Matti Narkia's Library tagged finland →  View Popular

"Coronary Heart Disease Mortality and Blood Cholesterol

In the Seven Countries study, there were great differences in coronary heart disease (CHD) mortality at similar blood cholesterol levels.

In this study Dr. Keys pointed to a correlation between deaths from coronary heart disease and serum cholesterol in 15 populations in seven countries.

Dr Ravnskov plotted his original data which was not available in the research summaries. Particularly interesting were differences between two localities within the same country or nearby islands in each of 4 of the seven countries.

West Finland had about 45 CHD (coronary heart disease) deaths at a median cholesterol level of 250 mg/dl. However North Karelia, also in Finland, had over 200 CHD deaths at about 260 mg/dl.

The island of Crete had only 20 CHD deaths at cholesterol levels of about 200. The nearby island of Corfu had about 85 CHD deaths at a cholesterol level of about 190 mg/dl."

www.modern-diets-and-nutritional-diseases.com/seven-countries.html - Preview

modern-diets-and-nutritional-diseases blog_article Seven Countries Study Seven_Countries_study CVD CHD Ancel Keys cholesterol nutrition Crete Finland West_Finland North_Karelia Ravnskoff Ravnskov Japan

Calcium:magnesium ratio in local groundwater and incidence of acute myocardial infarction among males in rural Finland.
Kousa A, Havulinna AS, Moltchanova E, Taskinen O, Nikkarinen M, Eriksson J, Karvonen M.
Environ Health Perspect. 2006 May;114(5):730-4.
doi:10.1289/ehp.8438
PMID: 16675428

Results of this study with specific Bayesian statistical analysis support earlier findings of a protective role of Mg and low Ca:Mg ratio against coronary heart disease but do not support the earlier hypothesis of a protective role of Ca

ehp.niehs.nih.gov/...8438.html - Preview

2006 May study research epidemiological men calcium:magnesium ratio calcium magnesium local groundwater incidence of acute myocardial_infarction AMI CVD CHD nutrition rural Finland medline

Serum 25-hydroxyvitamin D and the risk of ovarian cancer.
Toriola AT, Surcel HM, Agborsangaya C, Grankvist K, Tuohimaa P, Toniolo P, Lukanova A, Pukkala E, Lehtinen M.
Eur J Cancer. 2009 Aug 25. [Epub ahead of print]
PMID: 19713101
doi:10.1016/j.ejca.2009.08.002

Conclusion
Overall, we did not observe a significant association between serum 25-OHD concentrations and the risk of ovarian cancer. However, we found evidence suggestive of an increased risk among women with low to insufficient serum 25-OHD concentrations.

www.sciencedirect.com/science - Preview

2009 August study researc epidemiological humans women Finnish Finland vitamin_D 25ohd calcidiol ovarian cancer ovarian_cancer risk nutrition medline Tuohimaa

Lack of association between serum levels of 25-hydroxyvitamin D and the subsequent risk of prostate cancer in Finnish men.
Faupel-Badger JM, Diaw L, Albanes D, Virtamo J, Woodson K, Tangrea JA.
Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2784-6.
PMID: 18086789
doi: 10.1158/1055-9965.EPI-07-0672

cebp.aacrjournals.org/...2784.long - Preview

2007 December cebp Faupel-Badger study research epidemiological humans Finnish SETTI ATBC vitamin_D 25ohd prostate cancer prostate_cancer PCa risk U-shaped nutrition U-shape Finland Nordic medline

Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events: the Kuopio ischaemic heart disease risk factor study.
Rissanen T, Voutilainen S, Nyyssönen K, Lakka TA, Salonen JT.
Circulation. 2000 Nov 28;102(22):2677-9.
PMID: 11094031

Methods and Results—We studied this association in the Kuopio Ischaemic Heart Disease Risk Factor Study, a prospective population study in Eastern Finland. Subjects were randomly selected and included 1871 men aged 42 to 60 years who had no clinical coronary heart disease at baseline examination. A total of 194 men had a fatal or nonfatal acute coronary event during follow-up. In a Cox proportional hazards’ model adjusting for other risk factors, men in the highest fifth of the proportion of serum DHA+DPA in all fatty acids had a 44% reduced risk (P=0.014) of acute coronary events compared with men in the lowest fifth. Men in the highest fifth of DHA+DPA who had a low hair content of mercury (<=2.0 µg/g) had a 67% reduced risk (P=0.016) of acute coronary events compared with men in the lowest fifth who had a high hair content of mercury (>2.0 µg/g). There was no association between proportion of eicosapentaenoic acid and the risk of acute coronary events.

