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Low vitamin D serum level is related to severe fibrosis and low responsiveness to IFN-based therapy in genotype 1 chronic hepatitis C - Wiley InterScience :: Journal :: Article PDF
Low vitamin D serum level is related to severe fibrosis and low responsiveness to IFN-based therapy in genotype 1 chronic hepatitis C
Salvatore Petta et al.
Hepatology, Volume 9999 Issue 999A, Page NA. Published Online: 4 Dec 2009
DOI: 10.1002/hep.23489
Conclusions:
G1 CHC patients had low 25(OH)D serum levels, possibly due to reduced CYP27A1 expression. Low vitamin D is linked to severe fibrosis and low SVR on IFN-based therapy. (HEPATOLOGY 2010.)
Chronic toxicity of dichloroacetate: Possible relation to thiamine deficiency in rats - ScienceDirect - Fundamental and Applied Toxicology
Chronic toxicity of dichloroacetate: possible relation to thiamine deficiency in rats.
Stacpoole PW, Harwood HJ Jr, Cameron DF, Curry SH, Samuelson DA, Cornwell PE, Sauberlich HE.
Fundam Appl Toxicol. 1990 Feb;14(2):327-37.
PMID: 2318357
We conclude that stimulation by DCA of thiamine-requiring enzymes may lead to depletion of total body thiamine stores and to both a fall in transketolase activity and an increase in oxalate accumulation in vivo. DCA neurotoxicity may thus be due, at least in part, to thiamine deficiency and may be preventable with thiamine treatm
Dietary Cod Protein Reduces Plasma C-Reactive Protein in Insulin-Resistant Men and Women -- Ouellet et al. 138 (12): 2386 -- Journal of Nutrition
Dietary cod protein reduces plasma C-reactive protein in insulin-resistant men and women.
Ouellet V, Weisnagel SJ, Marois J, Bergeron J, Julien P, Gougeon R, Tchernof A, Holub BJ, Jacques H.
J Nutr. 2008 Dec;138(12):2386-91.
PMID: 19022962
Therefore, these results show that CP can lower hsCRP, a marker of inflammation associated with insulin resistance and type 2 diabetes.
Can a Treatment for Sarcoidosis be Helpful for CFS or Fibromyalgia?
Is the MP Treatment for Sarcoidosis Helpful for Other Chronic Diseases?
MP’s Vitamin D Theories Are Not Supported by Lab Studies.
Updated July 2, 2008
"The MP treatment plan was originally designed to treat an inflammatory condition known as sarcoidosis. The treatment consists of using the drug Benicar, combined with the avoidance of all sources of vitamin D, and eventually adding various antibiotics, especially minocycline. After being used by sarcoidosis patients for some years, it was then theorized and claimed that the treatment could treat other inflammatory conditions. Eventually it was also claimed that it could treat fibromyalgia and CFS, conditions which are not recognized by the medical literature as being inflammatory in nature. "
Voices of reason in the vitamin D debate
"Maybe vitamin D isn’t the answer after all.
Not only does the above statement ring true, it’s also the title of a recent post on “Dr. Len’s Cancer Blog” – a website written by Dr. Len Lichtenfeld, Deputy Chief Medical Officer for the national office of the American Cancer Society, in order to facilitate communication with the public on important issues related to cancer. "
Vitamin D, nervous system and aging - ScienceDirect - Psychoneuroendocrinology
Vitamin D, nervous system and aging.
Tuohimaa P, Keisala T, Minasyan A, Cachat J, Kalueff A.
Psychoneuroendocrinology. 2009 Aug 4. [Epub ahead of print]
PMID: 19660871
Vitamin D metabolites as clinical markers in autoimmune and chronic disease. - Ann N Y Acad Sci. 2009 Sep;1173:384-90. - Wiley InterScience :: Article :: HTML Full Text
Vitamin D metabolites as clinical markers in autoimmune and chronic disease.
Blaney GP, Albert PJ, Proal AD.
Ann N Y Acad Sci. 2009 Sep;1173:384-90.
