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The Effect of Vitamin D2 and Vitamin D3 on Intestinal Calcium Absorption in Nigerian Children with Rickets -- Thacher et al. 94 (9): 3314 -- Journal of Clinical Endocrinology & Metabolism
The effect of vitamin D2 and vitamin D3 on intestinal calcium absorption in Nigerian children with rickets.
Thacher TD, Obadofin MO, O'Brien KO, Abrams SA.
J Clin Endocrinol Metab. 2009 Sep;94(9):3314-21. Epub 2009 Jun 30.
PMID: 19567516
Conclusions: Despite similar increases in 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D with vitamin D2 or vitamin D3, fractional calcium absorption did not increase, indicating that rickets in Nigerian children is not primarily due to vitamin D-deficient calcium malabsorption
Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sunny country? - Eur J Nutr. 2009 Nov 28. - SpringerLink - Journal Article
Is a lower dose of vitamin D supplementation enough to increase 25(OH)D status in a sunny country?
Pignotti GA, Genaro PS, Pinheiro MM, Szejnfeld VL, Martini LA.
Eur J Nutr. 2009 Nov 28. [Epub ahead of print]
PMID: 19946776
CONCLUSION: The dose given (400 IU/day) was not enough to achieve 25(OH)D concentration, considered optimal for bone health.
A phase 2 trial exploring the effects of high-dose (10,000 IU/day) vitamin D(3) in breast cancer patients with bone metastases. - Cancer. 2009 Nov 13. - Wiley InterScience :: Article :: HTML Full Text
A phase 2 trial exploring the effects of high-dose (10,000 IU/day) vitamin D(3) in breast cancer patients with bone metastases.
Amir E, Simmons CE, Freedman OC, Dranitsaris G, Cole DE, Vieth R, Ooi WS, Clemons M.
Cancer. 2009 Nov 13. [Epub ahead of print]
PMID: 19918922
DOI: 10.1002/cncr.24749
METHODS:
Patients with bone metastases treated with bisphosphonates were enrolled into this single-arm phase 2 study. Patients received 10,000 IU of vitamin D3 and 1000 mg of calcium supplementation each day for 4 months. The effect of this treatment on palliation, bone resorption markers, calcium metabolism, and toxicity were evaluated at baseline and monthly thereafter.
CONCLUSIONS:
Daily doses of 10,000 IU vitamin D3 for 4 months appear safe in patients without comorbid conditions causing hypersensitivity to vitamin D. Treatment reduced inappropriately elevated parathyroid hormone levels, presumably caused by long-term bisphosphonate use. There did not appear to be a significant palliative benefit nor any significant change in bone resorption. Cancer 2010. © 2009 American Cancer Society.
Marine-derived n-3 fatty acids and atherosclerosis in Japanese, Japanese Americans, and Whites: a cross-sectional study
Marine-derived n-3 fatty acids and atherosclerosis in Japanese, Japanese-American, and white men: a cross-sectional study.
Sekikawa A, Curb JD, Ueshima H, El-Saed A, Kadowaki T, Abbott RD, Evans RW, Rodriguez BL, Okamura T, Sutton-Tyrrell K, Nakamura Y, Masaki K, Edmundowicz D, Kashiwagi A, Willcox BJ, Takamiya T, Mitsunami K, Seto TB, Murata K, White RL, Kuller LH; ERA JUMP (Electron-Beam Tomography, Risk Factor Assessment Among Japanese and U.S. Men in the Post-World War II Birth Cohort) Study Group.
J Am Coll Cardiol. 2008 Aug 5;52(6):417-24.
PMID: 18672160
Conclusions
Very high levels of marine-derived n-3 FAs have anti-atherogenic properties independent of traditional cardiovascular risk factors and may contribute to lower burden of atherosclerosis in Japanese in Japan, which is unlikely due to genetic factors.
ERA JUMP: Omega-3 fatty acids and plaque - The Heart Scan Blog
"The results of the uniquely-constructed ERA JUMP Study were just released, a fascinating study of the relationship of omega-3 fatty acids to coronary and carotid plaque.
The study adds insight into why the Japanese experience only one third of the heart attacks of Americans, and why Japan occupies the bottom of the list for least heart attacks among all developed countries.
The Electron-Beam Tomography, Risk Factor Assessment Among Japanese and U.S. Men in the Post-World War II Birth Cohort Study (ERA JUMP), a collaborative U.S.-Japanese effort, compared three groups of men:
-- 281 Japanese men living in Japan
-- 306 non-Japanese men living in the U.S. (Pittsburgh, Pennsylvania)
-- 303 Japanese Americans (having both parents Japanese without “ethnic admixture”) living in Hawaii.
