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Anti-ageing pill developed that 'cuts wrinkles and makes skin look younger' - Telegraph
"A one-a-day pill the size of a Smartie that claims to be able to give younger looking skin and fewer wrinkles is being hailed as the latest weapon against ageing.
Known as Innéov Fermeté, it is claimed that taking one of these pills just once a day will lead to a younger appearance by harnessing the health-giving properties of tomatoes.
Scientists who designed the pill claim that trials have shown it dramatically slows down the ageing of the skin.
Jointly developed by food giant Nestlé and L’Oréal, the world’s biggest cosmetics company, the pill uses a compound found in tomatoes to promote the regeneration of new skin cells and protect old ones from damage.
The sweet red pill has already gone on sale in parts of Europe and South America. "
Researchers link calorie intake to cell lifespan, cancer development (w/ Video)
"Researchers from the University of Alabama at Birmingham (UAB) have discovered that restricting consumption of glucose, the most common dietary sugar, can extend the life of healthy human-lung cells and speed the death of precancerous human-lung cells, reducing cancer's spread and growth rate.
The research has wide-ranging potential in age-related science, including ways in which calorie-intake restriction can benefit longevity and help prevent diseases like cancer that have been linked to aging, said principal investigator Trygve Tollefsbol, Ph.D., D.O., a professor in the Department of Biology.
"These results further verify the potential health benefits of controlling calorie intake." Tollefsbol said. "Our research indicates that calorie reduction extends the lifespan of healthy human cells and aids the body's natural ability to kill off cancer-forming cells.
Vitamin D, aging, and cancer. Pentti Tuohimaa. 2008; Nutrition Reviews - Wiley InterScience
Vitamin D, aging, and cancer.
Tuohimaa P.
Nutr Rev. 2008 Oct;66(10 Suppl 2):S147-52. Review.
PMID: 18844842
DOI: 10.1111/j.1753-4887.2008.00095.x
Deficiency of the prohormone calcidiol (25OH vitamin D3) seems to be associated with several aging-related chronic diseases including cancer. Our results suggest that calcidiol is mainly responsible for differentiation homeostasis, whereas calcitriol might be more involved in calcium homeostasis. Therefore, an imbalance of calcidiol rather than calcitriol is a risk factor for cancer and chronic diseases. Calcidiol insufficiency, as well as insufficient solar exposure, is associated with increased risk of several solid cancers. Both a vitamin D3 deficiency and a high concentration of calcidiol may increase cancer risk. Similarly, aging phenomena show a U-shaped association with vitamin D bioactivity. Therefore, the chronic diseases and cancers related to aging might be prevented by an optimal concentration of serum calcidiol, which remains to be determined.
Vitamin D and aging. [J Steroid Biochem Mol Biol. 2009] - PubMed result
Vitamin D and aging.
Tuohimaa P.
J Steroid Biochem Mol Biol. 2009 Mar;114(1-2):78-84. Review.
PMID: 19444937
Fish Intake and Risk of Incident Atrial Fibrillation -- Mozaffarian et al. 110 (4): 368 -- Circulation
Fish intake and risk of incident atrial fibrillation.
Mozaffarian D, Psaty BM, Rimm EB, Lemaitre RN, Burke GL, Lyles MF, Lefkowitz D, Siscovick DS.
Circulation. 2004 Jul 27;110(4):368-73. Epub 2004 Jul 19.
PMID: 15262826
doi: 10.1161/01.CIR.0000138154.00779.A5
Conclusions— Among elderly adults, consumption of tuna or other broiled or baked fish, but not fried fish or fish sandwiches, is associated with lower incidence of AF. Fish intake may influence risk of this common cardiac arrhythmia.
A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women -- Gleason et al. 38 (1): 86 -- Age and Ageing
A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women.
Gleason CE, Carlsson CM, Barnet JH, Meade SA, Setchell KD, Atwood CS, Johnson SC, Ries ML, Asthana S.
Age Ageing. 2009 Jan;38(1):86-93. Epub 2008 Dec 2.
PMID: 19054783
doi:10.1093/ageing/afn227
Conclusions: these data suggest that administration of 100 mg/day of isoflavones was well tolerated. Plasma genistein and daidzein levels, but not equol, increased with isoflavone administration. Finally, data support the potential cognitive effects of soy isoflavones in older adults.
Tempeh and tofu, for better or worse | The Jakarta Post
"Consuming tempeh can reduce the risk of developing dementia in the elderly, but eating tofu can increase it, said a joint study between universities here and in Britain on Wednesday.
The study between University of Indonesia (UI), Indonesia Respati University, University of Loughborough and University of Oxford said people over 68 years of age who consumed tofu more than twice a day had a worse memory than those who rarely ate it.
