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Diagnosis and treatment of vitamin D deficiency; Expert Opinion on Pharmacotherapy - 9(1):Pages 107-118 - Informa Healthcare
Diagnosis and treatment of vitamin D deficiency.
Cannell JJ, Hollis BW, Zasloff M, Heaney RP.
Expert Opin Pharmacother. 2008 Jan;9(1):107-18.
PMID: 18076342
The recent discovery – in a randomised, controlled trial – that daily ingestion of 1100 IU of colecalciferol (vitamin D) over a 4-year period dramatically reduced the incidence of non-skin cancers makes it difficult to overstate the potential medical, social and economic implications of treating vitamin D deficiency. Not only are such deficiencies common, probably the rule, vitamin D deficiency stands implicated in a host of diseases other than cancer. The metabolic product of vitamin D is a potent, pleiotropic, repair and maintenance, secosteroid hormone that targets > 200 human genes in a wide variety of tissues, meaning it has as many mechanisms of action as genes it targets. A common misconception is that government agencies designed present intake recommendations to prevent or treat vitamin D deficiency. They did not. Instead, they are guidelines to prevent particular metabolic bone diseases. Official recommendations were never designed and are not effective in preventing or treating vitamin D deficiency and in no way limit the freedom of the physician – or responsibility – to do so. At this time, assessing serum 25-hydroxy-vitamin D is the only way to make the diagnosis and to assure that treatment is adequate and safe. The authors believe that treatment should be sufficient to maintain levels found in humans living naturally in a sun-rich environment, that is, > 40 ng/ml, year around. Three treatment modalities exist: sunlight, artificial ultraviolet B radiation or supplementation. All treatment modalities have their potential risks and benefits. Benefits of all treatment modalities outweigh potential risks and greatly outweigh the risk of no treatment. As a prolonged ‘vitamin D winter’, centred on the winter solstice, occurs at many temperate latitudes, ≤ 5000 IU (125 μg) of vitamin D/day may be required in obese, aged and/or dark-skinned patients
Multiple Sclerosis and You - Multiple Sclerosis (MS) Symptoms, Diagnosis and Treatments Blog - ms.about.com
Multiple Sclerosis Blog
By Julie Stachowiak, Ph.D.,
NEJM -- Coronary Calcium as a Predictor of Coronary Events in Four Racial or Ethnic Groups
Coronary calcium as a predictor of coronary events in four racial or ethnic groups.
Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, Liu K, Shea S, Szklo M, Bluemke DA, O'Leary DH, Tracy R, Watson K, Wong ND, Kronmal RA.
N Engl J Med. 2008 Mar 27;358(13):1336-45.
PMID: 18367736
Calcium scans may be effective screening tool for heart disease | Science Blog
"LOS ANGELES (September 29, 2009) -- A simple, non-invasive test appears to be an effective screening tool for identifying patients with silent heart disease who are at risk for a heart attack or sudden death. Coronary artery calcium scans can be done without triggering excessive additional testing and costs, according to the multi-center EISNER (Early Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research) study, led by investigators at the Cedars-Sinai Heart Institute. The findings appear in today's issue of the findings appear in today's issue of the Journal of the American College of Cardiology."
Are sunlight deprivation and influenza epidemics associated with the onset of acute leukemia? -- Timonen et al. 92 (11): 1553 -- Haematologica
Are sunlight deprivation and influenza epidemics associated with the onset of acute leukemia?
Timonen T, Näyhä S, Koskela T, Pukkala E.
Haematologica. 2007 Nov;92(11):1553-6.
PMID: 18024404
doi:10.3324/haematol.10799
Month of diagnosis of 7,423 cases of acute leukemia (AL) in Finland during 1964–2003 were linked with data on influenza and solar radiation. Acute myeloblastic leukemia (AML) showed the highest risk in the dark season. During the light season, the incidence decreased by 58% (95% confidence interval, 16–79%) per 1,000 kJ/m2/d increase of solar radiation. Independent of solar radiation, AML increased by 9% (95% confidence interval, 0–19%) during influenza epidemics. Reoccurring at the same time annually, darkness-related vitamin D deficiency and influenza could cause successive and co-operative mutations leading to AL with a short latency.
GrassrootsHealth | Vitamin D Action - Seminars
Dear Colleague:
What public health action could you take today that could possibly stop breast cancer and colon cancer, prevent type 1 diabetes and multiple sclerosis, and reduce the incidence of infectious diseases? What would be the economic impact of this action?
