Matti Narkia's Library tagged 2007 →  View Popular

"We often get requests to provide an easy-to-understand explanation for why increasing CO2 is a significant problem without relying on climate models and we are generally happy to oblige. The explanation has a number of separate steps which tend to sometimes get confused and so we will try to break it down carefully."

www.realclimate.org/...he-co2-problem-in-6-easy-steps - Preview

2007 August realclimate blog_article CO2 problem global warming global_warming climate change climate_change environment

Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions.
Pereira GC, Branco AF, Matos JA, Pereira SL, Parke D, Perkins EL, Serafim TL, Sardão VA, Santos MS, Moreno AJ, Holy J, Oliveira PJ.
J Pharmacol Exp Ther. 2007 Nov;323(2):636-49. Epub 2007 Aug 17.
PMID: 17704354
doi: 10.1124/jpet.107.128017

The present work shows that berberine is accumulated by mitochondria of a mouse melanoma cell line, leading to mitochondrial fragmentation and dysfunction, accompanied by decreased cellular energy charge. When the effect was compared with the results obtained on isolated mitochondrial fractions, it is observed that regardless of the system used, berberine is toxic for mitochondria. One major limitation of the present study (as in many others) is the lack of knowledge of the real concentration of berberine that reaches mitochondria in intact cells. Although we do not possess data regarding this aspect, it is wise to speculate that mitochondrial berberine concentrations will be much higher than in the bulk cytosol due to electrophoretic accumulation. We believe that the range of berberine concentrations accumulated by mitochondria in intact cells is within the range of concentrations used on isolated mitochondrial fractions in the present study. The present work not only provides insights on the mechanism by which berberine interferes with tumor cell proliferation, demonstrating previously unknown effects on mitochondrial physiology, but also raises a note of caution on the use of berberine as a nontoxic “natural” over-the-counter medication.

jpet.aspetjournals.org/...636.full - Preview

2007 November jpet study research in_vivo animal_study in_vitro Berberine melanoma cancer mitochondria anti-cancer herb herbs nutrition medline

Dietary cod protein improves insulin sensitivity in insulin-resistant men and women: a randomized controlled trial.
Ouellet V, Marois J, Weisnagel SJ, Jacques H.
Diabetes Care. 2007 Nov;30(11):2816-21. Epub 2007 Aug 6.
PMID: 17682120

CONCLUSIONS - Dietary cod protein improves insulin sensitivity in insulin-resistant individuals and thus could contribute to prevention of type 2 diabetes by reducing the metabolic complications related to insulin resistance.

care.diabetesjournals.org/...2816.long - Preview

2007 November study research clinical_trial rct humans insulin-resistant subjects cod protein fish cod_protein fish_protein insulin sensitivity insulin_sensitivity nutrition type_2 diabetes medline

Sweat gland epithelial and myoepithelial cells are vitamin D targets.
Koike N, Stumpf WE.
Exp Dermatol. 2007 Feb;16(2):94-7.
PMID: 17222221
DOI: 10.1111/j.1600-0625.2006.00513.x

Nuclear receptor binding of 1,25(OH)2-vitamin D3 (vitamin D) in skin keratinocytes of epidermis, hair sheaths and sebaceous glands was discovered through receptor microscopic autoradiography. Extended experiments with 3H-1,25(OH)2-vitamin D3 and its analog 3H-oxacalcitriol (OCT) now demonstrate nuclear receptor binding in sweat gland epithelium of secretory coils and ducts as well as in myoepithelial cells, as studied in paws of nude mice after i.v. injection. The results suggest genomic regulation of cell proliferation and differentiation, as well as of secretory and excretory functions, indicating potential therapies for impaired secretion as in hypohidrosis of aged and diseased skin.

www3.interscience.wiley.com/...HTMLSTART - Preview

2007 February study research in_vivo animal_study autoradiography skin Sweat gland epithelial glands myoepithelial cells vitamin_D targets VDR 1.25(OH)2D calcitriol nutrition

