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Statins do not eliminate risk of low HDL-cholesterol levelsl - theheart.org
"November 17, 2009 | Michael O'Riordan
Orlando, FL - Low levels of HDL cholesterol, even among statin-treated patients, are associated with a significantly increased risk of cardiovascular disease, particularly the risk of MI, a new study has shown. To reduce the residual risk of disease among these well-treated patients, researchers say clinicians should also focus on HDL-cholesterol levels, despite the failure of recent HDL-cholesterol-raising drugs and the lack of hard outcomes data.
"In common clinical practice, my sense is that among healthcare providers, once they aggressively lower LDL-cholesterol levels, the thinking is that they have done all they can do to remove their patient's cardiovascular disease risk," senior investigator Dr Richard Karas (Tufts Medical Center, Boston, MA) told heartwire. "The thinking is that because the LDL-cholesterol levels are so well treated, we won't have to worry about HDL cholesterol."
Presenting the results of a new meta-analysis here at the American Heart Association (AHA) 2009 Scientific Sessions, Karas stressed that the findings are not meant to minimize the use of statin medications for lowering LDL cholesterol, a cornerstone for reducing cardiovascular disease morbidity and mortality. Instead, he said, the results show that statins do not mitigate the risks associated with low HDL-cholesterol levels."
Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004 -- Looker et al. 88 (6): 1519 -- American Journal of Clinical Nutrition
Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004.
Looker AC, Pfeiffer CM, Lacher DA, Schleicher RL, Picciano MF, Yetley EA.
Am J Clin Nutr. 2008 Dec;88(6):1519-27.
PMID: 19064511
doi:10.3945/ajcn.2008.26182
Conclusions: Overall, mean serum 25(OH)D was lower in 2000–2004 than 1988–1994. Assay changes unrelated to changes in vitamin D status accounted for much of the difference in most population groups. In an adult subgroup, combined changes in BMI, milk intake, and sun protection appeared to contribute to a real decline in vitamin D status.
In summary, age-standardized mean serum 25(OH)D concentrations based on observed values were significantly lower in 2000–2004 than in 1988–1994 in all groups examined. Adjustment for assay changes noticeably reduced the difference between surveys. However, mean serum 25(OH)D concentrations remained significantly lower in males (except Mexican Americans) in NHANES 2000–2004 than in NHANES III, even after adjustment for assay differences. This remaining difference likely represents a real decline in vitamin D status. Changes in BMI, milk intake, and sun protection appeared to contribute to this decline in a subgroup of non-Hispanic white adults. The possibility that trends in overweight, sun protection, and milk intake may continue supports the need to continue monitoring the serum 25(OH)D status of the population
Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: Docosahexaenoic acid or eicosapentaenoic acid - ScienceDirect - Biochemical Pharmacology
Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: docosahexaenoic acid or eicosapentaenoic acid.
Saw CL, Huang Y, Kong AN.
Biochem Pharmacol. 2010 Feb 1;79(3):421-30. Epub 2009 Sep 8.
PMID: 19744468
Low vitamin D tied to heart, stroke deaths: MedlinePlus
"NEW YORK (Reuters Health) - Low vitamin D levels in the body may be deadly, according to a new study hinting that adults with lower, versus higher, blood levels of vitamin D may be more likely to die from heart disease or stroke.
Vitamin D is an essential vitamin mostly obtained from direct sunlight exposure, but also found in foods and multivitamins.
Dr. Annamari Kilkkinen, at the National Institute for Health and Welfare in Helsinki, Finland, and colleagues compared blood levels of vitamin D and deaths from heart disease or stroke over time in 2,817 men and 3,402 women in Finland."
Effects of Reducing Dietary Saturated Fatty Acids on Plasma Lipids and Lipoproteins in Healthy Subjects : The Delta Study, Protocol 1 -- Ginsberg et al. 18 (3): 441 -- Arteriosclerosis, Thrombosis, and Vascular Biology
Effects of reducing dietary saturated fatty acids on plasma lipids and lipoproteins in healthy subjects: the DELTA Study, protocol 1.
