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Retinol-induced Intestinal Tumorigenesis in Min/+ Mice and Importance of Vitamin D Status. - [Anticancer Res. 2009] - PubMed result
"Retinol-induced Intestinal Tumorigenesis in Min/+ Mice and Importance of Vitamin D Status.
Hetland RB, Alexander J, Berg JP, Svendsen C, Paulsen JE.
Anticancer Res. 2009 Nov;29(11):4353-60.
PMID: 20032378
The effects of life-long dietary exposure, starting in utero, to high retinol, low vitamin D, or high retinol in combination with low vitamin D on intestinal tumorigenesis in Min/+ mice were investigated. In males, high retinol alone significantly increased the number (2.6-fold) and size (1.3-fold) of small intestinal tumours; in females no significant increase in tumour number or size was seen. In both genders, low vitamin D intake alone did not affect intestinal tumorigenesis. In males, intake of the combined high retinol/low vitamin D diet did not further increase the effects caused by high retinol alone. In females, however, the high retinol/low vitamin D-induced increase in tumour number (3.1-fold) and tumour size (1.5-fold) exceeded that of high retinol alone. In conclusion, a high dietary intake of retinol stimulated intestinal tumorigenesis in Min/+ mice. Furthermore, the results indicate a combined effect of high retinol and low vitamin D on tumorigenesis in females"
Low vitamin D serum level is related to severe fibrosis and low responsiveness to IFN-based therapy in genotype 1 chronic hepatitis C - Wiley InterScience :: Journal :: Article PDF
Low vitamin D serum level is related to severe fibrosis and low responsiveness to IFN-based therapy in genotype 1 chronic hepatitis C
Salvatore Petta et al.
Hepatology, Volume 9999 Issue 999A, Page NA. Published Online: 4 Dec 2009
DOI: 10.1002/hep.23489
Conclusions:
G1 CHC patients had low 25(OH)D serum levels, possibly due to reduced CYP27A1 expression. Low vitamin D is linked to severe fibrosis and low SVR on IFN-based therapy. (HEPATOLOGY 2010.)
Relationships between 25-Hydroxyvitamin D Levels and Plasma Glucose and Lipid Levels in Pediatric Outpatients - ScienceDirect - The Journal of Pediatrics
Relationships between 25-Hydroxyvitamin D Levels and Plasma Glucose and Lipid Levels in Pediatric Outpatients.
Johnson MD, Nader NS, Weaver AL, Singh R, Kumar S.
J Pediatr. 2009 Nov 17. [Epub ahead of print]
PMID: 19926097
Conclusions
Low 25(OH) D levels in children and adolescents are associated with higher plasma glucose and lower HDL concentrations.
Weight-gain: the Fall and Vitamin D Conspiracy: Why We Eat More in Autumn and Winter and How Not to | Suite101.com
"The major factor which stimulates weight gain in winter months is vitamin D. Human bodies get vitamin D from sunlight; as the hours of sunlight become less with the onset of fall, so our levels of vitamin D decrease.
Low levels of vitamin D affect the brain's production of the hormone leptin. Leptin plays a vital role in controlling appetite and metabolism; so as the amount of vitamin D in our bodies decreases so does the leptin, and this causes an increase in our appetite and a change in our metabolism.
Researchers at Aberdeen University found that obese people had 10% less vitamin D than people of average weight. The study also found that excess body fat absorbed vitamin D so the body couldn’t use it. Scientists now believe that there is a direct correlation between obesity and low levels of vitamin D.
Serum 25-Hydroxyvitamin D Levels Among US Children Aged 1 to 11 Years: Do Children Need More Vitamin D? - [Pediatrics. 2009] - PubMed result
Serum 25-Hydroxyvitamin D Levels Among US Children Aged 1 to 11 Years: Do Children Need More Vitamin D?
Mansbach JM, Ginde AA, Camargo CA Jr.
Pediatrics. 2009 Nov;124(5):1404-1410.
PMID: 19951983
CONCLUSIONS: On the basis of a nationally representative sample of US children aged 1 to 11 years, millions of children may have suboptimal levels of 25(OH)D, especially non-Hispanic black and Hispanic children. More data in children are needed not only to understand better the health implications of specific serum levels of 25(OH)D but also to determine the appropriate vitamin D supplement requirements for children.
Vitamin D and mortality in older men and women. - Clin Endocrinol (Oxf). 2009 Nov;71(5):666-72. - Wiley InterScience :: Article :: HTML Full Text
Vitamin D and mortality in older men and women.
Pilz S, Dobnig H, Nijpels G, Heine RJ, Stehouwer CD, Snijder MB, van Dam RM, Dekker JM.
Clin Endocrinol (Oxf). 2009 Nov;71(5):666-72. Epub 2009 Feb 18.
PMID: 19226272
DOI: 10.1111/j.1365-2265.2009.03548.x
Conclusions Low 25(OH)D levels are associated with all-cause mortality and even more pronounced with cardiovascular mortality, but it remains unclear whether vitamin D deficiency is a cause or a consequence of a poor health status. Therefore, intervention studies are warranted to evaluate whether vitamin D supplementation reduces mortality and cardiovascular diseases.
Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community-dwelling women
Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community-dwelling women.
Semba RD, Houston DK, Ferrucci L, Cappola AR, Sun K, Guralnik JM, Fried LP.
Nutr Res. 2009 Aug;29(8):525-30.
PMID: 19761886
doi:10.1016/j.nutres.2009.07.007
Older community-dwelling women with low 25(OH)D levels are at an increased risk of death.
Association of vitamin D deficiency with cognitive impairment in older women. Cross-sectional study -- Annweiler et al., 10.1212/WNL.0b013e3181beecd3 -- Neurology
Association of vitamin D deficiency with cognitive impairment in older women. Cross-sectional study.
Annweiler C, Schott AM, Allali G, Bridenbaugh SA, Kressig RW, Allain P, Herrmann FR, Beauchet O.
Neurology. 2009 Sep 30. [Epub ahead of print]
PMID: 19794127
doi:10.1212/WNL.0b013e3181beecd3
Conclusions: 25-Hydroxyvitamin D deficiency was associated with cognitive impairment in this cohort of community-dwelling older women.
Vitamin D deficiency is associated with worse cognitive performance and lower bone density in older African Americans. - [J Natl Med Assoc. 2009] - PubMed result
Vitamin D deficiency is associated with worse cognitive performance and lower bone density in older African Americans.
Wilkins CH, Birge SJ, Sheline YI, Morris JC.
J Natl Med Assoc. 2009 Apr;101(4):349-54.
PMID: 19397226
CONCLUSIONS: Vitamin D deficiency in older African Americans was associated with worse cognitive performance and lower BMD of the hip
Correlation of symptoms with vitamin D deficiency and symptom response to cholecalciferol treatment: a randomized controlled trial. - Endocr Pract. 2009 May-Jun;15(3):203-12. - AACE Online - Article
Correlation of symptoms with vitamin D deficiency and symptom response to cholecalciferol treatment: a randomized controlled trial.
Arvold DS, Odean MJ, Dornfeld MP, Regal RR, Arvold JG, Karwoski GC, Mast DJ, Sanford PB, Sjoberg RJ.
Endocr Pract. 2009 May-Jun;15(3):203-12.
PMID: 19364687
Conclusions: Compared with participants in the placebo group, patients in the treatment group showed mild short-term improvement in the overall fibromyalgia impact score, but did not show significant improvement in most musculoskeletal symptoms or in activities of daily living.
Arch Gen Psychiatry -- Depression Is Associated With Decreased 25-Hydroxyvitamin D and Increased Parathyroid Hormone Levels in Older Adults, May 2008, Hoogendijk et al. 65 (5): 508
Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults.
Hoogendijk WJ, Lips P, Dik MG, Deeg DJ, Beekman AT, Penninx BW.
Arch Gen Psychiatry. 2008 May;65(5):508-12.
PMID: 18458202
Conclusion The results of this large population-based study show an association of depression status and severity with decreased serum 25(OH)D levels and increased serum PTH levels in older individuals.
Low vitamin D linked with CVD risk factors in teens - theheart.org
"March 18, 2009 | Marlene Busko
Palm Harbor, FL - In a large study of adolescents, low serum levels of 25-dihydroxyvitamin D (25[OH]D) strongly predicted prevalence of hypertension, hyperglycemia, and metabolic syndrome [1]. The findings were reported at the AHA 49th Annual Conference on Cardiovascular Disease Epidemiology and Prevention.
Adolescents with vitamin-D levels in the lowest quartile were almost four times more likely to have metabolic syndrome than those with vitamin-D levels in the highest quartile. "I think that is quite alarming," lead author Dr Jared P Reis (Johns Hopkins Medical Institutions, Baltimore, MD) said in an AHA podcast issued to the media."
Effects Of Vitamin D Deficiency Amplified By Shortage Of Estrogen
"Researchers at Johns Hopkins are reporting what is believed to be the first conclusive evidence in men that the long-term ill effects of vitamin D deficiency are amplified by lower levels of the key sex hormone estrogen, but not testosterone.
In a national study in 1010 men, to be presented Nov. 15 at the American Heart Association's (AHA) annual Scientific Sessions in Orlando, researchers say the new findings build on previous studies showing that deficiencies in vitamin D and low levels of estrogen, found naturally in differing amounts in men and women, were independent risk factors for hardened and narrowed arteries and weakened bones. Vitamin D is an essential part to keeping the body healthy, and can be obtained from fortified foods, such as milk and cereals, and by exposure to sunlight.
Lack of vitamin D may increase heart disease risk
"DALLAS, Jan. 8 — The same vitamin D deficiency that can result in weak bones now has been associated with an increased risk of cardiovascular disease, Framingham Heart Study researchers report in Circulation: Journal of the American Heart Association.