A group of physicians and researchers in the vitamin D field are presenting information at this conference to look at the current research and practice with vitamin D to enable everyone to take action today based on what’s known to solve the deficiency epidemic, and, to start the prevention of many diseases.
Diagnosis and treatment of vitamin D deficiency. - Expert Opin Pharmacother. 2008 Jan;9(1):107-18. (full text PDF)
Diagnosis and treatment of vitamin D deficiency.
Cannell JJ, Hollis BW, Zasloff M, Heaney RP.
Expert Opin Pharmacother. 2008 Jan;9(1):107-18.
PMID: 18076342
DOI 10.1517/14656566.9.1.107
Diagnosis and treatment of vitamin D deficiency; Expert Opinion on Pharmacotherapy - 9(1):Pages 107-118 - Informa Healthcare
Diagnosis and treatment of vitamin D deficiency.
Cannell JJ, Hollis BW, Zasloff M, Heaney RP.
Expert Opin Pharmacother. 2008 Jan;9(1):107-18.
PMID: 18076342
DOI 10.1517/14656566.9.1.107
Vitamin D Deficiency - Treatment and Diagnosis - UCSD-TV - University of California Television - San Diego
Vitamin D Deficiency - Treatment and Diagnosis
Season of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of sun-induced vitamin D - British Journal of Cancer
SSeason of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of sun-induced vitamin D.
Porojnicu AC, Robsahm TE, Ree AH, Moan J.
Br J Cancer. 2005 Sep 5;93(5):571-4.
PMID: 16136030
doi:10.1038/sj.bjc.6602722
Epidemiological data for this period indicate that season of diagnosis is a strong prognostic factor for Hodgkin's lymphoma, with approximately 20% lower case fatality for patients diagnosed during autumn vs winter diagnosis (RR = 0.783, 95% CI,-0.62 to 0.99; P = 0.041). Notably, the improved autumnal survival rate was higher than 60% (RR = 0.364, 95% CI, -0.15 to 0.87; P = 0.025) for patients younger than 30 years. This finding may be related to higher endogenous levels of vitamin D in autumn, with a favourable influence on the conventional therapy.
In conclusion, we have found that the prognosis of Hodgkin's lymphoma is significantly correlated with the season of diagnosis, particularly for patients younger than 30 years. This seasonal effect is presumably due to the vitamin D3 synthesis in skin during sun exposure. The present findings should encourage further investigations of the possible adjuvant role of vitamin D derivatives in cancer therapy
ASBMR - Contemporary Diagnosis and Treatment of Vitamin D-Related Disorders
Contemporary Diagnosis and Treatment of Vitamin D-Related Disorders
GrassrootsHealth | Vitamin D Action - Seminar - December 2008
Diagnosis and Treatment of Vitamin D Deficiency Seminar
December 2, 2008
Diagnosis & Treatment of Vitamin D Deficiency - Seminar Presentations (PDF Slides) - University of California, San Diego 2008
Diagnosis & Treatment of Vitamin D Deficiency
Wednesday, April 9, 2008 * 12:30pm - 6:00pm
Garren Auditorium, University of California, San Diego
Seminar Presentations
Symptom Checker - Check your medical symptoms - MayoClinic.com
What's causing your foot pain? Why does your child's throat hurt? And what should you do about it? Use this guide to discover the most common causes of the most common symptoms.
FreeMD® Your Virtual Doctor
Hi, I'm Dr. Stephen Schueler, an emergency room physician, and your virtual doctor. Type a symptom or condition into the box and a menu will appear. If you select a topic marked "Virtual Doctor" I will interview you and tell you what's wrong. I'll help you decide if you need to see a doctor, and why. Let's get started!
Know Cancer | Community, Support & Information on Treatment, Symptoms and Prevention
Know Cancer is dedicated to connecting, educating and empowering all people affected by the many forms of cancer. Through the power of knowledge and collective wisdom we will help people to prevent, endure and survive cancer. Our current focus is KnowCancer.com, an online community that provides social and professional support to patients and their loved ones. The website contains 3 main sections:
Education: a comprehensive library of cancer related content
Community: a cancer social network, blog, forum and an “ask the expert” section
Resources: a nationwide directory of cancer related businesses and organizations
Prostate Cancer: How is blood in urine diagnosed?
The evaluation for blood in urine consists of taking a history, performing a physical examination, evaluating the urine under a microscope, and obtaining a culture of the urine. A significant history would include whether or not there was any pain or discomfort associated with the hematuria, whether the blood was present in the beginning, end, or throughout the urinary stream, and finally, whether there is a personal history of smoking, kidney stones, injuries to the urinary tract, trouble urinating, or previous urologic evaluat
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