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The New England Journal of Medicine recently published an article from a joint collaboration between several cancer centers on both the east and west coast. A 52 year-old man with stage IV malignant melanoma, a very aggressive and potentially lethal form of skin cancer, donated blood to the scientists who have developed a technique to isolate specific CD4+ T cells and clone them in vitro.

AccuracyIn our bodies, our immune system is responsible for attacking all cells that may pose a threat to our well-being, whether they be bacteria, viruses, foreign bodies, or even cancerous cells. Each T cell is responsible for recognizing a specific cell line which is potentially threatening, then targeting (where the “T” comes from) those cells for destruction by the production of antibodies, and large vacuum cleaner-type cells called macrophages. The trouble with cancer is that the cells are multiplying very rapidly, and there are only a few circulating T cells which are specific to that cancerous cell line. Therefore the cancerous cells overwhelm our ability to tag them fast enough, and the cancer grows and spreads.

What the scientists in this study have done is isolate the T cells which are targeted towards the malignant melanoma. Then they used a chemical and biological process to multiply those T cells several thousands of times over. Finally, they injected those thousands of T cells back into the patient, and let them go to work. Now there were so many T cells compared to cancerous cells, that tagging them was easy and the body was naturally able to break down the cancer using its own immune system. The man went into complete remission and has stayed there for the past two years.

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2008 July brainblogger blog_article Smart Bomb Eradicating Cancer T-cells malignant melanoma immunr system immunity

SmartPlanet.com is the premier destination for savvy advice, thought-provoking analysis and expert discussion on the intersection of technology, business and life. Covering decisions that reach from the boardroom to the living room, SmartPlanet.com is the place to go for innovative insight and ideas that impact the world around you.

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SmartPlanet Smart Planet savvy advice analysis expert discussion experts technology business life tech insight ideas portal CBS people

Google’s street-level mapping imagery – called Street View – can at times be useful if you want to see what a place you’re trying to find looks like. However, if you’ve ever wanted to explore beyond a snapshot of a location, you’ve likely found the user experience fairly cumbersome, if not downright unusable at times.

Today, the Google Maps team has unveiled a new feature that makes actually navigating through Street View significantly better. Now, Maps will show you, “an oval when your mouse is following a road and a rectangle when moving across the facades of buildings.” Google refers to these shapes as “pancakes,” and once you figure out how exactly they work, they turn Street View into a fairly enjoyable – if not highly useful – experience.

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2009 June mashable news google maps google_maps Street View Street_View Google_Street_View usable Smart Navigation

Smart Keywords are an easy way to search websites right from the Location bar. Say you visit The Internet Movie Database (IMDB) all the time to look up things. You go to imdb.com and click in the search box and enter whatever you're searching for, and cli

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Mozilla Firefox Smart Keywords Keyword web browser browsers search popular

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Mozilla Firefox Keywords Keyword smart browser browsers web popular

Smart Archives is a rather simple WordPress plugin that will allow you to display your archives in a much "cleaner" format. You can see it in action on my archives page. You'll notice that everything on the page is hyperlinked (years, months, posts) and t

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Smart Archives WordPress plugin cms display format popular

Meet the next generation of USB flash drives: the U3 smart drive. It's\nwhat's inside that makes them smart.\nCarry and access your files easily\nKeep your data safe and secure\nComes with pre-loaded software\nHundreds of software titles available

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LinuxMCE is a free, open source add-on to Ubuntu including a 10' UI, complete whole-house media solution with pvr + distributed media, and the most advanced smarthome solution available. It is stable, easy to use, and requires no knowledge of Linux and on

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Smart remote control for with screen for videos, stereos and upnp media players.

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# Manage tasks, projects or processes
# Online service with no software
# Real-time and scheduled collaboration
# Update online or via e-mail

Smartsheet.com IS:

* Useful for tracking tasks, projects and processes
* Intelligent in its man

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Tildesley NT, Kennedy DO, Perry EK, Ballard CG, Wesnes KA, Scholey AB.
Positive modulation of mood and cognitive performance following administration of acute doses of Salvia lavandulaefolia essential oil to healthy young volunteers.
Physiol Behav. 2005

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Tildesley NT, Kennedy DO, Perry EK, Ballard CG, Savelev S, Wesnes KA, Scholey
AB.
Salvia lavandulaefolia (Spanish Sage) enhances memory in healthy young volunteers.
Pharmacol Biochem Behav. 2003 Jun;75(3):669-674.
PMID: 12895685 [PubMed - as supplie

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Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database of Systematic Reviews 2005, Issue 2. Art. No.: CD000269. DOI: 10.1002/14

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Fioravanti M, Flicker L. Efficacy of nicergoline in dementia and other age associated forms of cognitive impairment.
Cochrane Database Syst Rev. 2001;(4):CD003159. Review.
PMID: 11687175 [PubMed - indexed for MEDLINE]

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Nicergoline is an ergoloid mesylate derivative that is currently being used in the battle to treat senile dementia. Interestingly it has been found to improve mental agility through enhancing clarity and perception.
In this instance it is different to t

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Saletu B, Hitzenberger G, Grunberger J, Anderer P, Zyhlarz G, Linzmayer L, Rameis H.
Double-blind, placebo-controlled, pharmacokinetic and -dynamic studies with 2 new formulations of piracetam (infusion and sirup) under hypoxia in man.
Int J Clin Pharm

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Brain protection of nicergoline against hypoxia: EEG brain mapping and psychometry.
J Neural Transm Park Dis Dement Sect. 1990;2(4):305-25.
PMID: 2127674 [PubMed - indexed for MEDLINE]

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Hydergine study:
Saletu B, Grunberger J, Linzmayer L, Anderer P. Dose-response studies with co-dergocrine mesylate under hypoxia utilizing EEG mapping and psychometry.
Psychopharmacology (Berl). 1992;109(1-2):30-40.
PMID: 1365669 [PubMed - indexed for

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Saletu B, Grunberger J, Anderer R.
On brain protection of co-dergocrine mesylate (Hydergine) against hypoxic hypoxidosis of different severity: double-blind placebo-controlled quantitative EEG and psychometric studies.
Int J Clin Pharmacol Ther Toxicol.

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