PMID: 19758177
DOI: 10.1111/j.1749-6632.2009.04875.x
Vitamin D for Pain
According to peer-reviewed clinical research, inadequacies of vitamin D have been linked to chronic musculoskeletal pain of various types, muscle weakness or fatigue, fibromyalgia syndrome, rheumatic disorders, osteoarthritis, hyperesthesia, migraine headaches, and other somatic complaints. It also has been implicated in the mood disturbances of chronic fatigue syndrome and seasonal affective disorder.
Current best evidence demonstrates that supplemental vitamin D can help to resolve or alleviate chronic pain and fatigue syndromes in many patients who have been unresponsive to other therapies. Vitamin D therapy is easy for patients to self-administer, is well tolerated, and is very economical. The documents on this page provide detailed background information and practice recommendations.
Evidence-based decision making on micronutrients and chronic disease: long-term randomized controlled trials are not enough -- Ames et al. 86 (2): 522 -- American Journal of Clinical Nutrition
Evidence-based decision making on micronutrients and chronic disease: long-term randomized controlled trials are not enough.
Ames BN, McCann JC, Stampfer MJ, Willett WC.
Am J Clin Nutr. 2007 Aug;86(2):522-3; author reply 523-4.
PMID: 17684228
Causes of disturbances in acid-base balance - Acid-base balance, dentinogenesis and dental caries: Experimental studies in rats
The most common imbalance in the acid-base balance in the industrialized countries is mild chronic metabolic acidosis caused by the diet rich in the animal protein. Proteins are metabolized to organic acids. The typical American diet produces after metabolism approximately 100 meq of acid every day (Barzel 1995). This kind of a diet has been proved to cause aciduria and calciuria as a consequence of acidosis and thus a loss of total calcium of the body (Breslau et al. 1988, Schuette et al. 1980, Licata et al. 1981). Cola drinks that contain phosphoric acid are another acidosis-inducing ingredient of diet, especially among young people (Barzel 1995).
Nutrition, chronic disease, and the problem of proof -- Heaney 84 (3): 471 -- American Journal of Clinical Nutrition
Nutrition, chronic disease, and the problem of proof.
Heaney RP.
Am J Clin Nutr. 2006 Sep;84(3):471-2. No abstract available.
PMID: 16960157
Chronic Sunscreen Use Decreases Circulating Concentrations of 25-Hydroxyvitamin D: A Preliminary Study, December 1988, Matsuoka et al. 124 (12): 1802 - Arch Dermatol -- Abstract (free full text PDF available)
Matsuoka, L. Y., Wortsman, J., Hanifan, N. & Holick, M. F. (1988)
Chronic sunscreen use decreases circulating concentrations of 25-hydroxyvitamin D: a preliminary study.
Arch. Dermatol. 124:1802-1804
Long-latency deficiency disease: insights from calcium and vitamin D -- Heaney 78 (5): 912 -- American Journal of Clinical Nutrition
Long-latency deficiency disease: insights from calcium and vitamin D.
Heaney RP.
Am J Clin Nutr. 2003 Nov;78(5):912-9. Review.
PMID: 14594776
Vitamin D in preventive medicine: are we ignoring the evidence?
Vitamin D in preventive medicine: are we ignoring the evidence?
Zittermann A.
Br J Nutr. 2003 May;89(5):552-72. Review.
PMID: 12720576
Vitamin D is metabolised by a hepatic 25-hydroxylase into 25-hydroxyvitamin D (25(OH)D) and by a renal 1alpha-hydroxylase into the vitamin D hormone calcitriol. Calcitriol receptors are present in more than thirty different tissues. Apart from the kidney, several tissues also possess the enzyme 1alpha-hydroxylase, which is able to use circulating 25(OH)D as a substrate. Serum levels of 25(OH)D are the best indicator to assess vitamin D deficiency, insufficiency, hypovitaminosis, adequacy, and toxicity. European children and young adults often have circulating 25(OH)D levels in the insufficiency range during wintertime. Elderly subjects have mean 25(OH)D levels in the insufficiency range throughout the year. In institutionalized subjects 25(OH)D levels are often in the deficiency range. There is now general agreement that a low vitamin D status is involved in the pathogenesis of osteoporosis. Moreover, vitamin D insufficiency can lead to a disturbed muscle function. Epidemiological data also indicate a low vitamin D status in tuberculosis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases, hypertension, and specific types of cancer. Some intervention trials have demonstrated that supplementation with vitamin D or its metabolites is able: (i) to reduce blood pressure in hypertensive patients; (ii) to improve blood glucose levels in diabetics; (iii) to improve symptoms of rheumatoid arthritis and multiple sclerosis. The oral dose necessary to achieve adequate serum 25(OH)D levels is probably much higher than the current recommendations of 5-15 microg/d.
