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Fish Consumption and Depressive Symptoms in the General Population in Finland -- Tanskanen et al. 52 (4): 529 -- Psychiatr Serv
Fish consumption and depressive symptoms in the general population in Finland.
Tanskanen A, Hibbeln JR, Tuomilehto J, Uutela A, Haukkala A, Viinamäki H, Lehtonen J, Vartiainen E.
Psychiatr Serv. 2001 Apr;52(4):529-31.
PMID: 11274502
After the analysis adjusted for potential confounders, the likelihood of having depressive symptoms was significantly higher among infrequent fish consumers than among frequent consumers.
Low vitamin D tied to heart, stroke deaths: MedlinePlus
"NEW YORK (Reuters Health) - Low vitamin D levels in the body may be deadly, according to a new study hinting that adults with lower, versus higher, blood levels of vitamin D may be more likely to die from heart disease or stroke.
Vitamin D is an essential vitamin mostly obtained from direct sunlight exposure, but also found in foods and multivitamins.
Dr. Annamari Kilkkinen, at the National Institute for Health and Welfare in Helsinki, Finland, and colleagues compared blood levels of vitamin D and deaths from heart disease or stroke over time in 2,817 men and 3,402 women in Finland."
Defining Adequate Vitamin D Intake : Cross-sectional and Intervention Studies
Defining Adequate Vitamin D Intake : Cross-sectional and Intervention Studies
Viljakainen, Heli Tuulikki
University of Helsinki
2008-05-23
Doctoral dissertation (article-based)
In summary, vitamin D intake remains inadequate among the target groups of this thesis, as reflected by seasonal variation in calcitropic hormones and bone metabolism. Dietary intake of vitamin D should be increased to achieve at least an adequate vitamin D status (S-25-OHD>50 nmol/l) and possibly an optimal vitamin D status (S-25-OHD>80 nmol/l) throughout the year. This could be accomplished by introducing new vitamin D-fortified foods to the market.
Finland Startup Ecosystem: Anything But Cold
Last week, I had the pleasure of being invited out to Finland by Finnfacts on a whirlwind tour of new and established Finnish start ups. I was also delighted to attend the renown Nordic Technology Conference MindTrek, joined by other prominent figures from the international web and technology scene.
Over the next few days I’ll be sharing thoughts and details of some of the companies we visited, these include Floobs, RuntoShop and Muxlim. Though, for the moment, I’d like to share my perspective on the Finnish startup scene and community as a whole.
JAMA -- Neurological Development of 5-Year-Old Children Receiving a Low-Saturated Fat, Low-Cholesterol Diet Since Infancy: A Randomized Controlled Trial, August 23, 2000, Rask-Nissilä et al. 284 (8): 993
Neurological development of 5-year-old children receiving a low-saturated fat, low-cholesterol diet since infancy: A randomized controlled trial.
Rask-Nissilä L, Jokinen E, Terho P, Tammi A, Lapinleimu H, Rönnemaa T, Viikari J, Seppänen R, Korhonen T, Tuominen J, Välimäki I, Simell O.
JAMA. 2000 Aug 23-30;284(8):993-1000.
PMID: 10944645
Conclusion Our data indicate that repeated child-targeted dietary counseling of parents during the first 5 years of a child's life lessens age-associated increases in children's serum cholesterol and is compatible with normal neurological development
Association between serum 25(OH)D concentrations and bone stress fractures in Finnish young men. - JBMR Online - Journal of Bone and Mineral Research - 21(9):1483 - Full Text
Association between serum 25(OH)D concentrations and bone stress fractures in Finnish young men.
Ruohola JP, Laaksi I, Ylikomi T, Haataja R, Mattila VM, Sahi T, Tuohimaa P, Pihlajamäki H.
J Bone Miner Res. 2006 Sep;21(9):1483-8.
doi: 10.1359/jbmr.060607
Conclusions: A lower level of serum 25(OH)D concentration may be a generally predisposing element for bone stress fractures. Considering the obvious need of additional vitamin D in prevention of stress fractures, the effects of vitamin D fortification of foods and supplementation will be subjects of interest for future research
PMID: 16939407
Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls -- Cheng et al. 78 (3): 485 -- American Journal of Clinical Nutrition
Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls.
Cheng S, Tylavsky F, Kröger H, Kärkkäinen M, Lyytikäinen A, Koistinen A, Mahonen A, Alen M, Halleen J, Väänänen K, Lamberg-Allardt C.
Am J Clin Nutr. 2003 Sep;78(3):485-92. Erratum in: Am J Clin Nutr. 2006 Jan;83(1):174.
PMID: 12936933
CONCLUSIONS: Vitamin D-deficient girls have low cortical BMD and high iPTH concentrations, which are consistent with secondary hyperparathyroidism. A low vitamin D concentration accompanied by high bone resorption (TRAP 5b) may limit the accretion of bone mass in young girls.
