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NephroPal: Omega 3 Fatty Acid and Adiponectin Levels
"Friday, December 18, 2009
Omega 3 Fatty Acid and Adiponectin Levels
Today my wife was watching the Oprah show. A commercial came on and I looked up. It was a Christmas special on liposuction in the local area. Considering that the fat tissue (adipose tissue) is now viewed as an endocrine organ and not just a collection of fat cells, I have always thought that sucking out the fat cells maybe a bad idea. Yet, I have never seen proof of this. But, the science of the adipose tissue as an endocrine organ is relatively new. It seems that in the medical literature adiponectin is receiving the most attention from all of the other adipose hormones - or also referred to as adipokines. This is for good reason. As stated before, adiponectin has the following effects:
* reduces liver glucose production
* increases glucose uptake in the muscles and adipose tissues
* causes oxidation of fats which leads to less lipid production
* has anti-inflammatory properties
* protects the heart against ischemia and reduces myocardial infarct size
* acts as an anti-clotting factor
* increases nitric oxide production in the vasculature leading to a greater dilation of the vessels"
Tissue Phylloquinone and Menaquinones in Rats Are Affected by Age and Gender -- Huber et al. 129 (5): 1039 -- Journal of Nutrition
Tissue phylloquinone and menaquinones in rats are affected by age and gender.
Huber AM, Davidson KW, O'Brien-Morse ME, Sadowski JA.
J Nutr. 1999 May;129(5):1039-44.
PMID: 10222397
The results suggest that in extrahepatic tissues, certain menaquinones may be the predominant form of vitamin K. The specific tissue distribution and the general decline of MK-4 and MK-6 in extrahepatic tissues during aging suggest a vitamin K tissue dynamic that is affected not only by diet, but also by gender, age and the specific roles of phylloquinone, MK-4 and MK-6 in metabolism. All of these factors must be taken into account in establishing the nutrient requirement for vitamin K.
Calculated Ultraviolet Exposure Levels for a Healthy Vitamin D Status
An acknowledged benefit of exposure to ultraviolet radiation is synthesis of vitamin D in human skin. Here we have defined a standard vitamin D dose based upon recommended requirements for vitamin D, and present a web-based tool that enables the user to calculate associated exposure times for any time and place ( http://nadir.nilu.no/~olaeng/fastrt/VitD_quartMED.html). The recommended UV exposure times depends on latitude, time, total ozone, clouds, aerosols, surface reflectivity and altitude all of which can be specified by the user. A simpler version for non-experts is available at http://nadir.nilu.no/~olaeng/fastrt/VitD-ez_quartMED.html
Calculated Ultraviolet Exposure Levels for a Healthy Vitamin D Status - easy version
An acknowledged benefit of exposure to ultraviolet radiation is synthesis of vitamin D in human skin. Here we have defined a standard vitamin D dose based upon recommended requirements for vitamin D, and present a simplified web-based tool that enables the user to calculate associated exposure times for any time and place ( http://nadir.nilu.no/~olaeng/fastrt/VitD-ez_quartMED.html). This www page is a simplified version of the more complex web tool ( http://nadir.nilu.no/~olaeng/fastrt/VitD_quartMED.html). The simplified www page is convenient for users unfamiliar to radiative transfer modelling, because the model input is limited and more intuitive.
Vitamin D levels associated with survival in lymphoma patients
"ScienceDaily (Dec. 5, 2009) - A new study has found that the amount of vitamin D in patients being treated for diffuse large B-cell lymphoma was strongly associated with cancer progression and overall survival. The results will be presented at the annual meeting of the American Society of Hematology in New Orleans.
Also, several recent reports have concluded that vitamin D deficiency is associated with poor outcomes in other cancers, including breast, colon and head and neck cancer. This is the first study to look at lymphoma outcome.
Vitamin D and influenza - Wikipedia, the free encyclopedia
"Numerous studies link Vitamin D and influenza, as well as Vitamin D and respiratory infections more generally. This vitamin up-regulates genetic expression of various endogenous antimicrobial peptides (AMP), which exhibit broad-spectrum microbicidal activity against bacteria, fungi, and viruses. Reports discussed below indicate that susceptibility to influenza is reduced with higher levels of sun exposure or vitamin D supplementation. Seasonal variation of vitamin D levels in humans can help explain the seasonality of flu epidemics."
Vitamin D association with estradiol and progesterone in young women - Cancer Causes Control. 2009 Nov 15 - SpringerLink - Journal Article
Vitamin D association with estradiol and progesterone in young women.
Knight JA, Wong J, Blackmore KM, Raboud JM, Vieth R.