Ginsberg HN, Kris-Etherton P, Dennis B, Elmer PJ, Ershow A, Lefevre M, Pearson T, Roheim P, Ramakrishnan R, Reed R, Stewart K, Stewart P, Phillips K, Anderson N.
Arterioscler Thromb Vasc Biol. 1998 Mar;18(3):441-9.
PMID: 9514413
The reductions in total and LDL cholesterol achieved in these different subgroups indicate that diet can have a significant impact on risk for atherosclerotic cardiovascular disease in the total population.
Association of low intake of milk and vitamin D during pregnancy with decreased birth weight -- Mannion et al. 174 (9): 1273 -- Canadian Medical Association Journal
Association of low intake of milk and vitamin D during pregnancy with decreased birth weight.
Mannion CA, Gray-Donald K, Koski KG.
CMAJ. 2006 Apr 25;174(9):1273-7.
PMID: 16636326
doi:10.1503/cmaj.1041388.
Interpretation: Milk and vitamin D intakes during pregnancy are each associated with infant birth weight, independently of other risk factors.
Teenage girls and elderly women living in northern Europe have low winter vitamin D status - European Journal of Clinical Nutrition - Abstract of article
Teenage girls and elderly women living in northern Europe have low winter vitamin D status.
Andersen R, Mølgaard C, Skovgaard LT, Brot C, Cashman KD, Chabros E, Charzewska J, Flynn A, Jakobsen J, Kärkkäinen M, Kiely M, Lamberg-Allardt C, Moreiras O, Natri AM, O'brien M, Rogalska-Niedzwiedz M, Ovesen L.
Eur J Clin Nutr. 2005 Apr;59(4):533-41.
PMID: 15714215
doi:10.1038/sj.ejcn.1602108
CONCLUSION: Vitamin D status is low in northern Europe during winter. More than one-third of the adolescent girls have vitamin D status below 25 nmol/l and almost all are below 50 nmol/l. Two-thirds of the elderly community-dwelling women have vitamin D status below 50 nmol/l. Use of vitamin D supplements is a significant positive determinant for S-25OHD for both girls and women (P = 0.001). SPONSORSHIP: The European Fifth Framework Programme (Contract No. QLK1-CT-2000-00623)
Low serum 25-hydroxyvitamin D concentrations and secondary hyperparathyroidism in middle-aged white strict vegetarians -- Lamberg-Allardt et al. 58 (5): 684 -- American Journal of Clinical Nutrition
Low serum 25-hydroxyvitamin D concentrations and secondary hyperparathyroidism in middle-aged white strict vegetarians.
Lamberg-Allardt C, Kärkkäinen M, Seppänen R, Biström H.
Am J Clin Nutr. 1993 Nov;58(5):684-9.
PMID: 8237875
In conclusion, white strict vegetarians are at risk of vitamin D deficiency, at least in the winter, primarily because of a low dietary vitamin D intake, despite a normal sunlight exposure in summer. Low serum 25(OH)D concentrations are accompanied by high S-iPTH concentrations, which also are affected by a low calcium intake. The effect of these changes on bone health remains to be evaluated.
New Research by D*action Member Dr. Cedric Garland Suggests Role Low Levels of Vitamin D Play in Cancer Development
San Diego, CA (PRWEB) May 25, 2009 -- Coming on the heels of the publishing in the Annals of Epidemiology of a new study led by Dr. Cedric Garland, on the preventive measures of vitamin D, GrassrootsHealth D*action Project is calling on physicians, health clinics and groups throughout the country to recognize the need for determining vitamin D levels and to ensure the public have their blood levels of vitamin D tested.
According to research from the newly published study by Cedric F. Garland, Dr. P.H., FACE, Department of Family and Preventive Medicine and Moores Cancer Center of the University of California, San Diego (UCSD), "It is projected that raising the minimum year-around serum 25(OH)D level to 40-60 ng/ml (100-150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year, and three quarters of deaths from these diseases, in the US and Canada."
Low Protein Intake: The Impact on Calcium and Bone Homeostasis in Humans -- Kerstetter et al. 133 (3): 855S -- Journal of Nutrition
Kerstetter JE, O'Brien KO, Insogna KL.