But if they also ate tempeh, the risk of dementia was reduced.
"Tempeh consumption very likely offsets tofu's negative associations with memory," Professor Eef Hogervorst of the University of Loughborough said in a seminar on aging and health at UI campus in Depok, where she presented the result of the study.
The study involved 712 respondents from Jakarta, Citengah in West Java and Yogyakarta, with ages ranging from 52 to 99 years. "
Tofu and Cognitive Function: Food for Thought -- Grodstein et al. 19 (2): 207 -- Journal of the American College of Nutrition
Tofu and cognitive function: food for thought.
Grodstein F, Mayeux R, Stampfer MJ.
J Am Coll Nutr. 2000 Apr;19(2):207-9. Review.
PMID: 10763901
In addition, a plausible biologic hypothesis is generally an important part of judging epidemiologic relations. While high tofu intake may lead to lower plasma estrogen levels [12], we do not know how tofu influences estrogen levels in the brain; we also know very little about estrogen effects in men. Furthermore, data have not even consistently indicated that low endogenous estrogen levels are directly related to cognitive function in non-demented subjects [13]. The authors also posit a non-estrogen mediated hypothesis for the effects of tofu, namely that soy inhibits hippocampal tyrosine kinase and may block long-term potentiation (the likely mechanism by which humans learn and remember). Still, considerably more work must be done to substantiate this hypothesis.
Finally, the single measures of outcome used in this study may have limited value, as cognitive function and brain structure change over time. Factors which predict these measures at one point may or may not be the same as those which predict decline over time; fundamentally, the public health interest is in preventing cognitive decline, as the steepness of the decline trajectory likely provides an early marker for risk of the more clinically relevant result—dementia.
Tofu 'may raise risk of dementia' - BBC NEWS | Have Your Say
"Eating high levels of some soy products - including tofu - may raise the risk of memory loss, research suggests.
The study focused on 719 elderly Indonesians living in urban and rural regions of Java. '
The latest study suggests phytoestrogens - in high quantity - may actually heighten the risk of dementia.
Lead researcher Professor Eef Hogervorst said previous research had linked oestrogen therapy to a doubling of dementia risk in the over-65s.
She said oestrogens - and probably phytoestrogens - tended to promote growth among cells, not necessarily a good thing in the ageing brain.
Alternatively, high doses of oestrogens might promote the damage caused to cells by particles known as free radicals.
A third theory is that damage is caused not by the tofu, but by formaldehyde, which is sometimes used in Indonesia as a preservative.
The researchers admit that more research is required to ascertain whether the same effects are found in other ethnic groups.
However, previous research has also linked high tofu consumption to an increased risk of dementia in older Japanese American men.
The researchers found high tofu consumption - at least once a day - was associated with worse memory, particularly among the over-68s. "
High Tofu Intake Is Associated with Worse Memory in Elderly Indonesian Men and Women
High tofu intake is associated with worse memory in elderly Indonesian men and women.
Hogervorst E, Sadjimim T, Yesufu A, Kreager P, Rahardjo TB.
Dement Geriatr Cogn Disord. 2008;26(1):50-7. Epub 2008 Jun 27.
PMID: 18583909
DOI: 10.1159/000141484
CONCLUSION: The results for tofu consumption as a risk factor for low memory function may tie in with the Honolulu Asia Aging Study data. It is unclear whether these negative associations could be attributed to potential toxins or to its phytoestrogen levels. Estrogen (through which receptors phytoestrogens can exert effects) was found to increase dementia risk in women over 65 years of age. Tempe contains high levels of phytoestrogens, but (due to fermentation) also exhibits high folate levels which may exert protective effects. Future studies should validate these findings and investigate potential mechanisms.
Klotho (biology) - Wikipedia, the free encyclopedia
"The Klotho gene codes for a transmembrane protein that, in addition to other effects, provides some control over the sensitivity of the organism to insulin and appears to be involved in aging. Its discovery was documented in 1997 by Kuro-o et al.[1] The name of the gene comes from Klotho or Clotho, one of the Moirae, or Fates, in Greek mythology.
The Klotho protein is a novel β-glucuronidase (EC number 3.2.1.21) capable of hydrolyzing steroid β-glucuronides. Genetic variants in KLOTHO have been associated with human aging,[2] and Klotho protein has been shown to be a circulating factor detectable in serum that declines with age.[3]
Klotho-deficient mice manifest a syndrome resembling accelerated human aging"
Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community-dwelling women
Low serum 25-hydroxyvitamin D concentrations are associated with greater all-cause mortality in older community-dwelling women.