Teenage girls and elderly women living in northern Europe have low winter vitamin D status - European Journal of Clinical Nutrition - Abstract of article
Teenage girls and elderly women living in northern Europe have low winter vitamin D status.
Andersen R, Mølgaard C, Skovgaard LT, Brot C, Cashman KD, Chabros E, Charzewska J, Flynn A, Jakobsen J, Kärkkäinen M, Kiely M, Lamberg-Allardt C, Moreiras O, Natri AM, O'brien M, Rogalska-Niedzwiedz M, Ovesen L.
Eur J Clin Nutr. 2005 Apr;59(4):533-41.
PMID: 15714215
doi:10.1038/sj.ejcn.1602108
CONCLUSION: Vitamin D status is low in northern Europe during winter. More than one-third of the adolescent girls have vitamin D status below 25 nmol/l and almost all are below 50 nmol/l. Two-thirds of the elderly community-dwelling women have vitamin D status below 50 nmol/l. Use of vitamin D supplements is a significant positive determinant for S-25OHD for both girls and women (P = 0.001). SPONSORSHIP: The European Fifth Framework Programme (Contract No. QLK1-CT-2000-00623)
Differences in vitamin D status between countries in young adults and the elderly
Differences in vitamin D status between countries in young adults and the elderly.
McKenna MJ.
Am J Med. 1992 Jul;93(1):69-77.
PMID: 1385673
PURPOSE: To compare vitamin D status between countries in young adults and in the elderly. MATERIALS AND METHODS: Reports on vitamin D status (as assessed by serum 25-hydroxyvitamin D) from 1971 to 1990 were reviewed. Studies were grouped according to geographic regions: North America (including Canada and the United States); Scandinavia (including Denmark, Finland, Norway, and Sweden); and Central and Western Europe (including Belgium, France, Germany, Ireland, The Netherlands, Switzerland, and the United Kingdom). RESULTS: Vitamin D status varies with the season in young adults and in the elderly, and is lower during the winter in Europe than in both North America and Scandinavia. Oral vitamin D intake is lower in Europe than in both North America and Scandinavia. Hypovitaminosis D and related abnormalities in bone chemistry are most common in elderly residents in Europe but are reported in all elderly populations. CONCLUSIONS: The vitamin D status in young adults and the elderly varies widely with the country of residence. Adequate exposure to summer sunlight is the essential means to ample supply, but oral intake augmented by both fortification and supplementation is necessary to maintain baseline stores. All countries should adopt a fortification policy. It seems likely that the elderly would benefit additionally from a daily supplement of 10 micrograms of vitamin D.
Low serum 25-hydroxyvitamin D concentrations and secondary hyperparathyroidism in middle-aged white strict vegetarians -- Lamberg-Allardt et al. 58 (5): 684 -- American Journal of Clinical Nutrition
Low serum 25-hydroxyvitamin D concentrations and secondary hyperparathyroidism in middle-aged white strict vegetarians.
Lamberg-Allardt C, Kärkkäinen M, Seppänen R, Biström H.
Am J Clin Nutr. 1993 Nov;58(5):684-9.
PMID: 8237875
In conclusion, white strict vegetarians are at risk of vitamin D deficiency, at least in the winter, primarily because of a low dietary vitamin D intake, despite a normal sunlight exposure in summer. Low serum 25(OH)D concentrations are accompanied by high S-iPTH concentrations, which also are affected by a low calcium intake. The effect of these changes on bone health remains to be evaluated.
Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland). - Cancer Causes Control. 2000 Oct;11(9):847-52. - SpringerLink - Journal Article
Prostate cancer risk and prediagnostic serum 25-hydroxyvitamin D levels (Finland).
Ahonen MH, Tenkanen L, Teppo L, Hakama M, Tuohimaa P.
Cancer Causes Control. 2000 Oct;11(9):847-52.
PMID: 11075874
DOI: 10.1023/A:1008923802001
CONCLUSIONS: We conclude that low levels of 25-VD associated with an increased risk for subsequent earlier exposure and more aggressive development of prostate cancer, especially before the andropause.
Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density -- Outila et al. 74 (2): 206 -- American Journal of Clinical Nutrition
Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density.
Outila TA, Kärkkäinen MU, Lamberg-Allardt CJ.
Am J Clin Nutr. 2001 Aug;74(2):206-10.
PMID: 11470722
Conclusion: A large percentage of adolescent females have low vitamin D status during the winter in Finland, which seems to have negative effects on bone health.
A high prevalence of hypovitaminosis D in Finnish medical in- and outpatients. - J Intern Med. 2001 Jun;249(6):559-63. - Wiley InterScience :: Article :: HTML Full Text
A high prevalence of hypovitaminosis D in Finnish medical in- and outpatients.
Kauppinen-Mäkelin R, Tähtelä R, Löyttyniemi E, Kärkkäinen J, Välimäki MJ.
