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Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity - Diabetologia. 2004 Jun;47(6):1016-9 - SpringerLink - Journal Article
Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity.
Risérus U, Vessby B, Arner P, Zethelius B.
Diabetologia. 2004 Jun;47(6):1016-9. Epub 2004 May 28.
PMID: 15168020
DOI: 10.1007/s00125-004-1421-8
Conclusions/interpretation In obese men, t10c12CLA induces hyperproinsulinaemia that is related to impaired insulin sensitivity, independently of changes in insulin concentrations. These results are of clinical interest, as hyperproinsulinaemia predicts diabetes and cardiovascular disease. The use of weight-loss supplements containing this fatty acid is worrying.
Metabolic effects of conjugated linoleic acid in humans: the Swedish experience -- Risérus et al. 79 (6): 1146S -- American Journal of Clinical Nutrition
Metabolic effects of conjugated linoleic acid in humans: the Swedish
experience.
Riserus U, Smedman A, Basu S, Vessby B.
Am J Clin Nutr. 2004 Jun;79(6 Suppl):1146S-1148S.
PMID: 15159248
CONCLUSIONS
CLA and specifically the isolated isomers are interesting model fatty acids for studies of the effects of (structural differences of) unsaturated fatty acids in humans. Today, there is no clear indication for human use of CLA concentrates. The possible importance of the small reduction of body fat after supplementation with the commercially available CLA products, without evidence of an associated improvement in the metabolic profile, has to be weighed against the apparent reduction of HDL cholesterol and an increased lipid peroxidation. The possible health consequences of prolonged treatment periods are at present unknown. Human supplementation with high doses of the trans-10,cis-12 CLA isomer should be avoided while awaiting further information on possible effects and side effects. However, it cannot be excluded that future studies could point to clinical applications, eg, as a result of antitumorigenic properties or as a tool to prevent weight gain. This possibility certainly requires more research to increase the understanding of the mechanisms behind the effects of CLA and specific CLA isomers on a molecular level. More controlled studies in defined populations are needed, as are controlled studies for comparisons of the effects of different and well-defined (mixtures of) isomers and human studies of longer duration to secure long-term effects and safety
Omega-3 fatty acids enter plaque, resulting in increased stability and less inflammation - theheart.org
"June 21, 2006 | Michael O'Riordan
Rome, Italy - One of the possible ways in which long-chain omega-3 fatty acids play a role in decreasing cardiovascular events is by entering advanced atherosclerotic plaques. According to the results of a new study, investigators were able to show that the incorporation of eicosapentaenoic acid (EPA) into advanced plaque was associated with a decreased expression of various matrix metalloproteinases (MMPs) involved in causing plaque instability, as well as with decreased plaque inflammation.
These are results of the Omacor Carotid Endarterectomy Intervention (OCEAN) study, presented here this week at the International Symposium on Atherosclerosis by Dr Philip Calder (University of Southampton, UK).
"By increasing the availability of omega-3 fatty acids, they appear in advanced atherosclerotic plaques, indicated in this study by the carotid artery, and this results in lower numbers of macrophages, foam cells, and T cells, as well as the lower expression of inflammatory markers," said Calder. "Histologically, this results in a plaque that appears to be less inflamed and more stable. This may contribute to reduced mortality in patients consuming omega-3 fatty acids, for example, in the GISSI Prevenzione trial.""
THE LECTIN STORY
"While research in lectinology is in its infancy this information is critical to your health and it is important to begin to understand lectins NOW. Read the following report carefully. I'll get specific about how this all applies to you. ALL foods contain lectins. Some are your friends, others neutral, and others may be your enemies. Know your lectins. Avoid your enemies.
DEFINITION
Protein or glycoprotein substances, usually of plant origin, of non-immunoglobulin nature, capable of specific recognition of and reversible binding to, carbohydrate moieties of complex glycoconjugates without altering the covalent structure of any of the recognized glycosyl ligands. This group includes monovalent lectins (i.e. bacterial and plant toxins). These lectins bind to sugar moieties in cell walls or membranes and thereby change the physiology of the membrane to cause agglutination, mitosis, or other biochemical changes in the cell. (agglutination- clumping; mitosis-multiplication or division of a cell forming two daughter cells)
High levels of lectins (specialized proteins) may be found in grains (also known as cereals or pulses), legumes (that is 'beans' including peanuts), dairy and plants in the nightshade family. Many other foods contain lectins but are less well studied and the amounts of lectins present are not thought to be as high or as potentially toxic.!
High doses of vitamin D could cut relapse rate among MS sufferers - Times Online
"Powerful new evidence about the ability of vitamin D to stem a wide range of diseases has brought the prospect of a nationwide programme to prescribe it in Scotland as a dietary supplement significantly closer.
