

Depression as a predictor for coronary heart disease. a review and meta-analysis.
Rugulies R.
Am J Prev Med. 2002 Jul;23(1):51-61. Review.
PMID: 12093424

www.ajpm-online.net/...abstract - Preview

2002 July study review meta-analysis depression predictor CVD CHD myocardial infarction myocardial_infarction MI depressive disorder depressive_disorder epidemiological medline

Dietary protein and bone health: a systematic review and meta-analysis.
Darling AL, Millward DJ, Torgerson DJ, Hewitt CE, Lanham-New SA.
Am J Clin Nutr. 2009 Nov 4. [Epub ahead of print]
PMID: 19889822

www.ajcn.org/...1674 - Preview

2009 November ajcn study research systematic review meta-analysis Dietary protein bone health bone_health BMD osteoporosis nutrition medline

Effects of n-3 long-chain polyunsaturated fatty acids on depressed mood: systematic review of published trials.
Appleton KM, Hayward RC, Gunnell D, Peters TJ, Rogers PJ, Kessler D, Ness AR.
Am J Clin Nutr. 2006 Dec;84(6):1308-16. Review.
PMID: 17158410

Conclusions: Trial evidence that examines the effects of n–3 PUFAs on depressed mood is limited and is difficult to summarize and evaluate because of considerable heterogeneity. The evidence available provides little support for the use of n–3 PUFAs to improve depressed mood. Larger trials with adequate power to detect clinically important benefits are required.

www.ajcn.org/...1308 - Preview

2006 December ajcn study systematic review meta-analysis clinical_trials rcts humans omega-3 PUFA PUFAs nutrition medline depression depressed mood

Meta-analysis of vitamin D, calcium and the prevention of breast cancer.
Chen P, Hu P, Xie D, Qin Y, Wang F, Wang H.
Breast Cancer Res Treat. 2009 Oct 23. [Epub ahead of print]
PMID: 19851861

These results provide strong evidence that vitamin D and calcium have a chemopreventive effect against breast cancer.

www.ncbi.nlm.nih.gov/...19851861 - Preview

2009 October study review meta-analysis humans women vitamin_D 25ohd calcium breast cancer breast_cancer prevention risk nutrition medline

Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials.
Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, Orav JE, Stuck AE, Theiler R, Wong JB, Egli A, Kiel DP, Henschkowski J.
BMJ. 2009 Oct 1;339:b3692. doi: 10.1136/bmj.b3692.
PMID: 19797342
doi: 10.1136/bmj.b3692

Conclusions Supplemental vitamin D in a dose of 700-1000 IU a day reduced the risk of falling among older individuals by 19% and to a similar degree as active forms of vitamin D. Doses of supplemental vitamin D of less than 700 IU or serum 25-hydroxyvitamin D concentrations of less than 60 nmol/l may not reduce the risk of falling among older individuals.

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2009 October BMJ study review meta-analysis clinical_trials rcts humans elderly old older fall falls prevention vitamin_D supplementation nutrition Bischoff-Ferrari medline 25ohd 1.25(OH)2D calcitriol

Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
Cockayne S, Adamson J, Lanham-New S, Shearer MJ, Gilbody S, Torgerson DJ.
Arch Intern Med. 2006 Jun 26;166(12):1256-61. Review.
PMID: 16801507

Conclusions This systematic review suggests that supplementation with phytonadione and menaquinone-4 reduces bone loss. In the case of the latter, there is a strong effect on incident fractures among Japanese patients.

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2006 June archinte study review humans systematic meta-analysis clinical_trials rcts vitamin_K vitamin_K1 vitamin_K2 bone fractures fracture prevention supplementation nutrition MK-4 vitamin_K3 medline phytonadione menaquinone-4 osteoporosis

Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk.
Yin L, Grandi N, Raum E, Haug U, Arndt V, Brenner H.
Aliment Pharmacol Ther. 2009 Jul 1;30(2):113-25. Epub 2009 Apr 15.
PMID: 19392870
DOI: 10.1111/j.1365-2036.2009.04022.x

Conclusions Our results support suggestions that serum 25(OH)D is inversely related to CRC risk.