Conclusions—Our data provide further confirmation for the concept that fish oil–derived fatty acids reduce the risk of acute coronary events. However, a high mercury content in fish could attenuate this protective effect.

circ.ahajournals.org/...2677 - Preview

2000 November Circulation study research epidemiological humans Finland Kuopio CVD CHD omega-3 DHA DPA mercury nutrition MI myocardial_infarction medline risk myocardial infarction acute coronary events fish

Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis.
Salonen JT, Nyyssönen K, Salonen R, Lakka HM, Kaikkonen J, Porkkala-Sarataho E, Voutilainen S, Lakka TA, Rissanen T, Leskinen L, Tuomainen TP, Valkonen VP, Ristonmaa U, Poulsen HE.
J Intern Med. 2000 Nov;248(5):377-86.
PMID: 11123502
DOI: 10.1046/j.1365-2796.2000.00752.x

Conclusions. Our study shows that a combined supplementation with reasonable doses of both vitamin E and slow-release vitamin C can retard the progression of common carotid atherosclerosis in men. This may imply benefits with regard to other atherosclerosis-based events.

www3.interscience.wiley.com/...HTMLSTART - Preview

2000 November Salonen study research clinical_trial rct humans vitamin_C vitamin_E supplementation carotid artery IMT CIMT CVD arteriosclerosis progression nutrition antioxidants Finland Finnish hypercholesterolemic lipids medline

Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study.
Salonen RM, Nyyssönen K, Kaikkonen J, Porkkala-Sarataho E, Voutilainen S, Rissanen TH, Tuomainen TP, Valkonen VP, Ristonmaa U, Lakka HM, Vanharanta M, Salonen JT, Poulsen HE; Antioxidant Supplementation in Atherosclerosis Prevention Study.
Circulation. 2003 Feb 25;107(7):947-53.
PMID: 12600905
doi: 10.1161/01.CIR.0000050626.25057.51

Conclusions— These data replicate our 3-year findings confirming that the supplementation with combination of vitamin E and slow-release vitamin C slows down atherosclerotic progression in hypercholesterolemic persons.

circ.ahajournals.org/...947 - Preview

2003 February Circulation Salonen study research clinical_trial humans vitamin_C vitamin_E supplementation carotid artery IMT CIMT CVD arteriosclerosis progression nutrition antioxidants Finland Finnish hypercholesterolemic lipids medline

High dietary methionine intake increases the risk of acute coronary events in middle-aged men.
Virtanen JK, Voutilainen S, Rissanen TH, Happonen P, Mursu J, Laukkanen JA, Poulsen H, Lakka TA, Salonen JT.
Nutr Metab Cardiovasc Dis. 2006 Mar;16(2):113-20. Epub 2005 Nov 2.
PMID: 16487911
doi:10.1016/j.numecd.2005.05.005

Conclusions
The main finding of this study is that long-term, moderately high dietary methionine intake may increase the risk of acute coronary events in middle-aged Finnish men free of prior CHD. More prospective research is needed to confirm the role of dietary methionine in the development of CVD, and whether its effects are independent of homocysteine.

www.nmcd-journal.com/...abstract - Preview

2006 March Virtanen study research epidemiological humans middle-aged men Finnish Finland high dietary methionine intake acute coronary_events CVD CHD nutrition risk homocysteine medline

Glycemic index, glycemic load, and the risk of acute myocardial infarction in Finnish men: The Kuopio Ischaemic Heart Disease Risk Factor Study.
Mursu J, Virtanen JK, Rissanen TH, Tuomainen TP, Nykänen I, Laukkanen JA, Kortelainen R, Voutilainen S.
Nutr Metab Cardiovasc Dis. 2009 Oct 14. [Epub ahead of print]
PMID: 19836217
doi:10.1016/j.numecd.2009.08.001

Conclusions
Our results suggest that both high dietary GI and GL are associated with increased risk of AMI among overweight and GL possibly among less physically active men.

www.sciencedirect.com/science - Preview

2009 October study research epidemiological humans Finnish men Finland Mursu Virtanen glycemic_index GI glycemic_load GL acute myocardial_infarction AMI MI CVD nutrition CHD risk carbohydrates overweight medline

