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Vitamin D Newsletter Mar 2006 | Dr. Wactawski-Wende, New England Journal of Medicine, and Ethics
"Good research is good for medicine. The only thing more important than good research is ethical research. The February 16th issue of the New England Journal of Medicine (NEJM) had a research paper on vitamin D and colon cancer. Was it good research? Was it ethical research? At stake are the lives of 36,000 older American women who agreed to participate in the Women's Health Initiative. "
Conjugated linoleic acid improves insulin sensitivity in young, sedentary humans - [Med Sci Sports Exerc. 2004] - PubMed result
Conjugated linoleic acid improves insulin sensitivity in young, sedentary humans.
Eyjolfson V, Spriet LL, Dyck DJ.
Med Sci Sports Exerc. 2004 May;36(5):814-20.
PMID: 15126715
CONCLUSIONS: Our results indicate that a common dosage of a commercially available CLA supplement can improve ISI in young, sedentary individuals. However, there is considerable individual variability in the response. Additional studies are required to identify underlying metabolic changes in human skeletal muscle.
The effects of conjugated linoleic acid on human health-related outcomes
The effects of conjugated linoleic acid on human health-related outcomes.
Tricon S, Burdge GC, Williams CM, Calder PC, Yaqoob P.
Proc Nutr Soc. 2005 May;64(2):171-82. Review.
PMID: 15960862
Conjugated linoleic acid (CLA) is a collective term for a mixture of positional and geometric isomers of conjugated dienoic derivatives of linoleic acid. CLA has received considerable attention as a result of animal experiments that report anti-carcinogenic, anti-atherogenic and anti-diabetic properties, and modulation of body composition and immune function. Several studies of CLA supplementation in human subjects have now been published, but in contrast to animal studies there has been marked variation between reports on the health-related outcomes. The consensus from seventeen published studies in human subjects is that CLA does not affect body weight or body composition. Some detrimental effects of the trans-10,cis-12 CLA isomer have also been reported in terms of altered blood lipid composition and impaired insulin sensitivity. Finally, CLA has only limited effects on immune functions in man. However, there have been reports of some interesting isomer-specific effects of CLA on the blood lipid profile, but not on immune function. These isomer-specific effects need further investigation. Until more is known, CLA supplementation in man should be considered with caution.
Effects of a short-term intervention with a paleolithic diet in healthy volunteers - European Journal of Clinical Nutrition - Abstract of article
Effects of a short-term intervention with a paleolithic diet in healthy volunteers.
Osterdahl M, Kocturk T, Koochek A, Wändell PE.
Eur J Clin Nutr. 2008 May;62(5):682-5. Epub 2007 May 16.
PMID: 17522610
Conclusion: This short-term intervention showed some favourable effects by the diet, but further studies, including control group, are needed.
Defining Adequate Vitamin D Intake : Cross-sectional and Intervention Studies
Defining Adequate Vitamin D Intake : Cross-sectional and Intervention Studies
Viljakainen, Heli Tuulikki
University of Helsinki
2008-05-23
Doctoral dissertation (article-based)
In summary, vitamin D intake remains inadequate among the target groups of this thesis, as reflected by seasonal variation in calcitropic hormones and bone metabolism. Dietary intake of vitamin D should be increased to achieve at least an adequate vitamin D status (S-25-OHD>50 nmol/l) and possibly an optimal vitamin D status (S-25-OHD>80 nmol/l) throughout the year. This could be accomplished by introducing new vitamin D-fortified foods to the market.
Calcium and vitamin D intakes may be positively associated with brain lesions in depressed and non-depressed elders
Calcium and vitamin D intakes may be positively associated with brain lesions in depressed and nondepressed elders.
Payne ME, Anderson JJ, Steffens DC.
Nutr Res. 2008 May;28(5):285-92.
PMID: 19083421
doi: 10.1016/j.nutres.2008.02.013
In conclusion, calcium and vitamin D consumption were associated with brain lesions in elderly subjects even after controlling for potentially explanatory variables. These associations may be due to vascular calcification or other mechanism. The possibility of adverse effects of high intakes of calcium and vitamin D needs to be further explored in longitudinal studies of elderly subjects.
Aggressive Vitamin D Treatment for Osteoporosis
"May 19, 2008 (Orlando, Florida) — A new study shows that a proactive vitamin D treatment plan should be considered when caring for all osteoporosis patients, and that such treatment might help decrease the likelihood of developing vitamin D deficiency.