Cancer Causes Control. 2009 Nov 15. [Epub ahead of print]
PMID: 19916051
Conclusions Higher levels of vitamin D may reduce progesterone and estradiol, providing a potential mechanism for reduction in breast cancer risk from increased vitamin D exposure in young women
Postmenopausal women with higher testosterone levels
"Postmenopausal women who have higher testosterone levels may be at greater risk of heart disease, insulin resistance and the metabolic syndrome compared to women with lower testosterone levels, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). This new information is an important step, say researchers, in understanding the role that hormones play in women's health."
ERA JUMP: Omega-3 fatty acids and plaque - The Heart Scan Blog
"The results of the uniquely-constructed ERA JUMP Study were just released, a fascinating study of the relationship of omega-3 fatty acids to coronary and carotid plaque.
The study adds insight into why the Japanese experience only one third of the heart attacks of Americans, and why Japan occupies the bottom of the list for least heart attacks among all developed countries.
The Electron-Beam Tomography, Risk Factor Assessment Among Japanese and U.S. Men in the Post-World War II Birth Cohort Study (ERA JUMP), a collaborative U.S.-Japanese effort, compared three groups of men:
-- 281 Japanese men living in Japan
-- 306 non-Japanese men living in the U.S. (Pittsburgh, Pennsylvania)
-- 303 Japanese Americans (having both parents Japanese without “ethnic admixture”) living in Hawaii.
The last group represents a group that is genetically similar to the group in Japan, but exposed to an American diet and lifestyle.
Three main measures were compared:
-- Blood levels of omega-3 fatty acids, EPA and DHA)
-- Carotid intimal-medial thickness (CIMT, the thickness of the carotid artery lining that can serve as an index of body-wide atherosclerosis)
-- Coronary calcium (heart scan) scores."
Vegan Diet May Treat Diabetes - CBS News
"(WebMD) Eating a low-fat vegan diet may be better at managing type 2 diabetes than traditional diets, according to a new study.
Researchers found 43 percent of people with type 2 diabetes who followed a low-fat vegan diet for 22 weeks reduced their need to take medications to manage their disease compared with 26 percent of those who followed the diet recommended by the American Diabetes Association (ADA).
In addition, participants who followed the vegan diet experienced greater reductions in cholesterol levels and weight loss than those on the other diet."
Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer in elderly men. - [Cancer Causes Control. 2009] - PubMed result
Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer in elderly men.
Tang JY, Parimi N, Wu A, John Boscardin W, Shikany JM, Chren MM, Cummings SR, Epstein EH Jr, Bauer DC; for the Osteoporotic Fractures in Men (MrOS) Study Group.
Cancer Causes Control. 2009 Nov 18. [Epub ahead of print]
PMID: 19921445
Our results suggest that a diagnosis of NMSC is not a surrogate for adequate 25(OH)D levels or increased UV exposure, and high 25(OH)D levels may be associated with a reduced risk of NMSC.
Vitamin D could ease symptoms for MS sufferers - ABC News (Australian Broadcasting Corporation)
"Posted Tue Nov 17, 2009 4:01pm AEDT
Updated Tue Nov 17, 2009 4:27pm AEDT
Researchers are advising people with MS to take safe levels of vitamin D supplements.
Researchers are advising people with MS to take safe levels of vitamin D supplements. (ABC News: Giulio Saggin, file photo)
* Audio: New research shows Vitamin D may slow the progress of MS (The World Today)
Australian scientists have found that Vitamin D may slow the progression of multiple sclerosis (MS).
Figures showing that people living in Tasmania are seven times more likely to develop MS than Queenslanders had suggested a link between sunlight exposure and the disease. "
Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers. - [Psychiatry Res. 2007] - PubMed result
Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers.
Conklin SM, Harris JI, Manuck SB, Yao JK, Hibbeln JR, Muldoon MF.
Psychiatry Res. 2007 Jul 30;152(1):1-10. Epub 2007 Mar 23.PMID: 17383013
Arch Intern Med -- 25-Hydroxyvitamin D Levels and the Risk of Mortality in the General Population, Aug 11/25, 2008, Melamed et al. 168 (15): 1629 (full text)
25-hydroxyvitamin D levels and the risk of mortality in the general population.
Melamed ML, Michos ED, Post W, Astor B.
Arch Intern Med. 2008 Aug 11;168(15):1629-37.
PMID: 18695076
Conclusion The lowest quartile of 25(OH)D level (<17.8 ng/mL) is independently associated with all-cause mortality in the general population.
Low vitamin D tied to heart, stroke deaths: MedlinePlus
"NEW YORK (Reuters Health) - Low vitamin D levels in the body may be deadly, according to a new study hinting that adults with lower, versus higher, blood levels of vitamin D may be more likely to die from heart disease or stroke.
