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Meat, eggs, dairy products, and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort -- Pala et al. 90 (3): 602 -- American Journal of Clinical Nutrition
Meat, eggs, dairy products, and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Pala V, Krogh V, Berrino F, Sieri S, Grioni S, Tjønneland A, Olsen A, Jakobsen MU, Overvad K, Clavel-Chapelon F, Boutron-Ruault MC, Romieu I, Linseisen J, Rohrmann S, Boeing H, Steffen A, Trichopoulou A, Benetou V, Naska A, Vineis P, Tumino R, Panico S, Masala G, Agnoli C, Engeset D, Skeie G, Lund E, Ardanaz E, Navarro C, Sánchez MJ, Amiano P, Svatetz CA, Rodriguez L, Wirfält E, Manjer J, Lenner P, Hallmans G, Peeters PH, van Gils CH, Bueno-de-Mesquita HB, van Duijnhoven FJ, Key TJ, Spencer E, Bingham S, Khaw KT, Ferrari P, Byrnes G, Rinaldi S, Norat T, Michaud DS, Riboli E.
Am J Clin Nutr. 2009 Sep;90(3):602-12. Epub 2009 Jun 2.
PMID: 19491385
doi:10.3945/ajcn.2008.27173
Conclusions: We have not consistently identified intakes of meat, eggs, or dairy products as risk factors for breast cancer. Future studies should investigate the possible role of high-temperature cooking in the relation of red meat intake with breast cancer risk.
Association of vitamin D deficiency with cognitive impairment in older women. Cross-sectional study -- Annweiler et al., 10.1212/WNL.0b013e3181beecd3 -- Neurology
Association of vitamin D deficiency with cognitive impairment in older women. Cross-sectional study.
Annweiler C, Schott AM, Allali G, Bridenbaugh SA, Kressig RW, Allain P, Herrmann FR, Beauchet O.
Neurology. 2009 Sep 30. [Epub ahead of print]
PMID: 19794127
doi:10.1212/WNL.0b013e3181beecd3
Conclusions: 25-Hydroxyvitamin D deficiency was associated with cognitive impairment in this cohort of community-dwelling older women.
Vitamin D and mood disorders among women: an integrative review. - [J Midwifery Womens Health. 2008 Sep-Oct] - PubMed result
Vitamin D and mood disorders among women: an integrative review.
Murphy PK, Wagner CL.
J Midwifery Womens Health. 2008 Sep-Oct;53(5):440-6. Review.
PMID: 18761297
Four of six studies reviewed imparted significant results, with all four showing an association between low 25(OH)D levels and higher incidences of four mood disorders: premenstrual syndrome, seasonal affective disorder, non-specified mood disorder, and major depressive disorder. This review indicates a possible biochemical mechanism occurring between vitamin D and mood disorders affecting women, warranting further studies of these variables using rigorous methodologies.
Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans -- Tricon et al. 80 (3): 614 -- American Journal of Clinical Nutrition
Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans.
Tricon S, Burdge GC, Kew S, Banerjee T, Russell JJ, Jones EL, Grimble RF, Williams CM, Yaqoob P, Calder PC.
Am J Clin Nutr. 2004 Sep;80(3):614-20.
PMID: 15321800
Conclusion: Divergent effects of cis-9,trans-11 CLA and trans-10,cis-12 CLA appear on the blood lipid profile in healthy humans: trans-10,cis-12 CLA increases LDL:HDL cholesterol and total:HDL cholesterol, whereas cis-9,trans-11 CLA decreases them.
Coenzyme Q10 - September 15, 2005 - American Family Physician
Coenzyme Q10.
Bonakdar RA, Guarneri E.
Am Fam Physician. 2005 Sep 15;72(6):1065-70. Review.