www3.interscience.wiley.com/...HTMLSTART - Preview

2009 July study review meta-analysis humans vitamin_D status 25OHD colorectal cancer colorectal_cancer risk cancer_risk nutrition medline

Review and meta-analysis on vitamin D receptor polymorphisms and cancer risk.
Raimondi S, Johansson H, Maisonneuve P, Gandini S.
Carcinogenesis. 2009 Jul;30(7):1170-80. Epub 2009 Apr 29. Review.
PMID: 19403841

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2009 Jyly study review meta-analysis humans vitamin_D receptor VDR polymorphisms polymorphism genotype genetics genes cancer risk cancer_risk FokI BsmI nutrition medline

Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials.
Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B.
JAMA. 2005 May 11;293(18):2257-64. Review.
PMID: 15886381

Conclusions Oral vitamin D supplementation between 700 to 800 IU/d appears to reduce the risk of hip and any nonvertebral fractures in ambulatory or institutionalized elderly persons. An oral vitamin D dose of 400 IU/d is not sufficient for fracture prevention.

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2005 May JAMA study review systematic meta-analysis humans clinical_trials rcts Bischoff-Ferrari Willett Giovannucci vitamin_D nonvertebral fracture prevention fractures hip bone osteoporosis nutrition medline elderly old older

Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials.
Autier P, Gandini S.
Arch Intern Med. 2007 Sep 10;167(16):1730-7. Review.
PMID: 17846391

Conclusions Intake of ordinary doses of vitamin D supplements seems to be associated with decreases in total mortality rates. The relationship between baseline vitamin D status, dose of vitamin D supplements, and total mortality rates remains to be investigated. Population-based, placebo-controlled randomized trials with total mortality as the main end point should be organized for confirming these findings.

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2007 September study review meta-analysis clinical_trials rcts humans vitamin_D supplementation total mortality all-cause all-causes nutrition medline

The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis.
Pittas AG, Lau J, Hu FB, Dawson-Hughes B.
J Clin Endocrinol Metab. 2007 Jun;92(6):2017-29. Epub 2007 Mar 27. Review.
PMID: 17389701

.CONCLUSIONS: Vitamin D and calcium insufficiency may negatively influence glycemia, whereas combined supplementation with both nutrients may be beneficial in optimizing glucose metabolism.

jcem.endojournals.org/...2017 - Preview

2007 June study review systematic meta-analysis humans vitamin_D calcium role type_2 diabetes nutrition medline insufficiency deficiency glycemia glucose metabolism

Effect of Vitamin D on falls: a meta-analysis.
Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, Staehelin HB, Bazemore MG, Zee RY, Wong JB.
JAMA. 2004 Apr 28;291(16):1999-2006. Review.
PMID: 15113819

jama.ama-assn.org/...1999 - Preview

2004 April JAMA study review meta-analysis humans Bischoff-Ferrari Willett vitamin_D supplementation falls old older elderly clinical_trials rct nutrition medline

Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, Newmark HL, Giovannucci E, Wei M, Holick MF.
Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis.
Am J Prev Med. 2007 Mar;32(3):210-6.
PMID: 17296473

www.sciencedirect.com/science - Preview

2007 March Optimal Status Colorectal Cancer Prevention 25ohd calcidiol colon colorectal_cancer medline nutrition supplementation study meta-analysis review humans holick vitamin_D

Conclusion: The associations suggest that replacing SFAs with PUFAs rather than MUFAs or carbohydrates prevents CHD over a wide range of intakes.

Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies.
Jakobsen MU, O'Reilly EJ, Heitmann BL, Pereira MA, Bälter K, Fraser GE, Goldbourt U, Hallmans G, Knekt P, Liu S, Pietinen P, Spiegelman D, Stevens J, Virtamo J, Willett WC, Ascherio A.
Am J Clin Nutr. 2009 May;89(5):1425-32. Epub 2009 Feb 11.
PMID: 19211817
doi:10.3945/ajcn.2008.27124

www.ajcn.org/...1425 - Preview

2009 May ajcn study review pooled analysis meta-analysis epidemiological humans CHD prevention risk CVD PUFA SFA MUFA carbohydrates carbohydrate Willett nutrition medline CHD_risk