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Serum 25-hydroxyvitamin D and the risk of ovarian cancer.
Toriola AT, Surcel HM, Agborsangaya C, Grankvist K, Tuohimaa P, Toniolo P, Lukanova A, Pukkala E, Lehtinen M.
Eur J Cancer. 2009 Aug 25. [Epub ahead of print]
PMID: 19713101
doi:10.1016/j.ejca.2009.08.002

Conclusion
Overall, we did not observe a significant association between serum 25-OHD concentrations and the risk of ovarian cancer. However, we found evidence suggestive of an increased risk among women with low to insufficient serum 25-OHD concentrations.

www.sciencedirect.com/science - Preview

2009 August study researc epidemiological humans women Finnish Finland vitamin_D 25ohd calcidiol ovarian cancer ovarian_cancer risk nutrition medline Tuohimaa

Lack of association between serum levels of 25-hydroxyvitamin D and the subsequent risk of prostate cancer in Finnish men.
Faupel-Badger JM, Diaw L, Albanes D, Virtamo J, Woodson K, Tangrea JA.
Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2784-6.
PMID: 18086789
doi: 10.1158/1055-9965.EPI-07-0672

cebp.aacrjournals.org/...2784.long - Preview

2007 December cebp Faupel-Badger study research epidemiological humans Finnish SETTI ATBC vitamin_D 25ohd prostate cancer prostate_cancer PCa risk U-shaped nutrition U-shape Finland Nordic medline

Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis.
Salonen JT, Nyyssönen K, Salonen R, Lakka HM, Kaikkonen J, Porkkala-Sarataho E, Voutilainen S, Lakka TA, Rissanen T, Leskinen L, Tuomainen TP, Valkonen VP, Ristonmaa U, Poulsen HE.
J Intern Med. 2000 Nov;248(5):377-86.
PMID: 11123502
DOI: 10.1046/j.1365-2796.2000.00752.x

Conclusions. Our study shows that a combined supplementation with reasonable doses of both vitamin E and slow-release vitamin C can retard the progression of common carotid atherosclerosis in men. This may imply benefits with regard to other atherosclerosis-based events.

www3.interscience.wiley.com/...HTMLSTART - Preview

2000 November Salonen study research clinical_trial rct humans vitamin_C vitamin_E supplementation carotid artery IMT CIMT CVD arteriosclerosis progression nutrition antioxidants Finland Finnish hypercholesterolemic lipids medline

Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study.
Salonen RM, Nyyssönen K, Kaikkonen J, Porkkala-Sarataho E, Voutilainen S, Rissanen TH, Tuomainen TP, Valkonen VP, Ristonmaa U, Lakka HM, Vanharanta M, Salonen JT, Poulsen HE; Antioxidant Supplementation in Atherosclerosis Prevention Study.
Circulation. 2003 Feb 25;107(7):947-53.
PMID: 12600905
doi: 10.1161/01.CIR.0000050626.25057.51

Conclusions— These data replicate our 3-year findings confirming that the supplementation with combination of vitamin E and slow-release vitamin C slows down atherosclerotic progression in hypercholesterolemic persons.

circ.ahajournals.org/...947 - Preview

2003 February Circulation Salonen study research clinical_trial humans vitamin_C vitamin_E supplementation carotid artery IMT CIMT CVD arteriosclerosis progression nutrition antioxidants Finland Finnish hypercholesterolemic lipids medline

Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland.
Virtanen JK, Voutilainen S, Rissanen TH, Mursu J, Tuomainen TP, Korhonen MJ, Valkonen VP, Seppänen K, Laukkanen JA, Salonen JT.
Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):228-33. Epub 2004 Nov 11.
PMID: 15539625
doi: 10.1161/01.ATV.0000150040.20950.61

Conclusions— High content of mercury in hair may be a risk factor for acute coronary events and CVD, CHD, and all-cause mortality in middle-aged eastern Finnish men. Mercury may also attenuate the protective effects of fish on cardiovascular health.