Twice single doses of 100,000 IU of vitamin D in winter is adequate and safe for prevention of vitamin D deficiency in healthy children from Ushuaia, Tierra Del Fuego, Argentina.
Tau C, Ciriani V, Scaiola E, Acuña M.
J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):651-4. Epub 2007 Jan 25.
PMID: 17257830
doi:10.1016/j.jsbmb.2006.12.027

These results disclosed that to prevent vitamin D deficiency for children at zones of risk at the south of our country, double supplementation of 100,000 IU of vitamin D during autumn and winter, would be adequate and safe.

www.sciencedirect.com/science - Preview

2007 March study reserach clinical_trial humans children vitamin_D deficiency prevention 25ohd winter Ushuaia Tierra_Del_Fuego nutrition medline high-dose supplementation twice single doses two Argentina

Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials.
Rosenfeldt FL, Haas SJ, Krum H, Hadj A, Ng K, Leong JY, Watts GF.
J Hum Hypertens. 2007 Apr;21(4):297-306. Epub 2007 Feb 8.
PMID: 17287847

We conclude that coenzyme Q10 has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side effects.

www.nature.com/...1002138a.html - Preview

2007 April study review meta-analysis clinical_trials humans Coenzyme Q10 Coenzyme_Q10 hypertension nutrtion medline blood_pressure bp CVD ubiquinone ubidecarenone coq10

"Ihan hyviä neuvoja.On ehkä kuitenkin hyvä palauttaa mieliin myös se,
että verisuonten sisäseinämien rasvoittuminen ja/tai kalkkiutuminen on
ateroskleroosin myöhäisvaihe, jota sitäkin tietysti kannattaa yrittää
estää tai ainakin hidastaa, Ymmärtääkseni nykykäsityksen mukaan
ateroskleroosi ei kuitenkaan suinkaan ala verisuonen sisäkalvolta,
vaan verisuonen seinämän sisältä: "

groups.google.com/...49056e0dbc2b204c - Preview

2007 lokakuu groups.google groups google sfnet.keskustelu.terveys Narkia ateroskleroosi SVT

"Karppaus on elämäntapa lohjalaiselle Majamäen perheelle. Ruokapöydässä on tarjolla useimmiten lihaa ja kalaa, raikkaita salaatteja ja vihanneksia.
7-vuotias Johannes ja maaliskuussa neljä vuotta täyttävä Mikael syövät päiväkodissa ja koulussa samaa ruokaa kuin muutkin lapset, mutta noudattavat kotona vanhempiensa tavoin hiilihydraattitietoista ruokavaliota.
-Kenenkään terveyttä ei kaada, jos viikon 21:stä ruokailusta viisi on kouluaterioita. Pääasia on, että kotiruokailu on kunnossa, Mirka Majamäki sanoo.
Alunperin hän kiinnostui Antti Heikkilän ravitsemusohjeista, mutta kuvailee nykyisin itseään "omatekoiseksi karpiksi", joka etsii tietoa kirjoista ja internetistä. Vaikutteita kertyy myös Italian, Kiinan ja Japanin kiehtovista ruokakulttuureista.

Kiinalainen ruoka kiinnostaa

Mirka majamäki on ravintoon erikoistunut antropologi ja teki gradunsakin kiinalaisesta ateriasta.
Hän tutustui puolen vuoden ajan paikallisiin tapoihin pääasiassa Pekingissä ja muistelee yhä miehensä Hannun kanssa sikäläisten raaka-aineiden taattua tuoreutta: ravintolassa kanalta katkaistiin kaula vasta tilauksen jälkeen ja kalat nostettiin elävinä haavilla altaasta.
Karpeille kiinalainen ruoka sopii mainiosti.
-Eihän siitä tarvitse jättää kuin riisi pois, Mirka neuvoo.
-Kiinassa riisi tulee pöytään vasta viimeisenä, eikä sitä syödä juhla-aterioilla ollenkaan.
Pariskunta ostaa mahdollisimman suuren osan ruokatarvikkeista lähikaupasta, mutta hakee aasialaiset erikoisuudet Helsingistä. Samalla reissulla voi poiketa Hakaniemen halliin etsimään luista naudanlihaa, lampaan munuaisia, broilerin kivipiiroja tai muuta harvinaisempaa herkku"

