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"THURSDAY, Dec. 17 (HealthDay News) -- In a surprise finding, Canadian researchers report that the immediate effect of the fish oil fatty acids that are good for the heart is a short-term increase in blood fats and the molecules that help them form clots.

"We were surprised to find that the acute response has some potentially negative effects in comparison to what you might expect from chronic, long-term intake," said Lindsay E. Robinson, an associate professor of nutrition at the University of Guelph, and leader of the group reporting the finding in the January issue of the Journal of Nutrition.

However, the study results shouldn't affect the current recommendation for eating more oily fish to get the omega-3 polyunsaturated acids that reduce the risk of blood clots that can cause heart attacks and stroke, Robinson said.

"The recommendation to increase intake is very well-studied, and this doesn't change it," she said.

And the effects were seen in a selected group of middle-aged men with metabolic syndrome, a combination of high blood pressure, obesity and elevated blood fat levels, Robinson noted.

In the study, eight men had controlled intake of three regimens: high doses of omega-3 fatty acids, low doses of them and just plain water. Robinson and her colleagues measured several blood components involved in clotting, including fats and clotting factors such as plasminogen-activator inhibitor-1 (PAI-1) for the following eight hours.

PAI-1 inhibits the destruction of blood clots, so high levels of it in the blood increase the risk of artery-blocking clots.

The researchers found that both omega-3 fatty acid regimens increased blood fat and clotting factor activity. But the increase in clotting factor was greater for the higher doses of omega-3 fatty acids than for the lower intakes.

Robinson said her group hopes to do further studies of the immediate effects of omega-3 fatty acid intake. "We need to look at the mechanisms, why blood lipid levels go up," she said. It's possible that there are important dif

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2009 December MedlinePlus news fish_oil omega-3 middle-aged men metabolic_syndrome postprandial plasminogen-activator_inhibitor-1 PAL-1 nutrition blood_fat clotting_factor activity

Phytase activity in the human and rat small intestine.
Iqbal TH, Lewis KO, Cooper BT.
Gut. 1994 Sep;35(9):1233-6.
PMID: 7959229

www.ncbi.nlm.nih.gov/...PMC1375699 - Preview

1994 September study research human humans rat rats small intestine phytase activity grains nutrition medline

"A convenient, non-threatening way to connect to other people who share similar interests and live nearby." \n- Time

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Meetup local Meetups community clubs groups gatherings meeting meetings social activity popular

Limited effect of eicosapentaenoic acid on T-lymphocyte and natural killer cell numbers and functions in healthy young males.
Miles EA, Banerjee T, Wells SJ, Calder PC.
Nutrition. 2006 May;22(5):512-9.
PMID: 16600816
doi:10.1016/j.nut.2005.11.011

www.nutritionjrnl.com/...abstract - Preview

2006 May nutritionjrnl study research clinical_trial rct humans young men fish_oil omega-3 EPA EPA-rich PUFA PUFas T-cells immunity immune response natural_killer_cells NK_cells activity cytokines IL-4 nutrition medline

Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y.
Thies F, Nebe-von-Caron G, Powell JR, Yaqoob P, Newsholme EA, Calder PC.
Am J Clin Nutr. 2001 Mar;73(3):539-48.
PMID: 11237929

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2001 March ajcn clinical_trial rct humans elderly older old fish_oil immunity immmune response natural_killer_cells NK_cells activity omega-3 ALA DHA EPA omega-6 AA GLA PUFA PUFAs nutrition medline fish oil

White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell proliferation.
Grube BJ, Eng ET, Kao YC, Kwon A, Chen S.
J Nutr. 2001 Dec;131(12):3288-93.
PMID: 11739882

jn.nutrition.org/...3288 - Preview

2001 December jn study research in_vitro breast cancer breast_cancer aromatase anti-aromatase activity diet nutrition medline white button mushroom white_button_mushroom Agaricus_bisporus Agaricus herb herbs mushrooms prevention cancer_prevention

Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus).
Chen S, Oh SR, Phung S, Hur G, Ye JJ, Kwok SL, Shrode GE, Belury M, Adams LS, Williams D.
Cancer Res. 2006 Dec 15;66(24):12026-34.
PMID: 17178902
doi: 10.1158/0008-5472.CAN-06-2206

cancerres.aacrjournals.org/...12026 - Preview

2006 December study research in_vitro in_ivo animal white button mushroom extract white_button_mushroom Agaricus_bisporus Agaricus mushrooms herb herbs anti-aromatase activity aromatase breast cancer breast_cancer growth-inhibitory medline nutrition

Immunoregulatory and anti-inflammatory effects of n-3 polyunsaturated fatty acids.
Calder PC.
Braz J Med Biol Res. 1998 Apr;31(4):467-90. Review.
PMID: 9698798

www.ncbi.nlm.nih.gov/...9698798 - Preview

1998 April study review omega-3 PUFA fish_oil EPA DHA cell-mediated immunity cell-mediated_immunity T-cells cytotoxicity natural_killer_cells NK_cells activity macrophages anti-inflammatory PGE2 nutrition medline immune system function response

Effect of docosahexaenoic acid-rich fish oil supplementation on human leukocyte function.
Gorjão R, Verlengia R, Lima TM, Soriano FG, Boaventura MF, Kanunfre CC, Peres CM, Sampaio SC, Otton R, Folador A, Martins EF, Curi TC, Portiolli EP, Newsholme P, Curi R.
Clin Nutr. 2006 Dec;25(6):923-38. Epub 2006 May 11.
PMID: 16697494
doi:10.1016/j.clnu.2006.03.004

www.journals.elsevierhealth.com/...abstract - Preview

2006 December study research clinical_trial humans men fish oil fish_oil DHA EPA DHA-rich EPA-rich omega-3 phagocytic activity phagocytosis chemotaxis lymphocytes phagocytes gene expression genes immune function immunity nutrition medline

Effect of stable fish oil on arterial thrombogenesis, platelet aggregation, and superoxide dismutase activity.
Chen LY, Jokela R, Li DY, Bavry AA, Sandler H, Sjöquist M, Saldeen T, Mehta JL.
J Cardiovasc Pharmacol. 2000 Mar;35(3):502-5. Erratum in: J Cardiovasc Pharmacol 2000 May;35(5):829. Bowry A [corrected to Bavry AA].
PMID: 10710138

journals.lww.com/...articleviewer.aspx - Preview

2000 May study research in_vivo animal_study dietary stable fish oil fish_oil omega-3 thrombosis platelet aggregation platelet_aggregation superoxide_dismutase SOD activity supplementation nutrition medline thrombogenesis CVD

Stimulation of innate immunity by oral administration of dahi containing probiotic Lactobacillus casei in mice.
Jain S, Yadav H, Sinha PR.
J Med Food. 2008 Dec;11(4):652-6.
PMID: 19053856
doi:10.1089/jmf.2006.0132

www.liebertonline.com/...jmf.2006.0132 - Preview

2008 December study research in_vivo animal_study dahi yoghurt yogurt probiotic probiotics Lactobacillus_casei lactic_acid_bacteria nutrition medline innate immunity immune function response lactobacilli immunostimulant phagocytic activity macrophages

Inhibitors of brain phospholipase A2 activity: their neuropharmacological effects and therapeutic importance for the treatment of neurologic disorders.
Farooqui AA, Ong WY, Horrocks LA.
Pharmacol Rev. 2006 Sep;58(3):591-620. Review.
PMID: 16968951

PlsEtn-PLA2 may be mainly involved in generating docosahexaenoic acid (DHA), a 22-carbon essential fatty acid with 6 double bonds.

...

