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Deficiency of K2 in both mice and humans is associated with coronary calcification; low vitamin K2 levels are associated with increased activity of Gla matrix protein, an enzyme that causes calcium deposition in artery walls. People who take warfarin (Coumadin®), a potent blocker of vitamin K2, experience more arterial and heart valve calcification.

The 2004 Rotterdam Heart Study was the experience that really brought this concept closer to our interests. This well-conducted study of 4800 Dutch demonstrated an association of vitamin K2 intake with 57% reduction in cardiovascular events and lesser degrees of aortic calcification (another surrogate for atherosclerosis). Benefit appeared to be associated with a daily K2 intake of 32.7 micrograms per day (Geleijnse JM et al 2004). An important corollary of this study is that it suggests that a vitamin K2-mediated reduction in coronary calcification is accompanied by reduced likelihood of heart attack and other events.

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trackyourplaque info news vitamin_K2 CVD CHD cardiovascular events cardiovascular_events reduction coronary calcification deficiency nutrition

Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis.
Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, Oikawa S, Sasaki J, Hishida H, Itakura H, Kita T, Kitabatake A, Nakaya N, Sakata T, Shimada K, Shirato K; Japan EPA lipid intervention study (JELIS) Investigators.
Lancet. 2007 Mar 31;369(9567):1090-8. Erratum in: Lancet. 2007 Jul 21;370(9583):220.
PMID: 17398308
doi:10.1016/S0140-6736(07)60527-3

Interpretation
EPA is a promising treatment for prevention of major coronary events, and especially non-fatal coronary events, in Japanese hypercholesterolaemic patients

www.thelancet.com/...abstract - Preview

2007 March Lancet study research clinical_trial rct JELIS humans omega-3 EPA Japan nutrition medline CVD CHD prevention major coronary events hypercholesterolemic patients

Coronary calcium as a predictor of coronary events in four racial or ethnic groups.
Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, Liu K, Shea S, Szklo M, Bluemke DA, O'Leary DH, Tracy R, Watson K, Wong ND, Kronmal RA.
N Engl J Med. 2008 Mar 27;358(13):1336-45.
PMID: 18367736

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2008 March NEJM study research epidemiological humans CHD CVD diagnosis diagnostic tool predictor coronary calcium scan scanning scanner heart events heart_scan score calcium_score artery arteries medline ethnicity race scans

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CNN.com Live CNN Events Breaking News top stories

The Harvard School of Public Health delivers live and on demand video of symposia, graduation, courses, and other important events taking place at the school.

The school employs both Windows Media technology as well as RealNetwork's technology.

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The mission of Harvard@Home is to provide the Harvard community and the broader public with opportunities for rich in-depth exploration of a wealth of topics through Web-based video programs of the highest caliber.
Harvard@Home enables you to experience some of the exciting teaching, cutting-edge research, and noteworthy events that define and distinguish the University today--right from your desktop. View the latest Harvard@Home release or explore more than fifty programs linked from our "Program List," covering subjects ranging from the arts to social sciences, from history to current affairs, from literature to science and math. All of our video-streamed, multimedia presentations bring you inside the Harvard classroom to hear current, real-life lectures or provide you with a front-row seat at recent University panels, Alumni College forums, and other special events. Harvard@Home is free and open to the public.
In addition to the programs we produce, Harvard@Home also provides technical consultation and professional referrals to colleagues who wish to capture, edit, encode, or stream video and audio for University events and projects.

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MIT World is a free and open site that provides on demand video of significant public events at MIT. MIT World's video index contains more than 600 videos. Browse the Videos

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Cloverr is like your hard drive on the internet. You can store links, pictures, notes, events, Flickr photos, YouTube videos and so on. They are all regarded as files. We are currently in private beta. You can sign in if you already have an account, or become a private beta tester now.

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Conclusions In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events.

Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.
Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM Jr, Kastelein JJ, Koenig W, Libby P, Lorenzatti AJ, MacFadyen JG, Nordestgaard BG, Shepherd J, Willerson JT, Glynn RJ; JUPITER Study Group.
N Engl J Med. 2008 Nov 20;359(21):2195-207. Epub 2008 Nov 9.
PMID: 18997196

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2008 November NEJM study research clinical_trial rct humans healthy_subjects elevated hs-CRP CRP rosuvastatin statin statins JUPITER LDL cardiovascular events cardiovascular_events CVD CHD MI stroke death risk incidence major medline diabetes

Conclusions These data suggest that the C-reactive protein level is a stronger predictor of cardiovascular events than the LDL cholesterol level and that it adds prognostic information to that conveyed by the Framingham risk score.

Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events.
Ridker PM, Rifai N, Rose L, Buring JE, Cook NR.
N Engl J Med. 2002 Nov 14;347(20):1557-65.
PMID: 12432042

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2002 November NEJM study research epidemiological humans women CVD CHD risk factor factors risk_factor risk_factors CRP LDL Comparison preditor predition medline first cardiovascular events cardiovascular_events MI stroke C-reactive_protein

Upcoming.org is a social events calendar driven by people just like you!\nDiscover new events, share them with your friends, and add your own.\n

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User Interface Engineering is a leading research, training, and consulting firm specializing in web site and product usability. Jared M. Spool founded the company back in 1988 and has built UIE into the largest organization of its kind in the world.

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Eventful is a web service which aims to help users to search for and share information about events. Eventful is a service of Eventful, Inc. (formerly EVDB, Inc.) of San Diego, California. EVDB stands for "Events and Venues Database", and anyone may add i

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Future adverse cardiac events can be predicted by persistently low plasma adiponectin concentrations in men and marked reductions of adiponectin in women after acute myocardial infarction.\nKojima S, Funahashi T, Otsuka F, Maruyoshi H, Yamashita T, Kajiwara I, Shimomura H, Miyao Y, Fujimoto K, Sugiyama S, Sakamoto T, Yoshimura M, Ogawa H.\nAtherosclerosis. 2007 Sep;194(1):204-13. Epub 2006 Sep 12.\nPMID: 16970953 \ndoi:10.1016/j.atherosclerosis.2006.07.028\n

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2007 September study research epidemiological humans patients acute infarction AMI MI CVD CHD plasma adiponectin levels level concentration prognosis gender predictor prediction medicine health medline CVD_events events myocardial

Leptin, but not adiponectin, is a predictor of recurrent cardiovascular events in men: results from the LIPID study.
Söderberg S, Colquhoun D, Keech A, Yallop J, Barnes EH, Pollicino C, Simes J, Tonkin AM, Nestel P; LIPID Study Investigators.
Int J Obes (Lond). 2009 Jan;33(1):123-30. Epub 2008 Dec 9.
PMID: 19050671

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2009 January study research epidemiological himans men leptin adiponectin CVD risk prediction risk_prediction predictor pravastatin atherosclerosis events CVD_events recurrent medicine health medline

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The Eventful Web Services API allows you to build tools and applications that interact with Eventful.

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Eventful web service events Venues Database EVDB webservice webservices search info Information demand imported delicious search_engine search_engines

Eventful is a web service which aims to help users to search for and share information about events. Eventful is a service of Eventful, Inc. (formerly EVDB, Inc.) of San Diego, California. EVDB stands for "Events and Venues Database", and anyone may add i

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