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Twice single doses of 100,000 IU of vitamin D in winter is adequate and safe for prevention of vitamin D deficiency in healthy children from Ushuaia, Tierra Del Fuego, Argentina - ScienceDirect - The Journal of Steroid Biochemistry and Molecular Biology
Twice single doses of 100,000 IU of vitamin D in winter is adequate and safe for prevention of vitamin D deficiency in healthy children from Ushuaia, Tierra Del Fuego, Argentina.
Tau C, Ciriani V, Scaiola E, Acuña M.
J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):651-4. Epub 2007 Jan 25.
PMID: 17257830
doi:10.1016/j.jsbmb.2006.12.027
These results disclosed that to prevent vitamin D deficiency for children at zones of risk at the south of our country, double supplementation of 100,000 IU of vitamin D during autumn and winter, would be adequate and safe.
Vitamin D association with estradiol and progesterone in young women - Cancer Causes Control. 2009 Nov 15 - SpringerLink - Journal Article
Vitamin D association with estradiol and progesterone in young women.
Knight JA, Wong J, Blackmore KM, Raboud JM, Vieth R.
Cancer Causes Control. 2009 Nov 15. [Epub ahead of print]
PMID: 19916051
Conclusions Higher levels of vitamin D may reduce progesterone and estradiol, providing a potential mechanism for reduction in breast cancer risk from increased vitamin D exposure in young women
Lack of vitamin D may increase heart disease risk
"DALLAS, Jan. 8 — The same vitamin D deficiency that can result in weak bones now has been associated with an increased risk of cardiovascular disease, Framingham Heart Study researchers report in Circulation: Journal of the American Heart Association.
“Vitamin D deficiency is associated with increased cardiovascular risk, above and beyond established cardiovascular risk factors,” said Thomas J. Wang, M.D., assistant professor of medicine at Harvard Medical School in Boston, Mass. “The higher risk associated with vitamin D deficiency was particularly evident among individuals with high blood pressure.”
In a study of 1,739 offspring from Framingham Heart Study participants (average age 59, all Caucasian), researchers found that those with blood levels of vitamin D below15 nanograms per milliliter (ng/mL) had twice the risk of a cardiovascular event such as a heart attack, heart failure or stroke in the next five years compared to those with higher levels of vitamin D."
Low vitamin D levels associated with several risk factors in teenagers
"• Low levels of vitamin D were associated with increased risk of high blood pressure, high blood sugar and metabolic syndrome in teenagers.
• The highest levels of vitamin D were found in whites, the lowest levels in blacks and intermediate levels in Mexican-Americans.
PALM HARBOR, Fla., March 11, 2009 — Low levels of vitamin D were associated with an increased risk of high blood pressure, high blood sugar and metabolic syndrome in teenagers, researchers reported at the American Heart Association’s 49th Annual Conference on Cardiovascular Disease Epidemiology and Prevention."
Vitamin D Deficiency and Risk of Cardiovascular Disease -- Wang et al. 117 (4): 503 -- Circulation
Vitamin D deficiency and risk of cardiovascular disease.
Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, Benjamin EJ, D'Agostino RB, Wolf M, Vasan RS.
Circulation. 2008 Jan 29;117(4):503-11. Epub 2008 Jan 7.
PMID: 18180395
doi: 10.1161/CIRCULATIONAHA.107.706127
Conclusions— Vitamin D deficiency is associated with incident cardiovascular disease. Further clinical and experimental studies may be warranted to determine whether correction of vitamin D deficiency could contribute to the prevention of cardiovascular disease.
Vitamin D Shows Heart Benefits in Study - Well Blog - NYTimes.com
"A new study suggests many Americans aren’t getting anywhere nearly enough of the vitamin, and it may be affecting their heart health.
In the study, researchers looked at tens of thousands of healthy adults 50 and older whose vitamin D levels had been measured during routine checkups. A majority, they found, were deficient in the vitamin. About two-thirds had less vitamin D in their bloodstreams than the authors considered healthy, and many were extremely deficient.
Less than two years later, the researchers found, those who had extremely low levels of the vitamin were almost twice as likely to have died or suffered a stroke than those with adequate amounts. They also had more coronary artery disease and were twice as likely to have developed heart failure.
The findings, which are being presented today at an American Heart Association conference in Orlando, don’t prove that lack of vitamin D causes heart disease; they only suggest a link between the two. "
Safety of vitamin D3 in adults with multiple sclerosis -- Kimball et al. 86 (3): 645 -- American Journal of Clinical Nutrition
Safety of vitamin D3 in adults with multiple sclerosis.