The last group represents a group that is genetically similar to the group in Japan, but exposed to an American diet and lifestyle.
Three main measures were compared:
-- Blood levels of omega-3 fatty acids, EPA and DHA)
-- Carotid intimal-medial thickness (CIMT, the thickness of the carotid artery lining that can serve as an index of body-wide atherosclerosis)
-- Coronary calcium (heart scan) scores."
High doses of vitamin D could cut relapse rate among MS sufferers - Times Online
"Powerful new evidence about the ability of vitamin D to stem a wide range of diseases has brought the prospect of a nationwide programme to prescribe it in Scotland as a dietary supplement significantly closer.
Reports at the weekend suggested that experts were increasingly convinced that the so-called sunshine drug — whose significance was first revealed in detail by The Times last year — could make a difference to the country’s appalling health record.
New research suggests that high doses of vitamin D could dramatically cut the relapse rate in people with multiple sclerosis. According to scientists in Canada, more than a third of sufferers taking high levels of supplement
Safety of vitamin D3 in adults with multiple sclerosis -- Kimball et al. 86 (3): 645 -- American Journal of Clinical Nutrition
Safety of vitamin D3 in adults with multiple sclerosis.
Kimball SM, Ursell MR, O'Connor P, Vieth R.
Am J Clin Nutr. 2007 Sep;86(3):645-51.
PMID: 17823429
Conclusions: Patients' serum 25(OH)D concentrations reached twice the top of the physiologic range without eliciting hypercalcemia or hypercalciuria. The data support the feasibility of pharmacologic doses of vitamin D3 for clinical research, and they provide objective evidence that vitamin D intake beyond the current upper limit is safe by a large margin.
Vitamin D and MS: Burton
"Dr. Jodie Burton is the acting principal investigator (PI) of the dose-escalation trial of oral vitamin D3 with calcium supplementation in patients with multiple sclerosis with Dr. O'Connor. She started the trial as his fellow, while doing an additional 2 years of training in MS specifically after she received her neurology certification. She completed her fellowship training in 2007. Now she is staff doing clinical research and continuing with the vitamin D trial. As of August 2009, she will be Assistant Professor in Neurology in the Department of Clinical Neuroscience in Calgary and at the University of Calgary. She will be part of the MS team there with Dr. Luanne Metz and the MS group.
Please scroll down for an abstract of the trial:
A Phase I/II dose-escalation trial of oral vitamin D3 with calcium supplementation in patients with multiple sclerosis."
Conclusions:
High-dose VD3 (~10 000 IU/day, possibly higher) in MS is safe and tolerable, with evidence of clinical improvement.
High Doses of Vitamin D Cut MS Relapses
"April 28, 2009 (Seattle) -- High doses of vitamin D dramatically cut the relapse rate in people with multiple sclerosis, a study shows.
Sixteen percent of 25 people with multiple sclerosis (MS) given an average of 14,000 international units (IU) of vitamin D a day for a year suffered relapses, says Jodie Burton, MD, a neurologist at the University of Toronto. In contrast, close to 40% of 24 MS patients who took an average of 1,000 IU a day -- the amount recommended by many MS specialists -- relapsed, she says.
Also, people taking high-dose vitamin D suffered 41% fewer relapses than the year before the study began, compared with 17% of those taking typical doses.
People taking high doses of vitamin D did not suffer any significant side effects, Burton tells WebMD."
Meta-analysis of vitamin D, calcium and the prevention of breast cancer. - [Breast Cancer Res Treat. 2009] - PubMed Result
Meta-analysis of vitamin D, calcium and the prevention of breast cancer.
Chen P, Hu P, Xie D, Qin Y, Wang F, Wang H.
Breast Cancer Res Treat. 2009 Oct 23. [Epub ahead of print]
PMID: 19851861
These results provide strong evidence that vitamin D and calcium have a chemopreventive effect against breast cancer.
NEJM -- Coronary Calcium as a Predictor of Coronary Events in Four Racial or Ethnic Groups
Coronary calcium as a predictor of coronary events in four racial or ethnic groups.
Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, Liu K, Shea S, Szklo M, Bluemke DA, O'Leary DH, Tracy R, Watson K, Wong ND, Kronmal RA.
N Engl J Med. 2008 Mar 27;358(13):1336-45.