Semba RD, Houston DK, Ferrucci L, Cappola AR, Sun K, Guralnik JM, Fried LP.
Nutr Res. 2009 Aug;29(8):525-30.
PMID: 19761886
doi:10.1016/j.nutres.2009.07.007
Older community-dwelling women with low 25(OH)D levels are at an increased risk of death.
Vitamin D and aging. [J Steroid Biochem Mol Biol. 2009] - PubMed result
Vitamin D and aging.
Tuohimaa P.
J Steroid Biochem Mol Biol. 2009 Mar;114(1-2):78-84. Review.
PMID: 19444937
Diet, evolution and aging--the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet - Eur J Nutr. 2001 Oct;40(5):200-13 - SpringerLink - Journal Article
Diet, evolution and aging--the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet.
Frassetto L, Morris RC Jr, Sellmeyer DE, Todd K, Sebastian A.
Eur J Nutr. 2001 Oct;40(5):200-13. Review.
PMID: 11842945
Vitamin D and cognitive performance in adults: a systematic review. - Eur J Neurol. 2009 Oct;16(10):1083-9. - Wiley InterScience :: Article :: HTML Full Text
Vitamin D and cognitive performance in adults: a systematic review.
Annweiler C, Allali G, Allain P, Bridenbaugh S, Schott AM, Kressig RW, Beauchet O.
Eur J Neurol. 2009 Oct;16(10):1083-9. Epub 2009 Jul 29.
PMID: 19659751
DOI: 10.1111/j.1468-1331.2009.02755.x
This systematic review shows that the association between serum 25OHD concentrations and cognitive performance is not yet clearly established. The inconclusive results of the reviewed studies could be due to methodology, types of the cognitive tasks used and/or the cellular mechanisms of vitamin D.
Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women -- Richards et al. 86 (5): 1420 -- American Journal of Clinical Nutrition
Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women.
Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, Nessa A, Lu X, Surdulescu GL, Swaminathan R, Spector TD, Aviv A.
Am J Clin Nutr. 2007 Nov;86(5):1420-5.
PMID: 17991655
Plasma Vitamin D and 25OHD Responses of Young and Old Men to Supplementation with Vitamin D3 -- Harris and Dawson-Hughes 21 (4): 357 -- Journal of the American College of Nutrition
Plasma vitamin D and 25OHD responses of young and old men to supplementation with vitamin D3.
Harris SS, Dawson-Hughes B.
J Am Coll Nutr. 2002 Aug;21(4):357-62.
PMID: 12166534
Conclusions: There appears to be no age-related impairment among men in the absorption or metabolism of 20 µg/day of vitamin D3 taken orally for at least eight weeks.
Vitamin D, nervous system and aging - ScienceDirect - Psychoneuroendocrinology
Vitamin D, nervous system and aging.
Tuohimaa P, Keisala T, Minasyan A, Cachat J, Kalueff A.
Psychoneuroendocrinology. 2009 Aug 4. [Epub ahead of print]
PMID: 19660871
25(OH)D Serum Levels Decline With Age Earlier in Women Than in Men and Less Efficiently Prevent Compensatory Hyperparathyroidism in Older Adults -- Maggio et al. 60 (11): 1414 -- Journals of Gerontology Series A: Biological Sciences and Medical Sciences
25(OH)D Serum levels decline with age earlier in women than in men and less efficiently prevent compensatory hyperparathyroidism in older adults.
Maggio D, Cherubini A, Lauretani F, Russo RC, Bartali B, Pierandrei M, Ruggiero C, Macchiarulo MC, Giorgino R, Minisola S, Ferrucci L.
J Gerontol A Biol Sci Med Sci. 2005 Nov;60(11):1414-9.
PMID: 16339327
Conclusions. These findings suggest that the age-associated fall of serum 25(OH)D starts earlier in women than in men and that higher levels of 25(OH)D are required in older compared to younger persons to avoid the age-associated compensatory hyperparathyroidism.
Age-Related Changes in the 25-Hydroxyvitamin D Versus Parathyroid Hormone Relationship Suggest a Different Reason Why Older Adults Require More Vitamin D -- Vieth et al. 88 (1): 185 -- Journal of Clinical Endocrinology & Metabolism
Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D.
Vieth R, Ladak Y, Walfish PG.
J Clin Endocrinol Metab. 2003 Jan;88(1):185-91.
PMID: 12519850
This study shows that all age groups exhibit a high prevalence of 25(OH)D insufficiency and secondary hyperparathyroidism. Older adults are just as efficient in maintaining 25(OH)D, but they need more vitamin D to produce the higher 25(OH)D concentrations required to overcome the hyperparathyroidism associated with their diminishing renal function
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