YouTube - Vitamin D and Prevention of Chronic Diseases
Vitamin D and Prevention of Chronic Diseases. A presentation by professor Michael F. Holick
Vitamin D in the Spotlight; This critical nutrient builds bones, helps fight infection and may protect against some cancers. Do we get enough? - AccessMyLibrary - Promoting library advocacy
For many years, vitamin D was boring--even to doctors. Because it was considered good for bones and not much else, multitaskers like vitamin A, B vitamins and vitamin E hogged all the press. But recent studies have thrust this long-neglected nutrient into the spotlight. Scientists now think vitamin D may affect everything from diabetes to cancer. They're also finding that many people don't have enough of it.
New endogenous anti-inflammatory and proresolving lipid mediators: implications for rheumatic diseases. - [Nat Clin Pract Rheumatol. 2007] - PubMed Result
New endogenous anti-inflammatory and proresolving lipid mediators: implications for rheumatic diseases.
Yacoubian S, Serhan CN.
Nat Clin Pract Rheumatol. 2007 Oct;3(10):570-9; quiz 1 p following 589. Review.
PMID: 17906612
Fish consumption and risk of major chronic disease in men. - Am J Clin Nutr. 2008 Dec
Fish consumption and risk of major chronic disease in men.
Virtanen JK, Mozaffarian D, Chiuve SE, Rimm EB.
Am J Clin Nutr. 2008 Dec;88(6):1618-25.
PMID: 19064523
doi:10.3945/ajcn.2007.25816
Conclusions: Modest fish consumption was associated with a lower risk of total cardiovascular disease, consistent with cardiac mortality benefits but not with total cancer or overall major chronic disease; n–6 fatty acid consumption did not influence these relations.
Sulbutiamine - Wikipedia, the free encyclopedia
Sulbutiamine (brand name: Arcalion) is a precursor to thiamine (i.e., vitamin B1). As a dimer of two structurally modified thiamine residues, sulbutiamine retains many of the features of thiamine. However, the thiazole rings are open, the alcohol groups are esterified, and a disulfide bridge connects the two thiamine analogues.
Sulbutiamine is indicated for the treatment of asthenia.[1] Its ability to reduce fatigue is also considered desirable by athletes, and it is available for over-the-counter sale as a nutritional supplement. In one study of chronic fatigue patients, sulbutiamine did not demonstrate sustained benefits over the placebo, which raises doubts about its clinical efficacy.[2] However, the authors of that study suggest that additional research is needed to evalulate the potential usefulness of sulbutiamine in the treatment of chronic fatigue.
Sulbutiamine may be beneficial for cognition. Indeed, the demonstrated ability of sulbutiamine to improve memory in rats[3] and patients of schizophrenia[3] suggests that it is a nootropic.
Recent research also shows support for the use of sulbutiamine in the treatment of erectile dysfunction
Aging is characterized by a profound reduction in anti-inflammatory lipoxin A4 levels. - ScienceDirect - Experimental Gerontology :
Aging is characterized by a profound reduction in anti-inflammatory lipoxin A4 levels.
Gangemi S, Pescara L, D'Urbano E, Basile G, Nicita-Mauro V, Davì G, Romano M.
Exp Gerontol. 2005 Jul;40(7):612-4.
PMID: 15935589
doi:10.1016/j.exger.2005.04.004
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