Kimball SM, Ursell MR, O'Connor P, Vieth R.
Am J Clin Nutr. 2007 Sep;86(3):645-51.
PMID: 17823429
Conclusions: Patients' serum 25(OH)D concentrations reached twice the top of the physiologic range without eliciting hypercalcemia or hypercalciuria. The data support the feasibility of pharmacologic doses of vitamin D3 for clinical research, and they provide objective evidence that vitamin D intake beyond the current upper limit is safe by a large margin.
Vitamin D and MS
"This website is about Vitamin D and MS
Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS), with an uncertain cause. Colleen Hayes and Donald Achaeson have suggested that insufficient sunlight exposure and chronic viral infections might be unrelated environmental risk factors for MS. These risk factors may act synergistically to enable the pathogenic autoimmune response.
The prevalence of MS is highest where environmental supplies of vitamin D are lowest. Sunshine enables the production of vitamin D3 (VD3) in the skin. Epidemiological studies have shown that higher vitamin D blood levels are associated with lower risk, less relapses and a slower progression of multiple sclerosis. Higher vitamin D levels can be achieved in part by increased oral intake of VD3.
Optimal health requires serum 25 hydroxyvitamin D levels higher than 20 ng/ml (50 nmol/L) P Lips, 40 ng/ml (100 nmol/L) P Heaney or at least 40 ng/ml (100 nmol/L) R Vieth. "
Vitamin D and cognitive performance in adults: a systematic review. - Eur J Neurol. 2009 Oct;16(10):1083-9. - Wiley InterScience :: Article :: HTML Full Text
Vitamin D and cognitive performance in adults: a systematic review.
Annweiler C, Allali G, Allain P, Bridenbaugh S, Schott AM, Kressig RW, Beauchet O.
Eur J Neurol. 2009 Oct;16(10):1083-9. Epub 2009 Jul 29.
PMID: 19659751
DOI: 10.1111/j.1468-1331.2009.02755.x
This systematic review shows that the association between serum 25OHD concentrations and cognitive performance is not yet clearly established. The inconclusive results of the reviewed studies could be due to methodology, types of the cognitive tasks used and/or the cellular mechanisms of vitamin D.
Higher Levels of Vitamin D May Be Associated with a Lower Risk of Lung Cancer in Women and Younger Subjects by Derrick DeSilva Jr., M.D. - Alternative Health Blog - Alternative Health Journal
"In a prospective study involving 6,937 men and women, higher levels of vitamin D were associated with a significantly lower risk of lung cancer in women and younger participants. During a maximum follow-up of 24 years, 122 cases of lung cancer were identified. After adjusting for potential confounders, higher serum 25-hydroxyvitamin D levels were associated with reduced risk of lung cancer risk in women (84% reduced risk) and younger participants (66% reduced risk). No association was observed between vitamin D status and lung cancer risk in men and older participants. "
ACS :: Vitamin D Has Role in Colon Cancer Prevention
"Vitamin D may be more important to colon cancer prevention than previously believed, according to a study published in the Journal of the American Medical Association (Vol. 290, No. 22: 2959-2967).
The study examined people with no symptoms of colon cancer to determine what role diet, exercise, smoking, and other behaviors played in the development or not of colon polyps, small growths in the colon that can turn into cancer if they aren't removed."
Prevalence of low serum vitamin D concentration in an urban population of elderly women in Poland. - [Pol Arch Med Wewn. 2009] - PubMed result
Prevalence of low serum vitamin D concentration in an urban population of elderly women in Poland.
Napiórkowska L, Budlewski T, Jakubas-Kwiatkowska W, Hamzy V, Gozdowski D, Franek E.
Pol Arch Med Wewn. 2009 Nov;119(11):699-703.
PMID: 19920793
CONCLUSIONS: The prevalence of low vitamin D concentrations in an urban population of elderly women in Poland is very high. Lower vitamin D levels are associated with a higher PTH concentration
Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer in elderly men. - [Cancer Causes Control. 2009] - PubMed result
Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer in elderly men.
Tang JY, Parimi N, Wu A, John Boscardin W, Shikany JM, Chren MM, Cummings SR, Epstein EH Jr, Bauer DC; for the Osteoporotic Fractures in Men (MrOS) Study Group.