Reports at the weekend suggested that experts were increasingly convinced that the so-called sunshine drug — whose significance was first revealed in detail by The Times last year — could make a difference to the country’s appalling health record.
New research suggests that high doses of vitamin D could dramatically cut the relapse rate in people with multiple sclerosis. According to scientists in Canada, more than a third of sufferers taking high levels of supplement
Questions about vitamin D - The Globe and Mail
"This is not one of our usual hour-long live discussions. Rather, this is an online question-and-answer session. Your questions and Dr. Vieth's answers will appear at the bottom of this page after 1 p.m. EDT today."
Schizophrenia and Gluten - NephroPal: Schizophrenia
I have been reading a case report by Kraft, Westman, 2009 of a 70 year old obese, Caucasian female who was suffering from Schizophrenia since the age of 17. Her symptoms included paranoia, hallucinations (auditory and visual), and many hospitalizations for psychosis and suicide attempts. Her daily diet included "egg and cheese sandwich, diet soda, water, pimento cheese, barbecued pork, chicken salad, hamburger helper, macaroni and cheese, and potatoes." Instead, she was asked to follow a low carbohydrate diet of: "unlimited meats and eggs, 4 ounces of hard cheese, 2 cups of salad vegetables, and 1 cup of low carbohydrate
vegetables per day. This diet restricts carbohydrate intake to fewer than 20 grams per day." The diet was also grain free.
Natural inhalation exposure to coal smoke and wood smoke induces lung cancer in mice and rats. - .[Biomed Environ Sci. 1988] - PubMed Result
Natural inhalation exposure to coal smoke and wood smoke induces lung cancer in mice and rats.
Liang CK, Quan NY, Cao SR, He XZ, Ma F.
Biomed Environ Sci. 1988 Jun;1(1):42-50.
PMID: 3268107
Animal Pharm: Benefits of High-Saturated Fat Diets (Part I)
What's a 46% fat diet?
Perhaps what our stone-age ancestors consumed during happy, reproductive, fertile times?
The diet compared 6% Sat Fat (low fat) to 18% Sat Fat (high fat) in a little discussed publication by Krauss et al, one of the founders of NMR lipoprotein density technology here in the Bay Area.
Vitamin D and Its Role in Cancer and Immunity: A Prescription for Sunlight -- Mullin and Dobs 22 (3): 305 -- Nutrition in Clinical Practice
Vitamin d and its role in cancer and immunity: a prescription for sunlight.
Mullin GE, Dobs A.
Nutr Clin Pract. 2007 Jun;22(3):305-22. Review.
PMID: 17507731
DOI: 10.1177/0115426507022003305
Vitamin K and the Prevention of Fractures: Systematic Review and Meta-analysis of Randomized Controlled Trials, June 26, 2006, Cockayne et al. 166 (12): 1256 - Arch Intern Med
Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials.
Cockayne S, Adamson J, Lanham-New S, Shearer MJ, Gilbody S, Torgerson DJ.
Arch Intern Med. 2006 Jun 26;166(12):1256-61. Review.
PMID: 16801507
Conclusions This systematic review suggests that supplementation with phytonadione and menaquinone-4 reduces bone loss. In the case of the latter, there is a strong effect on incident fractures among Japanese patients.
Vitamin D treatment in multiple sclerosis - ScienceDirect - Journal of the Neurological Sciences
Vitamin D treatment in multiple sclerosis.
Myhr KM.
J Neurol Sci. 2009 Jun 22. [Epub ahead of print]
PMID: 19549608
doi:10.1016/j.jns.2009.05.002
Epidemiological evidence combined with clinical and laboratory analyses, and experimental animal models, suggest a possible influence of vitamin D on MS susceptibility as well as clinical disease activity.
Supplement with vitamin D may reduce the risk of developing MS. An intervention may also reduce the risk of conversion from a first clinical event suggestive of MS to clinical definite MS, as well as reduce the relapse rate among patients with relapsing remitting MS. More studies are, however, needed to determine optimal dose and serum level for vitamin D, as well as target populations and optimal timing for intervention.
A high prevalence of hypovitaminosis D in Finnish medical in- and outpatients. - J Intern Med. 2001 Jun;249(6):559-63. - Wiley InterScience :: Article :: HTML Full Text
A high prevalence of hypovitaminosis D in Finnish medical in- and outpatients.
Kauppinen-Mäkelin R, Tähtelä R, Löyttyniemi E, Kärkkäinen J, Välimäki MJ.
J Intern Med. 2001 Jun;249(6):559-63.