Vitamin D deficiency is widespread among patients being treated for osteoporosis, and such deficiency should be treated aggressively, according to the findings presented here at the American Association of Clinical Endocrinologists 17th Annual Meeting and Clinical Congress."
Serum Vitamin D and Risk of Prostate Cancer in a Case-Control Analysis Nested Within the European Prospective Investigation into Cancer and Nutrition (EPIC) -- Travis et al. 169 (10): 1223 -- American Journal of Epidemiology
Serum vitamin D and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition (EPIC).
Travis RC, Crowe FL, Allen NE, Appleby PN, Roddam AW, Tjønneland A, Olsen A, Linseisen J, Kaaks R, Boeing H, Kröger J, Trichopoulou A, Dilis V, Trichopoulos D, Vineis P, Palli D, Tumino R, Sieri S, Bueno-de-Mesquita HB, van Duijnhoven FJ, Chirlaque MD, Barricarte A, Larrañaga N, González CA, Argüelles MV, Sánchez MJ, Stattin P, Hallmans G, Khaw KT, Bingham S, Rinaldi S, Slimani N, Jenab M, Riboli E, Key TJ.
Am J Epidemiol. 2009 May 15;169(10):1223-32. Epub 2009 Apr 9.
PMID: 19359375
In summary, the results of this large nested case-control study provide no evidence in support of a protective effect of circulating concentrations of vitamin D on the risk of prostate cancer.
The Worst Mistake In The History Of The Human Race" by Jared Diamond, Prof. UCLA School of Medicine - Discover-May 1987, pp. 64-66
"The Worst Mistake In The History Of The Human Race"
by Jared Diamond, Prof. UCLA School of Medicine
Discover-May 1987, pp. 64-66
Food chain as origin of vitamin D in fish - ScienceDirect - Comparative Biochemistry and Physiology Part A: Physiology
Food chain as origin of vitamin D in fish
D. Sunita Rao and N. Raghuramulu.
Comparative Biochemistry and Physiology Part A: Physiology
Volume 114, Issue 1, May 1996, Pages 15-19
doi:10.1016/0300-9629(95)02024-1
Plankton, the chief food source of fish, was assessed as the possible dietary origin of vitamin D in fish. The presence of vitamin D compounds were examined in fresh water phytoplankton and zooplankton employing a series of chromatographic procedures. Abundant amounts of provitamins D and vitamins D (D2 and D3) were found in the fresh water plankton. The high amount of vitamin D observed may be due to exposure of plankton to sunlight because the plankton were caught during the summer month. Thus, plankton may be an important contributor to vitamin D in fish.
Hypovitaminosis D is associated with insulin resistance and {beta} cell dysfunction -- Chiu et al. 79 (5): 820 -- American Journal of Clinical Nutrition
Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction.
Chiu KC, Chu A, Go VL, Saad MF.
Am J Clin Nutr. 2004 May;79(5):820-5.
PMID: 15113720
Conclusions: The data show a positive correlation of 25(OH)D concentration with insulin sensitivity and a negative effect of hypovitaminosis D on ß cell function. Subjects with hypovitaminosis D are at higher risk of insulin resistance and the metabolic syndrome. Further studies are required to explore the underlying mechanisms.
Vitamin D Receptor Expression in Normal, Premalignant, and Malignant Human Lung Tissue - Cancer Epidemiology, Biomarkers & Prevention
Vitamin D receptor expression in normal, premalignant, and malignant human lung tissue.
Menezes RJ, Cheney RT, Husain A, Tretiakova M, Loewen G, Johnson CS, Jayaprakash V, Moysich KB, Salgia R, Reid ME.
Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1104-10.
PMID: 18483332
doi: 10.1158/1055-9965.EPI-07-2713
onclusions: VDR expression spanned the lung carcinogenesis spectrum. Nuclear expression was similar across various histologies, whereas cytoplasmic expression decreased with increasing histologic grade. These results indicate that there is potential for the use of calcitriol as a chemopreventive agent against the development of lung cancer. (Cancer Epidemiol Biomarkers Prev 2008;17(5):1104–10)
Vitamin D in Cancer Patients: Above All, Do No Harm -- Goodwin 27 (13): 2117 -- Journal of Clinical Oncology
Vitamin D in cancer patients: above all, do no harm.