Serum Long-Chain n-3 Polyunsaturated Fatty Acids and Risk of Hospital Diagnosis of Atrial Fibrillation in Men.
Virtanen JK, Mursu J, Voutilainen S, Tuomainen TP.
Circulation. 2009 Dec 8;120(23):2315-21. Epub 2009 Nov 23.
PMID: 19933935
doi: 10.1161/CIRCULATIONAHA.109.852657

Conclusions— An increased concentration of long-chain n-3 PUFAs in serum, a marker of fish or fish oil consumption, may protect against AF. Serum docosahexaenoic acid concentration had the greatest impact.

circ.ahajournals.org/...2315 - Preview

2009 December Circulation Virtanen study research epidemiological humans Finnish men Finland atrial_fibrillation AF CVD arrhythmia serum omega-3 nutrition DHA long-chain PUFA medline level concentration risk cardiac

Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study.
McGrath J, Saari K, Hakko H, Jokelainen J, Jones P, Järvelin MR, Chant D, Isohanni M.
Schizophr Res. 2004 Apr 1;67(2-3):237-45.
PMID: 14984883

Conclusion: Vitamin D supplementation during the first year of life is associated with a reduced risk of schizophrenia in males. Preventing hypovitaminosis D during early life may reduce the incidence of schizophrenia.

www.schres-journal.com/...abstract - Preview

2004 April study research epidemiological humans infants Finnish Finland vitamin_D supplementation nutrition schizophrenia risk calcitriol brain growth development medline birth cohort

Fish consumption and depressive symptoms in the general population in Finland.
Tanskanen A, Hibbeln JR, Tuomilehto J, Uutela A, Haukkala A, Viinamäki H, Lehtonen J, Vartiainen E.
Psychiatr Serv. 2001 Apr;52(4):529-31.
PMID: 11274502

After the analysis adjusted for potential confounders, the likelihood of having depressive symptoms was significantly higher among infrequent fish consumers than among frequent consumers.

psychservices.psychiatryonline.org/...529 - Preview

2001 April study research epidemiological humans omega-3 fish consumption depression Finland Tanskanen Tuomilehto nutrition medline Paleolithic diet Paleolithic_diet evolution

"NEW YORK (Reuters Health) - Low vitamin D levels in the body may be deadly, according to a new study hinting that adults with lower, versus higher, blood levels of vitamin D may be more likely to die from heart disease or stroke.

Vitamin D is an essential vitamin mostly obtained from direct sunlight exposure, but also found in foods and multivitamins.

Dr. Annamari Kilkkinen, at the National Institute for Health and Welfare in Helsinki, Finland, and colleagues compared blood levels of vitamin D and deaths from heart disease or stroke over time in 2,817 men and 3,402 women in Finland."

www.nlm.nih.gov/...fullstory_91248.html - Preview

2009 October medlineplus news vitamin_D deficiency status low_levels CVD CHD stroke risk death Finland humans nutrition epidemiological low levels

Defining Adequate Vitamin D Intake : Cross-sectional and Intervention Studies
Viljakainen, Heli Tuulikki
University of Helsinki
2008-05-23
Doctoral dissertation (article-based)

In summary, vitamin D intake remains inadequate among the target groups of this thesis, as reflected by seasonal variation in calcitropic hormones and bone metabolism. Dietary intake of vitamin D should be increased to achieve at least an adequate vitamin D status (S-25-OHD>50 nmol/l) and possibly an optimal vitamin D status (S-25-OHD>80 nmol/l) throughout the year. This could be accomplished by introducing new vitamin D-fortified foods to the market.

oa.doria.fi/37651 - Preview

2008 May Heli Viljakainen Helsinki University doctoral dissertation Vitamin_D Defining definition adequate intake AI requirement requirements epidemiological clinical_trials humans nutrition Finland bone health osteoporosis prevention studies thesis

www.vuodenluontokuva.fi/default.asp - Preview

vuodenluontokuva vuoden luontokuva luonto kuva valokuva nature photo photos valokuvia valokuvat Finland Suomi metsän emäntä kuukkeli 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999

Last week, I had the pleasure of being invited out to Finland by Finnfacts on a whirlwind tour of new and established Finnish start ups. I was also delighted to attend the renown Nordic Technology Conference MindTrek, joined by other prominent figures from the international web and technology scene.