karppaus.info/...viewtopic.php - Preview

2007 TS Viikkoliite Extra: karppaus VHH Mirka Majamäki hiilaritietoisuus vähähiilihydraattinen ruokavalio

n-3 Fatty acids and cardiovascular disease: actions and molecular mechanisms.
Torrejon C, Jung UJ, Deckelbaum RJ.
Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec;77(5-6):319-26. Epub 2007 Dec 3. Review. Erratum in: Prostaglandins Leukot Essent Fatty Acids. 2008 Feb;78(2):157.
PMID: 18060753
doi: 10.1016/j.plefa.2007.10.014.

In conclusion, a growing body of evidence, encompassing human to cellular and molecular studies are defining the roles for n-3 FA as bioactive agents for reducing the risks of and treating CVD.

www.ncbi.nlm.nih.gov/...PMC2386438 - Preview

2007 November study review humans omega-3 CVD atherosclerosis actions molecular mechanisms molecular_mechanisms nutrition medline biological effects mechanism plaque stabilization stability plaques atherosclerotic atheroma bioactive agents risk

Fatty acid intake and the risk of community-acquired pneumonia in U.S. women.
Alperovich M, Neuman MI, Willett WC, Curhan GC.
Nutrition. 2007 Mar;23(3):196-202. Epub 2007 Jan 22.
PMID: 17236748
doi: 10.1016/j.nut.2006.11.007.

Conclusions
Fatty acid intake may affect the risk of community-acquired pneumonia in young and middle-aged women. Higher dietary intake of palmitic acid and possibly DHA and EPA may increase the risk of community-acquired pneumonia in women while higher oleic acid intake may decrease the risk.

www.ncbi.nlm.nih.gov/...PMC2293281 - Preview

2007 March study research epidemiological humans women fatty acid acids intake omega-3 EPA DHA fish_oil palmitic_acid community-acquired pneumonia risk pneumonia_risk Willett nutrition medline oleic_acid olive_oil

Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats.
Schurgers LJ, Spronk HM, Soute BA, Schiffers PM, DeMey JG, Vermeer C.
Blood. 2007 Apr 1;109(7):2823-31.
PMID: 17138823
DOI 10.1182/blood-2006-07-035345.

This is the first study in rats demonstrating that AC and the resulting decreased arterial distensibility are reversible by high-VK intakenstrating that AC and the resulting decreased arterial distensibility are reversible by high-VK intake

bloodjournal.hematologylibrary.org/...2823 - Preview

2007 April Blood study research in_vivo animal_study arterial_calcification arterial calcification Matrix Gla protein MGP vitamin_K vitamin_K2 vitamin_K1 reversible reversed reversal warfarin nutrition medline regression warfarin-induced arteries CVD CHD

