Matti Narkia's Library tagged artery →  View Popular

Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis.
Salonen JT, Nyyssönen K, Salonen R, Lakka HM, Kaikkonen J, Porkkala-Sarataho E, Voutilainen S, Lakka TA, Rissanen T, Leskinen L, Tuomainen TP, Valkonen VP, Ristonmaa U, Poulsen HE.
J Intern Med. 2000 Nov;248(5):377-86.
PMID: 11123502
DOI: 10.1046/j.1365-2796.2000.00752.x

Conclusions. Our study shows that a combined supplementation with reasonable doses of both vitamin E and slow-release vitamin C can retard the progression of common carotid atherosclerosis in men. This may imply benefits with regard to other atherosclerosis-based events.

www3.interscience.wiley.com/...HTMLSTART - Preview

2000 November Salonen study research clinical_trial rct humans vitamin_C vitamin_E supplementation carotid artery IMT CIMT CVD arteriosclerosis progression nutrition antioxidants Finland Finnish hypercholesterolemic lipids medline

Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study.
Salonen RM, Nyyssönen K, Kaikkonen J, Porkkala-Sarataho E, Voutilainen S, Rissanen TH, Tuomainen TP, Valkonen VP, Ristonmaa U, Lakka HM, Vanharanta M, Salonen JT, Poulsen HE; Antioxidant Supplementation in Atherosclerosis Prevention Study.
Circulation. 2003 Feb 25;107(7):947-53.
PMID: 12600905
doi: 10.1161/01.CIR.0000050626.25057.51

Conclusions— These data replicate our 3-year findings confirming that the supplementation with combination of vitamin E and slow-release vitamin C slows down atherosclerotic progression in hypercholesterolemic persons.

circ.ahajournals.org/...947 - Preview

2003 February Circulation Salonen study research clinical_trial humans vitamin_C vitamin_E supplementation carotid artery IMT CIMT CVD arteriosclerosis progression nutrition antioxidants Finland Finnish hypercholesterolemic lipids medline

July 28, 2008 | Sue Hughes
Pittsburgh, PA and Shiga, Japan - The low rate of atherosclerosis and heart disease in Japanese people may be related to their very high levels of marine-derived omega-3 fatty acids rather than genetic factors, a new study suggests [1].

The study, published in the August 5, 2008 issue of the Journal of the American College of Cardiology (available online July 28), was conducted by a group led by Dr Akira Sekikawa (University of Pittsburgh, PA, and Shiga University of Medical Science, Japan).

They found that compared with white or Japanese American men living in the US, Japanese men living in Japan had twice the blood levels of omega-3 fatty acids—a finding that was independently linked to low levels of atherosclerosis.

"The death rate from coronary heart disease in Japan has always been puzzlingly low. Our study suggests that the very low rates of coronary heart disease among Japanese living in Japan may be due to their lifelong high consumption of fish," Sekikawa said."

Results showed that the Japanese men had the lowest levels of atherosclerosis, whereas whites and Japanese Americans had similar higher levels. The Japanese men also had twofold higher levels of marine-derived omega-3 fatty acids than white and Japanese Americans.

In addition, the significant differences between Japanese and American men in multivariable-adjusted IMT and CAC prevalence became nonsignificant after adjustment further for marine-derived omega-3 fatty acids.

www.theheart.org/...884341.do - Preview

2008 July theheart.org news ERA JUMP Japan USA Japanese whites CVD CHD carotid IMT CIMT omega-3 EPA DHA epidemiological atherosclerosis nutrition coronary artery calcification CAC Americans

July 29, 2008 — The low rate of atherosclerosis and heart disease in Japanese people may be related to their very high levels of marine-derived omega-3 fatty acids rather than genetic factors, a new study suggests [1].

The study, known as Electron-Beam Tomography, Risk Factor Assessment Among Japanese and US Men in the Post-World War II Birth Cohort (ERA JUMP) included 868 randomly selected men aged 40 to 49. Of these, 281 were Japanese men living in Japan; 306 were white men living in the US, and 281 were third- or fourth-generation Japanese American men from Hawaii. All study participants had a physical examination, completed a lifestyle questionnaire, and had blood tests to measure cholesterol levels and levels of omega-3 fatty acids. Atherosclerosis was assessed by measuring carotid intima-medial thickness (IMT) and coronary artery calcification (CAC).

Results showed that the Japanese men had the lowest levels of atherosclerosis, whereas whites and Japanese Americans had similar higher levels. The Japanese men also had twofold higher levels of marine-derived omega-3 fatty acids than white and Japanese Americans.

