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Diet, evolution and aging--the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet.
Frassetto L, Morris RC Jr, Sellmeyer DE, Todd K, Sebastian A.
Eur J Nutr. 2001 Oct;40(5):200-13. Review.
PMID: 11842945

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2001 October ejn study review humans Frassetto Sebastian acid-base acid_base nutrition evolution diet net_acid_load protein organic anions aging post-agricultural inversion potassium-to-sodium potassium sodium base-to-chloride base chloride medline

Fruit and vegetables: the unexpected natural answer to the question of osteoporosis prevention?
Lanham-New SA.
Am J Clin Nutr. 2006 Jun;83(6):1254-5.
PMID: 16762933

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2006 June ajcn Lanham-New medline nutrition fruit vegetables food diet foods bone health mineral content osteoporosis acid_alkaline acid_base acid-base balance alkaline study phytochemicals phytoestrogens vitamin_K

Origins and evolution of the Western diet: health implications for the 21st century.
Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, Watkins BA, O'Keefe JH, Brand-Miller J.
Am J Clin Nutr. 2005 Feb;81(2):341-54. Review.
PMID: 15699220

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2005 February ajcn diet health nutrition paleolithic preagricultural glycemic glycemic_load fatty acid macronutrient acid_base acid-base acid_alkaline balance potassium fiber hunter-gatherers evolution food foods disease study Cordain Sebastian review

Positive effects of vegetable and fruit consumption and calcium intake on bone mineral accrual in boys during growth from childhood to adolescence: the University of Saskatchewan Pediatric Bone Mineral Accrual Study.
Vatanparast H, Baxter-Jones A, Faulkner RA, Bailey DA, Whiting SJ.
Am J Clin Nutr. 2005 Sep;82(3):700-6.
PMID: 16155286

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2005 September ajcn medline nutrition fruit vegetables foods calcium intake bone mineral osteoporosis health acid_alkaline acid_base acid-base balance content study research

Various selected vegetables, fruits, mushrooms and red wine residue inhibit bone resorption in rats.
Mühlbauer RC, Lozano A, Reinli A, Wetli H.
J Nutr. 2003 Nov;133(11):3592-7.
PMID: 14608079

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2003 November jn nutrition fruit vegetables diet wine red bone resorption acid acid_alkaline acid_base acid-base balance osteoporosis study research red_wine medline

Calcium, protein, and fruit and vegetables as dietary determinants of bone health.
New SA, Millward DJ.
Am J Clin Nutr. 2003 May;77(5):1340-1; author reply 1341.
PMID: 12716695

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2003 May New letter reply nutrition fruit vegetables calcium bone health acid_alkaline acid_base acid-base balance osteoporosis study research

Low dietary potassium intakes and high dietary estimates of net endogenous acid production are associated with low bone mineral density in premenopausal women and increased markers of bone resorption in postmenopausal women.
Macdonald HM, New SA, Fraser WD, Campbell MK, Reid DM.
Am J Clin Nutr. 2005 Apr;81(4):923-33.
PMID: 15817873

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2005 April ajcn nutrition potassium fruit vegetables dietary intake bone resorption mineral density BMD acid acid_alkaline acid_base acid-base balance osteoporosis menopause study research

The acid-base hypothesis: diet and bone in the Framingham Osteoporosis Study.
Tucker KL, Hannan MT, Kiel DP.
Eur J Nutr. 2001 Oct;40(5):231-7.
PMID: 11842948

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2001 October ejn nutrition diet bone health osteoporosis acid_alkaline acid_base acid-base balance study research Framingham medline

Jehle S, Zanetti A, Muser J, Hulter HN, Krapf R.
Partial neutralization of the acidogenic Western diet with potassium citrate increases bone mass in postmenopausal women with osteopenia.
J Am Soc Nephrol. 2006 Nov;17(11):3213-22. Epub 2006 Oct 11

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2006 November Neutralization Acidogenic Western Diet Potassium Citrate Bone Postmenopausal Women Osteopenia osteoporosis acidosis acid_base acid acid-base alkaline base nutrition medline study science research

Zwart SR, Hargens AR, Smith SM.
The ratio of animal protein intake to potassium intake is a predictor of bone resorption in space flight analogues and in ambulatory subjects.
Am J Clin Nutr. 2004 Oct;80(4):1058-65.
PMID: 15447920

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2004 October ajcn ration animal protein potassium intake bone resorption acidosis acid_base acid-base acid alkaline base metabolic osteoporosis study research medline nutrition diet foods

Zwart SR, Davis-Street JE, Paddon-Jones D, Ferrando AA, Wolfe RR, Smith SM.
Amino acid supplementation alters bone metabolism during simulated weightlessness.
J Appl Physiol. 2005 Jul;99(1):134-40. Epub 2005 Feb 3.
PMID: 15691900

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2005 July Amino supplementation bone metabolism weightlessness acid-base acid_base acidosis alkaline base osteoporosis acid supplements nutrition medline medicine study research dietary

Welch AA, Bingham SA, Reeve J, Khaw KT. More acidic dietary acid-base load is associated with reduced calcaneal broadband ultrasound attenuation in women but not in men: results from the EPIC-Norfolk cohort study.
Am J Clin Nutr. 2007 Apr;85(4):1134-41.