Over the next few days I’ll be sharing thoughts and details of some of the companies we visited, these include Floobs, RuntoShop and Muxlim. Though, for the moment, I’d like to share my perspective on the Finnish startup scene and community as a whole.

thenextweb.com/...finland-startup-community-cold - Preview

2009 October thenextweb blog_article Finland Startup Ecosystem startups business Finnish tech technology start_ups companies new

Neurological development of 5-year-old children receiving a low-saturated fat, low-cholesterol diet since infancy: A randomized controlled trial.
Rask-Nissilä L, Jokinen E, Terho P, Tammi A, Lapinleimu H, Rönnemaa T, Viikari J, Seppänen R, Korhonen T, Tuominen J, Välimäki I, Simell O.
JAMA. 2000 Aug 23-30;284(8):993-1000.
PMID: 10944645

Conclusion Our data indicate that repeated child-targeted dietary counseling of parents during the first 5 years of a child's life lessens age-associated increases in children's serum cholesterol and is compatible with normal neurological development

jama.ama-assn.org/...993 - Preview

2000 August Jama study clinical_trial rct humans infants children Finland low-saturated fat low-cholesterol diet LDL HDL lipid_profile CVD nutrition medline

Association between serum 25(OH)D concentrations and bone stress fractures in Finnish young men.
Ruohola JP, Laaksi I, Ylikomi T, Haataja R, Mattila VM, Sahi T, Tuohimaa P, Pihlajamäki H.
J Bone Miner Res. 2006 Sep;21(9):1483-8.
doi: 10.1359/jbmr.060607

Conclusions: A lower level of serum 25(OH)D concentration may be a generally predisposing element for bone stress fractures. Considering the obvious need of additional vitamin D in prevention of stress fractures, the effects of vitamin D fortification of foods and supplementation will be subjects of interest for future research
PMID: 16939407

www.jbmronline.org/...jbmr.060607 - Preview

2006 September study research epidemiological humans Finnish young men Finland vitamin_D 25ohd bone stress fractures nutrition Ruohola Laaksi Tuohimaa medline status low_levels serum

Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls.
Cheng S, Tylavsky F, Kröger H, Kärkkäinen M, Lyytikäinen A, Koistinen A, Mahonen A, Alen M, Halleen J, Väänänen K, Lamberg-Allardt C.
Am J Clin Nutr. 2003 Sep;78(3):485-92. Erratum in: Am J Clin Nutr. 2006 Jan;83(1):174.
PMID: 12936933

CONCLUSIONS: Vitamin D-deficient girls have low cortical BMD and high iPTH concentrations, which are consistent with secondary hyperparathyroidism. A low vitamin D concentration accompanied by high bone resorption (TRAP 5b) may limit the accretion of bone mass in young girls.

www.ajcn.org/...485 - Preview

2003 September ajcn study research epidemiological humans young girls Finnish Finland vitamin_D status 25ohd deficiency prevalence PTH BMD nutrition bone mass density cortical Lamberg-Allardt Cheng calcium intake secondary hyperparathyroidism iPTH medline

Teenage girls and elderly women living in northern Europe have low winter vitamin D status.
Andersen R, Mølgaard C, Skovgaard LT, Brot C, Cashman KD, Chabros E, Charzewska J, Flynn A, Jakobsen J, Kärkkäinen M, Kiely M, Lamberg-Allardt C, Moreiras O, Natri AM, O'brien M, Rogalska-Niedzwiedz M, Ovesen L.
Eur J Clin Nutr. 2005 Apr;59(4):533-41.
PMID: 15714215
doi:10.1038/sj.ejcn.1602108

CONCLUSION: Vitamin D status is low in northern Europe during winter. More than one-third of the adolescent girls have vitamin D status below 25 nmol/l and almost all are below 50 nmol/l. Two-thirds of the elderly community-dwelling women have vitamin D status below 50 nmol/l. Use of vitamin D supplements is a significant positive determinant for S-25OHD for both girls and women (P = 0.001). SPONSORSHIP: The European Fifth Framework Programme (Contract No. QLK1-CT-2000-00623)

www.nature.com/...1602108a.html - Preview

2005 April ejcn study research epidemiological humans teenage girls elderly women northern Europe vitamin_D status winter 25ohd deficiency prevalence nutrition Lamberg-Allardt low adolescent Finland Denmarki Ireland Poland old older medline