PMID: 16190504
Coenzyme Q10 is a vitamin-like substance used in the treatment of a variety of disorders primarily related to suboptimal cellular energy metabolism and oxidative injury. Studies supporting the efficacy of coenzyme Q10 appear most promising for neurodegenerative disorders such as Parkinson's disease and certain encephalomyopathies for which coenzyme Q10 has gained orphan drug status. Results in other areas of research, including treatment of congestive heart failure and diabetes, appear to be contradictory or need further clarification before proceeding with recommendations. Coenzyme Q10 appears to be a safe supplement with minimal side effects and low drug interaction potential.
Progesterone with Vitamin D Affords Better Neuroprotection against Excitotoxicity in Cultured Cortical Neurons than Progesterone Alone
Progesterone with vitamin D affords better neuroprotection against excitotoxicity in cultured cortical neurons than progesterone alone.
Atif F, Sayeed I, Ishrat T, Stein DG.
Mol Med. 2009 Sep-Oct;15(9-10):328-36. Epub 2009 Jun 26.
PMID: 19603099
Cooling Inflammation: anti-inflammatory diet
"Anti-inflammatory Diet
Components of an Anti-inflammatory Diet (focus on meats, fish, eggs and leafy vegetables)"
Hyperlipid: Physiological insulin resistance and palmitic acid again
"I like palmitic acid. It causes insulin resistance. Thank goodness.
Ted sent me this link. It's depressing.
I'm going to discuss a thought drug. I'm going to call it Palmitofake, and it can be developed by Pfizer, no, Fort Dodge. I particularly dislike FD for anaesthesia related reasons.
So what does Palmitofake do? BTW, if you didn't need any other hint you can tell this drug is going to bomb as there is neither an x, y or z in its name. Trust FD to screw up (in my mind).
Palmitofake is a fluoride substituted analogue of palmitic acid which irreversibly binds to the acyl-CoA interaction site of JNK1 and so inhibits the pathway by which palmitic acid keeps GLUT4 transporters off of the cell surface membrane, whole body-wide.
The logic to this is that the lipotoxin, palmitic acid (nature's second biggest mistake, the biggest was obviously cholesterol) can no longer keep glucose out of cells and metabolism can run, unimpaired by fat, for ever on glucose. Woo hoo bring on the glucose."
Whole Health Source: Palmitic Acid and Insulin Resistance: a New Paradigm
"We've been having an interesting discussion in the comments about a recently published paper by Dr. Stephen C. Benoit and colleagues (free full text). They showed that a butter-rich diet causes weight gain and insulin resistance in rats, compared to a low-fat diet or a diet based on olive oil. They published a thorough description of the diets' compositions, which is very much appreciated!
They went on to show that infusing palmitic acid (a 16-carbon saturated fat) directly into the brain of rats also caused insulin resistance relative to oleic acid (an 18-carbon monounsaturated fat, like in olive oil). Here's a representation of palmitic acid. The COOH end is the acid end, and the squiggly line is the fatty end. Thus it's called a "fatty acid", various forms of which are the fat currency of the body."
Animal Pharm: Palmitic Acid+ CARBS = Mouse Skeletal Muscle IR
"Peter at Hyperlipid and Stephan at Whole Health have dispelled yet again myths regarding the indictment of the 16:0 long-chained saturated fatty acid Palmitic Acid as the prime instigator of insulin resistance (IR). Researchers are always wrong -- it's... HIGH CARBS PLUS Palmitic acid.
Their brilliant posts discuss below:
--Sportzaid (FRUCTOSE) + Palmitate = IR RETARDNESS
--High Carb Lab Chow + Palmitate = IR in the brain
Yes. Such inferences applied to low carbers (LCers) is pure ridiculousness. Non-applicable.
Low/no carb + Palmitic Acid = GOOD THING. All the low-carb/high saturated fat (palmitic acid) and ketosis trials by Hays JH, Volek JS, and Krauss RM have shown reductions in blood insulin, blood glucoses (BG) and peripheral tissue insulin resistance (IR). Directly contrary to the high carb animal or human studies.