Mercury may increase the risk of cardiovascular diseases. In this study, high mercury content in hair increased the risk of cardiovascular morbidity and mortality in middle-aged Finnish men and attenuated the beneficial effects of fish oils on cardiovascular health. Regular consumption of fish with high mercury content should be avoided.

atvb.ahajournals.org/...228 - Preview

2005 January atvb Virtanen study research epidemiological humans Finnish men mercury fish oils all-cause mortality omega-3 DHA nutrition acute coronary events risk middle-aged medline

High dietary methionine intake increases the risk of acute coronary events in middle-aged men.
Virtanen JK, Voutilainen S, Rissanen TH, Happonen P, Mursu J, Laukkanen JA, Poulsen H, Lakka TA, Salonen JT.
Nutr Metab Cardiovasc Dis. 2006 Mar;16(2):113-20. Epub 2005 Nov 2.
PMID: 16487911
doi:10.1016/j.numecd.2005.05.005

Conclusions
The main finding of this study is that long-term, moderately high dietary methionine intake may increase the risk of acute coronary events in middle-aged Finnish men free of prior CHD. More prospective research is needed to confirm the role of dietary methionine in the development of CVD, and whether its effects are independent of homocysteine.

www.nmcd-journal.com/...abstract - Preview

2006 March Virtanen study research epidemiological humans middle-aged men Finnish Finland high dietary methionine intake acute coronary_events CVD CHD nutrition risk homocysteine medline

Glycemic index, glycemic load, and the risk of acute myocardial infarction in Finnish men: The Kuopio Ischaemic Heart Disease Risk Factor Study.
Mursu J, Virtanen JK, Rissanen TH, Tuomainen TP, Nykänen I, Laukkanen JA, Kortelainen R, Voutilainen S.
Nutr Metab Cardiovasc Dis. 2009 Oct 14. [Epub ahead of print]
PMID: 19836217
doi:10.1016/j.numecd.2009.08.001

Conclusions
Our results suggest that both high dietary GI and GL are associated with increased risk of AMI among overweight and GL possibly among less physically active men.

www.sciencedirect.com/science - Preview

2009 October study research epidemiological humans Finnish men Finland Mursu Virtanen glycemic_index GI glycemic_load GL acute myocardial_infarction AMI MI CVD nutrition CHD risk carbohydrates overweight medline

Serum Long-Chain n-3 Polyunsaturated Fatty Acids and Risk of Hospital Diagnosis of Atrial Fibrillation in Men.
Virtanen JK, Mursu J, Voutilainen S, Tuomainen TP.
Circulation. 2009 Dec 8;120(23):2315-21. Epub 2009 Nov 23.
PMID: 19933935
doi: 10.1161/CIRCULATIONAHA.109.852657

Conclusions— An increased concentration of long-chain n-3 PUFAs in serum, a marker of fish or fish oil consumption, may protect against AF. Serum docosahexaenoic acid concentration had the greatest impact.

circ.ahajournals.org/...2315 - Preview

2009 December Circulation Virtanen study research epidemiological humans Finnish men Finland atrial_fibrillation AF CVD arrhythmia serum omega-3 nutrition DHA long-chain PUFA medline level concentration risk cardiac

Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study.
McGrath J, Saari K, Hakko H, Jokelainen J, Jones P, Järvelin MR, Chant D, Isohanni M.
Schizophr Res. 2004 Apr 1;67(2-3):237-45.
PMID: 14984883

Conclusion: Vitamin D supplementation during the first year of life is associated with a reduced risk of schizophrenia in males. Preventing hypovitaminosis D during early life may reduce the incidence of schizophrenia.

www.schres-journal.com/...abstract - Preview

2004 April study research epidemiological humans infants Finnish Finland vitamin_D supplementation nutrition schizophrenia risk calcitriol brain growth development medline birth cohort

Last week, I had the pleasure of being invited out to Finland by Finnfacts on a whirlwind tour of new and established Finnish start ups. I was also delighted to attend the renown Nordic Technology Conference MindTrek, joined by other prominent figures from the international web and technology scene.