Long-chain polyunsaturated fatty acids are normal constituents of neural membrane phospholipids and products of the PLA2-catalyzed reaction. They include arachidonic acid (belonging to the n-6 class), eicosapentaenoic acid (EPA), and DHA (belonging to the n-3 class). Arachidonic acid is released by the action of cPLA2, and EPA and DHA are released by the action of PlsEtn-PLA2 on neural membrane phospholipids. In vitro, the addition of these fatty acids to the reaction mixture inhibits the PLA2-catalyzed reaction in a dose- and time-dependent manner.

pharmrev.aspetjournals.org/...591 - Preview

2006 September study review brain phospholipase_A2 activity PLA2 inhibitors EPA DHA AA neuropharmacological effects medline treatment neurologic disorders PlsEtn-PLA2 cPLA2

Docosahexaenoic acid decreases phospholipase A2 activity in the neurites/nerve growth cones of PC12 cells.
Martin RE.
J Neurosci Res. 1998 Dec 15;54(6):805-13.
PMID: 9856864
DOI: 10.1002/(SICI)1097-4547(19981215)54:6<805::AID-JNR8>3.0.CO;2-4

www3.interscience.wiley.com/...abstract - Preview

1998 December study research in_vitro DHA omega-3 PLA2 phospholipase_A2 activity reduction neuroprotective nutrition medline

Our Blogrollr widget will show off your recent activity as well as your all-time most viewed blogs

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Men in their 50s who increase their exercise regime live more than two years longer than couch potatoes of the same age, a new study shows.

Males in their middle years who do a lot of physical activity, equivalent to three hours a week of sport or heavy gardening, can outlive their sedentary peers by 2.3 years and moderate exercisers by just over a year, researchers found.

www.guardian.co.uk/...men-excercise-health-wellbeing - Preview

Physical Activity IHN Health News Life Expectancy Ageing The Guardian

Second Expert Report\n\nFood, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective\n\nIt began in 2001 with AICR and its international affiliate, WCRF-UK committing themselves to systematically review and analyze the total body of scientific evidence on the relationship of diet, physical activity and weight management to cancer risk. After a rigorous five-year process, Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective does just that.

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AICR Second Expert Report WCRF food nutrition physical activity physical_activity cancer prevention cancer_prevention global perspective info reference recommendations foods lifestyle

Welcome to dietandcancerreport.org where you can find the WCRF/AICR Expert Report, Food, Nutrition, Physical Activity and the Prevention of Cancer: a Global Perspective as well as the companion report, Policy and Action for Cancer Prevention. The most up to date reference and resource materials associated with both reports are available from this site

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diet and cancer report diet cancer reportt nutrition info prevention cancer_prevention food foods WCRF AICR cancer prevention expert Physical Activity Physical_Activity reference recommendations lifestyle physical activity diet_and_cancer_report

Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin.\nLiu PT, Stenger S, Tang DH, Modlin RL.\nJ Immunol. 2007 Aug 15;179(4):2060-3.\nPMID: 1767546

www.jimmunol.org/...2060 - Preview

2007 August study research in_vitro vitamin D vitamin_D vitamin_D-mediated antimicrobial activity antimicrobial_activity Mycobacterium_tuberculosis TB cathelicidin nutrition medline innate immunity innate_immunity calcitriol 1.25(OH)2d tuberculosis

ScienceDaily (Feb. 12, 2009) - That irresistible craving for a cheeseburger has its roots in the dramatic growth of the human brain and body that resulted from environmental changes some 2 million years ago.

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2009 February sciencedaily news obesity human evolution human_evolution human evolution brain diet nutrition nutritionally dense nutritionally_dense physical_acitivity physical activity

Liu PT, Stenger S, Tang DH, Modlin RL.
Cutting Edge: Vitamin D-Mediated Human Antimicrobial Activity against Mycobacterium tuberculosis Is Dependent on the Induction of Cathelicidin.
J Immunol. 2007 Aug 15;179(4):2060-3.
PMID: 17675463 [PubMed - in pr

www.jimmunol.org/...2060 - Preview

Vitamin-D VitaminD Human Antimicrobial Activity Mycobacterium tuberculosis tb immunity immune system bacterial infection infections Cathelicidin nutrition nutritional medicine medline study science peer-reviewed imported delicious vitamin_D