Palmitic acid has a special evolutionary, adaptive role in mammalian metabolism. Stephan showed that it likely 'fills in' when blood glucose starts to decline. "
Omega 3-tillskott bör sannolikt undvikas under influensapandemin - Läkartidningen sect=0 art=12663
Ett tillräckligt intag av omega 3-fettsyror i vår kost är viktigt såväl för normal utveckling av det lilla barnets hjärna som för att bibehålla hälsan hos vuxna individer. Vetenskapliga studier har visat gynnsam effekt på flera normalfysiologiska funktioner såsom syn och minnesförmåga samt på hjärtats retledningssystem och blodfetter. Det finns även epidemiologiskt stöd för att ett högt omega 3-intag sannolikt skyddar mot uppkomst av vissa tumörsjukdomar. Studier talar dessutom för att omega 3-syror kan dämpa inflammatorisk aktivitet.
På molekylär nivå medieras omega 3-syrornas effekter sannolikt via flera mekanismer såsom genreglering och förändrad balans mellan prostaglandiner och leukotriener samt genom direkta effekter på cellmembranernas struktur och funktion. I vår diet är fet fisk från kalla hav särskilt rik på omega 3-syror.
Är omega 3-syrorna då alltigenom nyttiga och sjukdomsförebyggande? Om man får tro hälsokosttillverkarna tycks det vara så. Under den nu allt snabbare accelererande influensapandemin kan det emellertid vara av vikt att belysa en potentiell hälsorisk med omega 3-syrorna.
Jämfört med vanlig influensa karakteriseras den nya influensan (H1N1) bl a av att individer som insjuknar drabbas av mer uttalade skador på luftvägsslemhinnan, och de tycks ha högre risk för aggressivt förlöpande viral pneumoni.
Effects of a Mediterranean-Style Diet on the Need for Antihyperglycemic Drug Therapy in Patients With Newly Diagnosed Type 2 Diabetes - Ann Intern Med
Effects of a Mediterranean-style diet on the need for antihyperglycemic drug therapy in patients with newly diagnosed type 2 diabetes: a randomized trial.
Esposito K, Maiorino MI, Ciotola M, Di Palo C, Scognamiglio P, Gicchino M, Petrizzo M, Saccomanno F, Beneduce F, Ceriello A, Giugliano D.
Ann Intern Med. 2009 Sep 1;151(5):306-14. Erratum in: Ann Intern Med. 2009 Oct 20;151(8):591.
PMID: 19721018
Conclusion: Compared with a low-fat diet, a low-carbohydrate, Mediterranean-style diet led to more favorable changes in glycemic control and coronary risk factors and delayed the need for antihyperglycemic drug therapy in overweight patients with newly diagnosed type 2 diabetes.
The Polyp Prevention Trial-Continued Follow-up Study: No Effect of a Low-Fat, High-Fiber, High-Fruit, and -Vegetable Diet on Adenoma Recurrence Eight Years after Randomization - Cancer Epidemiology, Biomarkers & Prevention
The polyp prevention trial continued follow-up study: no effect of a low-fat, high-fiber, high-fruit, and -vegetable diet on adenoma recurrence eight years after randomization.
Lanza E, Yu B, Murphy G, Albert PS, Caan B, Marshall JR, Lance P, Paskett ED, Weissfeld J, Slattery M, Burt R, Iber F, Shike M, Kikendall JW, Brewer BK, Schatzkin A; Polyp Prevention Trial Study Group.
Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1745-52.
PubMed PMID: 17855692
doi: 10.1158/1055-9965.EPI-07-0127
his study failed to show any effect of a low-fat, high-fiber, high-fruit and -vegetable eating pattern on adenoma recurrence even with 8 years of follow-up.
Effects of vitamin D supplementation on strength, physical performance, and falls in older persons: a systematic review. - Wiley InterScience :: Article :: HTML Full Text
Effects of vitamin D supplementation on strength, physical performance, and falls in older persons: a systematic review.
Latham NK, Anderson CS, Reid IR.
J Am Geriatr Soc. 2003 Sep;51(9):1219-26. Review.
PMID: 12919233
DOI: 10.1046/j.1532-5415.2003.51405.
Conclusion: Although there is insufficient evidence that vitamin D supplementation alone improves physical performance in older people, some data suggest a benefit from vitamin D combined with calcium supplementation, but this requires confirmation in large, well-designed trials.