Goodwin PJ.
J Clin Oncol. 2009 May 1;27(13):2117-9. Epub 2009 Apr 6.
PMID: 19349538
Serum 25-hydroxyvitamin D status of vegetarians, partial vegetarians, and nonvegetarians: the Adventist Health Study-2 -- Chan et al. 89 (5): 1686S -- American Journal of Clinical Nutrition
Serum 25-hydroxyvitamin D status of vegetarians, partial vegetarians, and nonvegetarians: the Adventist Health Study-2.
Chan J, Jaceldo-Siegl K, Fraser GE.
Am J Clin Nutr. 2009 May;89(5):1686S-1692S. Epub 2009 Apr 1.
PMID: 19339396
Conclusions: s25(OH)D concentrations were not associated with vegetarian status. Other factors, such as vitamin D supplementation, degree of skin pigmentation, and amount and intensity of sun exposure have greater influence on s25(OH)D than does diet.
Calcium and vitamin d supplementation decreases incidence of stress fractures in female navy recruits. - JBMR Online - Journal of Bone and Mineral Research - 23(5):741 - Full Text
Calcium and vitamin d supplementation decreases incidence of stress fractures in female navy recruits.
Lappe J, Cullen D, Haynatzki G, Recker R, Ahlf R, Thompson K.
J Bone Miner Res. 2008 May;23(5):741-9.
PMID: 18433305
doi: 10.1359/jbmr.080102
Conclusions: Generalizing the findings to the population of 14,416 women who entered basic training at the Great Lakes during the 24 mo of recruitment, calcium and vitamin D supplementation for the entire cohort would have prevented 187 persons from fracturing. Such a decrease in SFx would be associated with a significant decrease in morbidity and financial costs.
Hyperlipid: May 2009: ASTEROID destroys lipid hypothesis!
"Atheroma regression occurred in most patients and was not linked to the LDL cholesterol achieved"
Read that line very carefully. Now read it again. That's it, the rest of the post is just rambling on my part.
But is the lipid hypothesis dead? To quote Malcolm Kendrick from 2005 on a different study:
"The great ship Cholesterol-Lowering has ripped its guts out on the harsh rocks of evidence, but still it does not sink"
Executive summary: lower LDL cholesterol has no linkage to shrinkage of plaque.
An outbreak of hypervitaminosis D associated with the overfortification of milk from a home-delivery dairy. -- Blank et al. 85 (5): 656 -- American Journal of Public Health
An outbreak of hypervitaminosis D associated with the overfortification of milk from a home-delivery dairy.
Blank S, Scanlon KS, Sinks TH, Lett S, Falk H.
Am J Public Health. 1995 May;85(5):656-9.
PMID: 7733425
New Research by D*action Member Dr. Cedric Garland Suggests Role Low Levels of Vitamin D Play in Cancer Development
San Diego, CA (PRWEB) May 25, 2009 -- Coming on the heels of the publishing in the Annals of Epidemiology of a new study led by Dr. Cedric Garland, on the preventive measures of vitamin D, GrassrootsHealth D*action Project is calling on physicians, health clinics and groups throughout the country to recognize the need for determining vitamin D levels and to ensure the public have their blood levels of vitamin D tested.
According to research from the newly published study by Cedric F. Garland, Dr. P.H., FACE, Department of Family and Preventive Medicine and Moores Cancer Center of the University of California, San Diego (UCSD), "It is projected that raising the minimum year-around serum 25(OH)D level to 40-60 ng/ml (100-150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year, and three quarters of deaths from these diseases, in the US and Canada."
Calcium, protein, and fruit and vegetables as dietary determinants of bone health -- New and Millward 77 (5): 1340 -- American Journal of Clinical Nutrition
Calcium, protein, and fruit and vegetables as dietary determinants of bone health.
New SA, Millward DJ.
Am J Clin Nutr. 2003 May;77(5):1340-1; author reply 1341.
PMID: 12716695
Amount and type of protein influences bone health -- Heaney and Layman 87 (5): 1567S -- American Journal of Clinical Nutrition
Amount and type of protein influences bone health.
Heaney RP, Layman DK.
Am J Clin Nutr. 2008 May;87(5):1567S-1570S. Review.
PMID: 18469289
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