Over the next few days I’ll be sharing thoughts and details of some of the companies we visited, these include Floobs, RuntoShop and Muxlim. Though, for the moment, I’d like to share my perspective on the Finnish startup scene and community as a whole.

thenextweb.com/...finland-startup-community-cold - Preview

2009 October thenextweb blog_article Finland Startup Ecosystem startups business Finnish tech technology start_ups companies new

Association between serum 25(OH)D concentrations and bone stress fractures in Finnish young men.
Ruohola JP, Laaksi I, Ylikomi T, Haataja R, Mattila VM, Sahi T, Tuohimaa P, Pihlajamäki H.
J Bone Miner Res. 2006 Sep;21(9):1483-8.
doi: 10.1359/jbmr.060607

Conclusions: A lower level of serum 25(OH)D concentration may be a generally predisposing element for bone stress fractures. Considering the obvious need of additional vitamin D in prevention of stress fractures, the effects of vitamin D fortification of foods and supplementation will be subjects of interest for future research
PMID: 16939407

www.jbmronline.org/...jbmr.060607 - Preview

2006 September study research epidemiological humans Finnish young men Finland vitamin_D 25ohd bone stress fractures nutrition Ruohola Laaksi Tuohimaa medline status low_levels serum

Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls.
Cheng S, Tylavsky F, Kröger H, Kärkkäinen M, Lyytikäinen A, Koistinen A, Mahonen A, Alen M, Halleen J, Väänänen K, Lamberg-Allardt C.
Am J Clin Nutr. 2003 Sep;78(3):485-92. Erratum in: Am J Clin Nutr. 2006 Jan;83(1):174.
PMID: 12936933

CONCLUSIONS: Vitamin D-deficient girls have low cortical BMD and high iPTH concentrations, which are consistent with secondary hyperparathyroidism. A low vitamin D concentration accompanied by high bone resorption (TRAP 5b) may limit the accretion of bone mass in young girls.

www.ajcn.org/...485 - Preview

2003 September ajcn study research epidemiological humans young girls Finnish Finland vitamin_D status 25ohd deficiency prevalence PTH BMD nutrition bone mass density cortical Lamberg-Allardt Cheng calcium intake secondary hyperparathyroidism iPTH medline

Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density.
Outila TA, Kärkkäinen MU, Lamberg-Allardt CJ.
Am J Clin Nutr. 2001 Aug;74(2):206-10.
PMID: 11470722

Conclusion: A large percentage of adolescent females have low vitamin D status during the winter in Finland, which seems to have negative effects on bone health.

www.ajcn.org/...206 - Preview

2001 August ajcn study research epidemiological humans Finnish female adolescents girls vitamin_D winter PTH bone BMD 25ohd deficiency prevalence nutrition Finland iPTH Lamberg-Allardt Outila osteoporosis prevention

A high prevalence of hypovitaminosis D in Finnish medical in- and outpatients.
Kauppinen-Mäkelin R, Tähtelä R, Löyttyniemi E, Kärkkäinen J, Välimäki MJ.
J Intern Med. 2001 Jun;249(6):559-63.
PMID: 11422663
DOI: 10.1046/j.1365-2796.2001.00847.x

CONCLUSION: Hypovitaminosis D is very common amongst Finnish in- and outpatients in both sexes, causing secondary hyperparathyroidism in females. More extensive studies are warranted to elucidate the vitamin D status of the Finnish population.

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2001 June study research epidemiological humans medical patients inpatients outpatients Finnish Finland vitamin_D deficiency hypovitaminosis_D high prevalence nutrition 25ohd Kauppinen-Mäkelin Välimäki PTH iPTH secondary hyperparathyroidism medline

Vitamin D deficiency and bone health in healthy adults in Finland: could this be a concern in other parts of Europe?
Lamberg-Allardt CJ, Outila TA, Kärkkainen MU, Rita HJ, Valsta LM.
J Bone Miner Res. 2001 Nov;16(11):2066-73.
PMID: 11697803

Low vitamin D status was prevalent in these young adults in northern Europe in winter, although the vitamin D intake met the recommendation. This probably is not a local problem for northern Europe, because the natural sources of vitamin D are scarce and fortification is not very common in Europe, and with the exception of the southern part of Europe, sunshine is not very abundant in this part of the world. Thus, the results of this study indicate that more attention should be focused on vitamin D status and the sources of vitamin D in these countries.