Cancer Causes Control. 2009 Nov 18. [Epub ahead of print]
PMID: 19921445
Our results suggest that a diagnosis of NMSC is not a surrogate for adequate 25(OH)D levels or increased UV exposure, and high 25(OH)D levels may be associated with a reduced risk of NMSC.
Vitamin D could ease symptoms for MS sufferers - ABC News (Australian Broadcasting Corporation)
"Posted Tue Nov 17, 2009 4:01pm AEDT
Updated Tue Nov 17, 2009 4:27pm AEDT
Researchers are advising people with MS to take safe levels of vitamin D supplements.
Researchers are advising people with MS to take safe levels of vitamin D supplements. (ABC News: Giulio Saggin, file photo)
* Audio: New research shows Vitamin D may slow the progress of MS (The World Today)
Australian scientists have found that Vitamin D may slow the progression of multiple sclerosis (MS).
Figures showing that people living in Tasmania are seven times more likely to develop MS than Queenslanders had suggested a link between sunlight exposure and the disease. "
Vitamin D association with estradiol and progesterone in young women. - [Cancer Causes Control. 2009] - PubMed result
Vitamin D association with estradiol and progesterone in young women.
Knight JA, Wong J, Blackmore KM, Raboud JM, Vieth R.
Cancer Causes Control. 2009 Nov 15. [Epub ahead of print]
PMID: 19916051
CONCLUSIONS: Higher levels of vitamin D may reduce progesterone and estradiol, providing a potential mechanism for reduction in breast cancer risk from increased vitamin D exposure in young women.
New study links vitamin D deficiency to cardiovascular disease and death
"Study finds inadequate levels of Vitamin D may significantly increase risk of stroke, heart disease and death
MURRAY, UT – While mothers have known that feeding their kids milk builds strong bones, a new study by researchers at the Heart Institute at Intermountain Medical Center in Salt Lake City suggests that Vitamin D contributes to a strong and healthy heart as well – and that inadequate levels of the vitamin may significantly increase a person's risk of stroke, heart disease, and death, even among people who've never had heart disease.
For more than a year, the Intermountain Medical Center research team followed 27,686 patients who were 50 years of age or older with no prior history of cardiovascular disease. The participants had their blood Vitamin D levels tested during routine clinical care. The patients were divided into three groups based on their Vitamin D levels – normal (over 30 nanograms per milliliter), low (15-30 ng/ml), or very low (less than 15 ng/ml). The patients were then followed to see if they developed some form of heart disease."
Vitamin D and cardiovascular disease risk : Current Opinion in Clinical Nutrition & Metabolic Care
Vitamin D and cardiovascular disease risk.
Michos ED, Melamed ML.
Curr Opin Clin Nutr Metab Care. 2008 Jan;11(1):7-12. Review.
PMID: 18090651
doi: 10.1097/MCO.0b013e3282f2f4dd
Summary: Vitamin D deficiency is easy to screen for and easy to treat with supplementation. Further larger observational studies and randomized clinical trials are, however, needed to determine whether vitamin D supplementation could have any potential benefit in reducing future cardiovascular disease events and mortality risk.
Arch Intern Med -- 25-Hydroxyvitamin D Levels and the Risk of Mortality in the General Population, Aug 11/25, 2008, Melamed et al. 168 (15): 1629 (full text)
25-hydroxyvitamin D levels and the risk of mortality in the general population.
Melamed ML, Michos ED, Post W, Astor B.
Arch Intern Med. 2008 Aug 11;168(15):1629-37.
PMID: 18695076
Conclusion The lowest quartile of 25(OH)D level (<17.8 ng/mL) is independently associated with all-cause mortality in the general population.
Meta-analysis of vitamin D, calcium and the prevention of breast cancer. - [Breast Cancer Res Treat. 2009] - PubMed Result
Meta-analysis of vitamin D, calcium and the prevention of breast cancer.
Chen P, Hu P, Xie D, Qin Y, Wang F, Wang H.
Breast Cancer Res Treat. 2009 Oct 23. [Epub ahead of print]
PMID: 19851861
These results provide strong evidence that vitamin D and calcium have a chemopreventive effect against breast cancer.
Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women -- Richards et al. 86 (5): 1420 -- American Journal of Clinical Nutrition
Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women.
Richards JB, Valdes AM, Gardner JP, Paximadas D, Kimura M, Nessa A, Lu X, Surdulescu GL, Swaminathan R, Spector TD, Aviv A.
Am J Clin Nutr. 2007 Nov;86(5):1420-5.
PMID: 17991655
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