Vitamin D is an essential vitamin mostly obtained from direct sunlight exposure, but also found in foods and multivitamins.
Dr. Annamari Kilkkinen, at the National Institute for Health and Welfare in Helsinki, Finland, and colleagues compared blood levels of vitamin D and deaths from heart disease or stroke over time in 2,817 men and 3,402 women in Finland."
Chocolate Soothes the Stressed-Out Soul - Mental Health Disorders on MedicineNet.com
"THURSDAY, Nov. 12 (HealthDay News) -- Feeling stressed? A dose of dark chocolate could cheer you right up by lowering your stress hormone levels, a new study suggests.
Swiss researchers, who report their findings in the online issue of the Journal of Proteome Research, tracked volunteers who said they were highly stressed."
Optimal Serum 25-Hydroxyvitamin D Levels for Multiple Health Outcomes - SpringerLink - Book Chapter
Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes.
Bischoff-Ferrari HA.
Adv Exp Med Biol. 2008;624:55-71. Review.
PMID: 18348447
DOI: 10.1007/978-0-387-77574-6_5
Recent evidence suggests that higher vitamin D intakes beyond current recommendations may be associated with better health outcomes. In this chapter, evidence is summarized from different studies that evaluate threshold levels for serum 25(OH)D levels in relation to bone mineral density (BMD), lower extremity function, dental health, risk of falls, admission to nursing home, fractures, cancer prevention and incident hypertension. For all endpoints, the most advantageous serum levels for 25(OH)D appeared to be at least 75 nmol/l (30 ng/ml) and for cancer prevention, desirable 25(OH)D levels are between 90–120 nmol/l (36–48 ng/ml). An intake of no less than 1000IU (25 meg) of vitamin D3 (cholecalciferol) per day for all adults may bring at least 50% of the population up to 75 nmol/l. Thus, higher doses of vitamin D are needed to bring most individuals into the desired range. While estimates suggest that 2000 IU vitamin D3 per day may successfully and safely achieve this goal, the implications of 2000 IU or higher doses for the total adult population need to be addressed in future studies.
Serum 25-hydroxyvitamin D status of vegetarians, partial vegetarians, and nonvegetarians: the Adventist Health Study-2 -- Chan et al. 89 (5): 1686S -- American Journal of Clinical Nutrition
Serum 25-hydroxyvitamin D status of vegetarians, partial vegetarians, and nonvegetarians: the Adventist Health Study-2.
Chan J, Jaceldo-Siegl K, Fraser GE.
Am J Clin Nutr. 2009 May;89(5):1686S-1692S. Epub 2009 Apr 1.
PMID: 19339396
Conclusions: s25(OH)D concentrations were not associated with vegetarian status. Other factors, such as vitamin D supplementation, degree of skin pigmentation, and amount and intensity of sun exposure have greater influence on s25(OH)D than does diet.
Differences in vitamin D status between countries in young adults and the elderly
Differences in vitamin D status between countries in young adults and the elderly.
McKenna MJ.
Am J Med. 1992 Jul;93(1):69-77.
PMID: 1385673
PURPOSE: To compare vitamin D status between countries in young adults and in the elderly. MATERIALS AND METHODS: Reports on vitamin D status (as assessed by serum 25-hydroxyvitamin D) from 1971 to 1990 were reviewed. Studies were grouped according to geographic regions: North America (including Canada and the United States); Scandinavia (including Denmark, Finland, Norway, and Sweden); and Central and Western Europe (including Belgium, France, Germany, Ireland, The Netherlands, Switzerland, and the United Kingdom). RESULTS: Vitamin D status varies with the season in young adults and in the elderly, and is lower during the winter in Europe than in both North America and Scandinavia. Oral vitamin D intake is lower in Europe than in both North America and Scandinavia. Hypovitaminosis D and related abnormalities in bone chemistry are most common in elderly residents in Europe but are reported in all elderly populations. CONCLUSIONS: The vitamin D status in young adults and the elderly varies widely with the country of residence. Adequate exposure to summer sunlight is the essential means to ample supply, but oral intake augmented by both fortification and supplementation is necessary to maintain baseline stores. All countries should adopt a fortification policy. It seems likely that the elderly would benefit additionally from a daily supplement of 10 micrograms of vitamin D.
Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland). - Cancer Causes Control. 2000 Oct;11(9):847-52. - SpringerLink - Journal Article
Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland).
Ahonen MH, Tenkanen L, Teppo L, Hakama M, Tuohimaa P.
Cancer Causes Control. 2000 Oct;11(9):847-52.
PMID: 11075874
DOI: 10.1023/A:1008923802001
CONCLUSIONS: We conclude that low levels of 25-VD associated with an increased risk for subsequent earlier exposure and more aggressive development of prostate cancer, especially before the andropause.
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