The study, published in the August 5, 2008 issue of the Journal of the American College of Cardiology (available online July 28), was conducted by a group led by Dr Akira Sekikawa (University of Pittsburgh, PA, and Shiga University of Medical Science, Japan).

They found that compared with white or Japanese American men living in the US, Japanese men living in Japan had twice the blood levels of omega-3 fatty acids — a finding that was independently linked to low levels of atherosclerosis.

cme.medscape.com/...578221 - Preview

2008 July Medscape CME news ERA JUMP Japan USA Japanese whites CVD CHD carotid IMT CIMT omega-3 EPA DHA epidemiological atherosclerosis nutrition coronary artery calcification CAC Americans

Marine-derived n-3 fatty acids and atherosclerosis in Japanese, Japanese-American, and white men: a cross-sectional study.
Sekikawa A, Curb JD, Ueshima H, El-Saed A, Kadowaki T, Abbott RD, Evans RW, Rodriguez BL, Okamura T, Sutton-Tyrrell K, Nakamura Y, Masaki K, Edmundowicz D, Kashiwagi A, Willcox BJ, Takamiya T, Mitsunami K, Seto TB, Murata K, White RL, Kuller LH; ERA JUMP (Electron-Beam Tomography, Risk Factor Assessment Among Japanese and U.S. Men in the Post-World War II Birth Cohort) Study Group.
J Am Coll Cardiol. 2008 Aug 5;52(6):417-24.
PMID: 18672160

Conclusions
Very high levels of marine-derived n-3 FAs have anti-atherogenic properties independent of traditional cardiovascular risk factors and may contribute to lower burden of atherosclerosis in Japanese in Japan, which is unlikely due to genetic factors.

www.ncbi.nlm.nih.gov/...PMC2736602 - Preview

2008 August jacc bstudy research epidemiological humans Japan USA ERA JUMP omega-3 Japanese EPA DHA IMT CIMT CAC CVD CHD nutrition coronary artery calcification carotid calcium score heart_scan

Coronary calcium as a predictor of coronary events in four racial or ethnic groups.
Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, Liu K, Shea S, Szklo M, Bluemke DA, O'Leary DH, Tracy R, Watson K, Wong ND, Kronmal RA.
N Engl J Med. 2008 Mar 27;358(13):1336-45.
PMID: 18367736

content.nejm.org/...1336 - Preview

2008 March NEJM study research epidemiological humans CHD CVD diagnosis diagnostic tool predictor coronary calcium scan scanning scanner heart events heart_scan score calcium_score artery arteries medline ethnicity race scans

"LOS ANGELES (September 29, 2009) -- A simple, non-invasive test appears to be an effective screening tool for identifying patients with silent heart disease who are at risk for a heart attack or sudden death. Coronary artery calcium scans can be done without triggering excessive additional testing and costs, according to the multi-center EISNER (Early Identification of Subclinical Atherosclerosis by Noninvasive Imaging Research) study, led by investigators at the Cedars-Sinai Heart Institute. The findings appear in today's issue of the findings appear in today's issue of the Journal of the American College of Cardiology."

www.scienceblog.com/...-tool-heart-disease-25696.html - Preview

2009 September news scienceblog blog_article CHD CVD Calcium scans scan screening tool diagnosis diagnostic coronary artery arteries heart attack disease

It was observed that in post-menopausal women with documented heart disease from the Estrogen Replacement and Atherosclerosis (ERA) trial, a multicenter clinical trial evaluating the effects of hormone replacement therapy on atherosclerotic progression, in the group consuming the highest-saturated dietary fat diet (12.0% Sat Fat), an enlargement in coronary diameter of 0.01 mm and a 0.1% regression in coronary artery stenosis

drbganimalpharm.blogspot.com/...gh-saturated-fat-diets-in.html - Preview

2009 June Animal Pharm drbganimalpharm High-Saturated Fat Diets diet benefits sfa high-saturated-fat_diet nutrition CVD CHD coronary artery regression stenosis atherosclerosis saturated

Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients.
Targher G, Bertolini L, Padovani R, Zenari L, Scala L, Cigolini M, Arcaro G.
Clin Endocrinol (Oxf). 2006 Nov;65(5):593-7.
PMID: 17054459
DOI: 10.1111/j.1365-2265.2006.02633.x

CONCLUSIONS: Hypovitaminosis D is highly prevalent in type 2 diabetic adults and is strongly and independently associated with increased carotid IMT. Further investigation into whether vitamin D may play a role in the prevention of atherosclerosis appears to be warranted.