"18 645 patients with a total cholesterol of 6·5 mmol/L or greater were recruited from local physicians throughout Japan between 1996 and 1999. Patients were randomly assigned to receive either 1800 mg of EPA daily with statin (EPA group; n=9326) or statin only (controls; n=9319) with a 5-year follow-up. The primary endpoint was any major coronary event, including sudden cardiac death, fatal and non-fatal myocardial infarction, and other non-fatal events including unstable angina pectoris, angioplasty, stenting, or coronary artery bypass grafting. Analysis was by intention-to-treat.
Findings
At mean follow-up of 4·6 years, we detected the primary endpoint in 262 (2·8%) patients in the EPA group and 324 (3·5%) in controls—a 19% relative reduction in major coronary events (p=0·011). Post-treatment LDL cholesterol concentrations decreased 25%, from 4·7 mmol/L in both groups. Serum LDL cholesterol was not a significant factor in a reduction of risk for major coronary events. Unstable angina and non-fatal coronary events were also significantly reduced in the EPA group. Sudden cardiac death and coronary death did not differ between groups. In patients with a history of coronary artery disease who were given EPA treatment, major coronary events were reduced by 19% (secondary prevention subgroup: 158 [8·7%] in the EPA group vs 197 [10·7%] in the control group; p=0·048). In patients with no history of coronary artery disease, EPA treatment reduced major coronary events by 18%, but this finding was not significant (104 [1·4%] in the EPA group vs 127 [1·7%] in the control group; p=0·132)."

forums.rusmedserv.com/showthread.php - Preview

2007 April news JELIS Japan EPA omega-3 trial Japanese CVD CHD prevention nutrition statin statins

The polyp prevention trial continued follow-up study: no effect of a low-fat, high-fiber, high-fruit, and -vegetable diet on adenoma recurrence eight years after randomization.
Lanza E, Yu B, Murphy G, Albert PS, Caan B, Marshall JR, Lance P, Paskett ED, Weissfeld J, Slattery M, Burt R, Iber F, Shike M, Kikendall JW, Brewer BK, Schatzkin A; Polyp Prevention Trial Study Group.
Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1745-52.
PubMed PMID: 17855692
doi: 10.1158/1055-9965.EPI-07-0127

his study failed to show any effect of a low-fat, high-fiber, high-fruit and -vegetable eating pattern on adenoma recurrence even with 8 years of follow-up.

cebp.aacrjournals.org/...1745.long - Preview

2007 September study research clnical_trial rct Polyp Prevention Trial PPT follow-up no effect no_effect high fiber fruit vegetable vegetables Adenoma Recurrence nutrition medline colorectal cancer

Influence of a diet very high in vegetables, fruit, and fiber and low in fat on prognosis following treatment for breast cancer: the Women's Healthy Eating and Living (WHEL) randomized trial.
Pierce JP, Natarajan L, Caan BJ, Parker BA, Greenberg ER, Flatt SW, Rock CL, Kealey S, Al-Delaimy WK, Bardwell WA, Carlson RW, Emond JA, Faerber S, Gold EB, Hajek RA, Hollenbach K, Jones LA, Karanja N, Madlensky L, Marshall J, Newman VA, Ritenbaugh C, Thomson CA, Wasserman L, Stefanick ML.
JAMA. 2007 Jul 18;298(3):289-98.
PMID: 17635889

Conclusion Among survivors of early stage breast cancer, adoption of a diet that was very high in vegetables, fruit, and fiber and low in fat did not reduce additional breast cancer events or mortality during a 7.3-year follow-up period.

jama.ama-assn.org/...289 - Preview

2007 July JAMA study clinical_trial rct humans women breast cancer breast_cancer diet nutrition secondary prevention secondary_prevention very high vegetables fruit fiber low-fat low-fat_diet prognosis recurrence medline

"Lisa is one of early success stories: a heart scan score of 447 in her early 40's, modest reduction of CT heart scan score three years ago.

However, Lisa had a difficult time locating oil-based vitamin D. There has, in fact, been a national run on vitamin D and I'm told that even manufacturers are scrambling to keep up with the booming demand. So, she bought tablets instead and was taking 3000 units per day.

She came in for a routine check. Lisa's 25-OH-vitamin D3: 17 ng/ml, signifying severe deficiency, the same as if she were taking nothing at all. (Recall that we aim for 50 ng/ml.)