Eskimos have CHD despite high consumption of omega-3 fatty acids: the Alaska Siberia project. - [Int J Circumpolar Health. 2005] - PubMed result
Eskimos have CHD despite high consumption of omega-3 fatty acids: the Alaska Siberia project.
Ebbesson SO, Risica PM, Ebbesson LO, Kennish JM.
Int J Circumpolar Health. 2005 Sep;64(4):387-95.
PMID: 16277122
CONCLUSIONS: Average daily consumption of omega-3 FAs among Eskimos was high, with about 3-4 g/d reported, compared with 1-2 g/d used in intervention studies and the average consumption of 0.2 g/d by the American population. There was no association between current omega-3 FA consumption/blood concentrations and the presence of CHD.
Safety of vitamin D3 in adults with multiple sclerosis -- Kimball et al. 86 (3): 645 -- American Journal of Clinical Nutrition
Safety of vitamin D3 in adults with multiple sclerosis.
Kimball SM, Ursell MR, O'Connor P, Vieth R.
Am J Clin Nutr. 2007 Sep;86(3):645-51.
PMID: 17823429
Conclusions: Patients' serum 25(OH)D concentrations reached twice the top of the physiologic range without eliciting hypercalcemia or hypercalciuria. The data support the feasibility of pharmacologic doses of vitamin D3 for clinical research, and they provide objective evidence that vitamin D intake beyond the current upper limit is safe by a large margin.
Are we meat eaters or vegetarians? Part I | The Blog of Michael R. Eades, M.D.
"One of the problems – if it could be called a problem – in writing this blog and moderating the comments is most readers are pretty intelligent. Occasionally I have the angry vegetarian wander in, take me to task for my errant ways, and, after a comeback or two on my part, drift away to never be heard from again. Thanks to the confirmation bias, this blog pretty much selects against the non-meat eater. So, I tend to forget how many people there are out there who are pretty much clueless about basic nutrition, and how many people there are who bobble through life spouting cliches they’ve heard along the way as great nutritional truths. Based on the comments I get on this blog, it seems to me that most people are pretty nutritionally sophisticated and reasonable."
Are we meat eaters or vegetarians? Part II | The Blog of Michael R. Eades, M.D.
Meat eating made us human. The anthropological evidence strongly supports the idea that the addition of increasingly larger amounts of meat in the diet of our predecessors was essential in the evolution of the large human brain. Our large brains came at the metabolic expense of our guts, which shrank as our brains grew.
A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease. - Diabetologia - SpringerLink - Journal Article
A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease.
Lindeberg S, Jönsson T, Granfeldt Y, Borgstrand E, Soffman J, Sjöström K, Ahrén B.
Diabetologia. 2007 Sep;50(9):1795-807. Epub 2007 Jun 22.
PMID: 17583796
DOI: 10.1007/s00125-007-0716-y
Conclusions/interpretation A Palaeolithic diet may improve glucose tolerance independently of decreased waist circumference.
The joint effects of apolipoprotein B, apolipoprotein A1, LDL cholesterol, and HDL cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controls -- Parish et al., 10.1093/eurheartj/ehp221 -- European Heart Journal
The joint effects of apolipoprotein B, apolipoprotein A1, LDL cholesterol, and HDL cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controls.
Parish S, Peto R, Palmer A, Clarke R, Lewington S, Offer A, Whitlock G, Clark S, Youngman L, Sleight P, Collins R; International Studies of Infarct Survival Collaborators.
Eur Heart J. 2009 Sep;30(17):2137-46. Epub 2009 Jun 11.
PMID: 19520708
doi:10.1093/eurheartj/ehp221
Conclusion: Apolipoprotein ratios are more informative about risk than lipid fractions are. This suggests that, among lipoprotein particles of a particular type (LDL or HDL), some smaller and larger subtypes differ in their effects on risk. Direct measurements of even more specific subtypes of lipoprotein particles may be even more informative about risk.
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