J Intern Med. 2001 Jun;249(6):559-63.
PMID: 11422663
DOI: 10.1046/j.1365-2796.2001.00847.x
CONCLUSION: Hypovitaminosis D is very common amongst Finnish in- and outpatients in both sexes, causing secondary hyperparathyroidism in females. More extensive studies are warranted to elucidate the vitamin D status of the Finnish population.
Vitamin D deficiency and bone health in healthy adults in Finland: could this be a concern in other parts of Europe? - .[J Bone Miner Res. 2001] - PubMed Result
Vitamin D deficiency and bone health in healthy adults in Finland: could this be a concern in other parts of Europe?
Lamberg-Allardt CJ, Outila TA, Kärkkainen MU, Rita HJ, Valsta LM.
J Bone Miner Res. 2001 Nov;16(11):2066-73.
PMID: 11697803
Low vitamin D status was prevalent in these young adults in northern Europe in winter, although the vitamin D intake met the recommendation. This probably is not a local problem for northern Europe, because the natural sources of vitamin D are scarce and fortification is not very common in Europe, and with the exception of the southern part of Europe, sunshine is not very abundant in this part of the world. Thus, the results of this study indicate that more attention should be focused on vitamin D status and the sources of vitamin D in these countries.
Half of the patients with an acute hip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland. - Osteoporos Int. 2005 Dec;16(12):2018-24. - SpringerLink - Journal Article
Half of the patients with an acute hip fracture suffer from hypovitaminosis D: a prospective study in southeastern Finland.
Nurmi I, Kaukonen JP, Lüthje P, Naboulsi H, Tanninen S, Kataja M, Kallio ML, Leppilampi M.
Osteoporos Int. 2005 Dec;16(12):2018-24. Epub 2005 Aug 24.
PMID: 16133642
Half of the patients with a hip fracture suffered from hypovitaminosis D. The situation was worst in institutional and residential care, although there are personnel for taking care of vitamin D supplementation. In the late summer, one-third and in late winter two-thirds of the patients suffered from hypovitaminosis D. The geographical location of Finland indicates extensive efforts to increase the use of vitamin D supplements among elderly.
Vitamin D fortification as public health policy: significant improvement in vitamin D status in young Finnish men - European Journal of Clinical Nutrition - Abstract of article
Vitamin D fortification as public health policy: significant improvement in vitamin D status in young Finnish men.
Laaksi IT, Ruohola JP, Ylikomi TJ, Auvinen A, Haataja RI, Pihlajamäki HK, Tuohimaa PJ.
Eur J Clin Nutr. 2006 Aug;60(8):1035-8. Epub 2006 Feb 15.
PMID: 16482069
Development of a model for optimal food fortification: vitamin D among adults in Finland. - Eur J Nutr. 2007 Aug;46(5):264-70. - SpringerLink - Journal Article
Development of a model for optimal food fortification: vitamin D among adults in Finland.
Hirvonen T, Sinkko H, Valsta L, Hannila ML, Pietinen P.
Eur J Nutr. 2007 Aug;46(5):264-70. Epub 2007 May 18.
PMID: 17514377
Are sunlight deprivation and influenza epidemics associated with the onset of acute leukemia? -- Timonen et al. 92 (11): 1553 -- Haematologica
Are sunlight deprivation and influenza epidemics associated with the onset of acute leukemia?
Timonen T, Näyhä S, Koskela T, Pukkala E.
Haematologica. 2007 Nov;92(11):1553-6.
PMID: 18024404
doi:10.3324/haematol.10799
Month of diagnosis of 7,423 cases of acute leukemia (AL) in Finland during 1964–2003 were linked with data on influenza and solar radiation. Acute myeloblastic leukemia (AML) showed the highest risk in the dark season. During the light season, the incidence decreased by 58% (95% confidence interval, 16–79%) per 1,000 kJ/m2/d increase of solar radiation. Independent of solar radiation, AML increased by 9% (95% confidence interval, 0–19%) during influenza epidemics. Reoccurring at the same time annually, darkness-related vitamin D deficiency and influenza could cause successive and co-operative mutations leading to AL with a short latency.
Vitamin D Status and the Risk of Lung Cancer: A Cohort Study in Finland — Cancer Epidemiology, Biomarkers & Prevention
Vitamin D status and the risk of lung cancer: a cohort study in Finland.
Kilkkinen A, Knekt P, Heliövaara M, Rissanen H, Marniemi J, Hakulinen T, Aromaa A.
Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3274-8.
PMID: 18990771v
In conclusion, although there was no overall association between vitamin D and lung cancer risk, women and young participants with a higher level of vitamin D were observed to have a lower lung cancer risk. Although experimental data support the suppressing effect of vitamin D on the development of lung cancer, large epidemiologic studies from different populations with repeated measurements of vitamin D are warranted to confirm this finding. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3274–8)
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