In other words, vitamin D tablets do not work. It is shameful. I see numerous women taking calcium tablets with D--the vitamin D does not work. I've actually seen blood levels of zero on these preparations. "

heartscanblog.blogspot.com/...tamin-d-must-be-oil-based.html - Preview

2007 March heartscanblog Dr. William Davis blog_article vitamin_D must be an oil-based capsule a gel-cap nutrition

Safety of vitamin D3 in adults with multiple sclerosis.
Kimball SM, Ursell MR, O'Connor P, Vieth R.
Am J Clin Nutr. 2007 Sep;86(3):645-51.
PMID: 17823429

Conclusions: Patients' serum 25(OH)D concentrations reached twice the top of the physiologic range without eliciting hypercalcemia or hypercalciuria. The data support the feasibility of pharmacologic doses of vitamin D3 for clinical research, and they provide objective evidence that vitamin D intake beyond the current upper limit is safe by a large margin.

www.ajcn.org/...645 - Preview

2007 September ajcn study research Vieth vitamin_D clinical_trial humans patients high dose doses multiple sclerosis multiple_sclerosis MS nutrition high_dose high_doses high-dose calcium supplementation dose-escalation safety safe 25ohd pharmacological

Effectiveness and safety of vitamin D in relation to bone health.
Cranney A, Horsley T, O'Donnell S, Weiler H, Puil L, Ooi D, Atkinson S, Ward L, Moher D, Hanley D, Fang M, Yazdi F, Garritty C, Sampson M, Barrowman N, Tsertsvadze A, Mamaladze V.
Evid Rep Technol Assess (Full Rep). 2007 Aug;(158):1-235. Review.
PMID: 18088161

www.ncbi.nlm.nih.gov/...18088161 - Preview

2007 August study review vitamin_D effectiveness efficacy safety bone health bone_health osteoporosis nutrition medline evidence report reports technology assessessment

A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease.
Lindeberg S, Jönsson T, Granfeldt Y, Borgstrand E, Soffman J, Sjöström K, Ahrén B.
Diabetologia. 2007 Sep;50(9):1795-807. Epub 2007 Jun 22.
PMID: 17583796
DOI: 10.1007/s00125-007-0716-y

Conclusions/interpretation A Palaeolithic diet may improve glucose tolerance independently of decreased waist circumference.

www.springerlink.com/...h7628r66r0552222 - Preview

2007 September Diabetologia study research clinical_trial rct humans paleolithic diet paleolithic_diet Mediterranean Mediterranean_diet comparison glucose tolerance glucose_tolerance type_2 diabetes intolerance evolution nutition CVD CHD IHD medline

Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis.
Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, Oikawa S, Sasaki J, Hishida H, Itakura H, Kita T, Kitabatake A, Nakaya N, Sakata T, Shimada K, Shirato K; Japan EPA lipid intervention study (JELIS) Investigators.
Lancet. 2007 Mar 31;369(9567):1090-8. Erratum in: Lancet. 2007 Jul 21;370(9583):220.
PMID: 17398308
doi:10.1016/S0140-6736(07)60527-3

Interpretation
EPA is a promising treatment for prevention of major coronary events, and especially non-fatal coronary events, in Japanese hypercholesterolaemic patients

www.thelancet.com/...abstract - Preview

2007 March Lancet study research clinical_trial rct JELIS humans omega-3 EPA Japan nutrition medline CVD CHD prevention major coronary events hypercholesterolemic patients

Omega 3 fatty acids and the brain: review of studies in depression.
Sinclair AJ, Begg D, Mathai M, Weisinger RS.
Asia Pac J Clin Nutr. 2007;16 Suppl 1:391-7. Review.
PMID: 17392137

This paper discusses the clinical studies conducted in the area of depression and omega 3 PUFA and the possible mechanisms of action of these PUFA. It is clear from the literature that DHA is involved in a variety of processes in neural cells and that its role is far more complex than simply influencing cell membrane properties.

www.biovita.fi/...Sinclair2007.pdf - Preview

2007 study review humans omega-3 brain depression DHA E-EPA EPA membrane function dopamine BDNF AA turnover omega-6 nutrition medline