“Vitamin D deficiency is associated with increased cardiovascular risk, above and beyond established cardiovascular risk factors,” said Thomas J. Wang, M.D., assistant professor of medicine at Harvard Medical School in Boston, Mass. “The higher risk associated with vitamin D deficiency was particularly evident among individuals with high blood pressure.”
In a study of 1,739 offspring from Framingham Heart Study participants (average age 59, all Caucasian), researchers found that those with blood levels of vitamin D below15 nanograms per milliliter (ng/mL) had twice the risk of a cardiovascular event such as a heart attack, heart failure or stroke in the next five years compared to those with higher levels of vitamin D."
Low vitamin D levels associated with several risk factors in teenagers
"• Low levels of vitamin D were associated with increased risk of high blood pressure, high blood sugar and metabolic syndrome in teenagers.
• The highest levels of vitamin D were found in whites, the lowest levels in blacks and intermediate levels in Mexican-Americans.
PALM HARBOR, Fla., March 11, 2009 — Low levels of vitamin D were associated with an increased risk of high blood pressure, high blood sugar and metabolic syndrome in teenagers, researchers reported at the American Heart Association’s 49th Annual Conference on Cardiovascular Disease Epidemiology and Prevention."
Vitamin D Deficiency and Risk of Cardiovascular Disease -- Wang et al. 117 (4): 503 -- Circulation
Vitamin D deficiency and risk of cardiovascular disease.
Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, Benjamin EJ, D'Agostino RB, Wolf M, Vasan RS.
Circulation. 2008 Jan 29;117(4):503-11. Epub 2008 Jan 7.
PMID: 18180395
doi: 10.1161/CIRCULATIONAHA.107.706127
Conclusions— Vitamin D deficiency is associated with incident cardiovascular disease. Further clinical and experimental studies may be warranted to determine whether correction of vitamin D deficiency could contribute to the prevention of cardiovascular disease.
Vitamin D Shows Heart Benefits in Study - Well Blog - NYTimes.com
"A new study suggests many Americans aren’t getting anywhere nearly enough of the vitamin, and it may be affecting their heart health.
In the study, researchers looked at tens of thousands of healthy adults 50 and older whose vitamin D levels had been measured during routine checkups. A majority, they found, were deficient in the vitamin. About two-thirds had less vitamin D in their bloodstreams than the authors considered healthy, and many were extremely deficient.
Less than two years later, the researchers found, those who had extremely low levels of the vitamin were almost twice as likely to have died or suffered a stroke than those with adequate amounts. They also had more coronary artery disease and were twice as likely to have developed heart failure.
The findings, which are being presented today at an American Heart Association conference in Orlando, don’t prove that lack of vitamin D causes heart disease; they only suggest a link between the two. "
Low Vitamin D Levels May Raise Heart Risk
"Study Shows Vitamin D Supplements May Be Useful in Preventing Heart Disease
Nov. 16, 2009 (Orlando, Fla.) -- Some men with low levels of vitamin D in their blood are at particularly high risk of developing heart disease and weakened bones that can lead to osteoporosis, researchers report.
In a study of more than 1,000 men, those with low levels of both vitamin D and the sex hormone estrogen were at significantly increased risk of having cardiovascular disease, says study head Erin Michos, MD, a cardiologist at Johns Hopkins.
"They were also at dramatically increased risk of osteopenia," or bone loss that can lead to osteoporosis, she says.
"Our results suggest that vitamin D supplements, which are already prescribed to treat osteoporosis, may also be useful in preventing heart disease," Michos tells WebMD.
Men with low levels of vitamin D and testosterone, on the other hand, were not at heightened risk for heart disease or osteopenia."
Vitamin D and Memory - Amen Clinics
"One of the surprises over the past year has been all the research regarding Vitamin D and brain health. Give that many people are spending less time outdoors and more time in front of their computers, we all should be concerned, as Vitamin D comes in part from our exposure to the sun.
Low Vitamin D levels have been associated with pain, depression, MS, cancer and now perhaps even dementia. Here are the results of a new study that should cause all of us to pay attention. I frequently check the Vitamin D levels in my patients and frrequently see that they are below the optimal level. Get your levels checked if you have any of these concerns.
A new large-scale senior population study has found that a lack of vitamin D in the elderly could be linked to cognitive impairment.
The study, conducted on almost 2,000 adults over the age of 65, is the first of its scale to identify this relationship, and prompted researchers to suggest vitamin D supplementation as a possible means of reducing the risk of dementia. "
Prevalence of low serum vitamin D concentration in an urban population of elderly women in Poland. - [Pol Arch Med Wewn. 2009] - PubMed result
Prevalence of low serum vitamin D concentration in an urban population of elderly women in Poland.
Napiórkowska L, Budlewski T, Jakubas-Kwiatkowska W, Hamzy V, Gozdowski D, Franek E.
Pol Arch Med Wewn. 2009 Nov;119(11):699-703.
PMID: 19920793
CONCLUSIONS: The prevalence of low vitamin D concentrations in an urban population of elderly women in Poland is very high. Lower vitamin D levels are associated with a higher PTH concentration
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