Low protein intake: the impact on calcium and bone homeostasis in humans.
J Nutr. 2003 Mar;133(3):855S-861S. Review.
PMID: 12612169
Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries. - Wiley InterScience :: Article :: HTML Full Text
Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries.
Tuohimaa P, Tenkanen L, Ahonen M, Lumme S, Jellum E, Hallmans G, Stattin P, Harvei S, Hakulinen T, Luostarinen T, Dillner J, Lehtinen M, Hakama M.
Int J Cancer. 2004 Jan 1;108(1):104-8.
PMID: 14618623
DOI: 10.1002/ijc.11375
Low Vitamin D Status despite Abundant Sun Exposure -- Binkley et al. 92 (6): 2130 -- Journal of Clinical Endocrinology & Metabolism
Low vitamin D status despite abundant sun exposure.
Binkley N, Novotny R, Krueger D, Kawahara T, Daida YG, Lensmeyer G, Hollis BW, Drezner MK.
J Clin Endocrinol Metab. 2007 Jun;92(6):2130-5. Epub 2007 Apr 10.
PMID: 17426097
doi:10.1210/jc.2006-2250
CONCLUSIONS: These data suggest that variable responsiveness to UVB radiation is evident among individuals, causing some to have low vitamin D status despite abundant sun exposure. In addition, because the maximal 25(OH)D concentration produced by natural UV exposure appears to be approximately 60 ng/ml, it seems prudent to use this value as an upper limit when prescribing vitamin D supplementation.
Vitamin D may help prevent knee osteoarthritis | Health | Reuters
NEW YORK (Reuters Health) - Low levels of vitamin D are associated with the loss of cartilage in the knee joint of older individuals, researchers in Australia report
Low vitamin D levels may impair thinking | Health | Reuters
NEW YORK (Reuters Health) - New research suggests that low vitamin D levels in the body are associated with thinking or "cognitive" impairments in older men, but whether vitamin D supplements can help is not yet known.
In the study, an investigation of European men, subjects with low levels of vitamin D scored worse on a standard test of cognitive ability than did their peers with normal levels, Dr. David M. Lee, from the University of Manchester, UK, and co-researchers found. Although, the authors emphasize, the difference in scores was not that great.
Mediterranean diet
One of the fastest growing trends in dieting is the so-called Mediterranean diet. This formula for healthier nutrition has been said to have amazing benefits, including cancer prevention and diabetes control. If you're interested in learning more about this diet plan, you'll find useful information below.\n\n
Relationship Between Vitamin D Deficiency And Increased Inflammation In Healthy Women
According to a recent study in the Archives of Internal Medicine, 75 percent of Americans do not get enough Vitamin D. Researchers have found that the deficiency may negatively impact immune function and cardiovascular health and increase cancer risk. Now, a University of Missouri nutritional sciences researcher has found that vitamin D deficiency is associated with inflammation, a negative response of the immune system, in healthy women.
Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women - Journal of Inflammation | Full text |
Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH)D concentrations in healthy women.
Peterson CA, Heffernan ME.
J Inflamm (Lond). 2008 Jul 24;5:10.
PMID: 18652680
doi:10.1186/1476-9255-5-10
Conclusion
Serum 25(OH)D status is inversely related to TNF-α concentrations in healthy women, which may in part explain this vitamin's role in the prevention and treatment of inflammatory diseases. Results gleaned from this investigation also support the need to re-examine the biological basis for determining optimal vitamin D status.
Low Levels Of Vitamin D In Patients With Autoimmune Disease May Be Result, Not Cause, Of The Disease
ScienceDaily (Apr. 8, 2009) - Deficiency in vitamin D has been widely regarded as contributing to autoimmune disease, but a review appearing in Autoimmunity Reviews explains that low levels of vitamin D in patients with autoimmune disease may be a result rather than a cause of disease and that supplementing with vitamin D may actually exacerbate autoimmune disease.
Vitamin D: The alternative hypothesis. - ScienceDirect - Autoimmunity Reviews, 2009
Albert et al. Vitamin D: The alternative hypothesis.
Autoimmunity Reviews, 2009
doi:10.1016/j.autrev.2009.02.011
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