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African Americans, 25-hydroxyvitamin D, and osteoporosis: a paradox.
Aloia JF.
Am J Clin Nutr. 2008 Aug;88(2):545S-550S. Review.
PMID: 18689399

African Americans have lower serum 25-hydroxyvitamin D concentrations and a lower risk of fragility fractures than do other populations. I review the evidence on factors other than vitamin D that might explain this paradox and the calcium economy in different life stages.

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2008 August ajcn study review Aloia African Americans black humans 25ohd calcidiol vitamin_D status osteoporosis bone health paradox fractures nutrition fracture risk medline blacks African_Americans skin color

Statins and vitamin D.
Aloia JF, Li-Ng M, Pollack S.
Am J Cardiol. 2007 Oct 15;100(8):1329. Epub 2007 Jul 5. No abstract available.
PMID: 17920383

A total of 208 women were randomized to receive vitamin D3 (n=104) or placebo (n=104). 51 women were on statins. At baseline, the subjects on statins had a significantly higher 25-OHD level than the subjects who were not on statins (51.2 ± 20.1 nmol/L versus 43.2 ± 18.0 nmol/L respectively, p=0.008). This was also true when averaging 25-OHD levels across the 3-year study period and looking at active and placebo patients separately. 185 subjects had follow-up 25-OHD levels drawn every 6 months during the study. Higher levels were seen in the statin use subgroup whether they were on placebo or active vitamin D (Figure 1Figure 1). There was no interaction seen between vitamin D use and statin use, i.e. the impacts are additive (p=0.5502). This significant difference is comparable to the increase in 25-OHD levels seen in Pérez-Castrillón's study (41 ± 19 versus 47 ± 19 nmol/L, p=0.003) [1]. Although Pérez-Castrillón et al found a statistically significant relation between total cholesterol and 25-OHD (r=0.277, p=0.002), we did not find a significant relation between total cholesterol and 25-OHD in our study population.

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2007 October study letter comment review Aloia humans vitamin_D statins statin use 25ohd atorvastatin nutrition medline

Vitamin D intake to attain a desired serum 25-hydroxyvitamin D concentration.
Aloia JF, Patel M, Dimaano R, Li-Ng M, Talwar SA, Mikhail M, Pollack S, Yeh JK.
Am J Clin Nutr. 2008 Jun;87(6):1952-8.
PMID: 18541590

The mean daily dose was 86 microg (3440 IU). The use of computer simulations to obtain the most participants within the range of 75-220 nmol/L predicted an optimal daily dose of 115 microg/d (4600 IU). No hypercalcemia or hypercalciuria was observed. CONCLUSIONS: Determination of the intake required to attain serum 25(OH)D concentrations >75 nmol/L must consider the wide variability in the dose-response curve and basal 25(OH)D concentrations. Projection of the dose-response curves observed in this convenience sample onto the population of the third National Health and Nutrition Examination Survey suggests a dose of 95 microg/d (3800 IU) for those above a 25(OH)D threshold of 55 nmol/L and a dose of 125 microg/d (5000 IU) for those below that threshold.

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2008 June ajcn study research clinical_trial rct humans Aloia vitamin_D 25ohd supplementation dosing dosage dose-response requirement need nutrition medline

A randomized controlled trial of vitamin D3 supplementation for the prevention of symptomatic upper respiratory tract infections.
Li-Ng M, Aloia JF, Pollack S, Cunha BA, Mikhail M, Yeh J, Berbari N.
Epidemiol Infect. 2009 Mar 19:1-9. [Epub ahead of print]
PMID: 19296870

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2009 March study research clinical_trial rct humans adults vitamin_D supplemenration cold common common_cold flu URI prevention nutrition medline 25ohd Aloia