In conclusion, our results show that type 2 diabetic adults have significant reductions in serum 25(OH)D concentrations (vs matched controls) that predict preclinical atherosclerosis, independent of classical risk factors, renal function tests, inflammatory markers, use of medications and presence of the metabolic syndrome. These findings suggest the need for ongoing evaluation of the possible protective role of vitamin D3 supplementation in the development of atherosclerosis.

www3.interscience.wiley.com/...HTMLSTART - Preview

2006 November study research epidemiological humans patients diabetic type_2 diabetes vitamin_D 25ohd CVD carotid artery intima-media thickness CIMT IMT nutrition medline status deficiency low_levels hypovitaminosis_D HbA1C CRP hs-CRP hemoglobin

25-hydroxyvitamin D levels inversely associate with risk for developing coronary artery calcification.
de Boer IH, Kestenbaum B, Shoben AB, Michos ED, Sarnak MJ, Siscovick DS.
J Am Soc Nephrol. 2009 Aug;20(8):1805-12. Epub 2009 May 14.
PMID: 19443637
doi: 10.1681/ASN.2008111157

"In conclusion, lower 25-hydroxyvitamin D concentrations associate with increased risk for incident CAC. Accelerated development of atherosclerosis may underlie, in part, the increased cardiovascular risk associated with vitamin D deficiency."

jasn.asnjournals.org/...1805 - Preview

2009 August study research epidemiological humans coronary artery calcification CAC vitamin_D 25ohd CVD CHD nutrition medline

Increased intake of vitamin C-rich foods may reduce the risk of hardening of the arteries, and ultimately protect against heart disease, says a new study from Norway.\nWriting in the journal Nutrition, Metabolism and Cardiovascular Diseases, researchers from Ulleval University Hospital in Norway report that increased intakes of vitamin C and fruit and berries were associated with less thickening of the carotid artery.

www.nutraingredients.com/...-foods-may-boost-artery-health - Preview

2009 February news vitamin C vitamin_C vitamin_C--rich_foods foods carotid intima media thickness IMT CIMT artery arteries health CVD CHD atherosclerosis prevention berries fruit nutrition intima-media_thickness

Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation.\nAviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld L, Volkova N, Presser D, Attias J, Liker H, Hayek T.\nClin Nutr. 2004 Jun;23(3):423-33. Erratum in: Clin Nutr. 2008 Aug;27(4):671.\nPMID: 15158307

www.ncbi.nlm.nih.gov/...entrez - Preview

2004 June clinical_trial humans Pomegranate juice carotid artery stenosis reduction intima-media thickness intima-media_thickness blood_pressure BP LDL oxidation rct nutrition medline atherosclerosis IMT CIMT cvd study research

Zittermann A, Schleithoff SS, Koerfer R. \nVitamin D and vascular calcification.\nCurr Opin Lipidol. 2007 Feb;18(1):41-6. Review.\nPMID: 17218831 [PubMed - indexed for MEDLINE

www.co-lipidology.com/...d!-260396143!181195628!8091!-1 - Preview

vitamin D vascular calcification artery arterial arteries deficiency insufficiency medicine medline nutrition study zittermann science review peer-reviewed imported delicious vitamin_D

Tedgui A, Mallat Z.
Cytokines in atherosclerosis: pathogenic and regulatory pathways.
Physiol Rev. 2006 Apr;86(2):515-81. Review.
PMID: 16601268 [PubMed - indexed for MEDLINE]

physrev.physiology.org/...515 - Preview

atherosclerosis cardiology coronary cardiovascular artery arteriosclerosis disease medicine pathogenesis inflammatory heart CHD CVD physiology inflammation pathways Pathogenic Cytokines study science medline peer-reviewed review imported delicious

Xu YC, Leung SW, Yeung DK, Hu LH, Chen GH, Che CM, Man RY.
Structure-activity relationships of flavonoids for vascular relaxation in porcine coronary artery.
Phytochemistry. 2007 Mar 27; [Epub ahead of print]
PMID: 17395220 [PubMed - as supplied by pu

www.ncbi.nlm.nih.gov/...query.fcgi - Preview

flavonoids vascular relaxation coronary artery flavones isoflavones flavanones chalcones anthocyanidins flavanoles flavonols apigenin luteolin kaempferol and quercetin vasodilation vasodilator nutrition medicine study science medline peer-reviewed researc

Erkkila AT, Matthan NR, Herrington DM, Lichtenstein AH.
Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD.
J Lipid Res. 2006 Dec;47(12):2814-9. Epub 2006 Sep 18.
PMID: 16983146 [Pub

www.jlr.org/...2814 - Preview

nutrition PUFA EPA DHA ALA alpha-linolenic acid angiography coronary artery disease heart CAD CHD epidemiological finland finnish women reduced progression atherosclerosis medline medicine science study research peer-reviewed 2006 imported delicious