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2007 April ajcn acid acid-base acid_base acidosis alkaline base balance load EPIC diet dietary bone medline nutrition study research osteoporosis fracture risk potential renal PRAL

Dawson-Hughes B.
Interaction of dietary calcium and protein in bone health in humans.
J Nutr. 2003 Mar;133(3):852S-854S. Review.
PMID: 12612168

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2003 March jn study review protein calcium interaction bone mineral density fractures BMD acid-base acid_base acidosis balance osteoporosis health nutrition diet medline

Kerstetter JE, O'Brien KO, Insogna KL.
Low protein intake: the impact on calcium and bone homeostasis in humans.
J Nutr. 2003 Mar;133(3):855S-861S. Review.
PMID: 12612169

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2003 March jn study review dietary protein urinary calcium absorption parathyroid hormone PTH bone Low Intake acid acid-base acidosis acid_base osteoporosis nutrition medline bmd fracture fractures homeostasis

Sakhaee K, Maalouf NM, Abrams SA, Pak CY.
Effects of potassium alkali and calcium supplementation on bone turnover in postmenopausal women.
J Clin Endocrinol Metab. 2005 Jun;90(6):3528-33. Epub 2005 Mar 8.
PMID: 15755853

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2005 June Potassium Alkali Calcium Supplementation Bone Turnover acid acid-base acid_base acidosis alkaline base supplements study research nutrition medline osteoporosis diet dietary

Sebastian A, Harris ST, Ottaway JH, Todd KM, Morris RC Jr.
Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate.
N Engl J Med. 1994 Jun 23;330(25):1776-81.
PMID: 8190153 [PubMed - indexed for MEDL

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1994 June Mineral NEJM skeletal Metabolism Potassium Bicarbonate acid acid-base acid_base acidosis alkaline base balance bone bmd osteoporosis supplementation supplements study research nutrition medline dietary Sebastian

Frassetto LA, Nash E, Morris RC Jr, Sebastian A.
Comparative effects of potassium chloride and bicarbonate on
thiazide-induced reduction in urinary calcium excretion.
Kidney Int. 2000 Aug;58(2):748-52.
PMID: 10916098 [PubMed - indexed for MEDLINE]

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potassium chloride bicarbonate urinary calcium loss kcl khco3 comparison acid acid-base acidosis acid_base alkali alkaline base balance bone osteoporosis frassetto supplements supplementation study sebastian science nutrition nutritional medline medicine

Morris RC, Schmidlin O, Tanaka M, Forman A, Frassetto L, Sebastian A.
Differing effects of supplemental KCl and KHCO3: pathophysiological and clinical implications.
Semin Nephrol. 1999 Sep;19(5):487-93. Review.

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KCl KHCO3 potassium bicarbonate chloride comparison acid acid-base acid_base acidosis alkali alkaline base balance bone osteoporosis study supplementation supplements science sebastian frassetto nutrition nutritional medline medicine peer-reviewed import

Frassetto L, Morris RC Jr, Sebastian A.
Potassium bicarbonate reduces urinary nitrogen excretion in postmenopausal women.
J Clin Endocrinol Metab. 1997 Jan;82(1):254-9.
PMID: 8989270 [PubMed - indexed for MEDLINE]

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Potassium Bicarbonate metabolic acidosis nitrogen loss Urinary muscle KHCO3 acid acid-base acid_base alkali alkaline base balance study science research supplementation supplements nutrition nutritional sebastian frassetto medicine medline peer-reviewed

Frassetto L, Morris RC Jr, Sebastian A.
Long-term persistence of the urine calcium-lowering effect of potassium bicarbonate in postmenopausal women.
J Clin Endocrinol Metab. 2005 Feb;90(2):831-4. Epub 2004 Nov 30.
PMID: 15572425 [PubMed - indexed for M

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urine calcium Lowering urinary potassium bicarbonate acid acid-base acid_base acidosis alkaline alkali base bone bmd osteoporosis nutrition nutritional supplementation supplements study science research peer-reviewed medicine medline sebastian Frassetto