www.ncbi.nlm.nih.gov/...11697803 - Preview

2001 November study research epidemiological humans Finnish Finland healthy adults vitamin_D deficiency prevalence bone health concern Europe Lamberg-Allardt nutrition medline bone_health osteoporosis prevention PTH iPTH 25ohd

Half of the patients with an acute hip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland.
Nurmi I, Kaukonen JP, Lüthje P, Naboulsi H, Tanninen S, Kataja M, Kallio ML, Leppilampi M.
Osteoporos Int. 2005 Dec;16(12):2018-24. Epub 2005 Aug 24.
PMID: 16133642

Half of the patients with a hip fracture suffered from hypovitaminosis D. The situation was worst in institutional and residential care, although there are personnel for taking care of vitamin D supplementation. In the late summer, one-third and in late winter two-thirds of the patients suffered from hypovitaminosis D. The geographical location of Finland indicates extensive efforts to increase the use of vitamin D supplements among elderly.

www.springerlink.com/...n673170367372365 - Preview

2005 December study research epidemiological humans patients Finnish Finland acute hip fracture fractures vitamin_D hypovitaminosis_D deficiency prevalence 25ohd nutrition medline

Vitamin D fortification as public health policy: significant improvement in vitamin D status in young Finnish men.
Laaksi IT, Ruohola JP, Ylikomi TJ, Auvinen A, Haataja RI, Pihlajamäki HK, Tuohimaa PJ.
Eur J Clin Nutr. 2006 Aug;60(8):1035-8. Epub 2006 Feb 15.
PMID: 16482069

www.nature.com/...1602414a.html - Preview

2006 August ejcn study researc epidemiological young Finnish men Finland Tuohimaa Laaksi vitamin_D fortification 25ohd status improvement insufficiency deficiency nutrition winter wintertime milk medline

Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial.
Cheng S, Lyytikäinen A, Kröger H, Lamberg-Allardt C, Alén M, Koistinen A, Wang QJ, Suuriniemi M, Suominen H, Mahonen A, Nicholson PH, Ivaska KK, Korpela R, Ohlsson C, Väänänen KH, Tylavsky F.
Am J Clin Nutr. 2005 Nov;82(5):1115-26; quiz 1147-8.
PMID: 16280447

www.ajcn.org/...1115 - Preview

2005 November ajcn study research clinical_trial rct Finnish girls humans calcium dairy products vitamin_D supplementation bone mass nutrition Lamberg-Allardt medline body composition osteoporosis prevention health

Vitamin D fortification of milk products does not resolve hypovitaminosis D in young Finnish men.
Välimäki VV, Löyttyniemi E, Välimäki MJ.
Eur J Clin Nutr. 2007 Apr;61(4):493-7. Epub 2006 Nov 29.
PMID: 17136043
doi:10.1038/sj.ejcn.1602550

www.nature.com/...1602550a.html - Preview

2007 April ejcn bone mass young men milk fortification insufficiency deficiency status medline peer-reviewed nutrition medicine science research study osteoporosis hypovitaminosis 25ohd calcidiol finnish Finland vitamin_D Välimäki

Vitamin D intake is low and hypovitaminosis D common in healthy 9- to 15-year-old Finnish girls.
Lehtonen-Veromaa M, Möttönen T, Irjala K, Kärkkäinen M, Lamberg-Allardt C, Hakola P, Viikari J.
Eur J Clin Nutr. 1999 Sep;53(9):746-51.
PMID: 10509773

CONCLUSION: Hypovitaminosis D is fairly common in growing Finnish girls in the wintertime, and three months of vitamin D supplementation with 10 microg/d was insufficient in preventing hypovitaminosis D. The daily dietary vitamin D intake was insufficient (< 5 microg/d) in the majority of participants, while the calcium intake was usually sufficient.

www.ncbi.nlm.nih.gov/...10509773 - Preview

1999 September ejcn study research epidemiological humans girls adolescent young Finnish Finland vitamin_D deficiency intake Lehtonen-Veromaa Lamberg-Allardt hypovitaminosis_D winter wintertime nutrition medline 25ohd prevalence