PMID: 18367736
Calcium scans may be effective screening tool for heart disease | Science Blog
"LOS ANGELES (September 29, 2009) -- A simple, non-invasive test appears to be an effective screening tool for identifying patients with silent heart disease who are at risk for a heart attack or sudden death. Coronary artery calcium scans can be done without triggering excessive additional testing and costs, according to the multi-center EISNER (Early Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research) study, led by investigators at the Cedars-Sinai Heart Institute. The findings appear in today's issue of the findings appear in today's issue of the Journal of the American College of Cardiology."
Calcium and vitamin D intakes may be positively associated with brain lesions in depressed and non-depressed elders
Calcium and vitamin D intakes may be positively associated with brain lesions in depressed and nondepressed elders.
Payne ME, Anderson JJ, Steffens DC.
Nutr Res. 2008 May;28(5):285-92.
PMID: 19083421
doi: 10.1016/j.nutres.2008.02.013
In conclusion, calcium and vitamin D consumption were associated with brain lesions in elderly subjects even after controlling for potentially explanatory variables. These associations may be due to vascular calcification or other mechanism. The possibility of adverse effects of high intakes of calcium and vitamin D needs to be further explored in longitudinal studies of elderly subjects.
Vitamin D and Calcium in Sarcoidosis
A Review - Vitamin D and Calcium in Sarcoidosis\nTrevor G Marshall, PhD, 5 July 2003
Calcium, Dairy Foods, Vitamin D, and Colorectal Cancer Risk: The Fukuoka Colorectal Cancer Study — Cancer Epidemiology, Biomarkers & Prevention
Calcium, dairy foods, vitamin D, and colorectal cancer risk: the Fukuoka Colorectal Cancer Study.
Mizoue T, Kimura Y, Toyomura K, Nagano J, Kono S, Mibu R, Tanaka M, Kakeji Y, Maehara Y, Okamura T, Ikejiri K, Futami K, Yasunami Y, Maekawa T, Takenaka K, Ichimiya H, Imaizumi N.
Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2800-7.
PMID: 18843026
Calcium, Vitamin D and Cancer — Anticancer Research
Calcium, vitamin D and cancer.
Peterlik M, Grant WB, Cross HS.
Anticancer Res. 2009 Sep;29(9):3687-98. Review.
PMID: 19667166
Overview of general physiologic features and functions of vitamin D -- DeLuca 80 (6): 1689S -- American Journal of Clinical Nutrition
Overview of general physiologic features and functions of vitamin D.
DeLuca HF.
Am J Clin Nutr. 2004 Dec;80(6 Suppl):1689S-96S. Review.
PMID: 15585789
Calcium and vitamin d supplementation decreases incidence of stress fractures in female navy recruits. - JBMR Online - Journal of Bone and Mineral Research - 23(5):741 - Full Text
Calcium and vitamin d supplementation decreases incidence of stress fractures in female navy recruits.
Lappe J, Cullen D, Haynatzki G, Recker R, Ahlf R, Thompson K.
J Bone Miner Res. 2008 May;23(5):741-9.
PMID: 18433305
doi: 10.1359/jbmr.080102
Conclusions: Generalizing the findings to the population of 14,416 women who entered basic training at the Great Lakes during the 24 mo of recruitment, calcium and vitamin D supplementation for the entire cohort would have prevented 187 persons from fracturing. Such a decrease in SFx would be associated with a significant decrease in morbidity and financial costs.
Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls -- Cheng et al. 78 (3): 485 -- American Journal of Clinical Nutrition
Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls.
Cheng S, Tylavsky F, Kröger H, Kärkkäinen M, Lyytikäinen A, Koistinen A, Mahonen A, Alen M, Halleen J, Väänänen K, Lamberg-Allardt C.
Am J Clin Nutr. 2003 Sep;78(3):485-92. Erratum in: Am J Clin Nutr. 2006 Jan;83(1):174.
PMID: 12936933
CONCLUSIONS: Vitamin D-deficient girls have low cortical BMD and high iPTH concentrations, which are consistent with secondary hyperparathyroidism. A low vitamin D concentration accompanied by high bone resorption (TRAP 5b) may limit the accretion of bone mass in young girls.
NEJM -- Vitamin D3 and calcium to prevent hip fractures in the elderly women
Vitamin D3 and calcium to prevent hip fractures in the elderly women.
Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ.
N Engl J Med. 1992 Dec 3;327(23):1637-42.
PMID: 1331788
CONCLUSIONS. Supplementation with vitamin D3 and calcium reduces the risk of hip fractures and other nonvertebral fractures among elderly women.
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