PMID: 11422663
DOI: 10.1046/j.1365-2796.2001.00847.x
CONCLUSION: Hypovitaminosis D is very common amongst Finnish in- and outpatients in both sexes, causing secondary hyperparathyroidism in females. More extensive studies are warranted to elucidate the vitamin D status of the Finnish population.
Vitamin D and living in northern latitudes--an endemic risk area for vitamin D deficiency. - [Int J Circumpolar Health. 2008] - PubMed Result
Vitamin D and living in northern latitudes--an endemic risk area for vitamin D deficiency.
Huotari A, Herzig KH.
Int J Circumpolar Health. 2008 Jun;67(2-3):164-78. Review.
PMID: 18767337
CONCLUSIONS: Vitamin D plays a fundamental role in calcium and phosphate homeostasis. A deficiency of vitamin D has been attributed to several diseases. Since its production in the skin depends on exposure to UVB-radiation via the sunlight, the level of vitamin D is of crucial importance for the health of inhabitants who live in the Nordic latitudes where there is diminished exposure to sunlight during the winter season. Therefore, fortification or supplementation of vitamin D is necessary for most of the people living in the northern latitudes during the winter season to maintain adequate levels of circulating 25(OH)D3 to maintain optimal body function and prevent diseases.
Prospective Study of Serum 25-Hydroxyvitamin D Level, Cardiovascular Disease Mortality, and All-Cause Mortality in Older U.S. Adults.- Wiley InterScience :: Article :: HTML Full Text
Prospective Study of Serum 25-Hydroxyvitamin D Level, Cardiovascular Disease Mortality, and All-Cause Mortality in Older U.S. Adults.
Ginde AA, Scragg R, Schwartz RS, Camargo CA Jr.
J Am Geriatr Soc. 2009 Jun 22. [Epub ahead of print]
PMID: 19549021
DOI: 10.1111/j.1532-5415.2009.02359.x
CONCLUSION: In noninstitutionalized older adults, a group at high risk for all-cause mortality, serum 25(OH)D levels had an independent, inverse association with CVD and all-cause mortality. Randomized controlled trials of vitamin D supplementation in older adults are warranted to determine whether this association is causal and reversible.
Low carbohydrate diets improve atherogenic dyslipidemia even in the absence of weight loss - Nutrition & Metabolism | Full text
Low carbohydrate diets improve atherogenic dyslipidemia even in the absence of weight loss.
Feinman RD, Volek JS.
Nutr Metab (Lond). 2006 Jun 21;3:24.
PMID: 16790045
doi:10.1186/1743-7075-3-24
Animal Pharm: Benefits of High-Saturated Fat Diets (Part IV): REGRESSION IN HEART PATIENTS
It was observed that in post-menopausal women with documented heart disease from the Estrogen Replacement and Atherosclerosis (ERA) trial, a multicenter clinical trial evaluating the effects of hormone replacement therapy on atherosclerotic progression, in the group consuming the highest-saturated dietary fat diet (12.0% Sat Fat), an enlargement in coronary diameter of 0.01 mm and a 0.1% regression in coronary artery stenosis
How High Carbohydrate Foods Can Raise Risk For Heart Problems
ScienceDaily (June 27, 2009) - Doctors have known for decades that too much carbohydrate-laden foods like white bread and corn flakes can be detrimental to cardiac health. In a landmark study, new research from Tel Aviv University now shows exactly how these high carb foods increase the risk for heart problems.
The Heart Scan Blog: Beating the Heart Association diet is child's play
In response to the Heart Scan Blog post, Post-Traumatic Grain Disorder, Anne commented:
While on the American Heart Association diet my lipids peaked in 2003. I even tried the Ornish diet for a short time, but found it impossible.
Total Cholesterol: 201
Triglycerides: 263
HDL: 62
LDL: 86
After I stopped eating gluten (I am very sensitive), my lipid panel improved slightly. This past year I started eating to keep my blood sugar under control by eliminating sugars and other grains. Now this is my most recent lab:
Total Cholesterol: 162
Triglycerides: 80
HDL: 71
LDL: 75
Animal Pharm: Benefits of High-Saturated Fat Diets (Part III): My Paleo Peeps With High HDLs
It is not difficult to raise HDLs.
This is observed at TYP and in clinical practice ALL THE TIME.
Eliminating wheat/d*mn-dirty-GRAINS/carbs, adding some vitamin D, omega-3s, Taurine, and Slo-Niacin 1-2 grams/day. Throwing away the Mazola and any packaged food items. Oh yeah, and add some fat. Individuals may continue their EVO (but not too much b/c it cranks up hepatic lipase, see HERE) but they increase eggs 2-6 daily, add some (organic nitrate-free preferably) bacon and some coconut oil.
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